The Relation between Protein Malnutrition, Ethanol Consumption and Chromosomal Damage Induced by Cyclophosphamide in Bone Marrow Cells of Mice

Autores
Terreros, M. C.; De Luca, Julio César; Furnus, Cecilia Cristina; Dulout, Fernando Noel
Año de publicación
1995
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The effect of protein malnutrition and alcohol consumption on the yield of chromosomal damage induced by cycloPhosphamide (CP) was studied. Chromosomal damage induced in bone marrow cells of BALB/c mice was established by scoring the frequency of dicentric chromosomes in C-banded slides. Results obtained showed that CP induced a significant increase of chromosomal damage in comparison with untreated mice. In addition, the yield of dicentric chromosomes was higher in mice fed with the hypoproteic diet. The animals which received ethanol in drinking water before treatment with CP exhibited the highest frequency of dicentric chromosomes, with no relation with the diet. Statistical analysis of these results showed the additive effect of diet and CP and are explained taking into account the metabolic pathways of CP as well as the decrease of enzymatic levels and the physiological condition in under-nourished mice.
Facultad de Ciencias Veterinarias
Materia
Bioquímica
Biología
Chromosome
Cyclophosphamide
Diet
Ethanol
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/143574
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/143574
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling The Relation between Protein Malnutrition, Ethanol Consumption and Chromosomal Damage Induced by Cyclophosphamide in Bone Marrow Cells of MiceTerreros, M. C.De Luca, Julio CésarFurnus, Cecilia CristinaDulout, Fernando NoelBioquímicaBiologíaChromosomeCyclophosphamideDietEthanolThe effect of protein malnutrition and alcohol consumption on the yield of chromosomal damage induced by cycloPhosphamide (CP) was studied. Chromosomal damage induced in bone marrow cells of BALB/c mice was established by scoring the frequency of dicentric chromosomes in C-banded slides. Results obtained showed that CP induced a significant increase of chromosomal damage in comparison with untreated mice. In addition, the yield of dicentric chromosomes was higher in mice fed with the hypoproteic diet. The animals which received ethanol in drinking water before treatment with CP exhibited the highest frequency of dicentric chromosomes, with no relation with the diet. Statistical analysis of these results showed the additive effect of diet and CP and are explained taking into account the metabolic pathways of CP as well as the decrease of enzymatic levels and the physiological condition in under-nourished mice.Facultad de Ciencias Veterinarias1995info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf5-8http://sedici.unlp.edu.ar/handle/10915/143574enginfo:eu-repo/semantics/altIdentifier/issn/0916-7250info:eu-repo/semantics/altIdentifier/issn/1347-7439info:eu-repo/semantics/altIdentifier/doi/10.1292/jvms.57.5info:eu-repo/semantics/altIdentifier/pmid/7756424info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T11:04:39Zoai:sedici.unlp.edu.ar:10915/143574Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 11:04:39.448SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv The Relation between Protein Malnutrition, Ethanol Consumption and Chromosomal Damage Induced by Cyclophosphamide in Bone Marrow Cells of Mice
title The Relation between Protein Malnutrition, Ethanol Consumption and Chromosomal Damage Induced by Cyclophosphamide in Bone Marrow Cells of Mice
spellingShingle The Relation between Protein Malnutrition, Ethanol Consumption and Chromosomal Damage Induced by Cyclophosphamide in Bone Marrow Cells of Mice
Terreros, M. C.
Bioquímica
Biología
Chromosome
Cyclophosphamide
Diet
Ethanol
title_short The Relation between Protein Malnutrition, Ethanol Consumption and Chromosomal Damage Induced by Cyclophosphamide in Bone Marrow Cells of Mice
title_full The Relation between Protein Malnutrition, Ethanol Consumption and Chromosomal Damage Induced by Cyclophosphamide in Bone Marrow Cells of Mice
title_fullStr The Relation between Protein Malnutrition, Ethanol Consumption and Chromosomal Damage Induced by Cyclophosphamide in Bone Marrow Cells of Mice
title_full_unstemmed The Relation between Protein Malnutrition, Ethanol Consumption and Chromosomal Damage Induced by Cyclophosphamide in Bone Marrow Cells of Mice
title_sort The Relation between Protein Malnutrition, Ethanol Consumption and Chromosomal Damage Induced by Cyclophosphamide in Bone Marrow Cells of Mice
dc.creator.none.fl_str_mv Terreros, M. C.
De Luca, Julio César
Furnus, Cecilia Cristina
Dulout, Fernando Noel
author Terreros, M. C.
author_facet Terreros, M. C.
De Luca, Julio César
Furnus, Cecilia Cristina
Dulout, Fernando Noel
author_role author
author2 De Luca, Julio César
Furnus, Cecilia Cristina
Dulout, Fernando Noel
author2_role author
author
author
dc.subject.none.fl_str_mv Bioquímica
Biología
Chromosome
Cyclophosphamide
Diet
Ethanol
topic Bioquímica
Biología
Chromosome
Cyclophosphamide
Diet
Ethanol
dc.description.none.fl_txt_mv The effect of protein malnutrition and alcohol consumption on the yield of chromosomal damage induced by cycloPhosphamide (CP) was studied. Chromosomal damage induced in bone marrow cells of BALB/c mice was established by scoring the frequency of dicentric chromosomes in C-banded slides. Results obtained showed that CP induced a significant increase of chromosomal damage in comparison with untreated mice. In addition, the yield of dicentric chromosomes was higher in mice fed with the hypoproteic diet. The animals which received ethanol in drinking water before treatment with CP exhibited the highest frequency of dicentric chromosomes, with no relation with the diet. Statistical analysis of these results showed the additive effect of diet and CP and are explained taking into account the metabolic pathways of CP as well as the decrease of enzymatic levels and the physiological condition in under-nourished mice.
Facultad de Ciencias Veterinarias
description The effect of protein malnutrition and alcohol consumption on the yield of chromosomal damage induced by cycloPhosphamide (CP) was studied. Chromosomal damage induced in bone marrow cells of BALB/c mice was established by scoring the frequency of dicentric chromosomes in C-banded slides. Results obtained showed that CP induced a significant increase of chromosomal damage in comparison with untreated mice. In addition, the yield of dicentric chromosomes was higher in mice fed with the hypoproteic diet. The animals which received ethanol in drinking water before treatment with CP exhibited the highest frequency of dicentric chromosomes, with no relation with the diet. Statistical analysis of these results showed the additive effect of diet and CP and are explained taking into account the metabolic pathways of CP as well as the decrease of enzymatic levels and the physiological condition in under-nourished mice.
publishDate 1995
dc.date.none.fl_str_mv 1995
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/143574
url http://sedici.unlp.edu.ar/handle/10915/143574
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0916-7250
info:eu-repo/semantics/altIdentifier/issn/1347-7439
info:eu-repo/semantics/altIdentifier/doi/10.1292/jvms.57.5
info:eu-repo/semantics/altIdentifier/pmid/7756424
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
5-8
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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