Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platforms
- Autores
- Barrantes, Francisco José
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- parte de libro
- Estado
- versión aceptada
- Descripción
- Fil: Barrantes, Francisco J. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; Argentina
Fil: Barrantes, Francisco J. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Abstract: The relationships between neurotransmitter receptors and their membrane environment are complex, mutual (bidirectional) and physiologically important. Some of these relationships are established with subsets of the membrane lipid population, in the form of lipid platforms, lateral heterogeneities of the bilayer lipid having a dynamic chemical composition distinct from that of the bulk membrane. In addition to the equilibrium between the biosynthetic production, exocytic delivery and recycling of receptors on the one hand, and the endocytic internalization on the other, lateral diffusion, clustering and anchorage of receptors at the lipid platforms play key roles in determining the amount of active receptors at the synapse. Mobile receptors traffic between reservoir non-synaptic membranes and the synapse predominantly by thermally driven Brownian motion, and become immobilized at the perisynaptic region or the synapse proper by various mechanisms. These comprise: (a) clustering mediated by homotropic inter-molecular receptor-receptor associations; (b) heterotropic associations with non-receptor scaffolding proteins or the subjacent cytoskeletal meshwork, leading to diffusional “trapping”, and (c) protein-lipid interactions, particularly with the neutral lipid cholesterol. Preceded by a brief introduction on the currently used methods to study protein lateral mobility in membranes, this review assesses the contribution of some of these mechanisms to the supramolecular organization and dynamics of the paradigm neurotransmitter receptor of muscle and neuronal cells—the nicotinic acetylcholine receptor (nAChR). The translational mobility of nAChRs at these two cell surfaces differs in terms of diffusion coefficients and residence intervals at the synapse, which cover an ample range of time regimes. Neuronal α7 nAChRs exhibit diffusion coefficients similar to those of other neurotransmitter receptors and spend part of their lifetime confined to the perisynaptic region of glutamatergic (excitatory) and GABAergic (inhibitory) synapses; they may also be involved in the regulation of the dynamic equilibrium between excitation and inhibition in brain. - Fuente
- Postprint de la colaboración en la obra: Chattopadhyay, A. (eds.). Membrane organization and dynamics : Springer Series in Biophysics, vol 20. Cham : Springer, 2017
ISBN 978-3-319-66601-3 (online)
ISBN 978-3-319-66600-6 (impreso) - Materia
-
NEUROTRANSMISORES
MEMBRANAS CELULARES
LIPIDOS
QUIMICA CELULAR - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Pontificia Universidad Católica Argentina
- OAI Identificador
- oai:ucacris:123456789/8455
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Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platformsBarrantes, Francisco JoséNEUROTRANSMISORESMEMBRANAS CELULARESLIPIDOSQUIMICA CELULARFil: Barrantes, Francisco J. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; ArgentinaFil: Barrantes, Francisco J. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAbstract: The relationships between neurotransmitter receptors and their membrane environment are complex, mutual (bidirectional) and physiologically important. Some of these relationships are established with subsets of the membrane lipid population, in the form of lipid platforms, lateral heterogeneities of the bilayer lipid having a dynamic chemical composition distinct from that of the bulk membrane. In addition to the equilibrium between the biosynthetic production, exocytic delivery and recycling of receptors on the one hand, and the endocytic internalization on the other, lateral diffusion, clustering and anchorage of receptors at the lipid platforms play key roles in determining the amount of active receptors at the synapse. Mobile receptors traffic between reservoir non-synaptic membranes and the synapse predominantly by thermally driven Brownian motion, and become immobilized at the perisynaptic region or the synapse proper by various mechanisms. These comprise: (a) clustering mediated by homotropic inter-molecular receptor-receptor associations; (b) heterotropic associations with non-receptor scaffolding proteins or the subjacent cytoskeletal meshwork, leading to diffusional “trapping”, and (c) protein-lipid interactions, particularly with the neutral lipid cholesterol. Preceded by a brief introduction on the currently used methods to study protein lateral mobility in membranes, this review assesses the contribution of some of these mechanisms to the supramolecular organization and dynamics of the paradigm neurotransmitter receptor of muscle and neuronal cells—the nicotinic acetylcholine receptor (nAChR). The translational mobility of nAChRs at these two cell surfaces differs in terms of diffusion coefficients and residence intervals at the synapse, which cover an ample range of time regimes. Neuronal α7 nAChRs exhibit diffusion coefficients similar to those of other neurotransmitter receptors and spend part of their lifetime confined to the perisynaptic region of glutamatergic (excitatory) and GABAergic (inhibitory) synapses; they may also be involved in the regulation of the dynamic equilibrium between excitation and inhibition in brain.Springer2017info:eu-repo/semantics/bookPartinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_3248info:ar-repo/semantics/parteDeLibroapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/8455978-3-319-66601-3 (online)978-3-319-66600-6 (impreso)10.1007/978-3-319-66601-3_9Barrantes, F. J. Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platforms [en línea]. En: Chattopadhyay, A. (eds.). Membrane organization and dynamics : Springer Series in Biophysics, vol 20. Cham : Springer, 2017. doi: 10.1007/978-3-319-66601-3_9. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8455Postprint de la colaboración en la obra: Chattopadhyay, A. (eds.). Membrane organization and dynamics : Springer Series in Biophysics, vol 20. Cham : Springer, 2017ISBN 978-3-319-66601-3 (online)ISBN 978-3-319-66600-6 (impreso)reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:56:49Zoai:ucacris:123456789/8455instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:56:49.928Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse |
dc.title.none.fl_str_mv |
Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platforms |
title |
Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platforms |
spellingShingle |
Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platforms Barrantes, Francisco José NEUROTRANSMISORES MEMBRANAS CELULARES LIPIDOS QUIMICA CELULAR |
title_short |
Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platforms |
title_full |
Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platforms |
title_fullStr |
Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platforms |
title_full_unstemmed |
Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platforms |
title_sort |
Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platforms |
dc.creator.none.fl_str_mv |
Barrantes, Francisco José |
author |
Barrantes, Francisco José |
author_facet |
Barrantes, Francisco José |
author_role |
author |
dc.subject.none.fl_str_mv |
NEUROTRANSMISORES MEMBRANAS CELULARES LIPIDOS QUIMICA CELULAR |
topic |
NEUROTRANSMISORES MEMBRANAS CELULARES LIPIDOS QUIMICA CELULAR |
dc.description.none.fl_txt_mv |
Fil: Barrantes, Francisco J. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; Argentina Fil: Barrantes, Francisco J. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Abstract: The relationships between neurotransmitter receptors and their membrane environment are complex, mutual (bidirectional) and physiologically important. Some of these relationships are established with subsets of the membrane lipid population, in the form of lipid platforms, lateral heterogeneities of the bilayer lipid having a dynamic chemical composition distinct from that of the bulk membrane. In addition to the equilibrium between the biosynthetic production, exocytic delivery and recycling of receptors on the one hand, and the endocytic internalization on the other, lateral diffusion, clustering and anchorage of receptors at the lipid platforms play key roles in determining the amount of active receptors at the synapse. Mobile receptors traffic between reservoir non-synaptic membranes and the synapse predominantly by thermally driven Brownian motion, and become immobilized at the perisynaptic region or the synapse proper by various mechanisms. These comprise: (a) clustering mediated by homotropic inter-molecular receptor-receptor associations; (b) heterotropic associations with non-receptor scaffolding proteins or the subjacent cytoskeletal meshwork, leading to diffusional “trapping”, and (c) protein-lipid interactions, particularly with the neutral lipid cholesterol. Preceded by a brief introduction on the currently used methods to study protein lateral mobility in membranes, this review assesses the contribution of some of these mechanisms to the supramolecular organization and dynamics of the paradigm neurotransmitter receptor of muscle and neuronal cells—the nicotinic acetylcholine receptor (nAChR). The translational mobility of nAChRs at these two cell surfaces differs in terms of diffusion coefficients and residence intervals at the synapse, which cover an ample range of time regimes. Neuronal α7 nAChRs exhibit diffusion coefficients similar to those of other neurotransmitter receptors and spend part of their lifetime confined to the perisynaptic region of glutamatergic (excitatory) and GABAergic (inhibitory) synapses; they may also be involved in the regulation of the dynamic equilibrium between excitation and inhibition in brain. |
description |
Fil: Barrantes, Francisco J. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; Argentina |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/bookPart info:eu-repo/semantics/acceptedVersion http://purl.org/coar/resource_type/c_3248 info:ar-repo/semantics/parteDeLibro |
format |
bookPart |
status_str |
acceptedVersion |
dc.identifier.none.fl_str_mv |
https://repositorio.uca.edu.ar/handle/123456789/8455 978-3-319-66601-3 (online) 978-3-319-66600-6 (impreso) 10.1007/978-3-319-66601-3_9 Barrantes, F. J. Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platforms [en línea]. En: Chattopadhyay, A. (eds.). Membrane organization and dynamics : Springer Series in Biophysics, vol 20. Cham : Springer, 2017. doi: 10.1007/978-3-319-66601-3_9. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8455 |
url |
https://repositorio.uca.edu.ar/handle/123456789/8455 |
identifier_str_mv |
978-3-319-66601-3 (online) 978-3-319-66600-6 (impreso) 10.1007/978-3-319-66601-3_9 Barrantes, F. J. Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platforms [en línea]. En: Chattopadhyay, A. (eds.). Membrane organization and dynamics : Springer Series in Biophysics, vol 20. Cham : Springer, 2017. doi: 10.1007/978-3-319-66601-3_9. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8455 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
Postprint de la colaboración en la obra: Chattopadhyay, A. (eds.). Membrane organization and dynamics : Springer Series in Biophysics, vol 20. Cham : Springer, 2017 ISBN 978-3-319-66601-3 (online) ISBN 978-3-319-66600-6 (impreso) reponame:Repositorio Institucional (UCA) instname:Pontificia Universidad Católica Argentina |
reponame_str |
Repositorio Institucional (UCA) |
collection |
Repositorio Institucional (UCA) |
instname_str |
Pontificia Universidad Católica Argentina |
repository.name.fl_str_mv |
Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina |
repository.mail.fl_str_mv |
claudia_fernandez@uca.edu.ar |
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1836638346802102272 |
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13.070432 |