Free cholesterol transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis underlies the U-shape relationship between HDL-cholesterol and cardiovascular disease
- Autores
- Feng, Ma; Darabi, Maryam; Tubeuf, Emilie; Canicio, Aurélie; Lhomme, Marie; Frisdal, Eric; Lanfranchi Lebreton, Sandrine; Matheron, Lucrèce; Rached, Fabiana; Ponnaiah, Maharajah; Serrano, Carlos V.; Santos, Raul D.; Brites, Fernando Daniel; Bolbach, Gerard; Gautier, Emmanuel; Huby, Thierry; Carrie, Alain; Bruckert, Eric; Guerin, Maryse; Couvert, Philippe; Giral, Philippe; Lesnik, Philippe; Le Goff, Wilfried; Guillas, Isabelle; Kontush, Anatol
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background: Low concentrations of high-density lipoprotein cholesterol (HDL-C) represent a well-established cardiovascular risk factor. Paradoxically, extremely high HDL-C levels are equally associated with elevated cardiovascular risk, resulting in the U-shape relationship of HDL-C with cardiovascular disease. Mechanisms underlying this association are presently unknown. We hypothesised that the capacity of high-density lipoprotein (HDL) to acquire free cholesterol upon triglyceride-rich lipoprotein (TGRL) lipolysis by lipoprotein lipase underlies the non-linear relationship between HDL-C and cardiovascular risk. Methods: To assess our hypothesis, we developed a novel assay to evaluate the capacity of HDL to acquire free cholesterol (as fluorescent TopFluor® cholesterol) from TGRL upon in vitro lipolysis by lipoprotein lipase. Results: When the assay was applied to several populations markedly differing in plasma HDL-C levels, transfer of free cholesterol was significantly decreased in low HDL-C patients with acute myocardial infarction (−45%) and type 2 diabetes (–25%), and in subjects with extremely high HDL-C of >2.59 mmol/L (>100 mg/dL) (−20%) versus healthy normolipidaemic controls. When these data were combined and plotted against HDL-C concentrations, an inverse U-shape relationship was observed. Consistent with these findings, animal studies revealed that the capacity of HDL to acquire cholesterol upon lipolysis was reduced in low HDL-C apolipoprotein A-I knock-out mice and was negatively correlated with aortic accumulation of [3H]-cholesterol after oral gavage, attesting this functional characteristic as a negative metric of postprandial atherosclerosis. Conclusions: Free cholesterol transfer to HDL upon TGRL lipolysis may underlie the U-shape relationship between HDL-C and cardiovascular disease, linking HDL-C to triglyceride metabolism and atherosclerosis.
Fil: Feng, Ma. Inserm; Francia. Université Pierre et Marie Curie; Francia
Fil: Darabi, Maryam. Université Pierre et Marie Curie; Francia. Inserm; Francia
Fil: Tubeuf, Emilie. Inserm; Francia. Université Pierre et Marie Curie; Francia
Fil: Canicio, Aurélie. Université Pierre et Marie Curie; Francia. Inserm; Francia
Fil: Lhomme, Marie. Institute Of Cardiometabolism And Nutrition; Francia
Fil: Frisdal, Eric. Inserm; Francia. Université Pierre et Marie Curie; Francia
Fil: Lanfranchi Lebreton, Sandrine. Université Pierre et Marie Curie; Francia
Fil: Matheron, Lucrèce. Université Pierre et Marie Curie; Francia
Fil: Rached, Fabiana. Université Pierre et Marie Curie; Francia. Inserm; Francia
Fil: Ponnaiah, Maharajah. Institute Of Cardiometabolism And Nutrition; Francia
Fil: Serrano, Carlos V.. Instituto Do Coracao Do Hospital Das Clinicas; Brasil
Fil: Santos, Raul D.. Instituto Do Coracao Do Hospital Das Clinicas; Brasil
Fil: Brites, Fernando Daniel. Universidad de Buenos Aires; Argentina. Instituto Do Coracao Do Hospital Das Clinicas; Brasil
Fil: Bolbach, Gerard. Université Pierre et Marie Curie; Francia
Fil: Gautier, Emmanuel. Université Pierre et Marie Curie; Francia. Inserm; Francia
Fil: Huby, Thierry. Inserm; Francia. Université Pierre et Marie Curie; Francia
Fil: Carrie, Alain. Inserm; Francia. Université Pierre et Marie Curie; Francia
Fil: Bruckert, Eric. Inserm; Francia. Université Pierre et Marie Curie; Francia
Fil: Guerin, Maryse. Université Pierre et Marie Curie; Francia. Inserm; Francia
Fil: Couvert, Philippe. Inserm; Francia. Université Pierre et Marie Curie; Francia
Fil: Giral, Philippe. Université Pierre et Marie Curie; Francia. Inserm; Francia
Fil: Lesnik, Philippe. Université Pierre et Marie Curie; Francia. Inserm; Francia
Fil: Le Goff, Wilfried. Université Pierre et Marie Curie; Francia. Inserm; Francia
Fil: Guillas, Isabelle. Inserm; Francia. Université Pierre et Marie Curie; Francia
Fil: Kontush, Anatol. Inserm; Francia. Université Pierre et Marie Curie; Francia - Materia
-
APOLIPOPROTEINS
ATHEROSCLEROSIS
CETP
CHYLOMICRONS
HDL FUNCTION
HDL METABOLISM
LCAT
LIPOPROTEIN LIPASE
LIPOPROTEIN METABOLISM
POSTPRANDIAL LIPID METABOLISM - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/112911
Ver los metadatos del registro completo
| id |
CONICETDig_8c0604f805ce6f96e458b40c15e7bf33 |
|---|---|
| oai_identifier_str |
oai:ri.conicet.gov.ar:11336/112911 |
| network_acronym_str |
CONICETDig |
| repository_id_str |
3498 |
| network_name_str |
CONICET Digital (CONICET) |
| spelling |
Free cholesterol transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis underlies the U-shape relationship between HDL-cholesterol and cardiovascular diseaseFeng, MaDarabi, MaryamTubeuf, EmilieCanicio, AurélieLhomme, MarieFrisdal, EricLanfranchi Lebreton, SandrineMatheron, LucrèceRached, FabianaPonnaiah, MaharajahSerrano, Carlos V.Santos, Raul D.Brites, Fernando DanielBolbach, GerardGautier, EmmanuelHuby, ThierryCarrie, AlainBruckert, EricGuerin, MaryseCouvert, PhilippeGiral, PhilippeLesnik, PhilippeLe Goff, WilfriedGuillas, IsabelleKontush, AnatolAPOLIPOPROTEINSATHEROSCLEROSISCETPCHYLOMICRONSHDL FUNCTIONHDL METABOLISMLCATLIPOPROTEIN LIPASELIPOPROTEIN METABOLISMPOSTPRANDIAL LIPID METABOLISMhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: Low concentrations of high-density lipoprotein cholesterol (HDL-C) represent a well-established cardiovascular risk factor. Paradoxically, extremely high HDL-C levels are equally associated with elevated cardiovascular risk, resulting in the U-shape relationship of HDL-C with cardiovascular disease. Mechanisms underlying this association are presently unknown. We hypothesised that the capacity of high-density lipoprotein (HDL) to acquire free cholesterol upon triglyceride-rich lipoprotein (TGRL) lipolysis by lipoprotein lipase underlies the non-linear relationship between HDL-C and cardiovascular risk. Methods: To assess our hypothesis, we developed a novel assay to evaluate the capacity of HDL to acquire free cholesterol (as fluorescent TopFluor® cholesterol) from TGRL upon in vitro lipolysis by lipoprotein lipase. Results: When the assay was applied to several populations markedly differing in plasma HDL-C levels, transfer of free cholesterol was significantly decreased in low HDL-C patients with acute myocardial infarction (−45%) and type 2 diabetes (–25%), and in subjects with extremely high HDL-C of >2.59 mmol/L (>100 mg/dL) (−20%) versus healthy normolipidaemic controls. When these data were combined and plotted against HDL-C concentrations, an inverse U-shape relationship was observed. Consistent with these findings, animal studies revealed that the capacity of HDL to acquire cholesterol upon lipolysis was reduced in low HDL-C apolipoprotein A-I knock-out mice and was negatively correlated with aortic accumulation of [3H]-cholesterol after oral gavage, attesting this functional characteristic as a negative metric of postprandial atherosclerosis. Conclusions: Free cholesterol transfer to HDL upon TGRL lipolysis may underlie the U-shape relationship between HDL-C and cardiovascular disease, linking HDL-C to triglyceride metabolism and atherosclerosis.Fil: Feng, Ma. Inserm; Francia. Université Pierre et Marie Curie; FranciaFil: Darabi, Maryam. Université Pierre et Marie Curie; Francia. Inserm; FranciaFil: Tubeuf, Emilie. Inserm; Francia. Université Pierre et Marie Curie; FranciaFil: Canicio, Aurélie. Université Pierre et Marie Curie; Francia. Inserm; FranciaFil: Lhomme, Marie. Institute Of Cardiometabolism And Nutrition; FranciaFil: Frisdal, Eric. Inserm; Francia. Université Pierre et Marie Curie; FranciaFil: Lanfranchi Lebreton, Sandrine. Université Pierre et Marie Curie; FranciaFil: Matheron, Lucrèce. Université Pierre et Marie Curie; FranciaFil: Rached, Fabiana. Université Pierre et Marie Curie; Francia. Inserm; FranciaFil: Ponnaiah, Maharajah. Institute Of Cardiometabolism And Nutrition; FranciaFil: Serrano, Carlos V.. Instituto Do Coracao Do Hospital Das Clinicas; BrasilFil: Santos, Raul D.. Instituto Do Coracao Do Hospital Das Clinicas; BrasilFil: Brites, Fernando Daniel. Universidad de Buenos Aires; Argentina. Instituto Do Coracao Do Hospital Das Clinicas; BrasilFil: Bolbach, Gerard. Université Pierre et Marie Curie; FranciaFil: Gautier, Emmanuel. Université Pierre et Marie Curie; Francia. Inserm; FranciaFil: Huby, Thierry. Inserm; Francia. Université Pierre et Marie Curie; FranciaFil: Carrie, Alain. Inserm; Francia. Université Pierre et Marie Curie; FranciaFil: Bruckert, Eric. Inserm; Francia. Université Pierre et Marie Curie; FranciaFil: Guerin, Maryse. Université Pierre et Marie Curie; Francia. Inserm; FranciaFil: Couvert, Philippe. Inserm; Francia. Université Pierre et Marie Curie; FranciaFil: Giral, Philippe. Université Pierre et Marie Curie; Francia. Inserm; FranciaFil: Lesnik, Philippe. Université Pierre et Marie Curie; Francia. Inserm; FranciaFil: Le Goff, Wilfried. Université Pierre et Marie Curie; Francia. Inserm; FranciaFil: Guillas, Isabelle. Inserm; Francia. Université Pierre et Marie Curie; FranciaFil: Kontush, Anatol. Inserm; Francia. Université Pierre et Marie Curie; FranciaSage Publications Ltd2019-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/112911Feng, Ma; Darabi, Maryam; Tubeuf, Emilie; Canicio, Aurélie; Lhomme, Marie; et al.; Free cholesterol transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis underlies the U-shape relationship between HDL-cholesterol and cardiovascular disease; Sage Publications Ltd; European Journal of Preventive Cardiology; 12-2019; 1-112047-4873CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1177/2047487319894114info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/10.1177/2047487319894114info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:45:03Zoai:ri.conicet.gov.ar:11336/112911instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:45:03.522CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Free cholesterol transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis underlies the U-shape relationship between HDL-cholesterol and cardiovascular disease |
| title |
Free cholesterol transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis underlies the U-shape relationship between HDL-cholesterol and cardiovascular disease |
| spellingShingle |
Free cholesterol transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis underlies the U-shape relationship between HDL-cholesterol and cardiovascular disease Feng, Ma APOLIPOPROTEINS ATHEROSCLEROSIS CETP CHYLOMICRONS HDL FUNCTION HDL METABOLISM LCAT LIPOPROTEIN LIPASE LIPOPROTEIN METABOLISM POSTPRANDIAL LIPID METABOLISM |
| title_short |
Free cholesterol transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis underlies the U-shape relationship between HDL-cholesterol and cardiovascular disease |
| title_full |
Free cholesterol transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis underlies the U-shape relationship between HDL-cholesterol and cardiovascular disease |
| title_fullStr |
Free cholesterol transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis underlies the U-shape relationship between HDL-cholesterol and cardiovascular disease |
| title_full_unstemmed |
Free cholesterol transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis underlies the U-shape relationship between HDL-cholesterol and cardiovascular disease |
| title_sort |
Free cholesterol transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis underlies the U-shape relationship between HDL-cholesterol and cardiovascular disease |
| dc.creator.none.fl_str_mv |
Feng, Ma Darabi, Maryam Tubeuf, Emilie Canicio, Aurélie Lhomme, Marie Frisdal, Eric Lanfranchi Lebreton, Sandrine Matheron, Lucrèce Rached, Fabiana Ponnaiah, Maharajah Serrano, Carlos V. Santos, Raul D. Brites, Fernando Daniel Bolbach, Gerard Gautier, Emmanuel Huby, Thierry Carrie, Alain Bruckert, Eric Guerin, Maryse Couvert, Philippe Giral, Philippe Lesnik, Philippe Le Goff, Wilfried Guillas, Isabelle Kontush, Anatol |
| author |
Feng, Ma |
| author_facet |
Feng, Ma Darabi, Maryam Tubeuf, Emilie Canicio, Aurélie Lhomme, Marie Frisdal, Eric Lanfranchi Lebreton, Sandrine Matheron, Lucrèce Rached, Fabiana Ponnaiah, Maharajah Serrano, Carlos V. Santos, Raul D. Brites, Fernando Daniel Bolbach, Gerard Gautier, Emmanuel Huby, Thierry Carrie, Alain Bruckert, Eric Guerin, Maryse Couvert, Philippe Giral, Philippe Lesnik, Philippe Le Goff, Wilfried Guillas, Isabelle Kontush, Anatol |
| author_role |
author |
| author2 |
Darabi, Maryam Tubeuf, Emilie Canicio, Aurélie Lhomme, Marie Frisdal, Eric Lanfranchi Lebreton, Sandrine Matheron, Lucrèce Rached, Fabiana Ponnaiah, Maharajah Serrano, Carlos V. Santos, Raul D. Brites, Fernando Daniel Bolbach, Gerard Gautier, Emmanuel Huby, Thierry Carrie, Alain Bruckert, Eric Guerin, Maryse Couvert, Philippe Giral, Philippe Lesnik, Philippe Le Goff, Wilfried Guillas, Isabelle Kontush, Anatol |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
APOLIPOPROTEINS ATHEROSCLEROSIS CETP CHYLOMICRONS HDL FUNCTION HDL METABOLISM LCAT LIPOPROTEIN LIPASE LIPOPROTEIN METABOLISM POSTPRANDIAL LIPID METABOLISM |
| topic |
APOLIPOPROTEINS ATHEROSCLEROSIS CETP CHYLOMICRONS HDL FUNCTION HDL METABOLISM LCAT LIPOPROTEIN LIPASE LIPOPROTEIN METABOLISM POSTPRANDIAL LIPID METABOLISM |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Background: Low concentrations of high-density lipoprotein cholesterol (HDL-C) represent a well-established cardiovascular risk factor. Paradoxically, extremely high HDL-C levels are equally associated with elevated cardiovascular risk, resulting in the U-shape relationship of HDL-C with cardiovascular disease. Mechanisms underlying this association are presently unknown. We hypothesised that the capacity of high-density lipoprotein (HDL) to acquire free cholesterol upon triglyceride-rich lipoprotein (TGRL) lipolysis by lipoprotein lipase underlies the non-linear relationship between HDL-C and cardiovascular risk. Methods: To assess our hypothesis, we developed a novel assay to evaluate the capacity of HDL to acquire free cholesterol (as fluorescent TopFluor® cholesterol) from TGRL upon in vitro lipolysis by lipoprotein lipase. Results: When the assay was applied to several populations markedly differing in plasma HDL-C levels, transfer of free cholesterol was significantly decreased in low HDL-C patients with acute myocardial infarction (−45%) and type 2 diabetes (–25%), and in subjects with extremely high HDL-C of >2.59 mmol/L (>100 mg/dL) (−20%) versus healthy normolipidaemic controls. When these data were combined and plotted against HDL-C concentrations, an inverse U-shape relationship was observed. Consistent with these findings, animal studies revealed that the capacity of HDL to acquire cholesterol upon lipolysis was reduced in low HDL-C apolipoprotein A-I knock-out mice and was negatively correlated with aortic accumulation of [3H]-cholesterol after oral gavage, attesting this functional characteristic as a negative metric of postprandial atherosclerosis. Conclusions: Free cholesterol transfer to HDL upon TGRL lipolysis may underlie the U-shape relationship between HDL-C and cardiovascular disease, linking HDL-C to triglyceride metabolism and atherosclerosis. Fil: Feng, Ma. Inserm; Francia. Université Pierre et Marie Curie; Francia Fil: Darabi, Maryam. Université Pierre et Marie Curie; Francia. Inserm; Francia Fil: Tubeuf, Emilie. Inserm; Francia. Université Pierre et Marie Curie; Francia Fil: Canicio, Aurélie. Université Pierre et Marie Curie; Francia. Inserm; Francia Fil: Lhomme, Marie. Institute Of Cardiometabolism And Nutrition; Francia Fil: Frisdal, Eric. Inserm; Francia. Université Pierre et Marie Curie; Francia Fil: Lanfranchi Lebreton, Sandrine. Université Pierre et Marie Curie; Francia Fil: Matheron, Lucrèce. Université Pierre et Marie Curie; Francia Fil: Rached, Fabiana. Université Pierre et Marie Curie; Francia. Inserm; Francia Fil: Ponnaiah, Maharajah. Institute Of Cardiometabolism And Nutrition; Francia Fil: Serrano, Carlos V.. Instituto Do Coracao Do Hospital Das Clinicas; Brasil Fil: Santos, Raul D.. Instituto Do Coracao Do Hospital Das Clinicas; Brasil Fil: Brites, Fernando Daniel. Universidad de Buenos Aires; Argentina. Instituto Do Coracao Do Hospital Das Clinicas; Brasil Fil: Bolbach, Gerard. Université Pierre et Marie Curie; Francia Fil: Gautier, Emmanuel. Université Pierre et Marie Curie; Francia. Inserm; Francia Fil: Huby, Thierry. Inserm; Francia. Université Pierre et Marie Curie; Francia Fil: Carrie, Alain. Inserm; Francia. Université Pierre et Marie Curie; Francia Fil: Bruckert, Eric. Inserm; Francia. Université Pierre et Marie Curie; Francia Fil: Guerin, Maryse. Université Pierre et Marie Curie; Francia. Inserm; Francia Fil: Couvert, Philippe. Inserm; Francia. Université Pierre et Marie Curie; Francia Fil: Giral, Philippe. Université Pierre et Marie Curie; Francia. Inserm; Francia Fil: Lesnik, Philippe. Université Pierre et Marie Curie; Francia. Inserm; Francia Fil: Le Goff, Wilfried. Université Pierre et Marie Curie; Francia. Inserm; Francia Fil: Guillas, Isabelle. Inserm; Francia. Université Pierre et Marie Curie; Francia Fil: Kontush, Anatol. Inserm; Francia. Université Pierre et Marie Curie; Francia |
| description |
Background: Low concentrations of high-density lipoprotein cholesterol (HDL-C) represent a well-established cardiovascular risk factor. Paradoxically, extremely high HDL-C levels are equally associated with elevated cardiovascular risk, resulting in the U-shape relationship of HDL-C with cardiovascular disease. Mechanisms underlying this association are presently unknown. We hypothesised that the capacity of high-density lipoprotein (HDL) to acquire free cholesterol upon triglyceride-rich lipoprotein (TGRL) lipolysis by lipoprotein lipase underlies the non-linear relationship between HDL-C and cardiovascular risk. Methods: To assess our hypothesis, we developed a novel assay to evaluate the capacity of HDL to acquire free cholesterol (as fluorescent TopFluor® cholesterol) from TGRL upon in vitro lipolysis by lipoprotein lipase. Results: When the assay was applied to several populations markedly differing in plasma HDL-C levels, transfer of free cholesterol was significantly decreased in low HDL-C patients with acute myocardial infarction (−45%) and type 2 diabetes (–25%), and in subjects with extremely high HDL-C of >2.59 mmol/L (>100 mg/dL) (−20%) versus healthy normolipidaemic controls. When these data were combined and plotted against HDL-C concentrations, an inverse U-shape relationship was observed. Consistent with these findings, animal studies revealed that the capacity of HDL to acquire cholesterol upon lipolysis was reduced in low HDL-C apolipoprotein A-I knock-out mice and was negatively correlated with aortic accumulation of [3H]-cholesterol after oral gavage, attesting this functional characteristic as a negative metric of postprandial atherosclerosis. Conclusions: Free cholesterol transfer to HDL upon TGRL lipolysis may underlie the U-shape relationship between HDL-C and cardiovascular disease, linking HDL-C to triglyceride metabolism and atherosclerosis. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019-12 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/112911 Feng, Ma; Darabi, Maryam; Tubeuf, Emilie; Canicio, Aurélie; Lhomme, Marie; et al.; Free cholesterol transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis underlies the U-shape relationship between HDL-cholesterol and cardiovascular disease; Sage Publications Ltd; European Journal of Preventive Cardiology; 12-2019; 1-11 2047-4873 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/112911 |
| identifier_str_mv |
Feng, Ma; Darabi, Maryam; Tubeuf, Emilie; Canicio, Aurélie; Lhomme, Marie; et al.; Free cholesterol transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis underlies the U-shape relationship between HDL-cholesterol and cardiovascular disease; Sage Publications Ltd; European Journal of Preventive Cardiology; 12-2019; 1-11 2047-4873 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1177/2047487319894114 info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/10.1177/2047487319894114 |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Sage Publications Ltd |
| publisher.none.fl_str_mv |
Sage Publications Ltd |
| dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
| reponame_str |
CONICET Digital (CONICET) |
| collection |
CONICET Digital (CONICET) |
| instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
| _version_ |
1842268706220015616 |
| score |
13.13397 |