Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically...
- Autores
- Espinel-Ingroff, A.; Chakrabarti, A.; Chowdhary, A.; Córdoba, Susana Beatriz; Dannaoui, E.; Dufresne. P.; Fothergill, A.; Ghannoum, M.; Gonzalez, G. M.; Guarro, J.; Kidd, S.; Lass-Flörl, C.; Meis, J. F.; Pelaez, T.; Tortorano, A. M.; Turnidge, J.
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Clinical breakpoints (CBPs) have not been established for the Mucorales and any antifungal agent. In lieu of CBPs, epidemiologic cutoff values (ECVs) are proposed for amphotericin B, posaconazole, and itraconazole and four Mucorales species. Wild-type (WT) MIC distributions (organisms in a species-drug combination with no detectable acquired resistance mechanisms) were defined with available pooled CLSI MICs from 14 laboratories (Argentina, Australia, Canada, Europe, India, Mexico, and the United States) as follows: 10 Apophysomyces variabilis, 32 Cunninghamella bertholletiae, 136 Lichtheimia corymbifera, 10 Mucor indicus, 123 M. circinelloides, 19 M. ramosissimus, 349 Rhizopus arrhizus, 146 R. microsporus, 33 Rhizomucor pusillus, and 36 Syncephalastrum racemosum isolates. CLSI broth microdilution MICs were aggregated for the analyses. ECVs comprising ≥95% and ≥97.5% of the modeled populations were as follows: amphotericin B ECVs for L. corymbifera were 1 and 2 μg/ml, those for M. circinelloides were 1 and 2 μg/ml, those for R. arrhizus were 2 and 4 μg/ml, and those for R. microsporus were 2 and 2 μg/ml, respectively; posaconazole ECVs for L. corymbifera were 1 and 2, those for M. circinelloides were 4 and 4, those for R. arrhizus were 1 and 2, and those for R. microsporus were 1 and 2, respectively; both itraconazole ECVs for R. arrhizus were 2 μg/ml. ECVs may aid in detecting emerging resistance or isolates with reduced susceptibility (non-WT MICs) to the agents evaluated.
Facultad de Ciencias Veterinarias - Materia
-
Ciencias Médicas
Biología
Mucorales
epidemiologic cutoff values - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/146772
Ver los metadatos del registro completo
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Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of <i>Mucorales</i>Espinel-Ingroff, A.Chakrabarti, A.Chowdhary, A.Córdoba, Susana BeatrizDannaoui, E.Dufresne. P.Fothergill, A.Ghannoum, M.Gonzalez, G. M.Guarro, J.Kidd, S.Lass-Flörl, C.Meis, J. F.Pelaez, T.Tortorano, A. M.Turnidge, J.Ciencias MédicasBiologíaMucoralesepidemiologic cutoff valuesClinical breakpoints (CBPs) have not been established for the <i>Mucorales</i> and any antifungal agent. In lieu of CBPs, epidemiologic cutoff values (ECVs) are proposed for amphotericin B, posaconazole, and itraconazole and four <i>Mucorales</i> species. Wild-type (WT) MIC distributions (organisms in a species-drug combination with no detectable acquired resistance mechanisms) were defined with available pooled CLSI MICs from 14 laboratories (Argentina, Australia, Canada, Europe, India, Mexico, and the United States) as follows: 10 <i>Apophysomyces variabilis</i>, 32 <i>Cunninghamella bertholletiae</i>, 136 <i>Lichtheimia corymbifera</i>, 10 <i>Mucor indicus</i>, 123 <i>M. circinelloides</i>, 19 <i>M. ramosissimus</i>, 349 <i>Rhizopus arrhizus</i>, 146 <i>R. microsporus</i>, 33 <i>Rhizomucor pusillus</i>, and 36 <i>Syncephalastrum racemosum</i> isolates. CLSI broth microdilution MICs were aggregated for the analyses. ECVs comprising ≥95% and ≥97.5% of the modeled populations were as follows: amphotericin B ECVs for <i>L. corymbifera</i> were 1 and 2 μg/ml, those for <i>M. circinelloides</i> were 1 and 2 μg/ml, those for <i>R. arrhizus</i> were 2 and 4 μg/ml, and those for <i>R. microsporus</i> were 2 and 2 μg/ml, respectively; posaconazole ECVs for <i>L. corymbifera</i> were 1 and 2, those for <i>M. circinelloides</i> were 4 and 4, those for <i>R. arrhizus</i> were 1 and 2, and those for <i>R. microsporus</i> were 1 and 2, respectively; both itraconazole ECVs for <i>R. arrhizus</i> were 2 μg/ml. ECVs may aid in detecting emerging resistance or isolates with reduced susceptibility (non-WT MICs) to the agents evaluated.Facultad de Ciencias Veterinarias2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1745-1750http://sedici.unlp.edu.ar/handle/10915/146772enginfo:eu-repo/semantics/altIdentifier/issn/0066-4804info:eu-repo/semantics/altIdentifier/issn/1098-6596info:eu-repo/semantics/altIdentifier/doi/10.1128/aac.04435-14info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:37:28Zoai:sedici.unlp.edu.ar:10915/146772Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:37:28.545SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of <i>Mucorales</i> |
title |
Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of <i>Mucorales</i> |
spellingShingle |
Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of <i>Mucorales</i> Espinel-Ingroff, A. Ciencias Médicas Biología Mucorales epidemiologic cutoff values |
title_short |
Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of <i>Mucorales</i> |
title_full |
Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of <i>Mucorales</i> |
title_fullStr |
Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of <i>Mucorales</i> |
title_full_unstemmed |
Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of <i>Mucorales</i> |
title_sort |
Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of <i>Mucorales</i> |
dc.creator.none.fl_str_mv |
Espinel-Ingroff, A. Chakrabarti, A. Chowdhary, A. Córdoba, Susana Beatriz Dannaoui, E. Dufresne. P. Fothergill, A. Ghannoum, M. Gonzalez, G. M. Guarro, J. Kidd, S. Lass-Flörl, C. Meis, J. F. Pelaez, T. Tortorano, A. M. Turnidge, J. |
author |
Espinel-Ingroff, A. |
author_facet |
Espinel-Ingroff, A. Chakrabarti, A. Chowdhary, A. Córdoba, Susana Beatriz Dannaoui, E. Dufresne. P. Fothergill, A. Ghannoum, M. Gonzalez, G. M. Guarro, J. Kidd, S. Lass-Flörl, C. Meis, J. F. Pelaez, T. Tortorano, A. M. Turnidge, J. |
author_role |
author |
author2 |
Chakrabarti, A. Chowdhary, A. Córdoba, Susana Beatriz Dannaoui, E. Dufresne. P. Fothergill, A. Ghannoum, M. Gonzalez, G. M. Guarro, J. Kidd, S. Lass-Flörl, C. Meis, J. F. Pelaez, T. Tortorano, A. M. Turnidge, J. |
author2_role |
author author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Ciencias Médicas Biología Mucorales epidemiologic cutoff values |
topic |
Ciencias Médicas Biología Mucorales epidemiologic cutoff values |
dc.description.none.fl_txt_mv |
Clinical breakpoints (CBPs) have not been established for the <i>Mucorales</i> and any antifungal agent. In lieu of CBPs, epidemiologic cutoff values (ECVs) are proposed for amphotericin B, posaconazole, and itraconazole and four <i>Mucorales</i> species. Wild-type (WT) MIC distributions (organisms in a species-drug combination with no detectable acquired resistance mechanisms) were defined with available pooled CLSI MICs from 14 laboratories (Argentina, Australia, Canada, Europe, India, Mexico, and the United States) as follows: 10 <i>Apophysomyces variabilis</i>, 32 <i>Cunninghamella bertholletiae</i>, 136 <i>Lichtheimia corymbifera</i>, 10 <i>Mucor indicus</i>, 123 <i>M. circinelloides</i>, 19 <i>M. ramosissimus</i>, 349 <i>Rhizopus arrhizus</i>, 146 <i>R. microsporus</i>, 33 <i>Rhizomucor pusillus</i>, and 36 <i>Syncephalastrum racemosum</i> isolates. CLSI broth microdilution MICs were aggregated for the analyses. ECVs comprising ≥95% and ≥97.5% of the modeled populations were as follows: amphotericin B ECVs for <i>L. corymbifera</i> were 1 and 2 μg/ml, those for <i>M. circinelloides</i> were 1 and 2 μg/ml, those for <i>R. arrhizus</i> were 2 and 4 μg/ml, and those for <i>R. microsporus</i> were 2 and 2 μg/ml, respectively; posaconazole ECVs for <i>L. corymbifera</i> were 1 and 2, those for <i>M. circinelloides</i> were 4 and 4, those for <i>R. arrhizus</i> were 1 and 2, and those for <i>R. microsporus</i> were 1 and 2, respectively; both itraconazole ECVs for <i>R. arrhizus</i> were 2 μg/ml. ECVs may aid in detecting emerging resistance or isolates with reduced susceptibility (non-WT MICs) to the agents evaluated. Facultad de Ciencias Veterinarias |
description |
Clinical breakpoints (CBPs) have not been established for the <i>Mucorales</i> and any antifungal agent. In lieu of CBPs, epidemiologic cutoff values (ECVs) are proposed for amphotericin B, posaconazole, and itraconazole and four <i>Mucorales</i> species. Wild-type (WT) MIC distributions (organisms in a species-drug combination with no detectable acquired resistance mechanisms) were defined with available pooled CLSI MICs from 14 laboratories (Argentina, Australia, Canada, Europe, India, Mexico, and the United States) as follows: 10 <i>Apophysomyces variabilis</i>, 32 <i>Cunninghamella bertholletiae</i>, 136 <i>Lichtheimia corymbifera</i>, 10 <i>Mucor indicus</i>, 123 <i>M. circinelloides</i>, 19 <i>M. ramosissimus</i>, 349 <i>Rhizopus arrhizus</i>, 146 <i>R. microsporus</i>, 33 <i>Rhizomucor pusillus</i>, and 36 <i>Syncephalastrum racemosum</i> isolates. CLSI broth microdilution MICs were aggregated for the analyses. ECVs comprising ≥95% and ≥97.5% of the modeled populations were as follows: amphotericin B ECVs for <i>L. corymbifera</i> were 1 and 2 μg/ml, those for <i>M. circinelloides</i> were 1 and 2 μg/ml, those for <i>R. arrhizus</i> were 2 and 4 μg/ml, and those for <i>R. microsporus</i> were 2 and 2 μg/ml, respectively; posaconazole ECVs for <i>L. corymbifera</i> were 1 and 2, those for <i>M. circinelloides</i> were 4 and 4, those for <i>R. arrhizus</i> were 1 and 2, and those for <i>R. microsporus</i> were 1 and 2, respectively; both itraconazole ECVs for <i>R. arrhizus</i> were 2 μg/ml. ECVs may aid in detecting emerging resistance or isolates with reduced susceptibility (non-WT MICs) to the agents evaluated. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/146772 |
url |
http://sedici.unlp.edu.ar/handle/10915/146772 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/altIdentifier/issn/0066-4804 info:eu-repo/semantics/altIdentifier/issn/1098-6596 info:eu-repo/semantics/altIdentifier/doi/10.1128/aac.04435-14 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
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openAccess |
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http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
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application/pdf 1745-1750 |
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SEDICI (UNLP) - Universidad Nacional de La Plata |
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