Ayurveda medicine for the treatment of Parkinson's disease

Autores
Pérez Lloret, Santiago; Rey, Verónica; Rascol, Olivier
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Pérez Lloret, Santiago. Universidad de Toulouse III. Hospital Universitario. Departamento de Farmacología Clínica y Neurociencias; Francia
Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Facultad de Medicina. Laboratorio de Clínica Farmacológica y Epidemiología; Argentina
Fil: Rey, Verónica. Universidad de Toulouse III. Hospital Universitario. Departamento de Farmacología Clínica y Neurociencias; Francia
Fil: Rey, Verónica. Pontificia Universidad Católica Argentina. Facultad de Medicina. Laboratorio de Clínica Farmacológica y Epidemiología; Argentina
Fil: Rascol, Olivier. Universidad de Toulouse III. Hospital Universitario. Departamento de Farmacología Clínica y Neurociencias; Francia
Abstract: Abstract In most western countries, the symptomatic management of Parkinson’s Disease (PD) is usually achieved with medicinal products including levodopa (LD), dopamine agonists, MAO‐B inhibitors, COMT inhibitors, antimuscarinics and amantadine. The control of the quality of the production of such medications is strict and the assessment of the benefit‐risk ratio of these interventions is regulated by official recommendations which follow an evidence‐based approach. Ayurveda Indian medicine has used Mucuna Pruriens (MP) for the treatment of PD since ancient times. MP includes LD as an active moiety, among many others. A literature search was conducted between 1978‐2012 with the keywords Parkinson’s disease, ayurveda or mucuna pruriens. MP antagonized the effects of 6OHDA lesions in rats and when administered chronically it showed lower dyskinetic potential compared to L‐DOPA. MP also reduced Parkinsonian symptoms in an MPTP treated monkey with less dyskinesias compared to L‐DOPA. Four clinical trials of MP for PD treatment were found. Initially they were open‐label, uncontrolled studies, suggesting that MP might reduce parkinsonism severity. One double‐blind randomized crossover study was conducted in 8 PD patients, employing acute challenges of levodopa or MP. It showed that the effect of MP had a faster onset than LD, with shorter latencies to peak and increased on‐time. No other medium‐term (i.e., 6 months) randomized‐controlled trials (RCT) are available. According to the MDS EBM taskforce working procedures, an intervention is considered as “efficacious” when there is at least one high quality randomized controlled trial (RCT) showing a positive effect on studied outcomes with no conflicting data from other RCTs. Based on these premises, there is insufficient evidence to conclude the efficacy of MP in the treatment of PD. Thus its use in clinical practice remains open to investigation. It must also be emphasized that various MP formulations can be used, raising concerns about their quality, which is difficult to control, as regulation is limited. Impurities or variations in active moieties, can lead to unexpected adverse drug reactions. In conclusion, the use of MP in PD treatment remains open to investigation and thus cannot be recommended for clinical use
Fuente
International Journal of Integrative Medicine 2013, 1 (6)
Materia
MEDICINA AYURVEDA
ENFERMEDAD DE PARKINSON
TRATAMIENTO
ENFERMEDADES NEUROGENERATIVAS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/1622

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oai_identifier_str oai:ucacris:123456789/1622
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Ayurveda medicine for the treatment of Parkinson's diseasePérez Lloret, SantiagoRey, VerónicaRascol, OlivierMEDICINA AYURVEDAENFERMEDAD DE PARKINSONTRATAMIENTOENFERMEDADES NEUROGENERATIVASFil: Pérez Lloret, Santiago. Universidad de Toulouse III. Hospital Universitario. Departamento de Farmacología Clínica y Neurociencias; FranciaFil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Facultad de Medicina. Laboratorio de Clínica Farmacológica y Epidemiología; ArgentinaFil: Rey, Verónica. Universidad de Toulouse III. Hospital Universitario. Departamento de Farmacología Clínica y Neurociencias; FranciaFil: Rey, Verónica. Pontificia Universidad Católica Argentina. Facultad de Medicina. Laboratorio de Clínica Farmacológica y Epidemiología; ArgentinaFil: Rascol, Olivier. Universidad de Toulouse III. Hospital Universitario. Departamento de Farmacología Clínica y Neurociencias; FranciaAbstract: Abstract In most western countries, the symptomatic management of Parkinson’s Disease (PD) is usually achieved with medicinal products including levodopa (LD), dopamine agonists, MAO‐B inhibitors, COMT inhibitors, antimuscarinics and amantadine. The control of the quality of the production of such medications is strict and the assessment of the benefit‐risk ratio of these interventions is regulated by official recommendations which follow an evidence‐based approach. Ayurveda Indian medicine has used Mucuna Pruriens (MP) for the treatment of PD since ancient times. MP includes LD as an active moiety, among many others. A literature search was conducted between 1978‐2012 with the keywords Parkinson’s disease, ayurveda or mucuna pruriens. MP antagonized the effects of 6OHDA lesions in rats and when administered chronically it showed lower dyskinetic potential compared to L‐DOPA. MP also reduced Parkinsonian symptoms in an MPTP treated monkey with less dyskinesias compared to L‐DOPA. Four clinical trials of MP for PD treatment were found. Initially they were open‐label, uncontrolled studies, suggesting that MP might reduce parkinsonism severity. One double‐blind randomized crossover study was conducted in 8 PD patients, employing acute challenges of levodopa or MP. It showed that the effect of MP had a faster onset than LD, with shorter latencies to peak and increased on‐time. No other medium‐term (i.e., 6 months) randomized‐controlled trials (RCT) are available. According to the MDS EBM taskforce working procedures, an intervention is considered as “efficacious” when there is at least one high quality randomized controlled trial (RCT) showing a positive effect on studied outcomes with no conflicting data from other RCTs. Based on these premises, there is insufficient evidence to conclude the efficacy of MP in the treatment of PD. Thus its use in clinical practice remains open to investigation. It must also be emphasized that various MP formulations can be used, raising concerns about their quality, which is difficult to control, as regulation is limited. Impurities or variations in active moieties, can lead to unexpected adverse drug reactions. In conclusion, the use of MP in PD treatment remains open to investigation and thus cannot be recommended for clinical useInTech2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/16221848-884610.5772/56251Pérez Lloret, S., Rey M. V., Rascol, O. Ayurveda medicine for the treatment of Parkinson's disease [en línea]. International Journal of Integrative Medicine. 2013, 1 (6). doi: 10.5772/56251. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1622International Journal of Integrative Medicine 2013, 1 (6)reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaengenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:55:19Zoai:ucacris:123456789/1622instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:55:19.997Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Ayurveda medicine for the treatment of Parkinson's disease
title Ayurveda medicine for the treatment of Parkinson's disease
spellingShingle Ayurveda medicine for the treatment of Parkinson's disease
Pérez Lloret, Santiago
MEDICINA AYURVEDA
ENFERMEDAD DE PARKINSON
TRATAMIENTO
ENFERMEDADES NEUROGENERATIVAS
title_short Ayurveda medicine for the treatment of Parkinson's disease
title_full Ayurveda medicine for the treatment of Parkinson's disease
title_fullStr Ayurveda medicine for the treatment of Parkinson's disease
title_full_unstemmed Ayurveda medicine for the treatment of Parkinson's disease
title_sort Ayurveda medicine for the treatment of Parkinson's disease
dc.creator.none.fl_str_mv Pérez Lloret, Santiago
Rey, Verónica
Rascol, Olivier
author Pérez Lloret, Santiago
author_facet Pérez Lloret, Santiago
Rey, Verónica
Rascol, Olivier
author_role author
author2 Rey, Verónica
Rascol, Olivier
author2_role author
author
dc.subject.none.fl_str_mv MEDICINA AYURVEDA
ENFERMEDAD DE PARKINSON
TRATAMIENTO
ENFERMEDADES NEUROGENERATIVAS
topic MEDICINA AYURVEDA
ENFERMEDAD DE PARKINSON
TRATAMIENTO
ENFERMEDADES NEUROGENERATIVAS
dc.description.none.fl_txt_mv Fil: Pérez Lloret, Santiago. Universidad de Toulouse III. Hospital Universitario. Departamento de Farmacología Clínica y Neurociencias; Francia
Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Facultad de Medicina. Laboratorio de Clínica Farmacológica y Epidemiología; Argentina
Fil: Rey, Verónica. Universidad de Toulouse III. Hospital Universitario. Departamento de Farmacología Clínica y Neurociencias; Francia
Fil: Rey, Verónica. Pontificia Universidad Católica Argentina. Facultad de Medicina. Laboratorio de Clínica Farmacológica y Epidemiología; Argentina
Fil: Rascol, Olivier. Universidad de Toulouse III. Hospital Universitario. Departamento de Farmacología Clínica y Neurociencias; Francia
Abstract: Abstract In most western countries, the symptomatic management of Parkinson’s Disease (PD) is usually achieved with medicinal products including levodopa (LD), dopamine agonists, MAO‐B inhibitors, COMT inhibitors, antimuscarinics and amantadine. The control of the quality of the production of such medications is strict and the assessment of the benefit‐risk ratio of these interventions is regulated by official recommendations which follow an evidence‐based approach. Ayurveda Indian medicine has used Mucuna Pruriens (MP) for the treatment of PD since ancient times. MP includes LD as an active moiety, among many others. A literature search was conducted between 1978‐2012 with the keywords Parkinson’s disease, ayurveda or mucuna pruriens. MP antagonized the effects of 6OHDA lesions in rats and when administered chronically it showed lower dyskinetic potential compared to L‐DOPA. MP also reduced Parkinsonian symptoms in an MPTP treated monkey with less dyskinesias compared to L‐DOPA. Four clinical trials of MP for PD treatment were found. Initially they were open‐label, uncontrolled studies, suggesting that MP might reduce parkinsonism severity. One double‐blind randomized crossover study was conducted in 8 PD patients, employing acute challenges of levodopa or MP. It showed that the effect of MP had a faster onset than LD, with shorter latencies to peak and increased on‐time. No other medium‐term (i.e., 6 months) randomized‐controlled trials (RCT) are available. According to the MDS EBM taskforce working procedures, an intervention is considered as “efficacious” when there is at least one high quality randomized controlled trial (RCT) showing a positive effect on studied outcomes with no conflicting data from other RCTs. Based on these premises, there is insufficient evidence to conclude the efficacy of MP in the treatment of PD. Thus its use in clinical practice remains open to investigation. It must also be emphasized that various MP formulations can be used, raising concerns about their quality, which is difficult to control, as regulation is limited. Impurities or variations in active moieties, can lead to unexpected adverse drug reactions. In conclusion, the use of MP in PD treatment remains open to investigation and thus cannot be recommended for clinical use
description Fil: Pérez Lloret, Santiago. Universidad de Toulouse III. Hospital Universitario. Departamento de Farmacología Clínica y Neurociencias; Francia
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/1622
1848-8846
10.5772/56251
Pérez Lloret, S., Rey M. V., Rascol, O. Ayurveda medicine for the treatment of Parkinson's disease [en línea]. International Journal of Integrative Medicine. 2013, 1 (6). doi: 10.5772/56251. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1622
url https://repositorio.uca.edu.ar/handle/123456789/1622
identifier_str_mv 1848-8846
10.5772/56251
Pérez Lloret, S., Rey M. V., Rascol, O. Ayurveda medicine for the treatment of Parkinson's disease [en línea]. International Journal of Integrative Medicine. 2013, 1 (6). doi: 10.5772/56251. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1622
dc.language.none.fl_str_mv eng
eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv InTech
publisher.none.fl_str_mv InTech
dc.source.none.fl_str_mv International Journal of Integrative Medicine 2013, 1 (6)
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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