In vitro activity of combinations of zinc chelators with amphotericin B and posaconazole against six Mucorales species

Autores
Leonardelli, Florencia; Macedo, Daiana; Dudiuk, Catiana Beatriz; Theill, Laura; Cabeza, Matías Sebastián; Gamarra, Soledad; Garcia, Guillermo Manuel
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Mucormycosis is an emerging disease with high mortality rates. Few antifungal drugs are active against Mucorales. Considering the low efficacy of monotherapy, combination-therapy strategies have been described. It is known that fungi are susceptible to zinc deprivation, so we tested the in vitro effect of the zinc chelators clioquinol, phenanthroline, and N,N,N=,N=-tetrakis(2-pyridylmethyl)ethane-1,2-diamine combined with amphotericin B or posaconazole against 25 strains of Mucorales. Clioquinol-posaconazole was the most active combination, although results were strain dependent.
Fil: Leonardelli, Florencia. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Macedo, Daiana. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Dudiuk, Catiana Beatriz. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Theill, Laura. Universidad Nacional del Litoral; Argentina
Fil: Cabeza, Matías Sebastián. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Gamarra, Soledad. Universidad Nacional del Litoral; Argentina
Fil: Garcia, Guillermo Manuel. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Materia
ANTIFUNGAL SUSCEPTIBILITY TESTING
MUCORALES
POSACONAZOLE
ZINC CHELATORS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/152585
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/152585
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling In vitro activity of combinations of zinc chelators with amphotericin B and posaconazole against six Mucorales speciesLeonardelli, FlorenciaMacedo, DaianaDudiuk, Catiana BeatrizTheill, LauraCabeza, Matías SebastiánGamarra, SoledadGarcia, Guillermo ManuelANTIFUNGAL SUSCEPTIBILITY TESTINGMUCORALESPOSACONAZOLEZINC CHELATORShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Mucormycosis is an emerging disease with high mortality rates. Few antifungal drugs are active against Mucorales. Considering the low efficacy of monotherapy, combination-therapy strategies have been described. It is known that fungi are susceptible to zinc deprivation, so we tested the in vitro effect of the zinc chelators clioquinol, phenanthroline, and N,N,N=,N=-tetrakis(2-pyridylmethyl)ethane-1,2-diamine combined with amphotericin B or posaconazole against 25 strains of Mucorales. Clioquinol-posaconazole was the most active combination, although results were strain dependent.Fil: Leonardelli, Florencia. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Macedo, Daiana. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Dudiuk, Catiana Beatriz. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Theill, Laura. Universidad Nacional del Litoral; ArgentinaFil: Cabeza, Matías Sebastián. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Gamarra, Soledad. Universidad Nacional del Litoral; ArgentinaFil: Garcia, Guillermo Manuel. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaAmerican Society for Microbiology2019-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/152585Leonardelli, Florencia; Macedo, Daiana; Dudiuk, Catiana Beatriz; Theill, Laura; Cabeza, Matías Sebastián; et al.; In vitro activity of combinations of zinc chelators with amphotericin B and posaconazole against six Mucorales species; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 63; 5; 5-2019; 1-130066-4804CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://aac.asm.org/content/63/5/e00266-19.longinfo:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.00266-19info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:46:56Zoai:ri.conicet.gov.ar:11336/152585instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:46:56.379CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv In vitro activity of combinations of zinc chelators with amphotericin B and posaconazole against six Mucorales species
title In vitro activity of combinations of zinc chelators with amphotericin B and posaconazole against six Mucorales species
spellingShingle In vitro activity of combinations of zinc chelators with amphotericin B and posaconazole against six Mucorales species
Leonardelli, Florencia
ANTIFUNGAL SUSCEPTIBILITY TESTING
MUCORALES
POSACONAZOLE
ZINC CHELATORS
title_short In vitro activity of combinations of zinc chelators with amphotericin B and posaconazole against six Mucorales species
title_full In vitro activity of combinations of zinc chelators with amphotericin B and posaconazole against six Mucorales species
title_fullStr In vitro activity of combinations of zinc chelators with amphotericin B and posaconazole against six Mucorales species
title_full_unstemmed In vitro activity of combinations of zinc chelators with amphotericin B and posaconazole against six Mucorales species
title_sort In vitro activity of combinations of zinc chelators with amphotericin B and posaconazole against six Mucorales species
dc.creator.none.fl_str_mv Leonardelli, Florencia
Macedo, Daiana
Dudiuk, Catiana Beatriz
Theill, Laura
Cabeza, Matías Sebastián
Gamarra, Soledad
Garcia, Guillermo Manuel
author Leonardelli, Florencia
author_facet Leonardelli, Florencia
Macedo, Daiana
Dudiuk, Catiana Beatriz
Theill, Laura
Cabeza, Matías Sebastián
Gamarra, Soledad
Garcia, Guillermo Manuel
author_role author
author2 Macedo, Daiana
Dudiuk, Catiana Beatriz
Theill, Laura
Cabeza, Matías Sebastián
Gamarra, Soledad
Garcia, Guillermo Manuel
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ANTIFUNGAL SUSCEPTIBILITY TESTING
MUCORALES
POSACONAZOLE
ZINC CHELATORS
topic ANTIFUNGAL SUSCEPTIBILITY TESTING
MUCORALES
POSACONAZOLE
ZINC CHELATORS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Mucormycosis is an emerging disease with high mortality rates. Few antifungal drugs are active against Mucorales. Considering the low efficacy of monotherapy, combination-therapy strategies have been described. It is known that fungi are susceptible to zinc deprivation, so we tested the in vitro effect of the zinc chelators clioquinol, phenanthroline, and N,N,N=,N=-tetrakis(2-pyridylmethyl)ethane-1,2-diamine combined with amphotericin B or posaconazole against 25 strains of Mucorales. Clioquinol-posaconazole was the most active combination, although results were strain dependent.
Fil: Leonardelli, Florencia. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Macedo, Daiana. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Dudiuk, Catiana Beatriz. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Theill, Laura. Universidad Nacional del Litoral; Argentina
Fil: Cabeza, Matías Sebastián. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Gamarra, Soledad. Universidad Nacional del Litoral; Argentina
Fil: Garcia, Guillermo Manuel. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
description Mucormycosis is an emerging disease with high mortality rates. Few antifungal drugs are active against Mucorales. Considering the low efficacy of monotherapy, combination-therapy strategies have been described. It is known that fungi are susceptible to zinc deprivation, so we tested the in vitro effect of the zinc chelators clioquinol, phenanthroline, and N,N,N=,N=-tetrakis(2-pyridylmethyl)ethane-1,2-diamine combined with amphotericin B or posaconazole against 25 strains of Mucorales. Clioquinol-posaconazole was the most active combination, although results were strain dependent.
publishDate 2019
dc.date.none.fl_str_mv 2019-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/152585
Leonardelli, Florencia; Macedo, Daiana; Dudiuk, Catiana Beatriz; Theill, Laura; Cabeza, Matías Sebastián; et al.; In vitro activity of combinations of zinc chelators with amphotericin B and posaconazole against six Mucorales species; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 63; 5; 5-2019; 1-13
0066-4804
CONICET Digital
CONICET
url http://hdl.handle.net/11336/152585
identifier_str_mv Leonardelli, Florencia; Macedo, Daiana; Dudiuk, Catiana Beatriz; Theill, Laura; Cabeza, Matías Sebastián; et al.; In vitro activity of combinations of zinc chelators with amphotericin B and posaconazole against six Mucorales species; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 63; 5; 5-2019; 1-13
0066-4804
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://aac.asm.org/content/63/5/e00266-19.long
info:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.00266-19
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614512224763904
score 13.070432

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