Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice

Autores
Choi, Jung-Mi; Kim, Sung-Soo; Choi, Chan-Il; Cha, Hye Lim; Oh, Huy-Hyen; Ghil, Sungho; Lee, Young-Don; Birnbaumer, Lutz; Suh-Kim, Haeyoung
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Choi, Jung-Mi. Ajou University School of Medicine. Department of Anatomy; Corea del Sur
Fil: Kim, Sung-Soo. Ajou University School of Medicine. Department of Anatomy; Corea del Sur
Fil: Choi, Chan-Il. Ajou University School of Medicine. Department of Anatomy; Corea del Sur
Fil: Cha, Hye Lim. Ajou University School of Medicine. Department of Anatomy; Corea del Sur
Fil: Oh, Huy-Hyen. Ajou University School of Medicine. Department of Anatomy; Corea del Sur
Fil: Oh, Huy-Hyen. Ajou University School of Medicine. The Graduate School. Department of Biomedical Sciences; Corea del Sur
Fil: Ghil, Sungho. Kyonggi University. Department of Life Science; Corea del Sur
Fil: Lee, Young-Don. Ajou University School of Medicine. Department of Anatomy; Corea del Sur
Fil: Lee, Young-Don. Ajou University School of Medicine. The Graduate School. Department of Biomedical Sciences; Corea del Sur
Fil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Birnbaumer, Lutz. National Institute of Environmental Health Sciences. Neurobiology Laboratory; Estados Unidos
Fil: Suh-Kim, Haeyoung. Ajou University School of Medicine. Department of Anatomy; Corea del Sur
Fil: Suh-Kim, Haeyoung. Ajou University School of Medicine. The Graduate School. Department of Biomedical Sciences; Corea del Sur
Abstract: In mammals, initial detection of olfactory stimuli is mediated by sensory neurons in the main olfactory epithelium (MOE) and the vomeronasal organ (VNO). The heterotrimeric GTP-binding protein Go is widely expressed in the MOE and VNO of mice. Early studies indicated that Go expression in VNO sensory neurons is critical for directing social and sexual behaviors in female mice [Oboti L, et al. (2014) BMC Biol 12:31]. However, the physiological functions of Go in the MOE have remained poorly defined. Here, we examined the role of Go in the MOE using mice lacking the α subunit of Go Development of the olfactory bulb (OB) was perturbed in mutant mice as a result of reduced neurogenesis and increased cell death. The balance between cell types of OB interneurons was altered in mutant mice, with an increase in the number of tyrosine hydroxylase-positive interneurons at the expense of calbindin-positive interneurons. Sexual behavior toward female mice and preference for female urine odors by olfactory sensory neurons in the MOE were abolished in mutant male mice. Our data suggest that Go signaling is essential for the structural and functional integrity of the MOE and for specification of OB interneurons, which in turn are required for the transmission of pheromone signals and the initiation of mating behavior with the opposite sex.
Fuente
Proceedings of the National Academy of Sciences. 2016;113(39):10974-10979
Materia
PROTEINAS
OLFATO
SEXUALIDAD
COMPORTAMIENTO
APOPTOSIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/8760
Acceder
id RIUCA_ecfeb9c86756c06ceba597e249f1255b
oai_identifier_str oai:ucacris:123456789/8760
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient miceChoi, Jung-MiKim, Sung-SooChoi, Chan-IlCha, Hye LimOh, Huy-HyenGhil, SunghoLee, Young-DonBirnbaumer, LutzSuh-Kim, HaeyoungPROTEINASOLFATOSEXUALIDADCOMPORTAMIENTOAPOPTOSISFil: Choi, Jung-Mi. Ajou University School of Medicine. Department of Anatomy; Corea del SurFil: Kim, Sung-Soo. Ajou University School of Medicine. Department of Anatomy; Corea del SurFil: Choi, Chan-Il. Ajou University School of Medicine. Department of Anatomy; Corea del SurFil: Cha, Hye Lim. Ajou University School of Medicine. Department of Anatomy; Corea del SurFil: Oh, Huy-Hyen. Ajou University School of Medicine. Department of Anatomy; Corea del SurFil: Oh, Huy-Hyen. Ajou University School of Medicine. The Graduate School. Department of Biomedical Sciences; Corea del SurFil: Ghil, Sungho. Kyonggi University. Department of Life Science; Corea del SurFil: Lee, Young-Don. Ajou University School of Medicine. Department of Anatomy; Corea del SurFil: Lee, Young-Don. Ajou University School of Medicine. The Graduate School. Department of Biomedical Sciences; Corea del SurFil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Birnbaumer, Lutz. National Institute of Environmental Health Sciences. Neurobiology Laboratory; Estados UnidosFil: Suh-Kim, Haeyoung. Ajou University School of Medicine. Department of Anatomy; Corea del SurFil: Suh-Kim, Haeyoung. Ajou University School of Medicine. The Graduate School. Department of Biomedical Sciences; Corea del SurAbstract: In mammals, initial detection of olfactory stimuli is mediated by sensory neurons in the main olfactory epithelium (MOE) and the vomeronasal organ (VNO). The heterotrimeric GTP-binding protein Go is widely expressed in the MOE and VNO of mice. Early studies indicated that Go expression in VNO sensory neurons is critical for directing social and sexual behaviors in female mice [Oboti L, et al. (2014) BMC Biol 12:31]. However, the physiological functions of Go in the MOE have remained poorly defined. Here, we examined the role of Go in the MOE using mice lacking the α subunit of Go Development of the olfactory bulb (OB) was perturbed in mutant mice as a result of reduced neurogenesis and increased cell death. The balance between cell types of OB interneurons was altered in mutant mice, with an increase in the number of tyrosine hydroxylase-positive interneurons at the expense of calbindin-positive interneurons. Sexual behavior toward female mice and preference for female urine odors by olfactory sensory neurons in the MOE were abolished in mutant male mice. Our data suggest that Go signaling is essential for the structural and functional integrity of the MOE and for specification of OB interneurons, which in turn are required for the transmission of pheromone signals and the initiation of mating behavior with the opposite sex.National Academy of Sciences2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/87600027-8424 (impreso)1091-6490 (online)10.1073/pnas.161302611327625425Choi J-M, Kim S-S, Choi C-I, et al. Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice [en línea]. Proceedings of the National Academy of Sciences. 2016;113(39):10974-10979. doi:10.1073/pnas.1613026113 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8760Proceedings of the National Academy of Sciences. 2016;113(39):10974-10979reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:56:54Zoai:ucacris:123456789/8760instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:56:55.217Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice
title Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice
spellingShingle Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice
Choi, Jung-Mi
PROTEINAS
OLFATO
SEXUALIDAD
COMPORTAMIENTO
APOPTOSIS
title_short Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice
title_full Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice
title_fullStr Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice
title_full_unstemmed Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice
title_sort Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice
dc.creator.none.fl_str_mv Choi, Jung-Mi
Kim, Sung-Soo
Choi, Chan-Il
Cha, Hye Lim
Oh, Huy-Hyen
Ghil, Sungho
Lee, Young-Don
Birnbaumer, Lutz
Suh-Kim, Haeyoung
author Choi, Jung-Mi
author_facet Choi, Jung-Mi
Kim, Sung-Soo
Choi, Chan-Il
Cha, Hye Lim
Oh, Huy-Hyen
Ghil, Sungho
Lee, Young-Don
Birnbaumer, Lutz
Suh-Kim, Haeyoung
author_role author
author2 Kim, Sung-Soo
Choi, Chan-Il
Cha, Hye Lim
Oh, Huy-Hyen
Ghil, Sungho
Lee, Young-Don
Birnbaumer, Lutz
Suh-Kim, Haeyoung
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv PROTEINAS
OLFATO
SEXUALIDAD
COMPORTAMIENTO
APOPTOSIS
topic PROTEINAS
OLFATO
SEXUALIDAD
COMPORTAMIENTO
APOPTOSIS
dc.description.none.fl_txt_mv Fil: Choi, Jung-Mi. Ajou University School of Medicine. Department of Anatomy; Corea del Sur
Fil: Kim, Sung-Soo. Ajou University School of Medicine. Department of Anatomy; Corea del Sur
Fil: Choi, Chan-Il. Ajou University School of Medicine. Department of Anatomy; Corea del Sur
Fil: Cha, Hye Lim. Ajou University School of Medicine. Department of Anatomy; Corea del Sur
Fil: Oh, Huy-Hyen. Ajou University School of Medicine. Department of Anatomy; Corea del Sur
Fil: Oh, Huy-Hyen. Ajou University School of Medicine. The Graduate School. Department of Biomedical Sciences; Corea del Sur
Fil: Ghil, Sungho. Kyonggi University. Department of Life Science; Corea del Sur
Fil: Lee, Young-Don. Ajou University School of Medicine. Department of Anatomy; Corea del Sur
Fil: Lee, Young-Don. Ajou University School of Medicine. The Graduate School. Department of Biomedical Sciences; Corea del Sur
Fil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Birnbaumer, Lutz. National Institute of Environmental Health Sciences. Neurobiology Laboratory; Estados Unidos
Fil: Suh-Kim, Haeyoung. Ajou University School of Medicine. Department of Anatomy; Corea del Sur
Fil: Suh-Kim, Haeyoung. Ajou University School of Medicine. The Graduate School. Department of Biomedical Sciences; Corea del Sur
Abstract: In mammals, initial detection of olfactory stimuli is mediated by sensory neurons in the main olfactory epithelium (MOE) and the vomeronasal organ (VNO). The heterotrimeric GTP-binding protein Go is widely expressed in the MOE and VNO of mice. Early studies indicated that Go expression in VNO sensory neurons is critical for directing social and sexual behaviors in female mice [Oboti L, et al. (2014) BMC Biol 12:31]. However, the physiological functions of Go in the MOE have remained poorly defined. Here, we examined the role of Go in the MOE using mice lacking the α subunit of Go Development of the olfactory bulb (OB) was perturbed in mutant mice as a result of reduced neurogenesis and increased cell death. The balance between cell types of OB interneurons was altered in mutant mice, with an increase in the number of tyrosine hydroxylase-positive interneurons at the expense of calbindin-positive interneurons. Sexual behavior toward female mice and preference for female urine odors by olfactory sensory neurons in the MOE were abolished in mutant male mice. Our data suggest that Go signaling is essential for the structural and functional integrity of the MOE and for specification of OB interneurons, which in turn are required for the transmission of pheromone signals and the initiation of mating behavior with the opposite sex.
description Fil: Choi, Jung-Mi. Ajou University School of Medicine. Department of Anatomy; Corea del Sur
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/8760
0027-8424 (impreso)
1091-6490 (online)
10.1073/pnas.1613026113
27625425
Choi J-M, Kim S-S, Choi C-I, et al. Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice [en línea]. Proceedings of the National Academy of Sciences. 2016;113(39):10974-10979. doi:10.1073/pnas.1613026113 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8760
url https://repositorio.uca.edu.ar/handle/123456789/8760
identifier_str_mv 0027-8424 (impreso)
1091-6490 (online)
10.1073/pnas.1613026113
27625425
Choi J-M, Kim S-S, Choi C-I, et al. Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice [en línea]. Proceedings of the National Academy of Sciences. 2016;113(39):10974-10979. doi:10.1073/pnas.1613026113 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8760
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv National Academy of Sciences
publisher.none.fl_str_mv National Academy of Sciences
dc.source.none.fl_str_mv Proceedings of the National Academy of Sciences. 2016;113(39):10974-10979
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 12.982451

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