Ayurveda medicine for the treatment of Parkinson's disease
- Autores
- Pérez Lloret, Santiago; Rey, Verónica; Rascol, Olivier
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Pérez Lloret, Santiago. Universidad de Toulouse III. Hospital Universitario. Departamento de Farmacología Clínica y Neurociencias; Francia
Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Facultad de Medicina. Laboratorio de Clínica Farmacológica y Epidemiología; Argentina
Fil: Rey, Verónica. Universidad de Toulouse III. Hospital Universitario. Departamento de Farmacología Clínica y Neurociencias; Francia
Fil: Rey, Verónica. Pontificia Universidad Católica Argentina. Facultad de Medicina. Laboratorio de Clínica Farmacológica y Epidemiología; Argentina
Fil: Rascol, Olivier. Universidad de Toulouse III. Hospital Universitario. Departamento de Farmacología Clínica y Neurociencias; Francia
Abstract: Abstract In most western countries, the symptomatic management of Parkinson’s Disease (PD) is usually achieved with medicinal products including levodopa (LD), dopamine agonists, MAO‐B inhibitors, COMT inhibitors, antimuscarinics and amantadine. The control of the quality of the production of such medications is strict and the assessment of the benefit‐risk ratio of these interventions is regulated by official recommendations which follow an evidence‐based approach. Ayurveda Indian medicine has used Mucuna Pruriens (MP) for the treatment of PD since ancient times. MP includes LD as an active moiety, among many others. A literature search was conducted between 1978‐2012 with the keywords Parkinson’s disease, ayurveda or mucuna pruriens. MP antagonized the effects of 6OHDA lesions in rats and when administered chronically it showed lower dyskinetic potential compared to L‐DOPA. MP also reduced Parkinsonian symptoms in an MPTP treated monkey with less dyskinesias compared to L‐DOPA. Four clinical trials of MP for PD treatment were found. Initially they were open‐label, uncontrolled studies, suggesting that MP might reduce parkinsonism severity. One double‐blind randomized crossover study was conducted in 8 PD patients, employing acute challenges of levodopa or MP. It showed that the effect of MP had a faster onset than LD, with shorter latencies to peak and increased on‐time. No other medium‐term (i.e., 6 months) randomized‐controlled trials (RCT) are available. According to the MDS EBM taskforce working procedures, an intervention is considered as “efficacious” when there is at least one high quality randomized controlled trial (RCT) showing a positive effect on studied outcomes with no conflicting data from other RCTs. Based on these premises, there is insufficient evidence to conclude the efficacy of MP in the treatment of PD. Thus its use in clinical practice remains open to investigation. It must also be emphasized that various MP formulations can be used, raising concerns about their quality, which is difficult to control, as regulation is limited. Impurities or variations in active moieties, can lead to unexpected adverse drug reactions. In conclusion, the use of MP in PD treatment remains open to investigation and thus cannot be recommended for clinical use - Fuente
- International Journal of Integrative Medicine 2013, 1 (6)
- Materia
-
MEDICINA AYURVEDA
ENFERMEDAD DE PARKINSON
TRATAMIENTO
ENFERMEDADES NEUROGENERATIVAS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Pontificia Universidad Católica Argentina
- OAI Identificador
- oai:ucacris:123456789/1622
Ver los metadatos del registro completo
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Ayurveda medicine for the treatment of Parkinson's diseasePérez Lloret, SantiagoRey, VerónicaRascol, OlivierMEDICINA AYURVEDAENFERMEDAD DE PARKINSONTRATAMIENTOENFERMEDADES NEUROGENERATIVASFil: Pérez Lloret, Santiago. Universidad de Toulouse III. Hospital Universitario. Departamento de Farmacología Clínica y Neurociencias; FranciaFil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Facultad de Medicina. Laboratorio de Clínica Farmacológica y Epidemiología; ArgentinaFil: Rey, Verónica. Universidad de Toulouse III. Hospital Universitario. Departamento de Farmacología Clínica y Neurociencias; FranciaFil: Rey, Verónica. Pontificia Universidad Católica Argentina. Facultad de Medicina. Laboratorio de Clínica Farmacológica y Epidemiología; ArgentinaFil: Rascol, Olivier. Universidad de Toulouse III. Hospital Universitario. Departamento de Farmacología Clínica y Neurociencias; FranciaAbstract: Abstract In most western countries, the symptomatic management of Parkinson’s Disease (PD) is usually achieved with medicinal products including levodopa (LD), dopamine agonists, MAO‐B inhibitors, COMT inhibitors, antimuscarinics and amantadine. The control of the quality of the production of such medications is strict and the assessment of the benefit‐risk ratio of these interventions is regulated by official recommendations which follow an evidence‐based approach. Ayurveda Indian medicine has used Mucuna Pruriens (MP) for the treatment of PD since ancient times. MP includes LD as an active moiety, among many others. A literature search was conducted between 1978‐2012 with the keywords Parkinson’s disease, ayurveda or mucuna pruriens. MP antagonized the effects of 6OHDA lesions in rats and when administered chronically it showed lower dyskinetic potential compared to L‐DOPA. MP also reduced Parkinsonian symptoms in an MPTP treated monkey with less dyskinesias compared to L‐DOPA. Four clinical trials of MP for PD treatment were found. Initially they were open‐label, uncontrolled studies, suggesting that MP might reduce parkinsonism severity. One double‐blind randomized crossover study was conducted in 8 PD patients, employing acute challenges of levodopa or MP. It showed that the effect of MP had a faster onset than LD, with shorter latencies to peak and increased on‐time. No other medium‐term (i.e., 6 months) randomized‐controlled trials (RCT) are available. According to the MDS EBM taskforce working procedures, an intervention is considered as “efficacious” when there is at least one high quality randomized controlled trial (RCT) showing a positive effect on studied outcomes with no conflicting data from other RCTs. Based on these premises, there is insufficient evidence to conclude the efficacy of MP in the treatment of PD. Thus its use in clinical practice remains open to investigation. It must also be emphasized that various MP formulations can be used, raising concerns about their quality, which is difficult to control, as regulation is limited. Impurities or variations in active moieties, can lead to unexpected adverse drug reactions. In conclusion, the use of MP in PD treatment remains open to investigation and thus cannot be recommended for clinical useInTech2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/16221848-884610.5772/56251Pérez Lloret, S., Rey M. V., Rascol, O. Ayurveda medicine for the treatment of Parkinson's disease [en línea]. International Journal of Integrative Medicine. 2013, 1 (6). doi: 10.5772/56251. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1622International Journal of Integrative Medicine 2013, 1 (6)reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaengenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:55:19Zoai:ucacris:123456789/1622instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:55:19.997Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse |
dc.title.none.fl_str_mv |
Ayurveda medicine for the treatment of Parkinson's disease |
title |
Ayurveda medicine for the treatment of Parkinson's disease |
spellingShingle |
Ayurveda medicine for the treatment of Parkinson's disease Pérez Lloret, Santiago MEDICINA AYURVEDA ENFERMEDAD DE PARKINSON TRATAMIENTO ENFERMEDADES NEUROGENERATIVAS |
title_short |
Ayurveda medicine for the treatment of Parkinson's disease |
title_full |
Ayurveda medicine for the treatment of Parkinson's disease |
title_fullStr |
Ayurveda medicine for the treatment of Parkinson's disease |
title_full_unstemmed |
Ayurveda medicine for the treatment of Parkinson's disease |
title_sort |
Ayurveda medicine for the treatment of Parkinson's disease |
dc.creator.none.fl_str_mv |
Pérez Lloret, Santiago Rey, Verónica Rascol, Olivier |
author |
Pérez Lloret, Santiago |
author_facet |
Pérez Lloret, Santiago Rey, Verónica Rascol, Olivier |
author_role |
author |
author2 |
Rey, Verónica Rascol, Olivier |
author2_role |
author author |
dc.subject.none.fl_str_mv |
MEDICINA AYURVEDA ENFERMEDAD DE PARKINSON TRATAMIENTO ENFERMEDADES NEUROGENERATIVAS |
topic |
MEDICINA AYURVEDA ENFERMEDAD DE PARKINSON TRATAMIENTO ENFERMEDADES NEUROGENERATIVAS |
dc.description.none.fl_txt_mv |
Fil: Pérez Lloret, Santiago. Universidad de Toulouse III. Hospital Universitario. Departamento de Farmacología Clínica y Neurociencias; Francia Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Facultad de Medicina. Laboratorio de Clínica Farmacológica y Epidemiología; Argentina Fil: Rey, Verónica. Universidad de Toulouse III. Hospital Universitario. Departamento de Farmacología Clínica y Neurociencias; Francia Fil: Rey, Verónica. Pontificia Universidad Católica Argentina. Facultad de Medicina. Laboratorio de Clínica Farmacológica y Epidemiología; Argentina Fil: Rascol, Olivier. Universidad de Toulouse III. Hospital Universitario. Departamento de Farmacología Clínica y Neurociencias; Francia Abstract: Abstract In most western countries, the symptomatic management of Parkinson’s Disease (PD) is usually achieved with medicinal products including levodopa (LD), dopamine agonists, MAO‐B inhibitors, COMT inhibitors, antimuscarinics and amantadine. The control of the quality of the production of such medications is strict and the assessment of the benefit‐risk ratio of these interventions is regulated by official recommendations which follow an evidence‐based approach. Ayurveda Indian medicine has used Mucuna Pruriens (MP) for the treatment of PD since ancient times. MP includes LD as an active moiety, among many others. A literature search was conducted between 1978‐2012 with the keywords Parkinson’s disease, ayurveda or mucuna pruriens. MP antagonized the effects of 6OHDA lesions in rats and when administered chronically it showed lower dyskinetic potential compared to L‐DOPA. MP also reduced Parkinsonian symptoms in an MPTP treated monkey with less dyskinesias compared to L‐DOPA. Four clinical trials of MP for PD treatment were found. Initially they were open‐label, uncontrolled studies, suggesting that MP might reduce parkinsonism severity. One double‐blind randomized crossover study was conducted in 8 PD patients, employing acute challenges of levodopa or MP. It showed that the effect of MP had a faster onset than LD, with shorter latencies to peak and increased on‐time. No other medium‐term (i.e., 6 months) randomized‐controlled trials (RCT) are available. According to the MDS EBM taskforce working procedures, an intervention is considered as “efficacious” when there is at least one high quality randomized controlled trial (RCT) showing a positive effect on studied outcomes with no conflicting data from other RCTs. Based on these premises, there is insufficient evidence to conclude the efficacy of MP in the treatment of PD. Thus its use in clinical practice remains open to investigation. It must also be emphasized that various MP formulations can be used, raising concerns about their quality, which is difficult to control, as regulation is limited. Impurities or variations in active moieties, can lead to unexpected adverse drug reactions. In conclusion, the use of MP in PD treatment remains open to investigation and thus cannot be recommended for clinical use |
description |
Fil: Pérez Lloret, Santiago. Universidad de Toulouse III. Hospital Universitario. Departamento de Farmacología Clínica y Neurociencias; Francia |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013 |
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article |
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publishedVersion |
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https://repositorio.uca.edu.ar/handle/123456789/1622 1848-8846 10.5772/56251 Pérez Lloret, S., Rey M. V., Rascol, O. Ayurveda medicine for the treatment of Parkinson's disease [en línea]. International Journal of Integrative Medicine. 2013, 1 (6). doi: 10.5772/56251. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1622 |
url |
https://repositorio.uca.edu.ar/handle/123456789/1622 |
identifier_str_mv |
1848-8846 10.5772/56251 Pérez Lloret, S., Rey M. V., Rascol, O. Ayurveda medicine for the treatment of Parkinson's disease [en línea]. International Journal of Integrative Medicine. 2013, 1 (6). doi: 10.5772/56251. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1622 |
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