How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach
- Autores
- Lissoni, Paolo; Brivio, Fernando; Fumagalli, Luca; Rovelli, Franco; Colciago, Massimo; Messina, Giusy; Monzon, Alejandra; Pelizzoni, Francesco; Lissoni, Arianna; Porro, Giorgio; Di Fede, Giuseppe; Cardinali, Daniel Pedro
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Lissoni, Paolo. Instituto de Medicina Biológica; Italia
Fil: Brivio, Fernando. Instituto de Medicina Biológica; Italia
Fil: Fumagalli, Luca. Surgical Division; Italia
Fil: Rovelli, Franco. Instituto de Medicina Biológica; Italia
Fil: Colciago, Massimo. Instituto Nacional de Descanso y Atención al Adulto Mayor; Italia
Fil: Messina, Giusy. Instituto de Medicina Biológica; Italia
Fil: Monzon, Alejandra. Instituto de Medicina Biológica; Italia
Fil: Pelizzoni, Francesco. Instituto de Medicina Biológica; Italia
Fil: Lissoni, Arianna. Instituto de Medicina Biológica; Italia
Fil: Porro, Giorgio. Instituto de Medicina Biológica; Italia
Fil: Di Fede, Giuseppe. Instituto de Medicina Biológica; Italia
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; Argentina
Abstract: Recent advances in the area of the psycho-neuroendocrine-immunology have demonstrated that the inflammatory and immune reactions depend not only on immune factors, but also, they are under an intricate neuroendocrine regulation. In turn, the activity of the nervous and endocrine systems is affected by immune-inflammatory signals. Although most hormones and neuromodulators can potentially influence the immune function, main immunomodulatory properties seem to be exerted by opioid and cannabinoid systems. Brain opioid and cannabinoid systems are endocrinologically connected to the adrenal, and to the pineal gland, respectively. In addition, the neurohypophysis is also important for the neuroimmunomodulation through the release of vasopressin and oxytocin. Experimental evidence supports the conclusion that two fundamental functional circuits occur, including a brain opioid system-vasopressin-adrenal axis, characterized by a prevalent immunosuppressive activity, and a brain cannabinoid-oxytocin-pineal axis, which exerts an immunostimulatory role. The latter is relevant mainly for anticancer immunity. The opioid-adrenal functional axis is active in stress and depressive conditions, while the cannabinoid-pineal axis has been proven to be involved in pleasure perception and spiritual expansion of mind. The findings could explain the predisposition to severe systemic diseases played by stress and depression, and on the other hand the protective action of pleasure and spirituality in the onset of important pathologies. The clinical and therapeutic applications of these concepts may constitute a landmark for future Medicine. - Fuente
- Novel approaches in cancer study. 2021, 5 (5)
- Materia
-
CANNABINOIDES
CANCER
COVID-19
CITOQUINAS
MELATONINA
NEUROPROTECCION
INMUNOLOGIA
SISTEMA INMUNOLOGICO - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Pontificia Universidad Católica Argentina
- OAI Identificador
- oai:ucacris:123456789/13679
Ver los metadatos del registro completo
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How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approachLissoni, PaoloBrivio, FernandoFumagalli, LucaRovelli, FrancoColciago, MassimoMessina, GiusyMonzon, AlejandraPelizzoni, FrancescoLissoni, AriannaPorro, GiorgioDi Fede, GiuseppeCardinali, Daniel PedroCANNABINOIDESCANCERCOVID-19CITOQUINASMELATONINANEUROPROTECCIONINMUNOLOGIASISTEMA INMUNOLOGICOFil: Lissoni, Paolo. Instituto de Medicina Biológica; ItaliaFil: Brivio, Fernando. Instituto de Medicina Biológica; ItaliaFil: Fumagalli, Luca. Surgical Division; ItaliaFil: Rovelli, Franco. Instituto de Medicina Biológica; ItaliaFil: Colciago, Massimo. Instituto Nacional de Descanso y Atención al Adulto Mayor; ItaliaFil: Messina, Giusy. Instituto de Medicina Biológica; ItaliaFil: Monzon, Alejandra. Instituto de Medicina Biológica; ItaliaFil: Pelizzoni, Francesco. Instituto de Medicina Biológica; ItaliaFil: Lissoni, Arianna. Instituto de Medicina Biológica; ItaliaFil: Porro, Giorgio. Instituto de Medicina Biológica; ItaliaFil: Di Fede, Giuseppe. Instituto de Medicina Biológica; ItaliaFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; ArgentinaAbstract: Recent advances in the area of the psycho-neuroendocrine-immunology have demonstrated that the inflammatory and immune reactions depend not only on immune factors, but also, they are under an intricate neuroendocrine regulation. In turn, the activity of the nervous and endocrine systems is affected by immune-inflammatory signals. Although most hormones and neuromodulators can potentially influence the immune function, main immunomodulatory properties seem to be exerted by opioid and cannabinoid systems. Brain opioid and cannabinoid systems are endocrinologically connected to the adrenal, and to the pineal gland, respectively. In addition, the neurohypophysis is also important for the neuroimmunomodulation through the release of vasopressin and oxytocin. Experimental evidence supports the conclusion that two fundamental functional circuits occur, including a brain opioid system-vasopressin-adrenal axis, characterized by a prevalent immunosuppressive activity, and a brain cannabinoid-oxytocin-pineal axis, which exerts an immunostimulatory role. The latter is relevant mainly for anticancer immunity. The opioid-adrenal functional axis is active in stress and depressive conditions, while the cannabinoid-pineal axis has been proven to be involved in pleasure perception and spiritual expansion of mind. The findings could explain the predisposition to severe systemic diseases played by stress and depression, and on the other hand the protective action of pleasure and spirituality in the onset of important pathologies. The clinical and therapeutic applications of these concepts may constitute a landmark for future Medicine.Crimson2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/136792637-773X10.31031/NACS.2021.05.000622Lissoni, P. et al. How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach [en línea]. Novel approaches in cancer study. 2021, 5 (5). doi: 10.31031/NACS.2021.05.000622. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13679Novel approaches in cancer study. 2021, 5 (5)reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:58:30Zoai:ucacris:123456789/13679instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:58:30.402Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse |
dc.title.none.fl_str_mv |
How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach |
title |
How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach |
spellingShingle |
How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach Lissoni, Paolo CANNABINOIDES CANCER COVID-19 CITOQUINAS MELATONINA NEUROPROTECCION INMUNOLOGIA SISTEMA INMUNOLOGICO |
title_short |
How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach |
title_full |
How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach |
title_fullStr |
How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach |
title_full_unstemmed |
How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach |
title_sort |
How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach |
dc.creator.none.fl_str_mv |
Lissoni, Paolo Brivio, Fernando Fumagalli, Luca Rovelli, Franco Colciago, Massimo Messina, Giusy Monzon, Alejandra Pelizzoni, Francesco Lissoni, Arianna Porro, Giorgio Di Fede, Giuseppe Cardinali, Daniel Pedro |
author |
Lissoni, Paolo |
author_facet |
Lissoni, Paolo Brivio, Fernando Fumagalli, Luca Rovelli, Franco Colciago, Massimo Messina, Giusy Monzon, Alejandra Pelizzoni, Francesco Lissoni, Arianna Porro, Giorgio Di Fede, Giuseppe Cardinali, Daniel Pedro |
author_role |
author |
author2 |
Brivio, Fernando Fumagalli, Luca Rovelli, Franco Colciago, Massimo Messina, Giusy Monzon, Alejandra Pelizzoni, Francesco Lissoni, Arianna Porro, Giorgio Di Fede, Giuseppe Cardinali, Daniel Pedro |
author2_role |
author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
CANNABINOIDES CANCER COVID-19 CITOQUINAS MELATONINA NEUROPROTECCION INMUNOLOGIA SISTEMA INMUNOLOGICO |
topic |
CANNABINOIDES CANCER COVID-19 CITOQUINAS MELATONINA NEUROPROTECCION INMUNOLOGIA SISTEMA INMUNOLOGICO |
dc.description.none.fl_txt_mv |
Fil: Lissoni, Paolo. Instituto de Medicina Biológica; Italia Fil: Brivio, Fernando. Instituto de Medicina Biológica; Italia Fil: Fumagalli, Luca. Surgical Division; Italia Fil: Rovelli, Franco. Instituto de Medicina Biológica; Italia Fil: Colciago, Massimo. Instituto Nacional de Descanso y Atención al Adulto Mayor; Italia Fil: Messina, Giusy. Instituto de Medicina Biológica; Italia Fil: Monzon, Alejandra. Instituto de Medicina Biológica; Italia Fil: Pelizzoni, Francesco. Instituto de Medicina Biológica; Italia Fil: Lissoni, Arianna. Instituto de Medicina Biológica; Italia Fil: Porro, Giorgio. Instituto de Medicina Biológica; Italia Fil: Di Fede, Giuseppe. Instituto de Medicina Biológica; Italia Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; Argentina Abstract: Recent advances in the area of the psycho-neuroendocrine-immunology have demonstrated that the inflammatory and immune reactions depend not only on immune factors, but also, they are under an intricate neuroendocrine regulation. In turn, the activity of the nervous and endocrine systems is affected by immune-inflammatory signals. Although most hormones and neuromodulators can potentially influence the immune function, main immunomodulatory properties seem to be exerted by opioid and cannabinoid systems. Brain opioid and cannabinoid systems are endocrinologically connected to the adrenal, and to the pineal gland, respectively. In addition, the neurohypophysis is also important for the neuroimmunomodulation through the release of vasopressin and oxytocin. Experimental evidence supports the conclusion that two fundamental functional circuits occur, including a brain opioid system-vasopressin-adrenal axis, characterized by a prevalent immunosuppressive activity, and a brain cannabinoid-oxytocin-pineal axis, which exerts an immunostimulatory role. The latter is relevant mainly for anticancer immunity. The opioid-adrenal functional axis is active in stress and depressive conditions, while the cannabinoid-pineal axis has been proven to be involved in pleasure perception and spiritual expansion of mind. The findings could explain the predisposition to severe systemic diseases played by stress and depression, and on the other hand the protective action of pleasure and spirituality in the onset of important pathologies. The clinical and therapeutic applications of these concepts may constitute a landmark for future Medicine. |
description |
Fil: Lissoni, Paolo. Instituto de Medicina Biológica; Italia |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://repositorio.uca.edu.ar/handle/123456789/13679 2637-773X 10.31031/NACS.2021.05.000622 Lissoni, P. et al. How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach [en línea]. Novel approaches in cancer study. 2021, 5 (5). doi: 10.31031/NACS.2021.05.000622. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13679 |
url |
https://repositorio.uca.edu.ar/handle/123456789/13679 |
identifier_str_mv |
2637-773X 10.31031/NACS.2021.05.000622 Lissoni, P. et al. How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach [en línea]. Novel approaches in cancer study. 2021, 5 (5). doi: 10.31031/NACS.2021.05.000622. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13679 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Crimson |
publisher.none.fl_str_mv |
Crimson |
dc.source.none.fl_str_mv |
Novel approaches in cancer study. 2021, 5 (5) reponame:Repositorio Institucional (UCA) instname:Pontificia Universidad Católica Argentina |
reponame_str |
Repositorio Institucional (UCA) |
collection |
Repositorio Institucional (UCA) |
instname_str |
Pontificia Universidad Católica Argentina |
repository.name.fl_str_mv |
Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina |
repository.mail.fl_str_mv |
claudia_fernandez@uca.edu.ar |
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1836638361030230016 |
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13.070432 |