Antifungal activity of silver nanoparticles in combination with ketoconazole against Malassezia furfur

Autores
Mussin, Javier Esteban; Roldán, María Virginia; Rojas, Florencia Dinorah; Sosa, María de los Ángeles; Pellegri, Nora Susana; Giusiano, Gustavo Emilio
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Mussin, Javier Esteban. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina.
Fil: Mussin, Javier Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Nordeste; Argentina.
Fil: Roldán, María Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico. Instituto de Física de Rosario; Argentina.
Fil: Rojas, Florencia Dinorah. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina.
Fil: Rojas, Florencia Dinorah. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Nordeste; Argentina.
Fil: Sosa, María de los Ángeles. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina.
Fil: Pellegri, Nora Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico. Instituto de Física de Rosario; Argentina.
Fil: Giusiano, Gustavo Emilio. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina.
Fil: Giusiano, Gustavo Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Nordeste; Argentina.
Malassezia furfur is lipophilic and lipid-dependent yeast, inhabitant of human skin microbiota associated with several dermal disorders. In recent years, along with the advances in nanotechnology and the incentive to find new antimicrobialdrugs, there has been a growing interest in the utilization of nanoparticles for the treatment of skin microbial infections. This work aimed to study the in vitro inhibitory activity of silver nanoparticles (AgNP) against 41 M. furfurclinical isolates, visualize the interaction between AgNP-Malassezia, evaluate the synergism with ketoconazole (KTZ) and to produce an antimicrobial gel of AgNP?KTZ. The synthesized AgNP were randomly distributed around the yeastsurface and showed a fungicidal action with low minimal inhibitory concentration values. AgNP showed no antagonistic effect with KTZ. The broad-spectrum antimicrobial property with fungicidal action of AgNP and its accumulationin affected areas with a sustained release profile, added to the great antifungal activity of KTZ against Malassezia infections and other superficial mycoses, allowed us to obtain a gel based on carbopol formulated with AgNP?KTZwith the potential to improve the topical therapy of superficial malasseziosis, reduce the number of applications and, also, prevent the recurrence.
Fuente
Applied Microbiology and Biotechnology, 2019, vol.9, no. 131, p. 1-9.
Materia
Malassezia
Nanoparticles
Antifungal activity
Synergy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE)
Institución
Universidad Nacional del Nordeste
OAI Identificador
oai:repositorio.unne.edu.ar:123456789/54153
Acceder
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network_acronym_str RIUNNE
repository_id_str 4871
network_name_str Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE)
spelling Antifungal activity of silver nanoparticles in combination with ketoconazole against Malassezia furfurMussin, Javier EstebanRoldán, María VirginiaRojas, Florencia DinorahSosa, María de los ÁngelesPellegri, Nora SusanaGiusiano, Gustavo EmilioMalasseziaNanoparticlesAntifungal activitySynergyFil: Mussin, Javier Esteban. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina.Fil: Mussin, Javier Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Nordeste; Argentina.Fil: Roldán, María Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico. Instituto de Física de Rosario; Argentina.Fil: Rojas, Florencia Dinorah. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina.Fil: Rojas, Florencia Dinorah. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Nordeste; Argentina.Fil: Sosa, María de los Ángeles. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina.Fil: Pellegri, Nora Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico. Instituto de Física de Rosario; Argentina.Fil: Giusiano, Gustavo Emilio. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina.Fil: Giusiano, Gustavo Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Nordeste; Argentina.Malassezia furfur is lipophilic and lipid-dependent yeast, inhabitant of human skin microbiota associated with several dermal disorders. In recent years, along with the advances in nanotechnology and the incentive to find new antimicrobialdrugs, there has been a growing interest in the utilization of nanoparticles for the treatment of skin microbial infections. This work aimed to study the in vitro inhibitory activity of silver nanoparticles (AgNP) against 41 M. furfurclinical isolates, visualize the interaction between AgNP-Malassezia, evaluate the synergism with ketoconazole (KTZ) and to produce an antimicrobial gel of AgNP?KTZ. The synthesized AgNP were randomly distributed around the yeastsurface and showed a fungicidal action with low minimal inhibitory concentration values. AgNP showed no antagonistic effect with KTZ. The broad-spectrum antimicrobial property with fungicidal action of AgNP and its accumulationin affected areas with a sustained release profile, added to the great antifungal activity of KTZ against Malassezia infections and other superficial mycoses, allowed us to obtain a gel based on carbopol formulated with AgNP?KTZwith the potential to improve the topical therapy of superficial malasseziosis, reduce the number of applications and, also, prevent the recurrence.Springer2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfp. 1-9application/pdfMussin, Javier Esteban, et al., 2019. Antifungal activity of silver nanoparticles in combination with ketoconazole against Malassezia furfur. Applied Microbiology and Biotechnology. Berlín: Springer, vol.9, no. 131, p. 1-9. ISSN 0175-7598.0175-7598http://repositorio.unne.edu.ar/handle/123456789/54153Applied Microbiology and Biotechnology, 2019, vol.9, no. 131, p. 1-9.reponame:Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE)instname:Universidad Nacional del Nordesteenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/2.5/ar/Atribución-NoComercial-SinDerivadas 2.5 Argentina2025-09-29T14:29:05Zoai:repositorio.unne.edu.ar:123456789/54153instacron:UNNEInstitucionalhttp://repositorio.unne.edu.ar/Universidad públicaNo correspondehttp://repositorio.unne.edu.ar/oaiososa@bib.unne.edu.ar;sergio.alegria@unne.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:48712025-09-29 14:29:05.507Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) - Universidad Nacional del Nordestefalse
dc.title.none.fl_str_mv Antifungal activity of silver nanoparticles in combination with ketoconazole against Malassezia furfur
title Antifungal activity of silver nanoparticles in combination with ketoconazole against Malassezia furfur
spellingShingle Antifungal activity of silver nanoparticles in combination with ketoconazole against Malassezia furfur
Mussin, Javier Esteban
Malassezia
Nanoparticles
Antifungal activity
Synergy
title_short Antifungal activity of silver nanoparticles in combination with ketoconazole against Malassezia furfur
title_full Antifungal activity of silver nanoparticles in combination with ketoconazole against Malassezia furfur
title_fullStr Antifungal activity of silver nanoparticles in combination with ketoconazole against Malassezia furfur
title_full_unstemmed Antifungal activity of silver nanoparticles in combination with ketoconazole against Malassezia furfur
title_sort Antifungal activity of silver nanoparticles in combination with ketoconazole against Malassezia furfur
dc.creator.none.fl_str_mv Mussin, Javier Esteban
Roldán, María Virginia
Rojas, Florencia Dinorah
Sosa, María de los Ángeles
Pellegri, Nora Susana
Giusiano, Gustavo Emilio
author Mussin, Javier Esteban
author_facet Mussin, Javier Esteban
Roldán, María Virginia
Rojas, Florencia Dinorah
Sosa, María de los Ángeles
Pellegri, Nora Susana
Giusiano, Gustavo Emilio
author_role author
author2 Roldán, María Virginia
Rojas, Florencia Dinorah
Sosa, María de los Ángeles
Pellegri, Nora Susana
Giusiano, Gustavo Emilio
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Malassezia
Nanoparticles
Antifungal activity
Synergy
topic Malassezia
Nanoparticles
Antifungal activity
Synergy
dc.description.none.fl_txt_mv Fil: Mussin, Javier Esteban. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina.
Fil: Mussin, Javier Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Nordeste; Argentina.
Fil: Roldán, María Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico. Instituto de Física de Rosario; Argentina.
Fil: Rojas, Florencia Dinorah. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina.
Fil: Rojas, Florencia Dinorah. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Nordeste; Argentina.
Fil: Sosa, María de los Ángeles. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina.
Fil: Pellegri, Nora Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico. Instituto de Física de Rosario; Argentina.
Fil: Giusiano, Gustavo Emilio. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina.
Fil: Giusiano, Gustavo Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Nordeste; Argentina.
Malassezia furfur is lipophilic and lipid-dependent yeast, inhabitant of human skin microbiota associated with several dermal disorders. In recent years, along with the advances in nanotechnology and the incentive to find new antimicrobialdrugs, there has been a growing interest in the utilization of nanoparticles for the treatment of skin microbial infections. This work aimed to study the in vitro inhibitory activity of silver nanoparticles (AgNP) against 41 M. furfurclinical isolates, visualize the interaction between AgNP-Malassezia, evaluate the synergism with ketoconazole (KTZ) and to produce an antimicrobial gel of AgNP?KTZ. The synthesized AgNP were randomly distributed around the yeastsurface and showed a fungicidal action with low minimal inhibitory concentration values. AgNP showed no antagonistic effect with KTZ. The broad-spectrum antimicrobial property with fungicidal action of AgNP and its accumulationin affected areas with a sustained release profile, added to the great antifungal activity of KTZ against Malassezia infections and other superficial mycoses, allowed us to obtain a gel based on carbopol formulated with AgNP?KTZwith the potential to improve the topical therapy of superficial malasseziosis, reduce the number of applications and, also, prevent the recurrence.
description Fil: Mussin, Javier Esteban. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv Mussin, Javier Esteban, et al., 2019. Antifungal activity of silver nanoparticles in combination with ketoconazole against Malassezia furfur. Applied Microbiology and Biotechnology. Berlín: Springer, vol.9, no. 131, p. 1-9. ISSN 0175-7598.
0175-7598
http://repositorio.unne.edu.ar/handle/123456789/54153
identifier_str_mv Mussin, Javier Esteban, et al., 2019. Antifungal activity of silver nanoparticles in combination with ketoconazole against Malassezia furfur. Applied Microbiology and Biotechnology. Berlín: Springer, vol.9, no. 131, p. 1-9. ISSN 0175-7598.
0175-7598
url http://repositorio.unne.edu.ar/handle/123456789/54153
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Atribución-NoComercial-SinDerivadas 2.5 Argentina
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Atribución-NoComercial-SinDerivadas 2.5 Argentina
dc.format.none.fl_str_mv application/pdf
p. 1-9
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv Applied Microbiology and Biotechnology, 2019, vol.9, no. 131, p. 1-9.
reponame:Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE)
instname:Universidad Nacional del Nordeste
reponame_str Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE)
collection Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE)
instname_str Universidad Nacional del Nordeste
repository.name.fl_str_mv Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) - Universidad Nacional del Nordeste
repository.mail.fl_str_mv ososa@bib.unne.edu.ar;sergio.alegria@unne.edu.ar
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score 12.559606

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