Mhc-B haplotypes in "Campero-Inta" chicken synthetic line

• Autores: Iglesias, Gabriela M.; Canet, Zulma E.; Cantaro, Horacio; Miquel, María C.; Melo, Julián E.; Miller, Marcia M.; Berres, Mark E.; Fulton, Janet E.
• Año de publicación: 2019
• Idioma: inglés
• Tipo de recurso: artículo
• Fuente: Poultry Science. 2019, 98(11)
• Materia: COMPLEJO MAYOR DE HISTOCOMPATIBILIDAD; POLLOS; REPROUDCCION ANIMAL; HIBRIDACION; HAPLOTIPOS; INDUSTRIA ALIMENTARIA
• Institución: Pontificia Universidad Católica Argentina

Fil: Iglesias, Gabriela M. Universidad Nacional de Río Negro. Sede Alto Valle y Valle Medio. Escuela de Veterinaria y Producción Agroindustrial. Area de Genética; Argentina
Fil: Canet, Zulma E. Universidad Nacional de Rosario. Facultad de Ciencias Veterinarias. Cátedra de Genética; Argentina
Fil: Canet, Zulma E. Instituto Nacional de Tecnología Agropecuaria. Estación Experimental Agropecuaria Ing. Agr. Walter Kugler; Argentina
Fil: Cantaro, Horacio. Universidad Nacional de Río Negro. Sede Alto Valle y Valle Medio. Escuela de Veterinaria y Producción Agroindustrial. Area de Producción Aves y Pilíferos; Argentina
Fil: Cantaro, Horacio. Instituto Nacional de Tecnología Agropecuaria. Proyecto Nacional de Avicultura. Estación Experimental Agropecuaria Alto Valle. Programa Nacional de Producción Animal; Argentina
Fil: Miquel, María C. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Genética; Argentina
Fil: Melo, Julián E. Pontificia Universidad Católica Argentina. Facultad de Ingeniería y Ciencias Agrarias; Argentina
Fil: Melo, Julián E. Universidad Nacional de Luján. Departamento de Tecnología; Argentina
Fil: Miller, Marcia M. Beckman Research Institute of the City of Hope. Department of Molecular and Cellular Biology; Estados Unidos
Fil: Berres, Mark E. University of Wisconsin. Biotechnology Center; Estados Unidos
Fil: Fulton, Janet E. University of Wisconsin. Biotechnology Center; Estados Unidos
Fil: Fulton, Janet E. Hy-Line International; Estados Unidos
Abstract: The major histocompatibility complex-B (MHC-B) in chickens is a cluster of genes located on chromosome 16. The chicken MHC-B is known to be highly associated with resistance to numerous diseases caused by viruses, bacteria, and parasitic pathogens. Since the level of resistance varies with MHC-B haplotypes, identification and classification of different haplotypes within lines is important for sustaining lines. The "Campero-INTA" chicken breed is a meat-type free-range poultry breed that was developed specifically for small producers in Argentina. Campero-INTA was started by selection in populations produced by crosses between a variety of established lines. MHC-B variation was examined in 65 samples obtained in 2002 using the VNTR marker LEI0258, a marker for MHC-B region. These samples plus and an additional 55 samples from 2018 were examined for variation using the MHC-B specific SNP panel that encompasses ∼230,000 bp of the MHC-B region. Eleven MHC-B SNP haplotypes with 6 LEI0258 alleles were identified in the 120 samples representing the Campero-INTA AH (male) line. Seven haplotypes originate from the breeds originally used in the development of Campero-INTA AH line. Two appear to be recombinant haplotypes. The origin of the remaining 2 is not known, but may be associated with genes introduced from crosses with the Fayoumi breed conducted more recently to sustain the line.