Regional research priorities in brain and nervous system disorders

Autores
Ravindranath, Vijayalakshmi; Dang, Hoang-Minh; Goya, Rodolfo Gustavo; Mansour, Hader; Nimgaonkar, Vishwajit L.; Russell, Vivienne Ann; Xin, Yu
Año de publicación
2015
Idioma
inglés
Tipo de recurso
reseña artículo
Estado
versión publicada
Descripción
The characteristics of neurological, psychiatric, developmental and substance-use disorders in low-and middle-income countries are unique and the burden that they have will be different from country to country. Many of the differences are explained by the wide variation in population demographics and size, poverty, conflict, culture, land area and quality, and genetics. Neurological, psychiatric, developmental and substance-use disorders that result from, or are worsened by, a lack of adequate nutrition and infectious disease still afflict much of sub-Saharan Africa, although disorders related to increasing longevity, such as stroke, are on the rise. In the Middle East and North Africa, major depressive disorders and post-traumatic stress disorder are a primary concern because of the conflict-ridden environment. Consanguinity is a serious concern that leads to the high prevalence of recessive disorders in the Middle East and North Africa and possibly other regions. The burden of these disorders in Latin American and Asian countries largely surrounds stroke and vascular disease, dementia and lifestyle factors that are influenced by genetics. Although much knowledge has been gained over the past 10 years, the epidemiology of the conditions in low-and middle-income countries still needs more research. Prevention and treatments could be better informed with more longitudinal studies of risk factors. Challenges and opportunities for ameliorating nervous-system disorders can benefit from both local and regional research collaborations. The lack of resources and infrastructure for health-care and related research, both in terms of personnel and equipment, along with the stigma associated with the physical or behavioural manifestations of some disorders have hampered progress in understanding the disease burden and improving brain health. Individual countries, and regions within countries, have specific needs in terms of research priorities.
Instituto de Investigaciones Bioquímicas de La Plata
Materia
Ciencias Médicas
Nervous system disorders
Substance-use disorders
Biomedical Research
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/86398

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spelling Regional research priorities in brain and nervous system disordersRavindranath, VijayalakshmiDang, Hoang-MinhGoya, Rodolfo GustavoMansour, HaderNimgaonkar, Vishwajit L.Russell, Vivienne AnnXin, YuCiencias MédicasNervous system disordersSubstance-use disordersBiomedical ResearchThe characteristics of neurological, psychiatric, developmental and substance-use disorders in low-and middle-income countries are unique and the burden that they have will be different from country to country. Many of the differences are explained by the wide variation in population demographics and size, poverty, conflict, culture, land area and quality, and genetics. Neurological, psychiatric, developmental and substance-use disorders that result from, or are worsened by, a lack of adequate nutrition and infectious disease still afflict much of sub-Saharan Africa, although disorders related to increasing longevity, such as stroke, are on the rise. In the Middle East and North Africa, major depressive disorders and post-traumatic stress disorder are a primary concern because of the conflict-ridden environment. Consanguinity is a serious concern that leads to the high prevalence of recessive disorders in the Middle East and North Africa and possibly other regions. The burden of these disorders in Latin American and Asian countries largely surrounds stroke and vascular disease, dementia and lifestyle factors that are influenced by genetics. Although much knowledge has been gained over the past 10 years, the epidemiology of the conditions in low-and middle-income countries still needs more research. Prevention and treatments could be better informed with more longitudinal studies of risk factors. Challenges and opportunities for ameliorating nervous-system disorders can benefit from both local and regional research collaborations. The lack of resources and infrastructure for health-care and related research, both in terms of personnel and equipment, along with the stigma associated with the physical or behavioural manifestations of some disorders have hampered progress in understanding the disease burden and improving brain health. Individual countries, and regions within countries, have specific needs in terms of research priorities.Instituto de Investigaciones Bioquímicas de La Plata2015info:eu-repo/semantics/reviewinfo:eu-repo/semantics/publishedVersionRevisionhttp://purl.org/coar/resource_type/c_dcae04bcinfo:ar-repo/semantics/resenaArticuloapplication/pdfE198-E206http://sedici.unlp.edu.ar/handle/10915/86398enginfo:eu-repo/semantics/altIdentifier/issn/0028-0836info:eu-repo/semantics/altIdentifier/doi/10.1038/nature16036info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:16:54Zoai:sedici.unlp.edu.ar:10915/86398Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:16:54.439SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Regional research priorities in brain and nervous system disorders
title Regional research priorities in brain and nervous system disorders
spellingShingle Regional research priorities in brain and nervous system disorders
Ravindranath, Vijayalakshmi
Ciencias Médicas
Nervous system disorders
Substance-use disorders
Biomedical Research
title_short Regional research priorities in brain and nervous system disorders
title_full Regional research priorities in brain and nervous system disorders
title_fullStr Regional research priorities in brain and nervous system disorders
title_full_unstemmed Regional research priorities in brain and nervous system disorders
title_sort Regional research priorities in brain and nervous system disorders
dc.creator.none.fl_str_mv Ravindranath, Vijayalakshmi
Dang, Hoang-Minh
Goya, Rodolfo Gustavo
Mansour, Hader
Nimgaonkar, Vishwajit L.
Russell, Vivienne Ann
Xin, Yu
author Ravindranath, Vijayalakshmi
author_facet Ravindranath, Vijayalakshmi
Dang, Hoang-Minh
Goya, Rodolfo Gustavo
Mansour, Hader
Nimgaonkar, Vishwajit L.
Russell, Vivienne Ann
Xin, Yu
author_role author
author2 Dang, Hoang-Minh
Goya, Rodolfo Gustavo
Mansour, Hader
Nimgaonkar, Vishwajit L.
Russell, Vivienne Ann
Xin, Yu
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Nervous system disorders
Substance-use disorders
Biomedical Research
topic Ciencias Médicas
Nervous system disorders
Substance-use disorders
Biomedical Research
dc.description.none.fl_txt_mv The characteristics of neurological, psychiatric, developmental and substance-use disorders in low-and middle-income countries are unique and the burden that they have will be different from country to country. Many of the differences are explained by the wide variation in population demographics and size, poverty, conflict, culture, land area and quality, and genetics. Neurological, psychiatric, developmental and substance-use disorders that result from, or are worsened by, a lack of adequate nutrition and infectious disease still afflict much of sub-Saharan Africa, although disorders related to increasing longevity, such as stroke, are on the rise. In the Middle East and North Africa, major depressive disorders and post-traumatic stress disorder are a primary concern because of the conflict-ridden environment. Consanguinity is a serious concern that leads to the high prevalence of recessive disorders in the Middle East and North Africa and possibly other regions. The burden of these disorders in Latin American and Asian countries largely surrounds stroke and vascular disease, dementia and lifestyle factors that are influenced by genetics. Although much knowledge has been gained over the past 10 years, the epidemiology of the conditions in low-and middle-income countries still needs more research. Prevention and treatments could be better informed with more longitudinal studies of risk factors. Challenges and opportunities for ameliorating nervous-system disorders can benefit from both local and regional research collaborations. The lack of resources and infrastructure for health-care and related research, both in terms of personnel and equipment, along with the stigma associated with the physical or behavioural manifestations of some disorders have hampered progress in understanding the disease burden and improving brain health. Individual countries, and regions within countries, have specific needs in terms of research priorities.
Instituto de Investigaciones Bioquímicas de La Plata
description The characteristics of neurological, psychiatric, developmental and substance-use disorders in low-and middle-income countries are unique and the burden that they have will be different from country to country. Many of the differences are explained by the wide variation in population demographics and size, poverty, conflict, culture, land area and quality, and genetics. Neurological, psychiatric, developmental and substance-use disorders that result from, or are worsened by, a lack of adequate nutrition and infectious disease still afflict much of sub-Saharan Africa, although disorders related to increasing longevity, such as stroke, are on the rise. In the Middle East and North Africa, major depressive disorders and post-traumatic stress disorder are a primary concern because of the conflict-ridden environment. Consanguinity is a serious concern that leads to the high prevalence of recessive disorders in the Middle East and North Africa and possibly other regions. The burden of these disorders in Latin American and Asian countries largely surrounds stroke and vascular disease, dementia and lifestyle factors that are influenced by genetics. Although much knowledge has been gained over the past 10 years, the epidemiology of the conditions in low-and middle-income countries still needs more research. Prevention and treatments could be better informed with more longitudinal studies of risk factors. Challenges and opportunities for ameliorating nervous-system disorders can benefit from both local and regional research collaborations. The lack of resources and infrastructure for health-care and related research, both in terms of personnel and equipment, along with the stigma associated with the physical or behavioural manifestations of some disorders have hampered progress in understanding the disease burden and improving brain health. Individual countries, and regions within countries, have specific needs in terms of research priorities.
publishDate 2015
dc.date.none.fl_str_mv 2015
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