Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically...

Autores
Espinel-Ingroff, A.; Chakrabarti, A.; Chowdhary, A.; Córdoba, Susana Beatriz; Dannaoui, E.; Dufresne. P.; Fothergill, A.; Ghannoum, M.; Gonzalez, G. M.; Guarro, J.; Kidd, S.; Lass-Flörl, C.; Meis, J. F.; Pelaez, T.; Tortorano, A. M.; Turnidge, J.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Clinical breakpoints (CBPs) have not been established for the Mucorales and any antifungal agent. In lieu of CBPs, epidemiologic cutoff values (ECVs) are proposed for amphotericin B, posaconazole, and itraconazole and four Mucorales species. Wild-type (WT) MIC distributions (organisms in a species-drug combination with no detectable acquired resistance mechanisms) were defined with available pooled CLSI MICs from 14 laboratories (Argentina, Australia, Canada, Europe, India, Mexico, and the United States) as follows: 10 Apophysomyces variabilis, 32 Cunninghamella bertholletiae, 136 Lichtheimia corymbifera, 10 Mucor indicus, 123 M. circinelloides, 19 M. ramosissimus, 349 Rhizopus arrhizus, 146 R. microsporus, 33 Rhizomucor pusillus, and 36 Syncephalastrum racemosum isolates. CLSI broth microdilution MICs were aggregated for the analyses. ECVs comprising ≥95% and ≥97.5% of the modeled populations were as follows: amphotericin B ECVs for L. corymbifera were 1 and 2 μg/ml, those for M. circinelloides were 1 and 2 μg/ml, those for R. arrhizus were 2 and 4 μg/ml, and those for R. microsporus were 2 and 2 μg/ml, respectively; posaconazole ECVs for L. corymbifera were 1 and 2, those for M. circinelloides were 4 and 4, those for R. arrhizus were 1 and 2, and those for R. microsporus were 1 and 2, respectively; both itraconazole ECVs for R. arrhizus were 2 μg/ml. ECVs may aid in detecting emerging resistance or isolates with reduced susceptibility (non-WT MICs) to the agents evaluated.
Facultad de Ciencias Veterinarias
Materia
Ciencias Médicas
Biología
Mucorales
epidemiologic cutoff values
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/146772

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network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of <i>Mucorales</i>Espinel-Ingroff, A.Chakrabarti, A.Chowdhary, A.Córdoba, Susana BeatrizDannaoui, E.Dufresne. P.Fothergill, A.Ghannoum, M.Gonzalez, G. M.Guarro, J.Kidd, S.Lass-Flörl, C.Meis, J. F.Pelaez, T.Tortorano, A. M.Turnidge, J.Ciencias MédicasBiologíaMucoralesepidemiologic cutoff valuesClinical breakpoints (CBPs) have not been established for the <i>Mucorales</i> and any antifungal agent. In lieu of CBPs, epidemiologic cutoff values (ECVs) are proposed for amphotericin B, posaconazole, and itraconazole and four <i>Mucorales</i> species. Wild-type (WT) MIC distributions (organisms in a species-drug combination with no detectable acquired resistance mechanisms) were defined with available pooled CLSI MICs from 14 laboratories (Argentina, Australia, Canada, Europe, India, Mexico, and the United States) as follows: 10 <i>Apophysomyces variabilis</i>, 32 <i>Cunninghamella bertholletiae</i>, 136 <i>Lichtheimia corymbifera</i>, 10 <i>Mucor indicus</i>, 123 <i>M. circinelloides</i>, 19 <i>M. ramosissimus</i>, 349 <i>Rhizopus arrhizus</i>, 146 <i>R. microsporus</i>, 33 <i>Rhizomucor pusillus</i>, and 36 <i>Syncephalastrum racemosum</i> isolates. CLSI broth microdilution MICs were aggregated for the analyses. ECVs comprising ≥95% and ≥97.5% of the modeled populations were as follows: amphotericin B ECVs for <i>L. corymbifera</i> were 1 and 2 μg/ml, those for <i>M. circinelloides</i> were 1 and 2 μg/ml, those for <i>R. arrhizus</i> were 2 and 4 μg/ml, and those for <i>R. microsporus</i> were 2 and 2 μg/ml, respectively; posaconazole ECVs for <i>L. corymbifera</i> were 1 and 2, those for <i>M. circinelloides</i> were 4 and 4, those for <i>R. arrhizus</i> were 1 and 2, and those for <i>R. microsporus</i> were 1 and 2, respectively; both itraconazole ECVs for <i>R. arrhizus</i> were 2 μg/ml. ECVs may aid in detecting emerging resistance or isolates with reduced susceptibility (non-WT MICs) to the agents evaluated.Facultad de Ciencias Veterinarias2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1745-1750http://sedici.unlp.edu.ar/handle/10915/146772enginfo:eu-repo/semantics/altIdentifier/issn/0066-4804info:eu-repo/semantics/altIdentifier/issn/1098-6596info:eu-repo/semantics/altIdentifier/doi/10.1128/aac.04435-14info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:37:28Zoai:sedici.unlp.edu.ar:10915/146772Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:37:28.545SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of <i>Mucorales</i>
title Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of <i>Mucorales</i>
spellingShingle Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of <i>Mucorales</i>
Espinel-Ingroff, A.
Ciencias Médicas
Biología
Mucorales
epidemiologic cutoff values
title_short Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of <i>Mucorales</i>
title_full Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of <i>Mucorales</i>
title_fullStr Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of <i>Mucorales</i>
title_full_unstemmed Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of <i>Mucorales</i>
title_sort Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of <i>Mucorales</i>
dc.creator.none.fl_str_mv Espinel-Ingroff, A.
Chakrabarti, A.
Chowdhary, A.
Córdoba, Susana Beatriz
Dannaoui, E.
Dufresne. P.
Fothergill, A.
Ghannoum, M.
Gonzalez, G. M.
Guarro, J.
Kidd, S.
Lass-Flörl, C.
Meis, J. F.
Pelaez, T.
Tortorano, A. M.
Turnidge, J.
author Espinel-Ingroff, A.
author_facet Espinel-Ingroff, A.
Chakrabarti, A.
Chowdhary, A.
Córdoba, Susana Beatriz
Dannaoui, E.
Dufresne. P.
Fothergill, A.
Ghannoum, M.
Gonzalez, G. M.
Guarro, J.
Kidd, S.
Lass-Flörl, C.
Meis, J. F.
Pelaez, T.
Tortorano, A. M.
Turnidge, J.
author_role author
author2 Chakrabarti, A.
Chowdhary, A.
Córdoba, Susana Beatriz
Dannaoui, E.
Dufresne. P.
Fothergill, A.
Ghannoum, M.
Gonzalez, G. M.
Guarro, J.
Kidd, S.
Lass-Flörl, C.
Meis, J. F.
Pelaez, T.
Tortorano, A. M.
Turnidge, J.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Biología
Mucorales
epidemiologic cutoff values
topic Ciencias Médicas
Biología
Mucorales
epidemiologic cutoff values
dc.description.none.fl_txt_mv Clinical breakpoints (CBPs) have not been established for the <i>Mucorales</i> and any antifungal agent. In lieu of CBPs, epidemiologic cutoff values (ECVs) are proposed for amphotericin B, posaconazole, and itraconazole and four <i>Mucorales</i> species. Wild-type (WT) MIC distributions (organisms in a species-drug combination with no detectable acquired resistance mechanisms) were defined with available pooled CLSI MICs from 14 laboratories (Argentina, Australia, Canada, Europe, India, Mexico, and the United States) as follows: 10 <i>Apophysomyces variabilis</i>, 32 <i>Cunninghamella bertholletiae</i>, 136 <i>Lichtheimia corymbifera</i>, 10 <i>Mucor indicus</i>, 123 <i>M. circinelloides</i>, 19 <i>M. ramosissimus</i>, 349 <i>Rhizopus arrhizus</i>, 146 <i>R. microsporus</i>, 33 <i>Rhizomucor pusillus</i>, and 36 <i>Syncephalastrum racemosum</i> isolates. CLSI broth microdilution MICs were aggregated for the analyses. ECVs comprising ≥95% and ≥97.5% of the modeled populations were as follows: amphotericin B ECVs for <i>L. corymbifera</i> were 1 and 2 μg/ml, those for <i>M. circinelloides</i> were 1 and 2 μg/ml, those for <i>R. arrhizus</i> were 2 and 4 μg/ml, and those for <i>R. microsporus</i> were 2 and 2 μg/ml, respectively; posaconazole ECVs for <i>L. corymbifera</i> were 1 and 2, those for <i>M. circinelloides</i> were 4 and 4, those for <i>R. arrhizus</i> were 1 and 2, and those for <i>R. microsporus</i> were 1 and 2, respectively; both itraconazole ECVs for <i>R. arrhizus</i> were 2 μg/ml. ECVs may aid in detecting emerging resistance or isolates with reduced susceptibility (non-WT MICs) to the agents evaluated.
Facultad de Ciencias Veterinarias
description Clinical breakpoints (CBPs) have not been established for the <i>Mucorales</i> and any antifungal agent. In lieu of CBPs, epidemiologic cutoff values (ECVs) are proposed for amphotericin B, posaconazole, and itraconazole and four <i>Mucorales</i> species. Wild-type (WT) MIC distributions (organisms in a species-drug combination with no detectable acquired resistance mechanisms) were defined with available pooled CLSI MICs from 14 laboratories (Argentina, Australia, Canada, Europe, India, Mexico, and the United States) as follows: 10 <i>Apophysomyces variabilis</i>, 32 <i>Cunninghamella bertholletiae</i>, 136 <i>Lichtheimia corymbifera</i>, 10 <i>Mucor indicus</i>, 123 <i>M. circinelloides</i>, 19 <i>M. ramosissimus</i>, 349 <i>Rhizopus arrhizus</i>, 146 <i>R. microsporus</i>, 33 <i>Rhizomucor pusillus</i>, and 36 <i>Syncephalastrum racemosum</i> isolates. CLSI broth microdilution MICs were aggregated for the analyses. ECVs comprising ≥95% and ≥97.5% of the modeled populations were as follows: amphotericin B ECVs for <i>L. corymbifera</i> were 1 and 2 μg/ml, those for <i>M. circinelloides</i> were 1 and 2 μg/ml, those for <i>R. arrhizus</i> were 2 and 4 μg/ml, and those for <i>R. microsporus</i> were 2 and 2 μg/ml, respectively; posaconazole ECVs for <i>L. corymbifera</i> were 1 and 2, those for <i>M. circinelloides</i> were 4 and 4, those for <i>R. arrhizus</i> were 1 and 2, and those for <i>R. microsporus</i> were 1 and 2, respectively; both itraconazole ECVs for <i>R. arrhizus</i> were 2 μg/ml. ECVs may aid in detecting emerging resistance or isolates with reduced susceptibility (non-WT MICs) to the agents evaluated.
publishDate 2015
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info:eu-repo/semantics/publishedVersion
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dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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Creative Commons Attribution 4.0 International (CC BY 4.0)
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Creative Commons Attribution 4.0 International (CC BY 4.0)
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