Determinants of Tissue PCO₂ in Shock and Sepsis: Relationship to the Microcirculation
- Autores
- Dubin, Arnaldo; Edul, Vanina Siham Kanoore; Ince, Can
- Año de publicación
- 2009
- Idioma
- español castellano
- Tipo de recurso
- parte de libro
- Estado
- versión publicada
- Descripción
- The development of gastrointestinal tonometry was an important step in the monitoring of tissue dysoxia. It rapidly became a useful tool in basic research. In addition, and for the first time, a regional parameter could be used to detect and to treat hypoperfusion. From an experimental point of view, tonometry adequately tracks intramucosal acidosis, i.e., the increase in intramucosal-arterial PCO2 difference (ΔPCO2). Likewise, the increase in ΔPCO2 is better than other systemic and intestinal variables to show tissue hypoperfusion in normal volunteers and in experimental models. Intramucosal acidosis is a sensitive predictor of gastric and colonic mucosal ischemia. Furthermore, gastric tonometry is an insightful predictor of outcome. This usefulness has been shown in postoperative, critically ill, septic and shock patients. Gastric tonometry might also be used to assess the effect of vasoactive drugs. Finally, intramucosal pH (pHi) has been evaluated as a guide for resuscitation. Gutierrez et al. demonstrated in a randomized controlled trial that pHi-guided therapy could decrease mortality in critically ill patients.
Facultad de Ciencias Médicas - Materia
-
Ciencias Médicas
Microcirculatory perfusion
Venous and Tissue PCO2 - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
.jpg)
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/146227
Ver los metadatos del registro completo
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Determinants of Tissue PCO₂ in Shock and Sepsis: Relationship to the MicrocirculationDubin, ArnaldoEdul, Vanina Siham KanooreInce, CanCiencias MédicasMicrocirculatory perfusionVenous and Tissue PCO2The development of gastrointestinal tonometry was an important step in the monitoring of tissue dysoxia. It rapidly became a useful tool in basic research. In addition, and for the first time, a regional parameter could be used to detect and to treat hypoperfusion. From an experimental point of view, tonometry adequately tracks intramucosal acidosis, i.e., the increase in intramucosal-arterial PCO2 difference (ΔPCO2). Likewise, the increase in ΔPCO2 is better than other systemic and intestinal variables to show tissue hypoperfusion in normal volunteers and in experimental models. Intramucosal acidosis is a sensitive predictor of gastric and colonic mucosal ischemia. Furthermore, gastric tonometry is an insightful predictor of outcome. This usefulness has been shown in postoperative, critically ill, septic and shock patients. Gastric tonometry might also be used to assess the effect of vasoactive drugs. Finally, intramucosal pH (pHi) has been evaluated as a guide for resuscitation. Gutierrez et al. demonstrated in a randomized controlled trial that pHi-guided therapy could decrease mortality in critically ill patients.Facultad de Ciencias MédicasSpringer2009info:eu-repo/semantics/bookPartinfo:eu-repo/semantics/publishedVersionCapitulo de librohttp://purl.org/coar/resource_type/c_3248info:ar-repo/semantics/parteDeLibroapplication/pdf195-204http://sedici.unlp.edu.ar/handle/10915/146227spainfo:eu-repo/semantics/altIdentifier/isbn/978-0-387-92278-2info:eu-repo/semantics/altIdentifier/doi/10.1007/978-0-387-92278-2_19info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T11:04:38Zoai:sedici.unlp.edu.ar:10915/146227Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 11:04:38.41SEDICI (UNLP) - Universidad Nacional de La Platafalse |
| dc.title.none.fl_str_mv |
Determinants of Tissue PCO₂ in Shock and Sepsis: Relationship to the Microcirculation |
| title |
Determinants of Tissue PCO₂ in Shock and Sepsis: Relationship to the Microcirculation |
| spellingShingle |
Determinants of Tissue PCO₂ in Shock and Sepsis: Relationship to the Microcirculation Dubin, Arnaldo Ciencias Médicas Microcirculatory perfusion Venous and Tissue PCO2 |
| title_short |
Determinants of Tissue PCO₂ in Shock and Sepsis: Relationship to the Microcirculation |
| title_full |
Determinants of Tissue PCO₂ in Shock and Sepsis: Relationship to the Microcirculation |
| title_fullStr |
Determinants of Tissue PCO₂ in Shock and Sepsis: Relationship to the Microcirculation |
| title_full_unstemmed |
Determinants of Tissue PCO₂ in Shock and Sepsis: Relationship to the Microcirculation |
| title_sort |
Determinants of Tissue PCO₂ in Shock and Sepsis: Relationship to the Microcirculation |
| dc.creator.none.fl_str_mv |
Dubin, Arnaldo Edul, Vanina Siham Kanoore Ince, Can |
| author |
Dubin, Arnaldo |
| author_facet |
Dubin, Arnaldo Edul, Vanina Siham Kanoore Ince, Can |
| author_role |
author |
| author2 |
Edul, Vanina Siham Kanoore Ince, Can |
| author2_role |
author author |
| dc.subject.none.fl_str_mv |
Ciencias Médicas Microcirculatory perfusion Venous and Tissue PCO2 |
| topic |
Ciencias Médicas Microcirculatory perfusion Venous and Tissue PCO2 |
| dc.description.none.fl_txt_mv |
The development of gastrointestinal tonometry was an important step in the monitoring of tissue dysoxia. It rapidly became a useful tool in basic research. In addition, and for the first time, a regional parameter could be used to detect and to treat hypoperfusion. From an experimental point of view, tonometry adequately tracks intramucosal acidosis, i.e., the increase in intramucosal-arterial PCO2 difference (ΔPCO2). Likewise, the increase in ΔPCO2 is better than other systemic and intestinal variables to show tissue hypoperfusion in normal volunteers and in experimental models. Intramucosal acidosis is a sensitive predictor of gastric and colonic mucosal ischemia. Furthermore, gastric tonometry is an insightful predictor of outcome. This usefulness has been shown in postoperative, critically ill, septic and shock patients. Gastric tonometry might also be used to assess the effect of vasoactive drugs. Finally, intramucosal pH (pHi) has been evaluated as a guide for resuscitation. Gutierrez et al. demonstrated in a randomized controlled trial that pHi-guided therapy could decrease mortality in critically ill patients. Facultad de Ciencias Médicas |
| description |
The development of gastrointestinal tonometry was an important step in the monitoring of tissue dysoxia. It rapidly became a useful tool in basic research. In addition, and for the first time, a regional parameter could be used to detect and to treat hypoperfusion. From an experimental point of view, tonometry adequately tracks intramucosal acidosis, i.e., the increase in intramucosal-arterial PCO2 difference (ΔPCO2). Likewise, the increase in ΔPCO2 is better than other systemic and intestinal variables to show tissue hypoperfusion in normal volunteers and in experimental models. Intramucosal acidosis is a sensitive predictor of gastric and colonic mucosal ischemia. Furthermore, gastric tonometry is an insightful predictor of outcome. This usefulness has been shown in postoperative, critically ill, septic and shock patients. Gastric tonometry might also be used to assess the effect of vasoactive drugs. Finally, intramucosal pH (pHi) has been evaluated as a guide for resuscitation. Gutierrez et al. demonstrated in a randomized controlled trial that pHi-guided therapy could decrease mortality in critically ill patients. |
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2009 |
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2009 |
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