Data related to inflammation and cholesterol deposition triggered by macrophages exposition to modified LDL

Autores
Toledo, Juan; Esteve, Montserrat; Grasa, Mar; Ledda, Angelo; Garda, Horacio Alberto; Gulfo, José; Díaz Ludovico, Ivo; Ramella, Nahuel Alberto; González, Marina Cecilia
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This article supports experimental evidence on the time-dependent effect on gene expression related to inflammation and cholesterol deposition in lipid-loaded cells. The cells employed were human monocytes THP1 line transformed into macrophages by treatment with phorbol esters. Macrophages were treated at different times with oxidized low density lipoprotein (Ox-LDL) and then gene expression was measured. We also include data about the different types of oxidized lipoprotein obtained (low, media or high oxidation) for differential exposure with Cu ions. These data include characterization to lipid and protein peroxidative damage and also quantification of cell viability by exposure to native and modified LDL. The present article complements data published in "Decreased OxLDL uptake and cholesterol efflux in THP1 cells elicited by cortisol and by cortisone through 11β-hydroxysteroid dehydrogenase type 1" Ledda et al. (in press) [. 1].
Instituto de Investigaciones Bioquímicas de La Plata
Materia
Ciencias Médicas
Cell viability
Low density lipoprotein
Macrophages
Peroxidative damage
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/85990
Acceder
id SEDICI_133c5131befebd8ff70000ebdb4b609a
oai_identifier_str oai:sedici.unlp.edu.ar:10915/85990
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Data related to inflammation and cholesterol deposition triggered by macrophages exposition to modified LDLToledo, JuanEsteve, MontserratGrasa, MarLedda, AngeloGarda, Horacio AlbertoGulfo, JoséDíaz Ludovico, IvoRamella, Nahuel AlbertoGonzález, Marina CeciliaCiencias MédicasCell viabilityLow density lipoproteinMacrophagesPeroxidative damageThis article supports experimental evidence on the time-dependent effect on gene expression related to inflammation and cholesterol deposition in lipid-loaded cells. The cells employed were human monocytes THP1 line transformed into macrophages by treatment with phorbol esters. Macrophages were treated at different times with oxidized low density lipoprotein (Ox-LDL) and then gene expression was measured. We also include data about the different types of oxidized lipoprotein obtained (low, media or high oxidation) for differential exposure with Cu ions. These data include characterization to lipid and protein peroxidative damage and also quantification of cell viability by exposure to native and modified LDL. The present article complements data published in "Decreased OxLDL uptake and cholesterol efflux in THP1 cells elicited by cortisol and by cortisone through 11β-hydroxysteroid dehydrogenase type 1" Ledda et al. (in press) [. 1].Instituto de Investigaciones Bioquímicas de La Plata2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf251-257http://sedici.unlp.edu.ar/handle/10915/85990enginfo:eu-repo/semantics/altIdentifier/issn/2352-3409info:eu-repo/semantics/altIdentifier/doi/10.1016/j.dib.2016.05.046info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-22T16:57:33Zoai:sedici.unlp.edu.ar:10915/85990Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-22 16:57:33.446SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Data related to inflammation and cholesterol deposition triggered by macrophages exposition to modified LDL
title Data related to inflammation and cholesterol deposition triggered by macrophages exposition to modified LDL
spellingShingle Data related to inflammation and cholesterol deposition triggered by macrophages exposition to modified LDL
Toledo, Juan
Ciencias Médicas
Cell viability
Low density lipoprotein
Macrophages
Peroxidative damage
title_short Data related to inflammation and cholesterol deposition triggered by macrophages exposition to modified LDL
title_full Data related to inflammation and cholesterol deposition triggered by macrophages exposition to modified LDL
title_fullStr Data related to inflammation and cholesterol deposition triggered by macrophages exposition to modified LDL
title_full_unstemmed Data related to inflammation and cholesterol deposition triggered by macrophages exposition to modified LDL
title_sort Data related to inflammation and cholesterol deposition triggered by macrophages exposition to modified LDL
dc.creator.none.fl_str_mv Toledo, Juan
Esteve, Montserrat
Grasa, Mar
Ledda, Angelo
Garda, Horacio Alberto
Gulfo, José
Díaz Ludovico, Ivo
Ramella, Nahuel Alberto
González, Marina Cecilia
author Toledo, Juan
author_facet Toledo, Juan
Esteve, Montserrat
Grasa, Mar
Ledda, Angelo
Garda, Horacio Alberto
Gulfo, José
Díaz Ludovico, Ivo
Ramella, Nahuel Alberto
González, Marina Cecilia
author_role author
author2 Esteve, Montserrat
Grasa, Mar
Ledda, Angelo
Garda, Horacio Alberto
Gulfo, José
Díaz Ludovico, Ivo
Ramella, Nahuel Alberto
González, Marina Cecilia
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Cell viability
Low density lipoprotein
Macrophages
Peroxidative damage
topic Ciencias Médicas
Cell viability
Low density lipoprotein
Macrophages
Peroxidative damage
dc.description.none.fl_txt_mv This article supports experimental evidence on the time-dependent effect on gene expression related to inflammation and cholesterol deposition in lipid-loaded cells. The cells employed were human monocytes THP1 line transformed into macrophages by treatment with phorbol esters. Macrophages were treated at different times with oxidized low density lipoprotein (Ox-LDL) and then gene expression was measured. We also include data about the different types of oxidized lipoprotein obtained (low, media or high oxidation) for differential exposure with Cu ions. These data include characterization to lipid and protein peroxidative damage and also quantification of cell viability by exposure to native and modified LDL. The present article complements data published in "Decreased OxLDL uptake and cholesterol efflux in THP1 cells elicited by cortisol and by cortisone through 11β-hydroxysteroid dehydrogenase type 1" Ledda et al. (in press) [. 1].
Instituto de Investigaciones Bioquímicas de La Plata
description This article supports experimental evidence on the time-dependent effect on gene expression related to inflammation and cholesterol deposition in lipid-loaded cells. The cells employed were human monocytes THP1 line transformed into macrophages by treatment with phorbol esters. Macrophages were treated at different times with oxidized low density lipoprotein (Ox-LDL) and then gene expression was measured. We also include data about the different types of oxidized lipoprotein obtained (low, media or high oxidation) for differential exposure with Cu ions. These data include characterization to lipid and protein peroxidative damage and also quantification of cell viability by exposure to native and modified LDL. The present article complements data published in "Decreased OxLDL uptake and cholesterol efflux in THP1 cells elicited by cortisol and by cortisone through 11β-hydroxysteroid dehydrogenase type 1" Ledda et al. (in press) [. 1].
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/85990
url http://sedici.unlp.edu.ar/handle/10915/85990
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/2352-3409
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.dib.2016.05.046
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
251-257
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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