Chaperoning α7 neuronal nicotinic acetylcholine receptors

Autores
Vallés, Ana Sofía; Barrantes, Francisco José
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Vallés, Ana Sofía. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Barrantes, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; Argentina
Abstract: The α7 subtype of nicotinic acetylcholine receptors (AChRs) is one of the most abundant members of the Cys-loop family of receptors present in the central nervous system. It participates in various physiological processes and has received much attention as a potential therapeutic target for a variety of pathologies. The importance of understanding the mechanisms controlling AChR assembly and cell-surface delivery lies in the fact that these two processes are key to determining the functional pool of receptors actively engaged in synaptic transmission. Here we review recent studies showing that RIC-3, a protein originally identified in the worm Caenorhabditis elegans, modulates the expression of α7 AChRs in a subtype-specific manner. Potentiation of AChR expression by post-transcriptional events is also critically assessed.
Fuente
Biochimica et Biophysica Acta Vol. 1818, N° 3, 2012
Materia
RECEPTORES
PROTEINAS
MEMBRANAS CELULARES
RIC-3
NEUROBIOLOGIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/8768
Acceder
id RIUCA_921f0a9526e4c2a55589727e1eeccde3
oai_identifier_str oai:ucacris:123456789/8768
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Chaperoning α7 neuronal nicotinic acetylcholine receptorsVallés, Ana SofíaBarrantes, Francisco JoséRECEPTORESPROTEINASMEMBRANAS CELULARESRIC-3NEUROBIOLOGIAFil: Vallés, Ana Sofía. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Barrantes, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; ArgentinaAbstract: The α7 subtype of nicotinic acetylcholine receptors (AChRs) is one of the most abundant members of the Cys-loop family of receptors present in the central nervous system. It participates in various physiological processes and has received much attention as a potential therapeutic target for a variety of pathologies. The importance of understanding the mechanisms controlling AChR assembly and cell-surface delivery lies in the fact that these two processes are key to determining the functional pool of receptors actively engaged in synaptic transmission. Here we review recent studies showing that RIC-3, a protein originally identified in the worm Caenorhabditis elegans, modulates the expression of α7 AChRs in a subtype-specific manner. Potentiation of AChR expression by post-transcriptional events is also critically assessed.Elsevier B.V.2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/87680006-300210.1016/j.bbamem.2011.10.01222040696Vallés AS, Barrantes FJ. Chaperoning α7 neuronal nicotinic acetylcholine receptors. Biochimica et Biophysica Acta. 2012; 1818. https://doi.org/10.1016/j.bbamem.2011.10.012. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8768Biochimica et Biophysica Acta Vol. 1818, N° 3, 2012reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:56:54Zoai:ucacris:123456789/8768instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:56:55.237Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Chaperoning α7 neuronal nicotinic acetylcholine receptors
title Chaperoning α7 neuronal nicotinic acetylcholine receptors
spellingShingle Chaperoning α7 neuronal nicotinic acetylcholine receptors
Vallés, Ana Sofía
RECEPTORES
PROTEINAS
MEMBRANAS CELULARES
RIC-3
NEUROBIOLOGIA
title_short Chaperoning α7 neuronal nicotinic acetylcholine receptors
title_full Chaperoning α7 neuronal nicotinic acetylcholine receptors
title_fullStr Chaperoning α7 neuronal nicotinic acetylcholine receptors
title_full_unstemmed Chaperoning α7 neuronal nicotinic acetylcholine receptors
title_sort Chaperoning α7 neuronal nicotinic acetylcholine receptors
dc.creator.none.fl_str_mv Vallés, Ana Sofía
Barrantes, Francisco José
author Vallés, Ana Sofía
author_facet Vallés, Ana Sofía
Barrantes, Francisco José
author_role author
author2 Barrantes, Francisco José
author2_role author
dc.subject.none.fl_str_mv RECEPTORES
PROTEINAS
MEMBRANAS CELULARES
RIC-3
NEUROBIOLOGIA
topic RECEPTORES
PROTEINAS
MEMBRANAS CELULARES
RIC-3
NEUROBIOLOGIA
dc.description.none.fl_txt_mv Fil: Vallés, Ana Sofía. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Barrantes, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; Argentina
Abstract: The α7 subtype of nicotinic acetylcholine receptors (AChRs) is one of the most abundant members of the Cys-loop family of receptors present in the central nervous system. It participates in various physiological processes and has received much attention as a potential therapeutic target for a variety of pathologies. The importance of understanding the mechanisms controlling AChR assembly and cell-surface delivery lies in the fact that these two processes are key to determining the functional pool of receptors actively engaged in synaptic transmission. Here we review recent studies showing that RIC-3, a protein originally identified in the worm Caenorhabditis elegans, modulates the expression of α7 AChRs in a subtype-specific manner. Potentiation of AChR expression by post-transcriptional events is also critically assessed.
description Fil: Vallés, Ana Sofía. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/8768
0006-3002
10.1016/j.bbamem.2011.10.012
22040696
Vallés AS, Barrantes FJ. Chaperoning α7 neuronal nicotinic acetylcholine receptors. Biochimica et Biophysica Acta. 2012; 1818. https://doi.org/10.1016/j.bbamem.2011.10.012. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8768
url https://repositorio.uca.edu.ar/handle/123456789/8768
identifier_str_mv 0006-3002
10.1016/j.bbamem.2011.10.012
22040696
Vallés AS, Barrantes FJ. Chaperoning α7 neuronal nicotinic acetylcholine receptors. Biochimica et Biophysica Acta. 2012; 1818. https://doi.org/10.1016/j.bbamem.2011.10.012. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8768
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Biochimica et Biophysica Acta Vol. 1818, N° 3, 2012
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 13.13397

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