Therapeutic potential of melatonin and its analogs in Parkinson's disease: Focus on sleep and neuroprotection

• Autores: Srinivasan, Venkatramanujam; Cardinali, Daniel Pedro; Srinivasan, Uddanapalli S.; Kaur, Charanjit; Brown, Gregory M.; Spence, David Warren; Hardeland, Rudiger; Pandi Perumal, Seithikurippu R.
• Año de publicación: 2011
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: AGOMELATINE; INSOMNIA; LIGHT THERAPY; MELATONIN; OXIDATIVE STRESS; PARKINSON'S DISEASE; RAMELTEON; REM SLEEP BEHAVIOR DISORDER; TASIMELTEON
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Sleep disorders constitute major nonmotor features of Parkinson's disease (PD) that have a substantial effect on patients' quality of life and can be related to the progression of the neurodegenerative disease. They can also serve as preclinical markers for PD, as it is the case for rapid eye movement (REM)-associated sleep behavior disorder (RBD). Although the etiology of sleep disorders in PD remains undefined, the assessment of the components of the circadian system, including melatonin secretion, could give therapeutically valuable insight on their pathophysiopathology. Melatonin is a regulator of the sleep/wake cycle and also acts as an effective antioxidant and mitochondrial function protector. A reduction in the expression of melatonin MT1 and MT2 receptors has been documented in the substantia nigra of PD patients. The efficacy of melatonin for preventing neuronal cell death and for ameliorating PD symptoms has been demonstrated in animal models of PD employing neurotoxins. A small number of controlled trials indicate that melatonin is useful in treating disturbed sleep in PD, in particular RBD. Whether melatonin and the recently developed melatonergic agents (ramelteon, tasimelteon, agomelatine) have therapeutic potential in PD is also discussed.
Fil: Srinivasan, Venkatramanujam. No especifíca;
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Srinivasan, Uddanapalli S.. No especifíca;
Fil: Kaur, Charanjit. No especifíca;
Fil: Brown, Gregory M.. University of Toronto; Canadá
Fil: Spence, David Warren. No especifíca;
Fil: Hardeland, Rudiger. Universität Göttingen; Alemania
Fil: Pandi Perumal, Seithikurippu R.. No especifíca;