Design and development of nanoprobes radiolabelled with 99mTc for the diagnosis and monitoring of therapeutic interventions in oncology preclinical research

Autores
Salgueiro, Maria Jimena; Portillo, Mariano; Tesán, Fiorella; Nicoud, Melisa; Medina, Vanina; Moretton, Marcela; Chiappetta, Diego; Zubillaga, Marcela
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Salgueiro, Maria Jimena. Universidad de Buenos Aires; Argentina
Fil: Portillo, Mariano. Universidad de Buenos Aires; Argentina
Fil: Tesán, Fiorella. Universidad de Buenos Aires; Argentina
Fil: Nicoud, Melisa. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Nicoud, Melisa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Medina, Vanina. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Medina, Vanina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Moretton, Marcela. Universidad de Buenos Aires; Argentina
Fil: Moretton, Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Chiappetta, Diego. Universidad de Buenos Aires; Argentina
Fil: Chiappetta, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zubillaga, Marcela. Universidad de Buenos Aires; Argentina
Fil: Zubillaga, Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Previous studies employing polymeric micelles and molecular imaging for in vivo nanosystem characterization have led to the development of radionanoprobes (RNPs) designed for diagnosing and monitoring therapeutic interventions in preclinical oncology research, specifically within breast and colon cancer models. These models exhibit high GLUT1 expression on tumor cells and VEGFR expression on the tumor vasculature. We aimed to enhance the tumor-targeting specificity of these RNPs by functionalizing micelles with glucose and bevacizumab. The choice of 99mTc to label the nanoprobes is based on its availability and that direct labeling method is a widespread strategy to prepare radiopharmaceuticals using cold reagents and a 99Mo/99mTc generator. Soluplus® is an attractive polymer for synthesizing micelles that also allows their functionalization. With all the above, the objective of this work was to design, develop and characterize nanoprobes based on polymeric micelles and radiolabeled with 99mTc for the characterization of biological processes associated to the diagnosis, prognosis and monitoring of animal models of breast and colon cancer in preclinical research using molecular images.
Fuente
EJNMMI Radiopharmacy and Chemistry. 9, 2024.
Materia
MEDICINA
ONCOLOGIA
CANCER
NANOTECNOLOGIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/19910
Acceder
id RIUCA_73739f4f20425c818e827d98d9ccf683
oai_identifier_str oai:ucacris:123456789/19910
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Design and development of nanoprobes radiolabelled with 99mTc for the diagnosis and monitoring of therapeutic interventions in oncology preclinical researchSalgueiro, Maria JimenaPortillo, MarianoTesán, FiorellaNicoud, MelisaMedina, VaninaMoretton, MarcelaChiappetta, DiegoZubillaga, MarcelaMEDICINAONCOLOGIACANCERNANOTECNOLOGIAFil: Salgueiro, Maria Jimena. Universidad de Buenos Aires; ArgentinaFil: Portillo, Mariano. Universidad de Buenos Aires; ArgentinaFil: Tesán, Fiorella. Universidad de Buenos Aires; ArgentinaFil: Nicoud, Melisa. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Nicoud, Melisa. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Medina, Vanina. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Medina, Vanina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Moretton, Marcela. Universidad de Buenos Aires; ArgentinaFil: Moretton, Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Chiappetta, Diego. Universidad de Buenos Aires; ArgentinaFil: Chiappetta, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Zubillaga, Marcela. Universidad de Buenos Aires; ArgentinaFil: Zubillaga, Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaPrevious studies employing polymeric micelles and molecular imaging for in vivo nanosystem characterization have led to the development of radionanoprobes (RNPs) designed for diagnosing and monitoring therapeutic interventions in preclinical oncology research, specifically within breast and colon cancer models. These models exhibit high GLUT1 expression on tumor cells and VEGFR expression on the tumor vasculature. We aimed to enhance the tumor-targeting specificity of these RNPs by functionalizing micelles with glucose and bevacizumab. The choice of 99mTc to label the nanoprobes is based on its availability and that direct labeling method is a widespread strategy to prepare radiopharmaceuticals using cold reagents and a 99Mo/99mTc generator. Soluplus® is an attractive polymer for synthesizing micelles that also allows their functionalization. With all the above, the objective of this work was to design, develop and characterize nanoprobes based on polymeric micelles and radiolabeled with 99mTc for the characterization of biological processes associated to the diagnosis, prognosis and monitoring of animal models of breast and colon cancer in preclinical research using molecular images.Springer2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/199102365-421X10.1186/s41181-024-00300-zEJNMMI Radiopharmacy and Chemistry. 9, 2024.reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T11:00:14Zoai:ucacris:123456789/19910instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 11:00:15.078Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Design and development of nanoprobes radiolabelled with 99mTc for the diagnosis and monitoring of therapeutic interventions in oncology preclinical research
title Design and development of nanoprobes radiolabelled with 99mTc for the diagnosis and monitoring of therapeutic interventions in oncology preclinical research
spellingShingle Design and development of nanoprobes radiolabelled with 99mTc for the diagnosis and monitoring of therapeutic interventions in oncology preclinical research
Salgueiro, Maria Jimena
MEDICINA
ONCOLOGIA
CANCER
NANOTECNOLOGIA
title_short Design and development of nanoprobes radiolabelled with 99mTc for the diagnosis and monitoring of therapeutic interventions in oncology preclinical research
title_full Design and development of nanoprobes radiolabelled with 99mTc for the diagnosis and monitoring of therapeutic interventions in oncology preclinical research
title_fullStr Design and development of nanoprobes radiolabelled with 99mTc for the diagnosis and monitoring of therapeutic interventions in oncology preclinical research
title_full_unstemmed Design and development of nanoprobes radiolabelled with 99mTc for the diagnosis and monitoring of therapeutic interventions in oncology preclinical research
title_sort Design and development of nanoprobes radiolabelled with 99mTc for the diagnosis and monitoring of therapeutic interventions in oncology preclinical research
dc.creator.none.fl_str_mv Salgueiro, Maria Jimena
Portillo, Mariano
Tesán, Fiorella
Nicoud, Melisa
Medina, Vanina
Moretton, Marcela
Chiappetta, Diego
Zubillaga, Marcela
author Salgueiro, Maria Jimena
author_facet Salgueiro, Maria Jimena
Portillo, Mariano
Tesán, Fiorella
Nicoud, Melisa
Medina, Vanina
Moretton, Marcela
Chiappetta, Diego
Zubillaga, Marcela
author_role author
author2 Portillo, Mariano
Tesán, Fiorella
Nicoud, Melisa
Medina, Vanina
Moretton, Marcela
Chiappetta, Diego
Zubillaga, Marcela
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv MEDICINA
ONCOLOGIA
CANCER
NANOTECNOLOGIA
topic MEDICINA
ONCOLOGIA
CANCER
NANOTECNOLOGIA
dc.description.none.fl_txt_mv Fil: Salgueiro, Maria Jimena. Universidad de Buenos Aires; Argentina
Fil: Portillo, Mariano. Universidad de Buenos Aires; Argentina
Fil: Tesán, Fiorella. Universidad de Buenos Aires; Argentina
Fil: Nicoud, Melisa. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Nicoud, Melisa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Medina, Vanina. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Medina, Vanina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Moretton, Marcela. Universidad de Buenos Aires; Argentina
Fil: Moretton, Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Chiappetta, Diego. Universidad de Buenos Aires; Argentina
Fil: Chiappetta, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zubillaga, Marcela. Universidad de Buenos Aires; Argentina
Fil: Zubillaga, Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Previous studies employing polymeric micelles and molecular imaging for in vivo nanosystem characterization have led to the development of radionanoprobes (RNPs) designed for diagnosing and monitoring therapeutic interventions in preclinical oncology research, specifically within breast and colon cancer models. These models exhibit high GLUT1 expression on tumor cells and VEGFR expression on the tumor vasculature. We aimed to enhance the tumor-targeting specificity of these RNPs by functionalizing micelles with glucose and bevacizumab. The choice of 99mTc to label the nanoprobes is based on its availability and that direct labeling method is a widespread strategy to prepare radiopharmaceuticals using cold reagents and a 99Mo/99mTc generator. Soluplus® is an attractive polymer for synthesizing micelles that also allows their functionalization. With all the above, the objective of this work was to design, develop and characterize nanoprobes based on polymeric micelles and radiolabeled with 99mTc for the characterization of biological processes associated to the diagnosis, prognosis and monitoring of animal models of breast and colon cancer in preclinical research using molecular images.
description Fil: Salgueiro, Maria Jimena. Universidad de Buenos Aires; Argentina
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/19910
2365-421X
10.1186/s41181-024-00300-z
url https://repositorio.uca.edu.ar/handle/123456789/19910
identifier_str_mv 2365-421X
10.1186/s41181-024-00300-z
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv EJNMMI Radiopharmacy and Chemistry. 9, 2024.
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 13.070432

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