Fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and properties

Autores
Pasqualone, Magalí; Oberti, Tamara Gisela; Andreetta, Héctor Alfredo; Cortizo, María Susana
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Novel copolymers of vinyl acetate and dialkylfumarates, poly(VA-co-DRF) with R = isopropyl (DIPF) or octan-2-yl (DOF), were synthesized by radical copolymerization under microwave conditions. The products were characterized by ¹H NMR and FTIR spectroscopies, size exclusion chromatography and differential scanning calorimetry. Based on these copolymers three membranes supported on polyvinyl alcohol were prepared and their morphology, swelling and mechanical properties were studied. The swelling kinetic was analyzed and interpreted in light of the Fick transport model, showing that the water transport occurs through a non-Fickian diffusion mechanism. The results show that the membrane prepared of poly(VA-co-DOF) exhibited excellent properties as potential platform for transdermal delivery system: they exhibited good tensile strength, moderated swelling and form thin and transparent films.
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Materia
Ciencias Exactas
Química
fumarate
risedronate
vinyl acetate
water absorption capacity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/164159
Acceder
id SEDICI_02084de0e99b32fc974780ffa4d651b9
oai_identifier_str oai:sedici.unlp.edu.ar:10915/164159
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and propertiesPasqualone, MagalíOberti, Tamara GiselaAndreetta, Héctor AlfredoCortizo, María SusanaCiencias ExactasQuímicafumaraterisedronatevinyl acetatewater absorption capacityNovel copolymers of vinyl acetate and dialkylfumarates, poly(VA-co-DRF) with R = isopropyl (DIPF) or octan-2-yl (DOF), were synthesized by radical copolymerization under microwave conditions. The products were characterized by ¹H NMR and FTIR spectroscopies, size exclusion chromatography and differential scanning calorimetry. Based on these copolymers three membranes supported on polyvinyl alcohol were prepared and their morphology, swelling and mechanical properties were studied. The swelling kinetic was analyzed and interpreted in light of the Fick transport model, showing that the water transport occurs through a non-Fickian diffusion mechanism. The results show that the membrane prepared of poly(VA-co-DOF) exhibited excellent properties as potential platform for transdermal delivery system: they exhibited good tensile strength, moderated swelling and form thin and transparent films.Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas2013-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1683-1692http://sedici.unlp.edu.ar/handle/10915/164159enginfo:eu-repo/semantics/altIdentifier/issn/0957-4530info:eu-repo/semantics/altIdentifier/issn/1573-4838info:eu-repo/semantics/altIdentifier/doi/10.1007/s10856-013-4925-2info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:43:11Zoai:sedici.unlp.edu.ar:10915/164159Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:43:12.27SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and properties
title Fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and properties
spellingShingle Fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and properties
Pasqualone, Magalí
Ciencias Exactas
Química
fumarate
risedronate
vinyl acetate
water absorption capacity
title_short Fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and properties
title_full Fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and properties
title_fullStr Fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and properties
title_full_unstemmed Fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and properties
title_sort Fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and properties
dc.creator.none.fl_str_mv Pasqualone, Magalí
Oberti, Tamara Gisela
Andreetta, Héctor Alfredo
Cortizo, María Susana
author Pasqualone, Magalí
author_facet Pasqualone, Magalí
Oberti, Tamara Gisela
Andreetta, Héctor Alfredo
Cortizo, María Susana
author_role author
author2 Oberti, Tamara Gisela
Andreetta, Héctor Alfredo
Cortizo, María Susana
author2_role author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Química
fumarate
risedronate
vinyl acetate
water absorption capacity
topic Ciencias Exactas
Química
fumarate
risedronate
vinyl acetate
water absorption capacity
dc.description.none.fl_txt_mv Novel copolymers of vinyl acetate and dialkylfumarates, poly(VA-co-DRF) with R = isopropyl (DIPF) or octan-2-yl (DOF), were synthesized by radical copolymerization under microwave conditions. The products were characterized by ¹H NMR and FTIR spectroscopies, size exclusion chromatography and differential scanning calorimetry. Based on these copolymers three membranes supported on polyvinyl alcohol were prepared and their morphology, swelling and mechanical properties were studied. The swelling kinetic was analyzed and interpreted in light of the Fick transport model, showing that the water transport occurs through a non-Fickian diffusion mechanism. The results show that the membrane prepared of poly(VA-co-DOF) exhibited excellent properties as potential platform for transdermal delivery system: they exhibited good tensile strength, moderated swelling and form thin and transparent films.
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
description Novel copolymers of vinyl acetate and dialkylfumarates, poly(VA-co-DRF) with R = isopropyl (DIPF) or octan-2-yl (DOF), were synthesized by radical copolymerization under microwave conditions. The products were characterized by ¹H NMR and FTIR spectroscopies, size exclusion chromatography and differential scanning calorimetry. Based on these copolymers three membranes supported on polyvinyl alcohol were prepared and their morphology, swelling and mechanical properties were studied. The swelling kinetic was analyzed and interpreted in light of the Fick transport model, showing that the water transport occurs through a non-Fickian diffusion mechanism. The results show that the membrane prepared of poly(VA-co-DOF) exhibited excellent properties as potential platform for transdermal delivery system: they exhibited good tensile strength, moderated swelling and form thin and transparent films.
publishDate 2013
dc.date.none.fl_str_mv 2013-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/164159
url http://sedici.unlp.edu.ar/handle/10915/164159
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0957-4530
info:eu-repo/semantics/altIdentifier/issn/1573-4838
info:eu-repo/semantics/altIdentifier/doi/10.1007/s10856-013-4925-2
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
1683-1692
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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