Falls risk, circadian rhythms and melatonin : current perspectives

• Autores: Goswami, Nandu; Abulafia, Carolina Andrea; Vigo, Daniel Eduardo; Moser, Maximilian; Cornelissen, Germaine; Cardinali, Daniel Pedro
• Año de publicación: 2020
• Idioma: inglés
• Tipo de recurso: artículo
• Fuente: Clinical Interventions in Aging. 2020, 15
• Materia: ENVEJECIMIENTO; RITMO CIRCADIANO; MELATONINA; FISIOLOGIA; RIESGOS
• Institución: Pontificia Universidad Católica Argentina

Fil: Goswami, Nandu. Universidad Médica de Graz. Centro de Investigación Otto Loewi de Biología Vascular, Inmunología e Inflamación. División de fisiología; Austria
Fil: Abulafia, Carolina Andrea. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Abulafia, Carolina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Moser, Maximilian. Universidad Médica de Graz. Centro de Investigación Otto Loewi de Biología Vascular, Inmunología e Inflamación. División de fisiología; Austria
Fil: Cornelissen, Germaine. Universidad de Minnesota. Halberg Centro de Cronobiología; Estados Unidos
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Abstract: Aging is associated with weakening of the circadian system. The circadian amplitude of most physiological variables is reduced, while the circadian phase becomes more labile and tends to occur earlier with advancing age. As the incidence of falls in older persons could follow circadian variations, a better understanding of conditions in which falls occur can lead to the implementation of countermeasures (such as adjusting the scheduling of hospital staff, or changing the timing of anti-hypertensive medication if falls are related to undesirable circadian patterns of blood pressure and/or heart rate). This includes knowing the times of the day, days of the week, and times of the year when falls are more likely to occur at home or in the hospital. Additionally, the links between aging processes and factors associated with an increased risk of developing autonomic dysfunction are well established. A strong association between heart rate variability indexes and aging has been shown. Circadian rhythms of autonomous nervous system activity may play important role for maintenance of orthostatic tolerance. Whether one is concerned with disease prediction and prevention or maintenance of healthy aging, the study of circadian rhythms and the broader time structure underlying physiopathology is helpful in terms of screening, early diagnosis and prognosis, as well as the timely institution of prophylactic and/or palliative/ curative treatment. Timing the administration of such treatment as a function of circadian (and other) rhythms also could lead to reduction of falls in older persons.