Programmed Cell Death in the Small Intestine: Implications for the Pathogenesis of Celiac Disease

Autores
Pérez, Federico; Ruera, Carolina Naymé; Miculán, Emanuel Gonzalo; Carasi, Paula; Chirdo, Fernando Gabriel
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The small intestine has a high rate of cell turnover under homeostatic conditions, and this increases further in response to infection or damage. Epithelial cells mostly die by apoptosis, but recent studies indicate that this may also involve pro-inflammatory pathways of programmed cell death, such as pyroptosis and necroptosis. Celiac disease (CD), the most prevalent immune-based enteropathy, is caused by loss of oral tolerance to peptides derived from wheat, rye, and barley in genetically predisposed individuals. Although cytotoxic cells and gluten-specific CD4+ Th1 cells are the central players in the pathology, inflammatory pathways induced by cell death may participate in driving and sustaining the disease through the release of alarmins. In this review, we summarize the recent literature addressing the role of programmed cell death pathways in the small intestine, describing how these mechanisms may contribute to CD and discussing their potential implications.
Instituto de Estudios Inmunológicos y Fisiopatológicos
Materia
Biología
Celiac disease
Alarmins
Programmed cell death
Inflammation
Small intestine
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/125443
Acceder
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network_name_str SEDICI (UNLP)
spelling Programmed Cell Death in the Small Intestine: Implications for the Pathogenesis of Celiac DiseasePérez, FedericoRuera, Carolina NayméMiculán, Emanuel GonzaloCarasi, PaulaChirdo, Fernando GabrielBiologíaCeliac diseaseAlarminsProgrammed cell deathInflammationSmall intestineThe small intestine has a high rate of cell turnover under homeostatic conditions, and this increases further in response to infection or damage. Epithelial cells mostly die by apoptosis, but recent studies indicate that this may also involve pro-inflammatory pathways of programmed cell death, such as pyroptosis and necroptosis. Celiac disease (CD), the most prevalent immune-based enteropathy, is caused by loss of oral tolerance to peptides derived from wheat, rye, and barley in genetically predisposed individuals. Although cytotoxic cells and gluten-specific CD4+ Th1 cells are the central players in the pathology, inflammatory pathways induced by cell death may participate in driving and sustaining the disease through the release of alarmins. In this review, we summarize the recent literature addressing the role of programmed cell death pathways in the small intestine, describing how these mechanisms may contribute to CD and discussing their potential implications.Instituto de Estudios Inmunológicos y Fisiopatológicos2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/125443enginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/22/14/7426info:eu-repo/semantics/altIdentifier/issn/1422-0067info:eu-repo/semantics/altIdentifier/doi/10.3390/ijms22147426info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-17T10:12:48Zoai:sedici.unlp.edu.ar:10915/125443Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-17 10:12:48.334SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Programmed Cell Death in the Small Intestine: Implications for the Pathogenesis of Celiac Disease
title Programmed Cell Death in the Small Intestine: Implications for the Pathogenesis of Celiac Disease
spellingShingle Programmed Cell Death in the Small Intestine: Implications for the Pathogenesis of Celiac Disease
Pérez, Federico
Biología
Celiac disease
Alarmins
Programmed cell death
Inflammation
Small intestine
title_short Programmed Cell Death in the Small Intestine: Implications for the Pathogenesis of Celiac Disease
title_full Programmed Cell Death in the Small Intestine: Implications for the Pathogenesis of Celiac Disease
title_fullStr Programmed Cell Death in the Small Intestine: Implications for the Pathogenesis of Celiac Disease
title_full_unstemmed Programmed Cell Death in the Small Intestine: Implications for the Pathogenesis of Celiac Disease
title_sort Programmed Cell Death in the Small Intestine: Implications for the Pathogenesis of Celiac Disease
dc.creator.none.fl_str_mv Pérez, Federico
Ruera, Carolina Naymé
Miculán, Emanuel Gonzalo
Carasi, Paula
Chirdo, Fernando Gabriel
author Pérez, Federico
author_facet Pérez, Federico
Ruera, Carolina Naymé
Miculán, Emanuel Gonzalo
Carasi, Paula
Chirdo, Fernando Gabriel
author_role author
author2 Ruera, Carolina Naymé
Miculán, Emanuel Gonzalo
Carasi, Paula
Chirdo, Fernando Gabriel
author2_role author
author
author
author
dc.subject.none.fl_str_mv Biología
Celiac disease
Alarmins
Programmed cell death
Inflammation
Small intestine
topic Biología
Celiac disease
Alarmins
Programmed cell death
Inflammation
Small intestine
dc.description.none.fl_txt_mv The small intestine has a high rate of cell turnover under homeostatic conditions, and this increases further in response to infection or damage. Epithelial cells mostly die by apoptosis, but recent studies indicate that this may also involve pro-inflammatory pathways of programmed cell death, such as pyroptosis and necroptosis. Celiac disease (CD), the most prevalent immune-based enteropathy, is caused by loss of oral tolerance to peptides derived from wheat, rye, and barley in genetically predisposed individuals. Although cytotoxic cells and gluten-specific CD4+ Th1 cells are the central players in the pathology, inflammatory pathways induced by cell death may participate in driving and sustaining the disease through the release of alarmins. In this review, we summarize the recent literature addressing the role of programmed cell death pathways in the small intestine, describing how these mechanisms may contribute to CD and discussing their potential implications.
Instituto de Estudios Inmunológicos y Fisiopatológicos
description The small intestine has a high rate of cell turnover under homeostatic conditions, and this increases further in response to infection or damage. Epithelial cells mostly die by apoptosis, but recent studies indicate that this may also involve pro-inflammatory pathways of programmed cell death, such as pyroptosis and necroptosis. Celiac disease (CD), the most prevalent immune-based enteropathy, is caused by loss of oral tolerance to peptides derived from wheat, rye, and barley in genetically predisposed individuals. Although cytotoxic cells and gluten-specific CD4+ Th1 cells are the central players in the pathology, inflammatory pathways induced by cell death may participate in driving and sustaining the disease through the release of alarmins. In this review, we summarize the recent literature addressing the role of programmed cell death pathways in the small intestine, describing how these mechanisms may contribute to CD and discussing their potential implications.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/125443
url http://sedici.unlp.edu.ar/handle/10915/125443
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/22/14/7426
info:eu-repo/semantics/altIdentifier/issn/1422-0067
info:eu-repo/semantics/altIdentifier/doi/10.3390/ijms22147426
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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