Statin Related Myopathy and Vitamin D

• Autores: Mansur, José Luis
• Año de publicación: 2018
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: Medicina; Vitamin D; statins; Statin-Related Myopathy
• Institución: Universidad Nacional de La Plata

Statins are usually safe and well tolerated drugs, very effective for cardiovascular prevention. The presence of myopathy, rare, but with different incidence in different reports, is one of the causes of abandonment of its use. It has begun to report association between decreased vitamin D levels and increased risk of myopathy, on the one hand, and reports where patients who stop statins consumption due to myalgia, with vitamin D deficiency, can tolerate these drugs once the vitamin is supplemented to values desirable Another factor clearly related to myopathy is the presence of polymorphisms in enzyme genes that metabolize or transport statins. As many patients with vitamin D deficiency do not have pain or are completely asymptomatic (with or without statins), we may consider it as a risk factor for developing myopathy due to statins (such as the simultaneous administration of drugs that are metabolized by the same cytochrome P450 pathway, or the presence of mentioned polymorphisms). In conclusion, the finding that having Vitamin D deficiency is associated with statin myopathy, or is a risk factor to develop it, opens new perspectives for a huge number of patients who abandon this treatment due to this condition.
Facultad de Ciencias Médicas