Lipid composition of normal male rat islets

Autores
Díaz, Graciela; Cortizo, Ana María; García, María Elisa; Gagliardino, Juan José
Año de publicación
1988
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Lipid composition was studied in fresh isolated isolets from normal male rats. Extractable lipids represent 1856 μg per mg islet protein. In such extracts, phospholipids and neutral lipids reprsent 13.5% and 86.5%, respectively. Phosphatidylcholine (45.8%) and phosphatidyl-ethanolamine (20.6%) were the major components of the phospholipid fraction, and phosphatidylinositol (8.9%) was the minor component. Esterified cholesterol (38.5%), cholesterol (25.5%) and free fatty acids (24.4%) were the major components of the neutral lipid fraction. Fatty major components of the neutral lipid fraction. Fatty acids esterified to phospholipids account for 619.7 pmol/islet, and, 2710 pmol/islet were esterified to neutral lipids. In the phospholipid fraction, saturated and unsaturated fatty acids were in a similar proportion. Conversely, in the neutral lipids, two-thirds of the fatty acids were unsaturated. The ω6 family was the main component of the phospholipid unsaturated fatty acids. In the ω6 and ω3 families, the long-chain fatty acids represent the main components. In the neutral lipid fraction, a different percentage of each family was found: ω3>ω6>ω9. The long-chain polyunsaturated fatty acids were also predominant species in the ω6 and ω3 families. Further studies on the lipid composition of islets, obtained from rats with normal and altered islet functions, could provide new insights into the knowledge of the mechanism of insulin secretion.
Facultad de Ciencias Médicas
Materia
Ciencias Médicas
Lípidos
Páncreas
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/76582

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oai_identifier_str oai:sedici.unlp.edu.ar:10915/76582
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network_name_str SEDICI (UNLP)
spelling Lipid composition of normal male rat isletsDíaz, GracielaCortizo, Ana MaríaGarcía, María ElisaGagliardino, Juan JoséCiencias MédicasLípidosPáncreasLipid composition was studied in fresh isolated isolets from normal male rats. Extractable lipids represent 1856 μg per mg islet protein. In such extracts, phospholipids and neutral lipids reprsent 13.5% and 86.5%, respectively. Phosphatidylcholine (45.8%) and phosphatidyl-ethanolamine (20.6%) were the major components of the phospholipid fraction, and phosphatidylinositol (8.9%) was the minor component. Esterified cholesterol (38.5%), cholesterol (25.5%) and free fatty acids (24.4%) were the major components of the neutral lipid fraction. Fatty major components of the neutral lipid fraction. Fatty acids esterified to phospholipids account for 619.7 pmol/islet, and, 2710 pmol/islet were esterified to neutral lipids. In the phospholipid fraction, saturated and unsaturated fatty acids were in a similar proportion. Conversely, in the neutral lipids, two-thirds of the fatty acids were unsaturated. The ω6 family was the main component of the phospholipid unsaturated fatty acids. In the ω6 and ω3 families, the long-chain fatty acids represent the main components. In the neutral lipid fraction, a different percentage of each family was found: ω3>ω6>ω9. The long-chain polyunsaturated fatty acids were also predominant species in the ω6 and ω3 families. Further studies on the lipid composition of islets, obtained from rats with normal and altered islet functions, could provide new insights into the knowledge of the mechanism of insulin secretion.Facultad de Ciencias Médicas1988info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1125-1128http://sedici.unlp.edu.ar/handle/10915/76582enginfo:eu-repo/semantics/altIdentifier/hdl/11746/4541info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:13:30Zoai:sedici.unlp.edu.ar:10915/76582Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:13:30.759SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Lipid composition of normal male rat islets
title Lipid composition of normal male rat islets
spellingShingle Lipid composition of normal male rat islets
Díaz, Graciela
Ciencias Médicas
Lípidos
Páncreas
title_short Lipid composition of normal male rat islets
title_full Lipid composition of normal male rat islets
title_fullStr Lipid composition of normal male rat islets
title_full_unstemmed Lipid composition of normal male rat islets
title_sort Lipid composition of normal male rat islets
dc.creator.none.fl_str_mv Díaz, Graciela
Cortizo, Ana María
García, María Elisa
Gagliardino, Juan José
author Díaz, Graciela
author_facet Díaz, Graciela
Cortizo, Ana María
García, María Elisa
Gagliardino, Juan José
author_role author
author2 Cortizo, Ana María
García, María Elisa
Gagliardino, Juan José
author2_role author
author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Lípidos
Páncreas
topic Ciencias Médicas
Lípidos
Páncreas
dc.description.none.fl_txt_mv Lipid composition was studied in fresh isolated isolets from normal male rats. Extractable lipids represent 1856 μg per mg islet protein. In such extracts, phospholipids and neutral lipids reprsent 13.5% and 86.5%, respectively. Phosphatidylcholine (45.8%) and phosphatidyl-ethanolamine (20.6%) were the major components of the phospholipid fraction, and phosphatidylinositol (8.9%) was the minor component. Esterified cholesterol (38.5%), cholesterol (25.5%) and free fatty acids (24.4%) were the major components of the neutral lipid fraction. Fatty major components of the neutral lipid fraction. Fatty acids esterified to phospholipids account for 619.7 pmol/islet, and, 2710 pmol/islet were esterified to neutral lipids. In the phospholipid fraction, saturated and unsaturated fatty acids were in a similar proportion. Conversely, in the neutral lipids, two-thirds of the fatty acids were unsaturated. The ω6 family was the main component of the phospholipid unsaturated fatty acids. In the ω6 and ω3 families, the long-chain fatty acids represent the main components. In the neutral lipid fraction, a different percentage of each family was found: ω3>ω6>ω9. The long-chain polyunsaturated fatty acids were also predominant species in the ω6 and ω3 families. Further studies on the lipid composition of islets, obtained from rats with normal and altered islet functions, could provide new insights into the knowledge of the mechanism of insulin secretion.
Facultad de Ciencias Médicas
description Lipid composition was studied in fresh isolated isolets from normal male rats. Extractable lipids represent 1856 μg per mg islet protein. In such extracts, phospholipids and neutral lipids reprsent 13.5% and 86.5%, respectively. Phosphatidylcholine (45.8%) and phosphatidyl-ethanolamine (20.6%) were the major components of the phospholipid fraction, and phosphatidylinositol (8.9%) was the minor component. Esterified cholesterol (38.5%), cholesterol (25.5%) and free fatty acids (24.4%) were the major components of the neutral lipid fraction. Fatty major components of the neutral lipid fraction. Fatty acids esterified to phospholipids account for 619.7 pmol/islet, and, 2710 pmol/islet were esterified to neutral lipids. In the phospholipid fraction, saturated and unsaturated fatty acids were in a similar proportion. Conversely, in the neutral lipids, two-thirds of the fatty acids were unsaturated. The ω6 family was the main component of the phospholipid unsaturated fatty acids. In the ω6 and ω3 families, the long-chain fatty acids represent the main components. In the neutral lipid fraction, a different percentage of each family was found: ω3>ω6>ω9. The long-chain polyunsaturated fatty acids were also predominant species in the ω6 and ω3 families. Further studies on the lipid composition of islets, obtained from rats with normal and altered islet functions, could provide new insights into the knowledge of the mechanism of insulin secretion.
publishDate 1988
dc.date.none.fl_str_mv 1988
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/76582
url http://sedici.unlp.edu.ar/handle/10915/76582
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/hdl/11746/4541
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
1125-1128
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instname:Universidad Nacional de La Plata
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repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
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