Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na+/H+ exchanger
- Autores
- Camilión de Hurtado, María Cristina; Portiansky, Enrique Leo; Pérez, Néstor Gustavo; Rebolledo, Oscar Remigio; Cingolani, Horacio Eugenio
- Año de publicación
- 2002
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Objective: Experiments were performed to examine the effect of chronic inhibition of the Na+/H+ exchanger isoform-1 (NHE-1) on cardiac hypertrophy of spontaneously hypertensive rats (SHR). Methods: SHR were orally treated during 1 month with two different doses (0.3 and 3.0 mg/kg/day) of the NHE-1 inhibitor, cariporide, or nifedipine (10.0 mg/kg/day). Results: The two doses of cariporide did not differ in their effects after 1 month of treatment, since both induced a slight decrease in systolic blood pressure (SBP) of ∼6 mmHg and regression of the heart weight to body weight ratio (mg/g) from 3.28±0.05 to 3.04±0.05 (0.3 mg) and 2.99±0.10 (3.0 mg, P<0.05). Nifedipine, given for the same period, produced similar reduction in the hypertrophy index (3.03±0.05), but with a much greater decrease in arterial pressure (35.6±7.4 mmHg). Chronic treatment with cariporide induced a complete regression of the augmented cross sectional area of left ventricular myocytes without significant changes in collagen content, serum procollagen 1 propeptide levels or myocardial distensibility. Conclusions: NHE inhibition represents a novel approach to induce regression of pathological hypertrophy of the heart. The finding can be rationalized mechanistically by previous in vitro studies suggesting a role of the NHE in the development of myocardial hypertrophy.
Facultad de Ciencias Médicas
Facultad de Ciencias Veterinarias
Centro de Investigaciones Cardiovasculares - Materia
-
Ciencias Médicas
Fibrosis
Hypertension
Hypertrophy
Ion exchangers
Na/H exchanger - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
.jpg)
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/84662
Ver los metadatos del registro completo
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Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na+/H+ exchangerCamilión de Hurtado, María CristinaPortiansky, Enrique LeoPérez, Néstor GustavoRebolledo, Oscar RemigioCingolani, Horacio EugenioCiencias MédicasFibrosisHypertensionHypertrophyIon exchangersNa/H exchangerObjective: Experiments were performed to examine the effect of chronic inhibition of the Na<SUP>+</SUP>/H<SUP>+</SUP> exchanger isoform-1 (NHE-1) on cardiac hypertrophy of spontaneously hypertensive rats (SHR). Methods: SHR were orally treated during 1 month with two different doses (0.3 and 3.0 mg/kg/day) of the NHE-1 inhibitor, cariporide, or nifedipine (10.0 mg/kg/day). Results: The two doses of cariporide did not differ in their effects after 1 month of treatment, since both induced a slight decrease in systolic blood pressure (SBP) of ∼6 mmHg and regression of the heart weight to body weight ratio (mg/g) from 3.28±0.05 to 3.04±0.05 (0.3 mg) and 2.99±0.10 (3.0 mg, P<0.05). Nifedipine, given for the same period, produced similar reduction in the hypertrophy index (3.03±0.05), but with a much greater decrease in arterial pressure (35.6±7.4 mmHg). Chronic treatment with cariporide induced a complete regression of the augmented cross sectional area of left ventricular myocytes without significant changes in collagen content, serum procollagen 1 propeptide levels or myocardial distensibility. Conclusions: NHE inhibition represents a novel approach to induce regression of pathological hypertrophy of the heart. The finding can be rationalized mechanistically by previous in vitro studies suggesting a role of the NHE in the development of myocardial hypertrophy.Facultad de Ciencias MédicasFacultad de Ciencias VeterinariasCentro de Investigaciones Cardiovasculares2002info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf862-868http://sedici.unlp.edu.ar/handle/10915/84662enginfo:eu-repo/semantics/altIdentifier/issn/0008-6363info:eu-repo/semantics/altIdentifier/doi/10.1016/S0008-6363(01)00544-2info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T10:48:36Zoai:sedici.unlp.edu.ar:10915/84662Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 10:48:36.404SEDICI (UNLP) - Universidad Nacional de La Platafalse |
| dc.title.none.fl_str_mv |
Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na+/H+ exchanger |
| title |
Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na+/H+ exchanger |
| spellingShingle |
Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na+/H+ exchanger Camilión de Hurtado, María Cristina Ciencias Médicas Fibrosis Hypertension Hypertrophy Ion exchangers Na/H exchanger |
| title_short |
Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na+/H+ exchanger |
| title_full |
Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na+/H+ exchanger |
| title_fullStr |
Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na+/H+ exchanger |
| title_full_unstemmed |
Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na+/H+ exchanger |
| title_sort |
Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na+/H+ exchanger |
| dc.creator.none.fl_str_mv |
Camilión de Hurtado, María Cristina Portiansky, Enrique Leo Pérez, Néstor Gustavo Rebolledo, Oscar Remigio Cingolani, Horacio Eugenio |
| author |
Camilión de Hurtado, María Cristina |
| author_facet |
Camilión de Hurtado, María Cristina Portiansky, Enrique Leo Pérez, Néstor Gustavo Rebolledo, Oscar Remigio Cingolani, Horacio Eugenio |
| author_role |
author |
| author2 |
Portiansky, Enrique Leo Pérez, Néstor Gustavo Rebolledo, Oscar Remigio Cingolani, Horacio Eugenio |
| author2_role |
author author author author |
| dc.subject.none.fl_str_mv |
Ciencias Médicas Fibrosis Hypertension Hypertrophy Ion exchangers Na/H exchanger |
| topic |
Ciencias Médicas Fibrosis Hypertension Hypertrophy Ion exchangers Na/H exchanger |
| dc.description.none.fl_txt_mv |
Objective: Experiments were performed to examine the effect of chronic inhibition of the Na<SUP>+</SUP>/H<SUP>+</SUP> exchanger isoform-1 (NHE-1) on cardiac hypertrophy of spontaneously hypertensive rats (SHR). Methods: SHR were orally treated during 1 month with two different doses (0.3 and 3.0 mg/kg/day) of the NHE-1 inhibitor, cariporide, or nifedipine (10.0 mg/kg/day). Results: The two doses of cariporide did not differ in their effects after 1 month of treatment, since both induced a slight decrease in systolic blood pressure (SBP) of ∼6 mmHg and regression of the heart weight to body weight ratio (mg/g) from 3.28±0.05 to 3.04±0.05 (0.3 mg) and 2.99±0.10 (3.0 mg, P<0.05). Nifedipine, given for the same period, produced similar reduction in the hypertrophy index (3.03±0.05), but with a much greater decrease in arterial pressure (35.6±7.4 mmHg). Chronic treatment with cariporide induced a complete regression of the augmented cross sectional area of left ventricular myocytes without significant changes in collagen content, serum procollagen 1 propeptide levels or myocardial distensibility. Conclusions: NHE inhibition represents a novel approach to induce regression of pathological hypertrophy of the heart. The finding can be rationalized mechanistically by previous in vitro studies suggesting a role of the NHE in the development of myocardial hypertrophy. Facultad de Ciencias Médicas Facultad de Ciencias Veterinarias Centro de Investigaciones Cardiovasculares |
| description |
Objective: Experiments were performed to examine the effect of chronic inhibition of the Na<SUP>+</SUP>/H<SUP>+</SUP> exchanger isoform-1 (NHE-1) on cardiac hypertrophy of spontaneously hypertensive rats (SHR). Methods: SHR were orally treated during 1 month with two different doses (0.3 and 3.0 mg/kg/day) of the NHE-1 inhibitor, cariporide, or nifedipine (10.0 mg/kg/day). Results: The two doses of cariporide did not differ in their effects after 1 month of treatment, since both induced a slight decrease in systolic blood pressure (SBP) of ∼6 mmHg and regression of the heart weight to body weight ratio (mg/g) from 3.28±0.05 to 3.04±0.05 (0.3 mg) and 2.99±0.10 (3.0 mg, P<0.05). Nifedipine, given for the same period, produced similar reduction in the hypertrophy index (3.03±0.05), but with a much greater decrease in arterial pressure (35.6±7.4 mmHg). Chronic treatment with cariporide induced a complete regression of the augmented cross sectional area of left ventricular myocytes without significant changes in collagen content, serum procollagen 1 propeptide levels or myocardial distensibility. Conclusions: NHE inhibition represents a novel approach to induce regression of pathological hypertrophy of the heart. The finding can be rationalized mechanistically by previous in vitro studies suggesting a role of the NHE in the development of myocardial hypertrophy. |
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2002 |
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2002 |
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