Apoptosis induced by a snake venom metalloproteinase from bothrops alternatus venom in C2C12 muscle cells
- Autores
- Bustillo, Soledad; Van de Velde, Andrea Carolina; Matzner Perfumo, Verónica; Gay, Claudia Carolina; Leiva, Laura Cristina Ana
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Bustillo, Soledad. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Departamento de Bioquímica. Laboratorio de Investigación en Proteínas; Argentina
Fil: Van de Velde, Andrea Carolina. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Departamento de Bioquímica. Laboratorio de Investigación en Proteínas; Argentina.
Fil: Van de Velde, Andrea Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
Fil: Matzner Perfumo, Verónica. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Departamento de Bioquímica. Laboratorio de Investigación en Proteínas; Argentina.
Fil: Gay, Claudia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química Básica y Aplicada del Nordeste Argentino; Argentina.
Fil: Gay, Claudia Carolina. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Departamento de Bioquímica. Laboratorio de Investigación en Proteínas; Argentina
Fil: Leiva, Laura Cristina Ana. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Departamento de Bioquímica. Laboratorio de Investigación en Proteínas; Argentina
In this study, the apoptosis inducing effects of baltergin as well as its influence on cell adhesion and migration on muscles cells in vitro were studied. Morphological analysis made by scanning electron and pase contrast microscopy demonstrated typical futures of programmed cell death, apoptosis. This mechanism was confirmed by fluorescence staining, molecular analysis of endonuclease activity and increased mRNA expresión level of two representative genes (p53 and bax). On the other hand, baltergin exert an inhibition effect on myoblast cell adhesion and migration in vitro probably through a mechanism that involves the interaction of this enzyme with cell integrins. In conclusion, our results suggest that the absence of appropriate extracellular matrix contacts triggers anoikis. Therefore, this is the first report that demonstrated the mechanism of programmed cell death triggered by baltergin, a PIII metalloprotease isolated from Bothrops alternatus venom, in a myoblast cell line. - Fuente
- Apoptosis, 2017, vol. 22, no. 4, p. 491-501.
- Materia
-
Baltergin
Metalloproteinase
Bothrops alternatus
Anoikis
Apoptosis - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Universidad Nacional del Nordeste
- OAI Identificador
- oai:repositorio.unne.edu.ar:123456789/30330
Ver los metadatos del registro completo
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spelling |
Apoptosis induced by a snake venom metalloproteinase from bothrops alternatus venom in C2C12 muscle cellsBustillo, SoledadVan de Velde, Andrea CarolinaMatzner Perfumo, VerónicaGay, Claudia CarolinaLeiva, Laura Cristina AnaBalterginMetalloproteinaseBothrops alternatusAnoikisApoptosisFil: Bustillo, Soledad. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Departamento de Bioquímica. Laboratorio de Investigación en Proteínas; ArgentinaFil: Van de Velde, Andrea Carolina. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Departamento de Bioquímica. Laboratorio de Investigación en Proteínas; Argentina.Fil: Van de Velde, Andrea Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Matzner Perfumo, Verónica. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Departamento de Bioquímica. Laboratorio de Investigación en Proteínas; Argentina.Fil: Gay, Claudia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química Básica y Aplicada del Nordeste Argentino; Argentina.Fil: Gay, Claudia Carolina. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Departamento de Bioquímica. Laboratorio de Investigación en Proteínas; ArgentinaFil: Leiva, Laura Cristina Ana. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Departamento de Bioquímica. Laboratorio de Investigación en Proteínas; ArgentinaIn this study, the apoptosis inducing effects of baltergin as well as its influence on cell adhesion and migration on muscles cells in vitro were studied. Morphological analysis made by scanning electron and pase contrast microscopy demonstrated typical futures of programmed cell death, apoptosis. This mechanism was confirmed by fluorescence staining, molecular analysis of endonuclease activity and increased mRNA expresión level of two representative genes (p53 and bax). On the other hand, baltergin exert an inhibition effect on myoblast cell adhesion and migration in vitro probably through a mechanism that involves the interaction of this enzyme with cell integrins. In conclusion, our results suggest that the absence of appropriate extracellular matrix contacts triggers anoikis. Therefore, this is the first report that demonstrated the mechanism of programmed cell death triggered by baltergin, a PIII metalloprotease isolated from Bothrops alternatus venom, in a myoblast cell line.Springer2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfBustillo, Soledad, et al., 2017. Apoptosis induced by a snake venom metalloproteinase from bothrops alternatus venom in C2C12 muscle cells. Apoptosis. Suiza: Springer, vol. 22, no. 4, p. 491-501.ISSN 1360-8185.1360-8185http://repositorio.unne.edu.ar/handle/123456789/30330Apoptosis, 2017, vol. 22, no. 4, p. 491-501.reponame:Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE)instname:Universidad Nacional del Nordesteenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/2.5/ar/Atribución-NoComercial-SinDerivadas 2.5 Argentina2025-09-04T11:13:55Zoai:repositorio.unne.edu.ar:123456789/30330instacron:UNNEInstitucionalhttp://repositorio.unne.edu.ar/Universidad públicaNo correspondehttp://repositorio.unne.edu.ar/oaiososa@bib.unne.edu.ar;sergio.alegria@unne.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:48712025-09-04 11:13:55.807Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) - Universidad Nacional del Nordestefalse |
dc.title.none.fl_str_mv |
Apoptosis induced by a snake venom metalloproteinase from bothrops alternatus venom in C2C12 muscle cells |
title |
Apoptosis induced by a snake venom metalloproteinase from bothrops alternatus venom in C2C12 muscle cells |
spellingShingle |
Apoptosis induced by a snake venom metalloproteinase from bothrops alternatus venom in C2C12 muscle cells Bustillo, Soledad Baltergin Metalloproteinase Bothrops alternatus Anoikis Apoptosis |
title_short |
Apoptosis induced by a snake venom metalloproteinase from bothrops alternatus venom in C2C12 muscle cells |
title_full |
Apoptosis induced by a snake venom metalloproteinase from bothrops alternatus venom in C2C12 muscle cells |
title_fullStr |
Apoptosis induced by a snake venom metalloproteinase from bothrops alternatus venom in C2C12 muscle cells |
title_full_unstemmed |
Apoptosis induced by a snake venom metalloproteinase from bothrops alternatus venom in C2C12 muscle cells |
title_sort |
Apoptosis induced by a snake venom metalloproteinase from bothrops alternatus venom in C2C12 muscle cells |
dc.creator.none.fl_str_mv |
Bustillo, Soledad Van de Velde, Andrea Carolina Matzner Perfumo, Verónica Gay, Claudia Carolina Leiva, Laura Cristina Ana |
author |
Bustillo, Soledad |
author_facet |
Bustillo, Soledad Van de Velde, Andrea Carolina Matzner Perfumo, Verónica Gay, Claudia Carolina Leiva, Laura Cristina Ana |
author_role |
author |
author2 |
Van de Velde, Andrea Carolina Matzner Perfumo, Verónica Gay, Claudia Carolina Leiva, Laura Cristina Ana |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Baltergin Metalloproteinase Bothrops alternatus Anoikis Apoptosis |
topic |
Baltergin Metalloproteinase Bothrops alternatus Anoikis Apoptosis |
dc.description.none.fl_txt_mv |
Fil: Bustillo, Soledad. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Departamento de Bioquímica. Laboratorio de Investigación en Proteínas; Argentina Fil: Van de Velde, Andrea Carolina. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Departamento de Bioquímica. Laboratorio de Investigación en Proteínas; Argentina. Fil: Van de Velde, Andrea Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fil: Matzner Perfumo, Verónica. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Departamento de Bioquímica. Laboratorio de Investigación en Proteínas; Argentina. Fil: Gay, Claudia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química Básica y Aplicada del Nordeste Argentino; Argentina. Fil: Gay, Claudia Carolina. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Departamento de Bioquímica. Laboratorio de Investigación en Proteínas; Argentina Fil: Leiva, Laura Cristina Ana. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Departamento de Bioquímica. Laboratorio de Investigación en Proteínas; Argentina In this study, the apoptosis inducing effects of baltergin as well as its influence on cell adhesion and migration on muscles cells in vitro were studied. Morphological analysis made by scanning electron and pase contrast microscopy demonstrated typical futures of programmed cell death, apoptosis. This mechanism was confirmed by fluorescence staining, molecular analysis of endonuclease activity and increased mRNA expresión level of two representative genes (p53 and bax). On the other hand, baltergin exert an inhibition effect on myoblast cell adhesion and migration in vitro probably through a mechanism that involves the interaction of this enzyme with cell integrins. In conclusion, our results suggest that the absence of appropriate extracellular matrix contacts triggers anoikis. Therefore, this is the first report that demonstrated the mechanism of programmed cell death triggered by baltergin, a PIII metalloprotease isolated from Bothrops alternatus venom, in a myoblast cell line. |
description |
Fil: Bustillo, Soledad. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Departamento de Bioquímica. Laboratorio de Investigación en Proteínas; Argentina |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
Bustillo, Soledad, et al., 2017. Apoptosis induced by a snake venom metalloproteinase from bothrops alternatus venom in C2C12 muscle cells. Apoptosis. Suiza: Springer, vol. 22, no. 4, p. 491-501.ISSN 1360-8185. 1360-8185 http://repositorio.unne.edu.ar/handle/123456789/30330 |
identifier_str_mv |
Bustillo, Soledad, et al., 2017. Apoptosis induced by a snake venom metalloproteinase from bothrops alternatus venom in C2C12 muscle cells. Apoptosis. Suiza: Springer, vol. 22, no. 4, p. 491-501.ISSN 1360-8185. 1360-8185 |
url |
http://repositorio.unne.edu.ar/handle/123456789/30330 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/2.5/ar/ Atribución-NoComercial-SinDerivadas 2.5 Argentina |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/2.5/ar/ Atribución-NoComercial-SinDerivadas 2.5 Argentina |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
Apoptosis, 2017, vol. 22, no. 4, p. 491-501. reponame:Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) instname:Universidad Nacional del Nordeste |
reponame_str |
Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) |
collection |
Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) |
instname_str |
Universidad Nacional del Nordeste |
repository.name.fl_str_mv |
Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) - Universidad Nacional del Nordeste |
repository.mail.fl_str_mv |
ososa@bib.unne.edu.ar;sergio.alegria@unne.edu.ar |
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1842344208624517120 |
score |
12.623145 |