Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models

Autores
Martinel Lamas, Diego J.; Nicoud, Melisa Beatriz; Sterle, Helena Andrea; Carabajal, Eliana; Tesan, Fiorella C.; Perazzo, Juan C.; Cremaschi, Graciela A.; Rivera, Elena S.; Medina, Vanina Araceli
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Martinel Lamas, Diego J. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Martinel Lamas, Diego J.. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Martinel Lamas, Diego J. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Celular y Molecular; Argentina
Fil: Nicoud, Melisa Beatriz. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Celular y Molecular; Argentina
Fil: Nicoud, Melisa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sterle, Helena Andrea. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neuroinmunomodulación y Oncología Molecular; Argentina
Fil: Sterle, Helena Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Carabajal, Eliana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Tesan, Fiorella C. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Perazzo, Juan C. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Cremaschi, Graciela A. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neuroinmunomodulación y Oncología Molecular; Argentina
Fil: Cremaschi, Graciela A. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cremaschi, Graciela A. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Rivera, Elena S. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Medina, Vanina Araceli. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Celular y Molecular; Argentina
Fil: Medina, Vanina Araceli. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Medina, Vanina Araceli. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Abstract: The aim of the present work was to evaluate the potential protective effect of histamine on Doxorubicin (Dox)-induced hepatic and cardiac toxicity in different rodent species and in a triple-negative breast tumor-bearing mice model. Male Sprague Dawley rats and Balb/c mice were divided into four groups: control (received saline), histamine (5mg/kg for rats and 1mg/kg for mice, daily subcutaneous injection starting 24 h before treatment with Dox), Dox (2mg/kg, intraperitoneally injected three times a week for 2 weeks) and Dox+histamine (received both treatments). Tissue toxicity was evaluated by histopathological studies and oxidative stress and biochemical parameters. The combined effect of histamine and Dox was also investigated in vitro and in vivo in human MDA-MB-231 triple-negative breast cancer model. Heart and liver of Dox-treated animals displayed severe histological damage, loss of tissue weight, increased TBARS levels and DNA damage along with an augment in serum creatine kinase-myocardial band. Pretreatment with histamine prevented Dox-induced tissue events producing a significant preservation of the integrity of both rat and mouse myocardium and liver, through the reduction of Dox-induced oxidative stress and apoptosis. Histamine treatment preserved anti-tumor activity of Dox, exhibiting differential cytotoxicity and increasing the Dox-induced inhibition of breast tumor growth. Findings provide preclinical evidence indicating that histamine could be a promising candidate as a selective cytoprotective agent for the treatment of Dox-induced cardiac and hepatic toxicity, and encourage the translation to clinical practice.
Fuente
Cell Death Discovery vol. 1, 2015
Materia
MEDICINA
CANCER
ONCOLOGIA
HISTAMINA
ANIMALES DE LABORATORIO
EXPERIMENTACION EN LABORATORIO
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/8706
Acceder
id RIUCA_b9cf49d1e884c129ad7c5337f2cbf8cf
oai_identifier_str oai:ucacris:123456789/8706
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal modelsMartinel Lamas, Diego J.Nicoud, Melisa BeatrizSterle, Helena AndreaCarabajal, ElianaTesan, Fiorella C.Perazzo, Juan C.Cremaschi, Graciela A.Rivera, Elena S.Medina, Vanina AraceliMEDICINACANCERONCOLOGIAHISTAMINAANIMALES DE LABORATORIOEXPERIMENTACION EN LABORATORIOFil: Martinel Lamas, Diego J. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Martinel Lamas, Diego J.. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Martinel Lamas, Diego J. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Celular y Molecular; ArgentinaFil: Nicoud, Melisa Beatriz. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Celular y Molecular; ArgentinaFil: Nicoud, Melisa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sterle, Helena Andrea. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neuroinmunomodulación y Oncología Molecular; ArgentinaFil: Sterle, Helena Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Carabajal, Eliana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Tesan, Fiorella C. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Perazzo, Juan C. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Cremaschi, Graciela A. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neuroinmunomodulación y Oncología Molecular; ArgentinaFil: Cremaschi, Graciela A. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cremaschi, Graciela A. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Rivera, Elena S. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Medina, Vanina Araceli. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Celular y Molecular; ArgentinaFil: Medina, Vanina Araceli. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Medina, Vanina Araceli. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaAbstract: The aim of the present work was to evaluate the potential protective effect of histamine on Doxorubicin (Dox)-induced hepatic and cardiac toxicity in different rodent species and in a triple-negative breast tumor-bearing mice model. Male Sprague Dawley rats and Balb/c mice were divided into four groups: control (received saline), histamine (5mg/kg for rats and 1mg/kg for mice, daily subcutaneous injection starting 24 h before treatment with Dox), Dox (2mg/kg, intraperitoneally injected three times a week for 2 weeks) and Dox+histamine (received both treatments). Tissue toxicity was evaluated by histopathological studies and oxidative stress and biochemical parameters. The combined effect of histamine and Dox was also investigated in vitro and in vivo in human MDA-MB-231 triple-negative breast cancer model. Heart and liver of Dox-treated animals displayed severe histological damage, loss of tissue weight, increased TBARS levels and DNA damage along with an augment in serum creatine kinase-myocardial band. Pretreatment with histamine prevented Dox-induced tissue events producing a significant preservation of the integrity of both rat and mouse myocardium and liver, through the reduction of Dox-induced oxidative stress and apoptosis. Histamine treatment preserved anti-tumor activity of Dox, exhibiting differential cytotoxicity and increasing the Dox-induced inhibition of breast tumor growth. Findings provide preclinical evidence indicating that histamine could be a promising candidate as a selective cytoprotective agent for the treatment of Dox-induced cardiac and hepatic toxicity, and encourage the translation to clinical practice.Nature Research2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/87062058-771610.1038/cddiscovery.2015.59Martinel Lamas D et al. (2015) Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models. Cell Death Discovery 1, 15059. doi:10.1038/cddiscovery.2015.59. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8706Cell Death Discovery vol. 1, 2015reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:56:54Zoai:ucacris:123456789/8706instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:56:55.071Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models
title Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models
spellingShingle Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models
Martinel Lamas, Diego J.
MEDICINA
CANCER
ONCOLOGIA
HISTAMINA
ANIMALES DE LABORATORIO
EXPERIMENTACION EN LABORATORIO
title_short Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models
title_full Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models
title_fullStr Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models
title_full_unstemmed Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models
title_sort Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models
dc.creator.none.fl_str_mv Martinel Lamas, Diego J.
Nicoud, Melisa Beatriz
Sterle, Helena Andrea
Carabajal, Eliana
Tesan, Fiorella C.
Perazzo, Juan C.
Cremaschi, Graciela A.
Rivera, Elena S.
Medina, Vanina Araceli
author Martinel Lamas, Diego J.
author_facet Martinel Lamas, Diego J.
Nicoud, Melisa Beatriz
Sterle, Helena Andrea
Carabajal, Eliana
Tesan, Fiorella C.
Perazzo, Juan C.
Cremaschi, Graciela A.
Rivera, Elena S.
Medina, Vanina Araceli
author_role author
author2 Nicoud, Melisa Beatriz
Sterle, Helena Andrea
Carabajal, Eliana
Tesan, Fiorella C.
Perazzo, Juan C.
Cremaschi, Graciela A.
Rivera, Elena S.
Medina, Vanina Araceli
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv MEDICINA
CANCER
ONCOLOGIA
HISTAMINA
ANIMALES DE LABORATORIO
EXPERIMENTACION EN LABORATORIO
topic MEDICINA
CANCER
ONCOLOGIA
HISTAMINA
ANIMALES DE LABORATORIO
EXPERIMENTACION EN LABORATORIO
dc.description.none.fl_txt_mv Fil: Martinel Lamas, Diego J. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Martinel Lamas, Diego J.. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Martinel Lamas, Diego J. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Celular y Molecular; Argentina
Fil: Nicoud, Melisa Beatriz. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Celular y Molecular; Argentina
Fil: Nicoud, Melisa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sterle, Helena Andrea. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neuroinmunomodulación y Oncología Molecular; Argentina
Fil: Sterle, Helena Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Carabajal, Eliana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Tesan, Fiorella C. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Perazzo, Juan C. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Cremaschi, Graciela A. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neuroinmunomodulación y Oncología Molecular; Argentina
Fil: Cremaschi, Graciela A. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cremaschi, Graciela A. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Rivera, Elena S. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Medina, Vanina Araceli. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Celular y Molecular; Argentina
Fil: Medina, Vanina Araceli. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Medina, Vanina Araceli. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Abstract: The aim of the present work was to evaluate the potential protective effect of histamine on Doxorubicin (Dox)-induced hepatic and cardiac toxicity in different rodent species and in a triple-negative breast tumor-bearing mice model. Male Sprague Dawley rats and Balb/c mice were divided into four groups: control (received saline), histamine (5mg/kg for rats and 1mg/kg for mice, daily subcutaneous injection starting 24 h before treatment with Dox), Dox (2mg/kg, intraperitoneally injected three times a week for 2 weeks) and Dox+histamine (received both treatments). Tissue toxicity was evaluated by histopathological studies and oxidative stress and biochemical parameters. The combined effect of histamine and Dox was also investigated in vitro and in vivo in human MDA-MB-231 triple-negative breast cancer model. Heart and liver of Dox-treated animals displayed severe histological damage, loss of tissue weight, increased TBARS levels and DNA damage along with an augment in serum creatine kinase-myocardial band. Pretreatment with histamine prevented Dox-induced tissue events producing a significant preservation of the integrity of both rat and mouse myocardium and liver, through the reduction of Dox-induced oxidative stress and apoptosis. Histamine treatment preserved anti-tumor activity of Dox, exhibiting differential cytotoxicity and increasing the Dox-induced inhibition of breast tumor growth. Findings provide preclinical evidence indicating that histamine could be a promising candidate as a selective cytoprotective agent for the treatment of Dox-induced cardiac and hepatic toxicity, and encourage the translation to clinical practice.
description Fil: Martinel Lamas, Diego J. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/8706
2058-7716
10.1038/cddiscovery.2015.59
Martinel Lamas D et al. (2015) Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models. Cell Death Discovery 1, 15059. doi:10.1038/cddiscovery.2015.59. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8706
url https://repositorio.uca.edu.ar/handle/123456789/8706
identifier_str_mv 2058-7716
10.1038/cddiscovery.2015.59
Martinel Lamas D et al. (2015) Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models. Cell Death Discovery 1, 15059. doi:10.1038/cddiscovery.2015.59. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8706
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv Cell Death Discovery vol. 1, 2015
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 13.221938

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