How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach

Autores
Lissoni, Paolo; Brivio, Fernando; Fumagalli, Luca; Rovelli, Franco; Colciago, Massimo; Messina, Giusy; Monzon, Alejandra; Pelizzoni, Francesco; Lissoni, Arianna; Porro, Giorgio; Di Fede, Giuseppe; Cardinali, Daniel Pedro
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Lissoni, Paolo. Instituto de Medicina Biológica; Italia
Fil: Brivio, Fernando. Instituto de Medicina Biológica; Italia
Fil: Fumagalli, Luca. Surgical Division; Italia
Fil: Rovelli, Franco. Instituto de Medicina Biológica; Italia
Fil: Colciago, Massimo. Instituto Nacional de Descanso y Atención al Adulto Mayor; Italia
Fil: Messina, Giusy. Instituto de Medicina Biológica; Italia
Fil: Monzon, Alejandra. Instituto de Medicina Biológica; Italia
Fil: Pelizzoni, Francesco. Instituto de Medicina Biológica; Italia
Fil: Lissoni, Arianna. Instituto de Medicina Biológica; Italia
Fil: Porro, Giorgio. Instituto de Medicina Biológica; Italia
Fil: Di Fede, Giuseppe. Instituto de Medicina Biológica; Italia
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; Argentina
Abstract: Recent advances in the area of the psycho-neuroendocrine-immunology have demonstrated that the inflammatory and immune reactions depend not only on immune factors, but also, they are under an intricate neuroendocrine regulation. In turn, the activity of the nervous and endocrine systems is affected by immune-inflammatory signals. Although most hormones and neuromodulators can potentially influence the immune function, main immunomodulatory properties seem to be exerted by opioid and cannabinoid systems. Brain opioid and cannabinoid systems are endocrinologically connected to the adrenal, and to the pineal gland, respectively. In addition, the neurohypophysis is also important for the neuroimmunomodulation through the release of vasopressin and oxytocin. Experimental evidence supports the conclusion that two fundamental functional circuits occur, including a brain opioid system-vasopressin-adrenal axis, characterized by a prevalent immunosuppressive activity, and a brain cannabinoid-oxytocin-pineal axis, which exerts an immunostimulatory role. The latter is relevant mainly for anticancer immunity. The opioid-adrenal functional axis is active in stress and depressive conditions, while the cannabinoid-pineal axis has been proven to be involved in pleasure perception and spiritual expansion of mind. The findings could explain the predisposition to severe systemic diseases played by stress and depression, and on the other hand the protective action of pleasure and spirituality in the onset of important pathologies. The clinical and therapeutic applications of these concepts may constitute a landmark for future Medicine.
Fuente
Novel approaches in cancer study. 2021, 5 (5)
Materia
CANNABINOIDES
CANCER
COVID-19
CITOQUINAS
MELATONINA
NEUROPROTECCION
INMUNOLOGIA
SISTEMA INMUNOLOGICO
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/13679

id RIUCA_80ec5e8c649d89465f85cc082c88db2a
oai_identifier_str oai:ucacris:123456789/13679
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approachLissoni, PaoloBrivio, FernandoFumagalli, LucaRovelli, FrancoColciago, MassimoMessina, GiusyMonzon, AlejandraPelizzoni, FrancescoLissoni, AriannaPorro, GiorgioDi Fede, GiuseppeCardinali, Daniel PedroCANNABINOIDESCANCERCOVID-19CITOQUINASMELATONINANEUROPROTECCIONINMUNOLOGIASISTEMA INMUNOLOGICOFil: Lissoni, Paolo. Instituto de Medicina Biológica; ItaliaFil: Brivio, Fernando. Instituto de Medicina Biológica; ItaliaFil: Fumagalli, Luca. Surgical Division; ItaliaFil: Rovelli, Franco. Instituto de Medicina Biológica; ItaliaFil: Colciago, Massimo. Instituto Nacional de Descanso y Atención al Adulto Mayor; ItaliaFil: Messina, Giusy. Instituto de Medicina Biológica; ItaliaFil: Monzon, Alejandra. Instituto de Medicina Biológica; ItaliaFil: Pelizzoni, Francesco. Instituto de Medicina Biológica; ItaliaFil: Lissoni, Arianna. Instituto de Medicina Biológica; ItaliaFil: Porro, Giorgio. Instituto de Medicina Biológica; ItaliaFil: Di Fede, Giuseppe. Instituto de Medicina Biológica; ItaliaFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; ArgentinaAbstract: Recent advances in the area of the psycho-neuroendocrine-immunology have demonstrated that the inflammatory and immune reactions depend not only on immune factors, but also, they are under an intricate neuroendocrine regulation. In turn, the activity of the nervous and endocrine systems is affected by immune-inflammatory signals. Although most hormones and neuromodulators can potentially influence the immune function, main immunomodulatory properties seem to be exerted by opioid and cannabinoid systems. Brain opioid and cannabinoid systems are endocrinologically connected to the adrenal, and to the pineal gland, respectively. In addition, the neurohypophysis is also important for the neuroimmunomodulation through the release of vasopressin and oxytocin. Experimental evidence supports the conclusion that two fundamental functional circuits occur, including a brain opioid system-vasopressin-adrenal axis, characterized by a prevalent immunosuppressive activity, and a brain cannabinoid-oxytocin-pineal axis, which exerts an immunostimulatory role. The latter is relevant mainly for anticancer immunity. The opioid-adrenal functional axis is active in stress and depressive conditions, while the cannabinoid-pineal axis has been proven to be involved in pleasure perception and spiritual expansion of mind. The findings could explain the predisposition to severe systemic diseases played by stress and depression, and on the other hand the protective action of pleasure and spirituality in the onset of important pathologies. The clinical and therapeutic applications of these concepts may constitute a landmark for future Medicine.Crimson2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/136792637-773X10.31031/NACS.2021.05.000622Lissoni, P. et al. How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach [en línea]. Novel approaches in cancer study. 2021, 5 (5). doi: 10.31031/NACS.2021.05.000622. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13679Novel approaches in cancer study. 2021, 5 (5)reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:58:30Zoai:ucacris:123456789/13679instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:58:30.402Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach
title How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach
spellingShingle How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach
Lissoni, Paolo
CANNABINOIDES
CANCER
COVID-19
CITOQUINAS
MELATONINA
NEUROPROTECCION
INMUNOLOGIA
SISTEMA INMUNOLOGICO
title_short How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach
title_full How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach
title_fullStr How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach
title_full_unstemmed How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach
title_sort How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach
dc.creator.none.fl_str_mv Lissoni, Paolo
Brivio, Fernando
Fumagalli, Luca
Rovelli, Franco
Colciago, Massimo
Messina, Giusy
Monzon, Alejandra
Pelizzoni, Francesco
Lissoni, Arianna
Porro, Giorgio
Di Fede, Giuseppe
Cardinali, Daniel Pedro
author Lissoni, Paolo
author_facet Lissoni, Paolo
Brivio, Fernando
Fumagalli, Luca
Rovelli, Franco
Colciago, Massimo
Messina, Giusy
Monzon, Alejandra
Pelizzoni, Francesco
Lissoni, Arianna
Porro, Giorgio
Di Fede, Giuseppe
Cardinali, Daniel Pedro
author_role author
author2 Brivio, Fernando
Fumagalli, Luca
Rovelli, Franco
Colciago, Massimo
Messina, Giusy
Monzon, Alejandra
Pelizzoni, Francesco
Lissoni, Arianna
Porro, Giorgio
Di Fede, Giuseppe
Cardinali, Daniel Pedro
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CANNABINOIDES
CANCER
COVID-19
CITOQUINAS
MELATONINA
NEUROPROTECCION
INMUNOLOGIA
SISTEMA INMUNOLOGICO
topic CANNABINOIDES
CANCER
COVID-19
CITOQUINAS
MELATONINA
NEUROPROTECCION
INMUNOLOGIA
SISTEMA INMUNOLOGICO
dc.description.none.fl_txt_mv Fil: Lissoni, Paolo. Instituto de Medicina Biológica; Italia
Fil: Brivio, Fernando. Instituto de Medicina Biológica; Italia
Fil: Fumagalli, Luca. Surgical Division; Italia
Fil: Rovelli, Franco. Instituto de Medicina Biológica; Italia
Fil: Colciago, Massimo. Instituto Nacional de Descanso y Atención al Adulto Mayor; Italia
Fil: Messina, Giusy. Instituto de Medicina Biológica; Italia
Fil: Monzon, Alejandra. Instituto de Medicina Biológica; Italia
Fil: Pelizzoni, Francesco. Instituto de Medicina Biológica; Italia
Fil: Lissoni, Arianna. Instituto de Medicina Biológica; Italia
Fil: Porro, Giorgio. Instituto de Medicina Biológica; Italia
Fil: Di Fede, Giuseppe. Instituto de Medicina Biológica; Italia
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; Argentina
Abstract: Recent advances in the area of the psycho-neuroendocrine-immunology have demonstrated that the inflammatory and immune reactions depend not only on immune factors, but also, they are under an intricate neuroendocrine regulation. In turn, the activity of the nervous and endocrine systems is affected by immune-inflammatory signals. Although most hormones and neuromodulators can potentially influence the immune function, main immunomodulatory properties seem to be exerted by opioid and cannabinoid systems. Brain opioid and cannabinoid systems are endocrinologically connected to the adrenal, and to the pineal gland, respectively. In addition, the neurohypophysis is also important for the neuroimmunomodulation through the release of vasopressin and oxytocin. Experimental evidence supports the conclusion that two fundamental functional circuits occur, including a brain opioid system-vasopressin-adrenal axis, characterized by a prevalent immunosuppressive activity, and a brain cannabinoid-oxytocin-pineal axis, which exerts an immunostimulatory role. The latter is relevant mainly for anticancer immunity. The opioid-adrenal functional axis is active in stress and depressive conditions, while the cannabinoid-pineal axis has been proven to be involved in pleasure perception and spiritual expansion of mind. The findings could explain the predisposition to severe systemic diseases played by stress and depression, and on the other hand the protective action of pleasure and spirituality in the onset of important pathologies. The clinical and therapeutic applications of these concepts may constitute a landmark for future Medicine.
description Fil: Lissoni, Paolo. Instituto de Medicina Biológica; Italia
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/13679
2637-773X
10.31031/NACS.2021.05.000622
Lissoni, P. et al. How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach [en línea]. Novel approaches in cancer study. 2021, 5 (5). doi: 10.31031/NACS.2021.05.000622. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13679
url https://repositorio.uca.edu.ar/handle/123456789/13679
identifier_str_mv 2637-773X
10.31031/NACS.2021.05.000622
Lissoni, P. et al. How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach [en línea]. Novel approaches in cancer study. 2021, 5 (5). doi: 10.31031/NACS.2021.05.000622. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13679
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Crimson
publisher.none.fl_str_mv Crimson
dc.source.none.fl_str_mv Novel approaches in cancer study. 2021, 5 (5)
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 13.070432