Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platforms

Autores
Barrantes, Francisco José
Año de publicación
2017
Idioma
inglés
Tipo de recurso
parte de libro
Estado
versión aceptada
Descripción
Fil: Barrantes, Francisco J. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; Argentina
Fil: Barrantes, Francisco J. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Abstract: The relationships between neurotransmitter receptors and their membrane environment are complex, mutual (bidirectional) and physiologically important. Some of these relationships are established with subsets of the membrane lipid population, in the form of lipid platforms, lateral heterogeneities of the bilayer lipid having a dynamic chemical composition distinct from that of the bulk membrane. In addition to the equilibrium between the biosynthetic production, exocytic delivery and recycling of receptors on the one hand, and the endocytic internalization on the other, lateral diffusion, clustering and anchorage of receptors at the lipid platforms play key roles in determining the amount of active receptors at the synapse. Mobile receptors traffic between reservoir non-synaptic membranes and the synapse predominantly by thermally driven Brownian motion, and become immobilized at the perisynaptic region or the synapse proper by various mechanisms. These comprise: (a) clustering mediated by homotropic inter-molecular receptor-receptor associations; (b) heterotropic associations with non-receptor scaffolding proteins or the subjacent cytoskeletal meshwork, leading to diffusional “trapping”, and (c) protein-lipid interactions, particularly with the neutral lipid cholesterol. Preceded by a brief introduction on the currently used methods to study protein lateral mobility in membranes, this review assesses the contribution of some of these mechanisms to the supramolecular organization and dynamics of the paradigm neurotransmitter receptor of muscle and neuronal cells—the nicotinic acetylcholine receptor (nAChR). The translational mobility of nAChRs at these two cell surfaces differs in terms of diffusion coefficients and residence intervals at the synapse, which cover an ample range of time regimes. Neuronal α7 nAChRs exhibit diffusion coefficients similar to those of other neurotransmitter receptors and spend part of their lifetime confined to the perisynaptic region of glutamatergic (excitatory) and GABAergic (inhibitory) synapses; they may also be involved in the regulation of the dynamic equilibrium between excitation and inhibition in brain.
Fuente
Postprint de la colaboración en la obra: Chattopadhyay, A. (eds.). Membrane organization and dynamics : Springer Series in Biophysics, vol 20. Cham : Springer, 2017
ISBN 978-3-319-66601-3 (online)
ISBN 978-3-319-66600-6 (impreso)
Materia
NEUROTRANSMISORES
MEMBRANAS CELULARES
LIPIDOS
QUIMICA CELULAR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/8455

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network_name_str Repositorio Institucional (UCA)
spelling Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platformsBarrantes, Francisco JoséNEUROTRANSMISORESMEMBRANAS CELULARESLIPIDOSQUIMICA CELULARFil: Barrantes, Francisco J. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; ArgentinaFil: Barrantes, Francisco J. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAbstract: The relationships between neurotransmitter receptors and their membrane environment are complex, mutual (bidirectional) and physiologically important. Some of these relationships are established with subsets of the membrane lipid population, in the form of lipid platforms, lateral heterogeneities of the bilayer lipid having a dynamic chemical composition distinct from that of the bulk membrane. In addition to the equilibrium between the biosynthetic production, exocytic delivery and recycling of receptors on the one hand, and the endocytic internalization on the other, lateral diffusion, clustering and anchorage of receptors at the lipid platforms play key roles in determining the amount of active receptors at the synapse. Mobile receptors traffic between reservoir non-synaptic membranes and the synapse predominantly by thermally driven Brownian motion, and become immobilized at the perisynaptic region or the synapse proper by various mechanisms. These comprise: (a) clustering mediated by homotropic inter-molecular receptor-receptor associations; (b) heterotropic associations with non-receptor scaffolding proteins or the subjacent cytoskeletal meshwork, leading to diffusional “trapping”, and (c) protein-lipid interactions, particularly with the neutral lipid cholesterol. Preceded by a brief introduction on the currently used methods to study protein lateral mobility in membranes, this review assesses the contribution of some of these mechanisms to the supramolecular organization and dynamics of the paradigm neurotransmitter receptor of muscle and neuronal cells—the nicotinic acetylcholine receptor (nAChR). The translational mobility of nAChRs at these two cell surfaces differs in terms of diffusion coefficients and residence intervals at the synapse, which cover an ample range of time regimes. Neuronal α7 nAChRs exhibit diffusion coefficients similar to those of other neurotransmitter receptors and spend part of their lifetime confined to the perisynaptic region of glutamatergic (excitatory) and GABAergic (inhibitory) synapses; they may also be involved in the regulation of the dynamic equilibrium between excitation and inhibition in brain.Springer2017info:eu-repo/semantics/bookPartinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_3248info:ar-repo/semantics/parteDeLibroapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/8455978-3-319-66601-3 (online)978-3-319-66600-6 (impreso)10.1007/978-3-319-66601-3_9Barrantes, F. J. Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platforms [en línea]. En: Chattopadhyay, A. (eds.). Membrane organization and dynamics : Springer Series in Biophysics, vol 20. Cham : Springer, 2017. doi: 10.1007/978-3-319-66601-3_9. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8455Postprint de la colaboración en la obra: Chattopadhyay, A. (eds.). Membrane organization and dynamics : Springer Series in Biophysics, vol 20. Cham : Springer, 2017ISBN 978-3-319-66601-3 (online)ISBN 978-3-319-66600-6 (impreso)reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:56:49Zoai:ucacris:123456789/8455instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:56:49.928Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platforms
title Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platforms
spellingShingle Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platforms
Barrantes, Francisco José
NEUROTRANSMISORES
MEMBRANAS CELULARES
LIPIDOS
QUIMICA CELULAR
title_short Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platforms
title_full Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platforms
title_fullStr Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platforms
title_full_unstemmed Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platforms
title_sort Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platforms
dc.creator.none.fl_str_mv Barrantes, Francisco José
author Barrantes, Francisco José
author_facet Barrantes, Francisco José
author_role author
dc.subject.none.fl_str_mv NEUROTRANSMISORES
MEMBRANAS CELULARES
LIPIDOS
QUIMICA CELULAR
topic NEUROTRANSMISORES
MEMBRANAS CELULARES
LIPIDOS
QUIMICA CELULAR
dc.description.none.fl_txt_mv Fil: Barrantes, Francisco J. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; Argentina
Fil: Barrantes, Francisco J. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Abstract: The relationships between neurotransmitter receptors and their membrane environment are complex, mutual (bidirectional) and physiologically important. Some of these relationships are established with subsets of the membrane lipid population, in the form of lipid platforms, lateral heterogeneities of the bilayer lipid having a dynamic chemical composition distinct from that of the bulk membrane. In addition to the equilibrium between the biosynthetic production, exocytic delivery and recycling of receptors on the one hand, and the endocytic internalization on the other, lateral diffusion, clustering and anchorage of receptors at the lipid platforms play key roles in determining the amount of active receptors at the synapse. Mobile receptors traffic between reservoir non-synaptic membranes and the synapse predominantly by thermally driven Brownian motion, and become immobilized at the perisynaptic region or the synapse proper by various mechanisms. These comprise: (a) clustering mediated by homotropic inter-molecular receptor-receptor associations; (b) heterotropic associations with non-receptor scaffolding proteins or the subjacent cytoskeletal meshwork, leading to diffusional “trapping”, and (c) protein-lipid interactions, particularly with the neutral lipid cholesterol. Preceded by a brief introduction on the currently used methods to study protein lateral mobility in membranes, this review assesses the contribution of some of these mechanisms to the supramolecular organization and dynamics of the paradigm neurotransmitter receptor of muscle and neuronal cells—the nicotinic acetylcholine receptor (nAChR). The translational mobility of nAChRs at these two cell surfaces differs in terms of diffusion coefficients and residence intervals at the synapse, which cover an ample range of time regimes. Neuronal α7 nAChRs exhibit diffusion coefficients similar to those of other neurotransmitter receptors and spend part of their lifetime confined to the perisynaptic region of glutamatergic (excitatory) and GABAergic (inhibitory) synapses; they may also be involved in the regulation of the dynamic equilibrium between excitation and inhibition in brain.
description Fil: Barrantes, Francisco J. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; Argentina
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/bookPart
info:eu-repo/semantics/acceptedVersion
http://purl.org/coar/resource_type/c_3248
info:ar-repo/semantics/parteDeLibro
format bookPart
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/8455
978-3-319-66601-3 (online)
978-3-319-66600-6 (impreso)
10.1007/978-3-319-66601-3_9
Barrantes, F. J. Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platforms [en línea]. En: Chattopadhyay, A. (eds.). Membrane organization and dynamics : Springer Series in Biophysics, vol 20. Cham : Springer, 2017. doi: 10.1007/978-3-319-66601-3_9. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8455
url https://repositorio.uca.edu.ar/handle/123456789/8455
identifier_str_mv 978-3-319-66601-3 (online)
978-3-319-66600-6 (impreso)
10.1007/978-3-319-66601-3_9
Barrantes, F. J. Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platforms [en línea]. En: Chattopadhyay, A. (eds.). Membrane organization and dynamics : Springer Series in Biophysics, vol 20. Cham : Springer, 2017. doi: 10.1007/978-3-319-66601-3_9. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8455
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv Postprint de la colaboración en la obra: Chattopadhyay, A. (eds.). Membrane organization and dynamics : Springer Series in Biophysics, vol 20. Cham : Springer, 2017
ISBN 978-3-319-66601-3 (online)
ISBN 978-3-319-66600-6 (impreso)
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 13.070432