The epidemiology and etiopathogenesis of graves’ disease
- Autores
- Saban, Melina; Curriá, Marina Inés; Romeo, Horacio; Barreiro Arcos, María Laura
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- parte de libro
- Estado
- versión publicada
- Descripción
- Fil: Saban, Melina. Hospital Británico de Buenos Aires. División de Endocrinología, Metabolismo, Nutrición y Diabetes; Argentina
Fil: Curriá, Marina Inés. Hospital Británico de Buenos Aires. División de Endocrinología, Metabolismo, Nutrición y Diabetes; Argentina
Fil: Romeo, Horacio. Pontificia Universidad Católica Argentina. Facultad de Ingeniería y Ciencias Agrarias. Instituto de Investigaciones Biomédicas; Argentina
Fil: Barreiro Arcos, María Laura. Pontificia Universidad Católica Argentina. Facultad de Ingeniería y Ciencias Agrarias. Instituto de Investigaciones Biomédicas; Argentina
Abstract: Graves' disease (GD) is the most common cause of hyperthyroidism. GD is an endocrine autoimmune disorder caused by the presence in serum of TSH receptor-stimulating autoantibodies (TRAb) that induce the overproduction of 3,3',5'-triiodo-L-thyronine (T3) and L-thyroxine (T4) and enlargement of the thyroid gland. GD is also often accompanied by autoantibodies against other thyroid antigens such as thyroglobulin and thyroid peroxidase. The prevalence of GD is around 1-1.5 % worldwide, with an incidence of 20 to 50 new cases per 100,000 inhabitants per year with a considerably higher frequency in women than in men. In addition to hyperthyroidism, extrathyroidal manifestations including orbitopathy, thyroid dermopathy, and acropachy are frequently associated with GD. Genetic factors (such as HLA-DR3, CD40, CTLA-4, PTPN22, FOXP3, and CD25) and environmental and endogenous factors (such as age, emotional stress, smoking, female sex, pregnancy, bacterial and viral infections, and some drugs) contribute to the development of GD. Although the pathogenesis of GD has been better understood, directed treatments against the molecular mechanisms are lacking. Therapies for GD are presently based upon antithyroid drugs, but due to the high rate of recurrence in hyperthyroidism, ablation of the thyroid by either radioiodine treatment or surgical thyroidectomy is the only treatment available. In the present chapter, we provide updated knowledge on the epidemiology and etiopathogenesis of GD. - Fuente
- Karunakaran, P. Understanding and Managing Hyperthyroidism. Nueva York : Nova Science. 2023
- Materia
-
ENFERMEDAD DE GRAVES
AUTOINMUNIDAD
GLANDULA TIROIDES
HORMONA TIROIDEA
OFTALMOPATIA DE GRAVES
EPIDEMIOLOGIA - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Pontificia Universidad Católica Argentina
- OAI Identificador
- oai:ucacris:123456789/16519
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The epidemiology and etiopathogenesis of graves’ diseaseSaban, MelinaCurriá, Marina InésRomeo, HoracioBarreiro Arcos, María LauraENFERMEDAD DE GRAVESAUTOINMUNIDADGLANDULA TIROIDESHORMONA TIROIDEAOFTALMOPATIA DE GRAVESEPIDEMIOLOGIAFil: Saban, Melina. Hospital Británico de Buenos Aires. División de Endocrinología, Metabolismo, Nutrición y Diabetes; ArgentinaFil: Curriá, Marina Inés. Hospital Británico de Buenos Aires. División de Endocrinología, Metabolismo, Nutrición y Diabetes; ArgentinaFil: Romeo, Horacio. Pontificia Universidad Católica Argentina. Facultad de Ingeniería y Ciencias Agrarias. Instituto de Investigaciones Biomédicas; ArgentinaFil: Barreiro Arcos, María Laura. Pontificia Universidad Católica Argentina. Facultad de Ingeniería y Ciencias Agrarias. Instituto de Investigaciones Biomédicas; ArgentinaAbstract: Graves' disease (GD) is the most common cause of hyperthyroidism. GD is an endocrine autoimmune disorder caused by the presence in serum of TSH receptor-stimulating autoantibodies (TRAb) that induce the overproduction of 3,3',5'-triiodo-L-thyronine (T3) and L-thyroxine (T4) and enlargement of the thyroid gland. GD is also often accompanied by autoantibodies against other thyroid antigens such as thyroglobulin and thyroid peroxidase. The prevalence of GD is around 1-1.5 % worldwide, with an incidence of 20 to 50 new cases per 100,000 inhabitants per year with a considerably higher frequency in women than in men. In addition to hyperthyroidism, extrathyroidal manifestations including orbitopathy, thyroid dermopathy, and acropachy are frequently associated with GD. Genetic factors (such as HLA-DR3, CD40, CTLA-4, PTPN22, FOXP3, and CD25) and environmental and endogenous factors (such as age, emotional stress, smoking, female sex, pregnancy, bacterial and viral infections, and some drugs) contribute to the development of GD. Although the pathogenesis of GD has been better understood, directed treatments against the molecular mechanisms are lacking. Therapies for GD are presently based upon antithyroid drugs, but due to the high rate of recurrence in hyperthyroidism, ablation of the thyroid by either radioiodine treatment or surgical thyroidectomy is the only treatment available. In the present chapter, we provide updated knowledge on the epidemiology and etiopathogenesis of GD.Nova Science2023info:eu-repo/semantics/bookPartinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_3248info:ar-repo/semantics/parteDeLibroapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/16519979888697636610.52305/HCEE6098Saban, M. et al. The epidemiology and etiopathogenesis of graves’ disease [en línea]. En: Karunakaran, P. Understanding and Managing Hyperthyroidism. Nueva York : Nova Science. 2023. doi: 10.52305/HCEE6098. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16519Karunakaran, P. Understanding and Managing Hyperthyroidism. Nueva York : Nova Science. 2023reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:59:20Zoai:ucacris:123456789/16519instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:59:20.503Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse |
dc.title.none.fl_str_mv |
The epidemiology and etiopathogenesis of graves’ disease |
title |
The epidemiology and etiopathogenesis of graves’ disease |
spellingShingle |
The epidemiology and etiopathogenesis of graves’ disease Saban, Melina ENFERMEDAD DE GRAVES AUTOINMUNIDAD GLANDULA TIROIDES HORMONA TIROIDEA OFTALMOPATIA DE GRAVES EPIDEMIOLOGIA |
title_short |
The epidemiology and etiopathogenesis of graves’ disease |
title_full |
The epidemiology and etiopathogenesis of graves’ disease |
title_fullStr |
The epidemiology and etiopathogenesis of graves’ disease |
title_full_unstemmed |
The epidemiology and etiopathogenesis of graves’ disease |
title_sort |
The epidemiology and etiopathogenesis of graves’ disease |
dc.creator.none.fl_str_mv |
Saban, Melina Curriá, Marina Inés Romeo, Horacio Barreiro Arcos, María Laura |
author |
Saban, Melina |
author_facet |
Saban, Melina Curriá, Marina Inés Romeo, Horacio Barreiro Arcos, María Laura |
author_role |
author |
author2 |
Curriá, Marina Inés Romeo, Horacio Barreiro Arcos, María Laura |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
ENFERMEDAD DE GRAVES AUTOINMUNIDAD GLANDULA TIROIDES HORMONA TIROIDEA OFTALMOPATIA DE GRAVES EPIDEMIOLOGIA |
topic |
ENFERMEDAD DE GRAVES AUTOINMUNIDAD GLANDULA TIROIDES HORMONA TIROIDEA OFTALMOPATIA DE GRAVES EPIDEMIOLOGIA |
dc.description.none.fl_txt_mv |
Fil: Saban, Melina. Hospital Británico de Buenos Aires. División de Endocrinología, Metabolismo, Nutrición y Diabetes; Argentina Fil: Curriá, Marina Inés. Hospital Británico de Buenos Aires. División de Endocrinología, Metabolismo, Nutrición y Diabetes; Argentina Fil: Romeo, Horacio. Pontificia Universidad Católica Argentina. Facultad de Ingeniería y Ciencias Agrarias. Instituto de Investigaciones Biomédicas; Argentina Fil: Barreiro Arcos, María Laura. Pontificia Universidad Católica Argentina. Facultad de Ingeniería y Ciencias Agrarias. Instituto de Investigaciones Biomédicas; Argentina Abstract: Graves' disease (GD) is the most common cause of hyperthyroidism. GD is an endocrine autoimmune disorder caused by the presence in serum of TSH receptor-stimulating autoantibodies (TRAb) that induce the overproduction of 3,3',5'-triiodo-L-thyronine (T3) and L-thyroxine (T4) and enlargement of the thyroid gland. GD is also often accompanied by autoantibodies against other thyroid antigens such as thyroglobulin and thyroid peroxidase. The prevalence of GD is around 1-1.5 % worldwide, with an incidence of 20 to 50 new cases per 100,000 inhabitants per year with a considerably higher frequency in women than in men. In addition to hyperthyroidism, extrathyroidal manifestations including orbitopathy, thyroid dermopathy, and acropachy are frequently associated with GD. Genetic factors (such as HLA-DR3, CD40, CTLA-4, PTPN22, FOXP3, and CD25) and environmental and endogenous factors (such as age, emotional stress, smoking, female sex, pregnancy, bacterial and viral infections, and some drugs) contribute to the development of GD. Although the pathogenesis of GD has been better understood, directed treatments against the molecular mechanisms are lacking. Therapies for GD are presently based upon antithyroid drugs, but due to the high rate of recurrence in hyperthyroidism, ablation of the thyroid by either radioiodine treatment or surgical thyroidectomy is the only treatment available. In the present chapter, we provide updated knowledge on the epidemiology and etiopathogenesis of GD. |
description |
Fil: Saban, Melina. Hospital Británico de Buenos Aires. División de Endocrinología, Metabolismo, Nutrición y Diabetes; Argentina |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/bookPart info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_3248 info:ar-repo/semantics/parteDeLibro |
format |
bookPart |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://repositorio.uca.edu.ar/handle/123456789/16519 9798886976366 10.52305/HCEE6098 Saban, M. et al. The epidemiology and etiopathogenesis of graves’ disease [en línea]. En: Karunakaran, P. Understanding and Managing Hyperthyroidism. Nueva York : Nova Science. 2023. doi: 10.52305/HCEE6098. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16519 |
url |
https://repositorio.uca.edu.ar/handle/123456789/16519 |
identifier_str_mv |
9798886976366 10.52305/HCEE6098 Saban, M. et al. The epidemiology and etiopathogenesis of graves’ disease [en línea]. En: Karunakaran, P. Understanding and Managing Hyperthyroidism. Nueva York : Nova Science. 2023. doi: 10.52305/HCEE6098. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16519 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Nova Science |
publisher.none.fl_str_mv |
Nova Science |
dc.source.none.fl_str_mv |
Karunakaran, P. Understanding and Managing Hyperthyroidism. Nueva York : Nova Science. 2023 reponame:Repositorio Institucional (UCA) instname:Pontificia Universidad Católica Argentina |
reponame_str |
Repositorio Institucional (UCA) |
collection |
Repositorio Institucional (UCA) |
instname_str |
Pontificia Universidad Católica Argentina |
repository.name.fl_str_mv |
Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina |
repository.mail.fl_str_mv |
claudia_fernandez@uca.edu.ar |
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13.070432 |