Histamine therapeutic efficacy in metastatic melanoma : role of histamine H4 receptor agonists and opportunity for combination with radiation
- Autores
- Massari, Noelia A.; Nicoud, Melisa Beatriz; Sambuco, Lorena; Cricco, Graciela P.; Martinel Lamas, Diego J.; Herrero Ducloux, María V.; Blanco, Horacio; Rivera, Elena S.; Medina, Vanina Araceli
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Massari, Noelia A. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Radioisotopos; Argentina
Fil: Massari, Noelia A. Universidad Nacional de la Patagonia San Juan Bosco. Facultad de Ciencias Naturales. Departamento de Inmunología; Argentina
Fil: Nicoud, Melisa B. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Radioisotopos; Argentina
Fil: Nicoud, Melisa B. Pontificia Universidad Católica Argentina. Faculta de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Tumoral e Inflamación; Argenitna
Fil: Nicoud, Melisa B. Consejo Nacional de Investigaciones Científicas; Argentina
Fil: Sambuco, Lorena. Instituto de Inmunooncología; Argentina
Fil: Martinel Lamas, Diego J. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Radioisotopos; Argentina
Fil: Martinel Lamas, Diego J. Pontificia Universidad Católica Argentina. Faculta de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Tumoral e Inflamación; Argenitna
Fil: Martinel Lamas, Diego J. Consejo Nacional de Investigaciones Científicas; Argentina
Fil: Herrero Ducloux, María V. Universidad Nacional de la Patagonia San Juan Bosco. Facultad de Ciencias Naturales. Departamento de Patología; Argentina
Fil: Blanco, Horacio. Hospital Municipal de Oncología Marie Curie; Argentina
Fil: Rivera, Elena S. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Radioisotopos; Argentina
Fil: Medina, Vanina Araceli. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Radioisotopos; Argentina
Fil: Medina, Vanina Araceli. Pontificia Universidad Católica Argentina. Faculta de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Tumoral e Inflamación; Argenitna
Fil: Medina, Vanina Araceli. Consejo Nacional de Investigaciones Científicas; Argentina
Abstract: The aims of the work were to improve our knowledge of the role of H4R in melanoma proliferation and assess in vivo the therapeutic efficacy of histamine, clozapine and JNJ28610244, an H4R agonist, in a preclinical metastatic model of melanoma. Additionally, we aimed to investigate the combinatorial effect of histamine and gamma radiation on the radiobiological response of melanoma cells. Results indicate that 1205Lu metastatic melanoma cells express H4R and that histamine inhibits proliferation, in part through the stimulation of the H4R, and induces cell senescence and melanogenesis. Daily treatment with H4R agonists (1 mg/kg, sc) exhibited a significant in vivo antitumor effect and importantly, compounds reduced metastatic potential, particularly in the group treated with JNJ28610244, the H4R agonist with higher specificity. H4R is expressed in benign and malignant lesions of melanocytic lineage, highlighting the potential clinical use of histamine and H4R agonists. In addition, histamine increased radiosensitivity of melanoma cells in vitro and in vivo. We conclude that stimulation of H4R by specific ligands may represent a novel therapeutic strategy in those tumors that express this receptor. Furthermore, through increasing radiation-induced response, histamine could improve cancer radiotherapy for the treatment of melanoma. - Fuente
- Oncotarget, 2017, 8 (16)
- Materia
-
ONCOLOGIA
MELANOMA
CANCER DE PIEL
HISTAMINA
TRATAMIENTO MEDICO
RADIACION IONIZANTE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
.jpg)
- Institución
- Pontificia Universidad Católica Argentina
- OAI Identificador
- oai:ucacris:123456789/8369
Ver los metadatos del registro completo
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Histamine therapeutic efficacy in metastatic melanoma : role of histamine H4 receptor agonists and opportunity for combination with radiationMassari, Noelia A.Nicoud, Melisa BeatrizSambuco, LorenaCricco, Graciela P.Martinel Lamas, Diego J.Herrero Ducloux, María V.Blanco, HoracioRivera, Elena S.Medina, Vanina AraceliONCOLOGIAMELANOMACANCER DE PIELHISTAMINATRATAMIENTO MEDICORADIACION IONIZANTEFil: Massari, Noelia A. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Radioisotopos; ArgentinaFil: Massari, Noelia A. Universidad Nacional de la Patagonia San Juan Bosco. Facultad de Ciencias Naturales. Departamento de Inmunología; ArgentinaFil: Nicoud, Melisa B. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Radioisotopos; ArgentinaFil: Nicoud, Melisa B. Pontificia Universidad Católica Argentina. Faculta de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Tumoral e Inflamación; ArgenitnaFil: Nicoud, Melisa B. Consejo Nacional de Investigaciones Científicas; ArgentinaFil: Sambuco, Lorena. Instituto de Inmunooncología; ArgentinaFil: Martinel Lamas, Diego J. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Radioisotopos; ArgentinaFil: Martinel Lamas, Diego J. Pontificia Universidad Católica Argentina. Faculta de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Tumoral e Inflamación; ArgenitnaFil: Martinel Lamas, Diego J. Consejo Nacional de Investigaciones Científicas; ArgentinaFil: Herrero Ducloux, María V. Universidad Nacional de la Patagonia San Juan Bosco. Facultad de Ciencias Naturales. Departamento de Patología; ArgentinaFil: Blanco, Horacio. Hospital Municipal de Oncología Marie Curie; ArgentinaFil: Rivera, Elena S. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Radioisotopos; ArgentinaFil: Medina, Vanina Araceli. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Radioisotopos; ArgentinaFil: Medina, Vanina Araceli. Pontificia Universidad Católica Argentina. Faculta de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Tumoral e Inflamación; ArgenitnaFil: Medina, Vanina Araceli. Consejo Nacional de Investigaciones Científicas; ArgentinaAbstract: The aims of the work were to improve our knowledge of the role of H4R in melanoma proliferation and assess in vivo the therapeutic efficacy of histamine, clozapine and JNJ28610244, an H4R agonist, in a preclinical metastatic model of melanoma. Additionally, we aimed to investigate the combinatorial effect of histamine and gamma radiation on the radiobiological response of melanoma cells. Results indicate that 1205Lu metastatic melanoma cells express H4R and that histamine inhibits proliferation, in part through the stimulation of the H4R, and induces cell senescence and melanogenesis. Daily treatment with H4R agonists (1 mg/kg, sc) exhibited a significant in vivo antitumor effect and importantly, compounds reduced metastatic potential, particularly in the group treated with JNJ28610244, the H4R agonist with higher specificity. H4R is expressed in benign and malignant lesions of melanocytic lineage, highlighting the potential clinical use of histamine and H4R agonists. In addition, histamine increased radiosensitivity of melanoma cells in vitro and in vivo. We conclude that stimulation of H4R by specific ligands may represent a novel therapeutic strategy in those tumors that express this receptor. Furthermore, through increasing radiation-induced response, histamine could improve cancer radiotherapy for the treatment of melanoma.Impact Journals2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/83691949-255310.18632/oncotarget.15594Massari, N. A., et al. Histamine therapeutic efficacy in metastatic melanoma : role of histamine H4 receptor agonists and opportunity for combination with radiation [en línea]. Oncotarget. 2017, 8 (16). doi:10.18632/oncotarget.15594. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8369Oncotarget, 2017, 8 (16)reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:56:47Zoai:ucacris:123456789/8369instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:56:47.337Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse |
| dc.title.none.fl_str_mv |
Histamine therapeutic efficacy in metastatic melanoma : role of histamine H4 receptor agonists and opportunity for combination with radiation |
| title |
Histamine therapeutic efficacy in metastatic melanoma : role of histamine H4 receptor agonists and opportunity for combination with radiation |
| spellingShingle |
Histamine therapeutic efficacy in metastatic melanoma : role of histamine H4 receptor agonists and opportunity for combination with radiation Massari, Noelia A. ONCOLOGIA MELANOMA CANCER DE PIEL HISTAMINA TRATAMIENTO MEDICO RADIACION IONIZANTE |
| title_short |
Histamine therapeutic efficacy in metastatic melanoma : role of histamine H4 receptor agonists and opportunity for combination with radiation |
| title_full |
Histamine therapeutic efficacy in metastatic melanoma : role of histamine H4 receptor agonists and opportunity for combination with radiation |
| title_fullStr |
Histamine therapeutic efficacy in metastatic melanoma : role of histamine H4 receptor agonists and opportunity for combination with radiation |
| title_full_unstemmed |
Histamine therapeutic efficacy in metastatic melanoma : role of histamine H4 receptor agonists and opportunity for combination with radiation |
| title_sort |
Histamine therapeutic efficacy in metastatic melanoma : role of histamine H4 receptor agonists and opportunity for combination with radiation |
| dc.creator.none.fl_str_mv |
Massari, Noelia A. Nicoud, Melisa Beatriz Sambuco, Lorena Cricco, Graciela P. Martinel Lamas, Diego J. Herrero Ducloux, María V. Blanco, Horacio Rivera, Elena S. Medina, Vanina Araceli |
| author |
Massari, Noelia A. |
| author_facet |
Massari, Noelia A. Nicoud, Melisa Beatriz Sambuco, Lorena Cricco, Graciela P. Martinel Lamas, Diego J. Herrero Ducloux, María V. Blanco, Horacio Rivera, Elena S. Medina, Vanina Araceli |
| author_role |
author |
| author2 |
Nicoud, Melisa Beatriz Sambuco, Lorena Cricco, Graciela P. Martinel Lamas, Diego J. Herrero Ducloux, María V. Blanco, Horacio Rivera, Elena S. Medina, Vanina Araceli |
| author2_role |
author author author author author author author author |
| dc.subject.none.fl_str_mv |
ONCOLOGIA MELANOMA CANCER DE PIEL HISTAMINA TRATAMIENTO MEDICO RADIACION IONIZANTE |
| topic |
ONCOLOGIA MELANOMA CANCER DE PIEL HISTAMINA TRATAMIENTO MEDICO RADIACION IONIZANTE |
| dc.description.none.fl_txt_mv |
Fil: Massari, Noelia A. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Radioisotopos; Argentina Fil: Massari, Noelia A. Universidad Nacional de la Patagonia San Juan Bosco. Facultad de Ciencias Naturales. Departamento de Inmunología; Argentina Fil: Nicoud, Melisa B. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Radioisotopos; Argentina Fil: Nicoud, Melisa B. Pontificia Universidad Católica Argentina. Faculta de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Tumoral e Inflamación; Argenitna Fil: Nicoud, Melisa B. Consejo Nacional de Investigaciones Científicas; Argentina Fil: Sambuco, Lorena. Instituto de Inmunooncología; Argentina Fil: Martinel Lamas, Diego J. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Radioisotopos; Argentina Fil: Martinel Lamas, Diego J. Pontificia Universidad Católica Argentina. Faculta de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Tumoral e Inflamación; Argenitna Fil: Martinel Lamas, Diego J. Consejo Nacional de Investigaciones Científicas; Argentina Fil: Herrero Ducloux, María V. Universidad Nacional de la Patagonia San Juan Bosco. Facultad de Ciencias Naturales. Departamento de Patología; Argentina Fil: Blanco, Horacio. Hospital Municipal de Oncología Marie Curie; Argentina Fil: Rivera, Elena S. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Radioisotopos; Argentina Fil: Medina, Vanina Araceli. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Radioisotopos; Argentina Fil: Medina, Vanina Araceli. Pontificia Universidad Católica Argentina. Faculta de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Tumoral e Inflamación; Argenitna Fil: Medina, Vanina Araceli. Consejo Nacional de Investigaciones Científicas; Argentina Abstract: The aims of the work were to improve our knowledge of the role of H4R in melanoma proliferation and assess in vivo the therapeutic efficacy of histamine, clozapine and JNJ28610244, an H4R agonist, in a preclinical metastatic model of melanoma. Additionally, we aimed to investigate the combinatorial effect of histamine and gamma radiation on the radiobiological response of melanoma cells. Results indicate that 1205Lu metastatic melanoma cells express H4R and that histamine inhibits proliferation, in part through the stimulation of the H4R, and induces cell senescence and melanogenesis. Daily treatment with H4R agonists (1 mg/kg, sc) exhibited a significant in vivo antitumor effect and importantly, compounds reduced metastatic potential, particularly in the group treated with JNJ28610244, the H4R agonist with higher specificity. H4R is expressed in benign and malignant lesions of melanocytic lineage, highlighting the potential clinical use of histamine and H4R agonists. In addition, histamine increased radiosensitivity of melanoma cells in vitro and in vivo. We conclude that stimulation of H4R by specific ligands may represent a novel therapeutic strategy in those tumors that express this receptor. Furthermore, through increasing radiation-induced response, histamine could improve cancer radiotherapy for the treatment of melanoma. |
| description |
Fil: Massari, Noelia A. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Radioisotopos; Argentina |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017 |
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article |
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publishedVersion |
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https://repositorio.uca.edu.ar/handle/123456789/8369 1949-2553 10.18632/oncotarget.15594 Massari, N. A., et al. Histamine therapeutic efficacy in metastatic melanoma : role of histamine H4 receptor agonists and opportunity for combination with radiation [en línea]. Oncotarget. 2017, 8 (16). doi:10.18632/oncotarget.15594. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8369 |
| url |
https://repositorio.uca.edu.ar/handle/123456789/8369 |
| identifier_str_mv |
1949-2553 10.18632/oncotarget.15594 Massari, N. A., et al. Histamine therapeutic efficacy in metastatic melanoma : role of histamine H4 receptor agonists and opportunity for combination with radiation [en línea]. Oncotarget. 2017, 8 (16). doi:10.18632/oncotarget.15594. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8369 |
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eng |
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Impact Journals |
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