Current understanding of the roles of gut–brain axis in the cognitive deficits caused by perinatal stress exposure

Autores
Rubinstein Guichón, Mara Roxana; Burgueño, Adriana Laura; Quiroga, Sofia; Wald, Miriam Ruth; Genaro, Ana María
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Rubinstein Guichón, Mara Roxana. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Psiconeuroendocrinoinmunología; Argentina
Fil: Rubinstein Guichón, Mara Roxana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Burgueño, Adriana Laura. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Psiconeuroendocrinoinmunología; Argentina
Fil: Burgueño, Adriana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Quiroga, Sofia. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Psiconeuroendocrinoinmunología; Argentina
Fil: Quiroga, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Wald, Miriam Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Wald, Miriam Ruth. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Psiconeuroendocrinoinmunología; Argentina
Fil: Genaro, Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Genaro, Ana María. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Psiconeuroendocrinoinmunología; Argentina
Abstract: Abstract: The term ‘perinatal environment’ refers to the period surrounding birth, which plays a crucial role in brain development. It has been suggested that dynamic communication between the neuro–immune system and gut microbiota is essential in maintaining adequate brain function. This interaction depends on the mother’s status during pregnancy and/or the newborn environment. Here, we show experimental and clinical evidence that indicates that the perinatal period is a critical window in which stress-induced immune activation and altered microbiota compositions produce lasting behavioral consequences, although a clear causative relationship has not yet been established. In addition, we discuss potential early treatments for preventing the deleterious effect of perinatal stress exposure. In this sense, early environmental enrichment exposure (including exercise) and melatonin use in the perinatal period could be valuable in improving the negative consequences of early adversities. The evidence presented in this review encourages the realization of studies investigating the beneficial role of melatonin administration and environmental enrichment exposure in mitigating cognitive alteration in offspring under perinatal stress exposure. On the other hand, direct evidence of microbiota restoration as the main mechanism behind the beneficial effects of this treatment has not been fully demonstrated and should be explored in future studies.
Fuente
Cells. 2023, 12, 1735
Materia
STRESS PRENATAL
DEFICIT COGNITIVO
INTESTINOS
MELATONINA
CEREBRO
ENRIQUECIMIENTO AMBIENTAL
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/17342
Acceder
id RIUCA_d88ba4c739c9985b2d45ae04df17d882
oai_identifier_str oai:ucacris:123456789/17342
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Current understanding of the roles of gut–brain axis in the cognitive deficits caused by perinatal stress exposureRubinstein Guichón, Mara RoxanaBurgueño, Adriana LauraQuiroga, SofiaWald, Miriam RuthGenaro, Ana MaríaSTRESS PRENATALDEFICIT COGNITIVOINTESTINOSMELATONINACEREBROENRIQUECIMIENTO AMBIENTALFil: Rubinstein Guichón, Mara Roxana. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Psiconeuroendocrinoinmunología; ArgentinaFil: Rubinstein Guichón, Mara Roxana. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Burgueño, Adriana Laura. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Psiconeuroendocrinoinmunología; ArgentinaFil: Burgueño, Adriana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Quiroga, Sofia. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Psiconeuroendocrinoinmunología; ArgentinaFil: Quiroga, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Wald, Miriam Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Wald, Miriam Ruth. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Psiconeuroendocrinoinmunología; ArgentinaFil: Genaro, Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Genaro, Ana María. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Psiconeuroendocrinoinmunología; ArgentinaAbstract: Abstract: The term ‘perinatal environment’ refers to the period surrounding birth, which plays a crucial role in brain development. It has been suggested that dynamic communication between the neuro–immune system and gut microbiota is essential in maintaining adequate brain function. This interaction depends on the mother’s status during pregnancy and/or the newborn environment. Here, we show experimental and clinical evidence that indicates that the perinatal period is a critical window in which stress-induced immune activation and altered microbiota compositions produce lasting behavioral consequences, although a clear causative relationship has not yet been established. In addition, we discuss potential early treatments for preventing the deleterious effect of perinatal stress exposure. In this sense, early environmental enrichment exposure (including exercise) and melatonin use in the perinatal period could be valuable in improving the negative consequences of early adversities. The evidence presented in this review encourages the realization of studies investigating the beneficial role of melatonin administration and environmental enrichment exposure in mitigating cognitive alteration in offspring under perinatal stress exposure. On the other hand, direct evidence of microbiota restoration as the main mechanism behind the beneficial effects of this treatment has not been fully demonstrated and should be explored in future studies.MDPI2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/173422073-440910.3390/cells1213173537443769Rubinstein, M.R., Burgueño, A.L., Quiroga, S., Wald, M.R., Genaro, A.M. Current understanding of the roles of gut–brain axis in the cognitive deficits caused by perinatal stress exposure [en línea]. Cells. 2023, 12, 1735. doi: 10.3390/cells12131735. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/17342Cells. 2023, 12, 1735reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:59:33Zoai:ucacris:123456789/17342instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:59:34.236Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Current understanding of the roles of gut–brain axis in the cognitive deficits caused by perinatal stress exposure
title Current understanding of the roles of gut–brain axis in the cognitive deficits caused by perinatal stress exposure
spellingShingle Current understanding of the roles of gut–brain axis in the cognitive deficits caused by perinatal stress exposure
Rubinstein Guichón, Mara Roxana
STRESS PRENATAL
DEFICIT COGNITIVO
INTESTINOS
MELATONINA
CEREBRO
ENRIQUECIMIENTO AMBIENTAL
title_short Current understanding of the roles of gut–brain axis in the cognitive deficits caused by perinatal stress exposure
title_full Current understanding of the roles of gut–brain axis in the cognitive deficits caused by perinatal stress exposure
title_fullStr Current understanding of the roles of gut–brain axis in the cognitive deficits caused by perinatal stress exposure
title_full_unstemmed Current understanding of the roles of gut–brain axis in the cognitive deficits caused by perinatal stress exposure
title_sort Current understanding of the roles of gut–brain axis in the cognitive deficits caused by perinatal stress exposure
dc.creator.none.fl_str_mv Rubinstein Guichón, Mara Roxana
Burgueño, Adriana Laura
Quiroga, Sofia
Wald, Miriam Ruth
Genaro, Ana María
author Rubinstein Guichón, Mara Roxana
author_facet Rubinstein Guichón, Mara Roxana
Burgueño, Adriana Laura
Quiroga, Sofia
Wald, Miriam Ruth
Genaro, Ana María
author_role author
author2 Burgueño, Adriana Laura
Quiroga, Sofia
Wald, Miriam Ruth
Genaro, Ana María
author2_role author
author
author
author
dc.subject.none.fl_str_mv STRESS PRENATAL
DEFICIT COGNITIVO
INTESTINOS
MELATONINA
CEREBRO
ENRIQUECIMIENTO AMBIENTAL
topic STRESS PRENATAL
DEFICIT COGNITIVO
INTESTINOS
MELATONINA
CEREBRO
ENRIQUECIMIENTO AMBIENTAL
dc.description.none.fl_txt_mv Fil: Rubinstein Guichón, Mara Roxana. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Psiconeuroendocrinoinmunología; Argentina
Fil: Rubinstein Guichón, Mara Roxana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Burgueño, Adriana Laura. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Psiconeuroendocrinoinmunología; Argentina
Fil: Burgueño, Adriana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Quiroga, Sofia. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Psiconeuroendocrinoinmunología; Argentina
Fil: Quiroga, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Wald, Miriam Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Wald, Miriam Ruth. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Psiconeuroendocrinoinmunología; Argentina
Fil: Genaro, Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Genaro, Ana María. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Psiconeuroendocrinoinmunología; Argentina
Abstract: Abstract: The term ‘perinatal environment’ refers to the period surrounding birth, which plays a crucial role in brain development. It has been suggested that dynamic communication between the neuro–immune system and gut microbiota is essential in maintaining adequate brain function. This interaction depends on the mother’s status during pregnancy and/or the newborn environment. Here, we show experimental and clinical evidence that indicates that the perinatal period is a critical window in which stress-induced immune activation and altered microbiota compositions produce lasting behavioral consequences, although a clear causative relationship has not yet been established. In addition, we discuss potential early treatments for preventing the deleterious effect of perinatal stress exposure. In this sense, early environmental enrichment exposure (including exercise) and melatonin use in the perinatal period could be valuable in improving the negative consequences of early adversities. The evidence presented in this review encourages the realization of studies investigating the beneficial role of melatonin administration and environmental enrichment exposure in mitigating cognitive alteration in offspring under perinatal stress exposure. On the other hand, direct evidence of microbiota restoration as the main mechanism behind the beneficial effects of this treatment has not been fully demonstrated and should be explored in future studies.
description Fil: Rubinstein Guichón, Mara Roxana. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Psiconeuroendocrinoinmunología; Argentina
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/17342
2073-4409
10.3390/cells12131735
37443769
Rubinstein, M.R., Burgueño, A.L., Quiroga, S., Wald, M.R., Genaro, A.M. Current understanding of the roles of gut–brain axis in the cognitive deficits caused by perinatal stress exposure [en línea]. Cells. 2023, 12, 1735. doi: 10.3390/cells12131735. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/17342
url https://repositorio.uca.edu.ar/handle/123456789/17342
identifier_str_mv 2073-4409
10.3390/cells12131735
37443769
Rubinstein, M.R., Burgueño, A.L., Quiroga, S., Wald, M.R., Genaro, A.M. Current understanding of the roles of gut–brain axis in the cognitive deficits caused by perinatal stress exposure [en línea]. Cells. 2023, 12, 1735. doi: 10.3390/cells12131735. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/17342
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Cells. 2023, 12, 1735
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
_version_ 1836638371142696960
score 12.982451

Publicaciones similares