Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models

Autores
Martinel Lamas, Diego José; Nicoud, Melisa Beatriz; Sterle, Helena Andrea; Carabajal, Eliana; Tesan, Fiorella Carla; Perazzo, Juan C.; Cremaschi, Graciela Alicia; Rivera, Elena Susana; Medina, Vanina Araceli
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of the present work was to evaluate the potential protective effect of histamine on Doxorubicin (Dox)-induced hepatic and cardiac toxicity in different rodent species and in a triple-negative breast tumor-bearing mice model. Male Sprague Dawley rats and Balb/c mice were divided into four groups: control (received saline), histamine (5 mg/kg for rats and 1 mg/kg for mice, daily subcutaneous injection starting 24 h before treatment with Dox), Dox (2 mg/kg, intraperitoneally injected three times a week for 2 weeks) and Dox+histamine (received both treatments). Tissue toxicity was evaluated by histopathological studies and oxidative stress and biochemical parameters. The combined effect of histamine and Dox was also investigated in vitro and in vivo in human MDA-MB-231 triple-negative breast cancer model. Heart and liver of Dox-treated animals displayed severe histological damage, loss of tissue weight, increased TBARS levels and DNA damage along with an augment in serum creatine kinase-myocardial band. Pretreatment with histamine prevented Dox-induced tissue events producing a significant preservation of the integrity of both rat and mouse myocardium and liver, through the reduction of Dox-induced oxidative stress and apoptosis. Histamine treatment preserved anti-tumor activity of Dox, exhibiting differential cytotoxicity and increasing the Dox-induced inhibition of breast tumor growth. Findings provide preclinical evidence indicating that histamine could be a promising candidate as a selective cytoprotective agent for the treatment of Dox-induced cardiac and hepatic toxicity, and encourage the translation to clinical practice.
Fil: Martinel Lamas, Diego José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; Argentina. Pontificia Universidad Católica Argentina ; Argentina
Fil: Nicoud, Melisa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Católica Argentina ; Argentina
Fil: Sterle, Helena Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Católica Argentina ; Argentina
Fil: Carabajal, Eliana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; Argentina
Fil: Tesan, Fiorella Carla. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; Argentina
Fil: Perazzo, Juan C.. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; Argentina
Fil: Cremaschi, Graciela Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; Argentina
Fil: Rivera, Elena Susana. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; Argentina
Fil: Medina, Vanina Araceli. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; Argentina. Pontificia Universidad Católica Argentina ; Argentina
Materia
Breast cancer
Chemotherapy
Mechanisms of disease
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/44477
Acceder
id CONICETDig_4af51d2f6e7c8e2dd96e47199ca023df
oai_identifier_str oai:ri.conicet.gov.ar:11336/44477
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal modelsMartinel Lamas, Diego JoséNicoud, Melisa BeatrizSterle, Helena AndreaCarabajal, ElianaTesan, Fiorella CarlaPerazzo, Juan C.Cremaschi, Graciela AliciaRivera, Elena SusanaMedina, Vanina AraceliBreast cancerChemotherapyMechanisms of diseasehttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The aim of the present work was to evaluate the potential protective effect of histamine on Doxorubicin (Dox)-induced hepatic and cardiac toxicity in different rodent species and in a triple-negative breast tumor-bearing mice model. Male Sprague Dawley rats and Balb/c mice were divided into four groups: control (received saline), histamine (5 mg/kg for rats and 1 mg/kg for mice, daily subcutaneous injection starting 24 h before treatment with Dox), Dox (2 mg/kg, intraperitoneally injected three times a week for 2 weeks) and Dox+histamine (received both treatments). Tissue toxicity was evaluated by histopathological studies and oxidative stress and biochemical parameters. The combined effect of histamine and Dox was also investigated in vitro and in vivo in human MDA-MB-231 triple-negative breast cancer model. Heart and liver of Dox-treated animals displayed severe histological damage, loss of tissue weight, increased TBARS levels and DNA damage along with an augment in serum creatine kinase-myocardial band. Pretreatment with histamine prevented Dox-induced tissue events producing a significant preservation of the integrity of both rat and mouse myocardium and liver, through the reduction of Dox-induced oxidative stress and apoptosis. Histamine treatment preserved anti-tumor activity of Dox, exhibiting differential cytotoxicity and increasing the Dox-induced inhibition of breast tumor growth. Findings provide preclinical evidence indicating that histamine could be a promising candidate as a selective cytoprotective agent for the treatment of Dox-induced cardiac and hepatic toxicity, and encourage the translation to clinical practice.Fil: Martinel Lamas, Diego José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; Argentina. Pontificia Universidad Católica Argentina ; ArgentinaFil: Nicoud, Melisa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Católica Argentina ; ArgentinaFil: Sterle, Helena Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Católica Argentina ; ArgentinaFil: Carabajal, Eliana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; ArgentinaFil: Tesan, Fiorella Carla. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; ArgentinaFil: Perazzo, Juan C.. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; ArgentinaFil: Cremaschi, Graciela Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; ArgentinaFil: Rivera, Elena Susana. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; ArgentinaFil: Medina, Vanina Araceli. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; Argentina. Pontificia Universidad Católica Argentina ; ArgentinaCell Death Differentiation Association2015-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/44477Martinel Lamas, Diego José; Nicoud, Melisa Beatriz; Sterle, Helena Andrea; Carabajal, Eliana; Tesan, Fiorella Carla; et al.; Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models; Cell Death Differentiation Association; Cell Death Discovery; 1; 12-2015; 1-112058-7716CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/cddiscovery.2015.59info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/cddiscovery201559info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:45:54Zoai:ri.conicet.gov.ar:11336/44477instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:45:54.616CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models
title Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models
spellingShingle Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models
Martinel Lamas, Diego José
Breast cancer
Chemotherapy
Mechanisms of disease
title_short Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models
title_full Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models
title_fullStr Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models
title_full_unstemmed Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models
title_sort Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models
dc.creator.none.fl_str_mv Martinel Lamas, Diego José
Nicoud, Melisa Beatriz
Sterle, Helena Andrea
Carabajal, Eliana
Tesan, Fiorella Carla
Perazzo, Juan C.
Cremaschi, Graciela Alicia
Rivera, Elena Susana
Medina, Vanina Araceli
author Martinel Lamas, Diego José
author_facet Martinel Lamas, Diego José
Nicoud, Melisa Beatriz
Sterle, Helena Andrea
Carabajal, Eliana
Tesan, Fiorella Carla
Perazzo, Juan C.
Cremaschi, Graciela Alicia
Rivera, Elena Susana
Medina, Vanina Araceli
author_role author
author2 Nicoud, Melisa Beatriz
Sterle, Helena Andrea
Carabajal, Eliana
Tesan, Fiorella Carla
Perazzo, Juan C.
Cremaschi, Graciela Alicia
Rivera, Elena Susana
Medina, Vanina Araceli
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Breast cancer
Chemotherapy
Mechanisms of disease
topic Breast cancer
Chemotherapy
Mechanisms of disease
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The aim of the present work was to evaluate the potential protective effect of histamine on Doxorubicin (Dox)-induced hepatic and cardiac toxicity in different rodent species and in a triple-negative breast tumor-bearing mice model. Male Sprague Dawley rats and Balb/c mice were divided into four groups: control (received saline), histamine (5 mg/kg for rats and 1 mg/kg for mice, daily subcutaneous injection starting 24 h before treatment with Dox), Dox (2 mg/kg, intraperitoneally injected three times a week for 2 weeks) and Dox+histamine (received both treatments). Tissue toxicity was evaluated by histopathological studies and oxidative stress and biochemical parameters. The combined effect of histamine and Dox was also investigated in vitro and in vivo in human MDA-MB-231 triple-negative breast cancer model. Heart and liver of Dox-treated animals displayed severe histological damage, loss of tissue weight, increased TBARS levels and DNA damage along with an augment in serum creatine kinase-myocardial band. Pretreatment with histamine prevented Dox-induced tissue events producing a significant preservation of the integrity of both rat and mouse myocardium and liver, through the reduction of Dox-induced oxidative stress and apoptosis. Histamine treatment preserved anti-tumor activity of Dox, exhibiting differential cytotoxicity and increasing the Dox-induced inhibition of breast tumor growth. Findings provide preclinical evidence indicating that histamine could be a promising candidate as a selective cytoprotective agent for the treatment of Dox-induced cardiac and hepatic toxicity, and encourage the translation to clinical practice.
Fil: Martinel Lamas, Diego José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; Argentina. Pontificia Universidad Católica Argentina ; Argentina
Fil: Nicoud, Melisa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Católica Argentina ; Argentina
Fil: Sterle, Helena Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Católica Argentina ; Argentina
Fil: Carabajal, Eliana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; Argentina
Fil: Tesan, Fiorella Carla. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; Argentina
Fil: Perazzo, Juan C.. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; Argentina
Fil: Cremaschi, Graciela Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; Argentina
Fil: Rivera, Elena Susana. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; Argentina
Fil: Medina, Vanina Araceli. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; Argentina. Pontificia Universidad Católica Argentina ; Argentina
description The aim of the present work was to evaluate the potential protective effect of histamine on Doxorubicin (Dox)-induced hepatic and cardiac toxicity in different rodent species and in a triple-negative breast tumor-bearing mice model. Male Sprague Dawley rats and Balb/c mice were divided into four groups: control (received saline), histamine (5 mg/kg for rats and 1 mg/kg for mice, daily subcutaneous injection starting 24 h before treatment with Dox), Dox (2 mg/kg, intraperitoneally injected three times a week for 2 weeks) and Dox+histamine (received both treatments). Tissue toxicity was evaluated by histopathological studies and oxidative stress and biochemical parameters. The combined effect of histamine and Dox was also investigated in vitro and in vivo in human MDA-MB-231 triple-negative breast cancer model. Heart and liver of Dox-treated animals displayed severe histological damage, loss of tissue weight, increased TBARS levels and DNA damage along with an augment in serum creatine kinase-myocardial band. Pretreatment with histamine prevented Dox-induced tissue events producing a significant preservation of the integrity of both rat and mouse myocardium and liver, through the reduction of Dox-induced oxidative stress and apoptosis. Histamine treatment preserved anti-tumor activity of Dox, exhibiting differential cytotoxicity and increasing the Dox-induced inhibition of breast tumor growth. Findings provide preclinical evidence indicating that histamine could be a promising candidate as a selective cytoprotective agent for the treatment of Dox-induced cardiac and hepatic toxicity, and encourage the translation to clinical practice.
publishDate 2015
dc.date.none.fl_str_mv 2015-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/44477
Martinel Lamas, Diego José; Nicoud, Melisa Beatriz; Sterle, Helena Andrea; Carabajal, Eliana; Tesan, Fiorella Carla; et al.; Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models; Cell Death Differentiation Association; Cell Death Discovery; 1; 12-2015; 1-11
2058-7716
CONICET Digital
CONICET
url http://hdl.handle.net/11336/44477
identifier_str_mv Martinel Lamas, Diego José; Nicoud, Melisa Beatriz; Sterle, Helena Andrea; Carabajal, Eliana; Tesan, Fiorella Carla; et al.; Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models; Cell Death Differentiation Association; Cell Death Discovery; 1; 12-2015; 1-11
2058-7716
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/cddiscovery.2015.59
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/cddiscovery201559
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cell Death Differentiation Association
publisher.none.fl_str_mv Cell Death Differentiation Association
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.221938

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