The epidemiology and etiopathogenesis of graves’ disease

Autores
Saban, Melina; Curriá, Marina Inés; Romeo, Horacio; Barreiro Arcos, María Laura
Año de publicación
2023
Idioma
inglés
Tipo de recurso
parte de libro
Estado
versión publicada
Descripción
Fil: Saban, Melina. Hospital Británico de Buenos Aires. División de Endocrinología, Metabolismo, Nutrición y Diabetes; Argentina
Fil: Curriá, Marina Inés. Hospital Británico de Buenos Aires. División de Endocrinología, Metabolismo, Nutrición y Diabetes; Argentina
Fil: Romeo, Horacio. Pontificia Universidad Católica Argentina. Facultad de Ingeniería y Ciencias Agrarias. Instituto de Investigaciones Biomédicas; Argentina
Fil: Barreiro Arcos, María Laura. Pontificia Universidad Católica Argentina. Facultad de Ingeniería y Ciencias Agrarias. Instituto de Investigaciones Biomédicas; Argentina
Abstract: Graves' disease (GD) is the most common cause of hyperthyroidism. GD is an endocrine autoimmune disorder caused by the presence in serum of TSH receptor-stimulating autoantibodies (TRAb) that induce the overproduction of 3,3',5'-triiodo-L-thyronine (T3) and L-thyroxine (T4) and enlargement of the thyroid gland. GD is also often accompanied by autoantibodies against other thyroid antigens such as thyroglobulin and thyroid peroxidase. The prevalence of GD is around 1-1.5 % worldwide, with an incidence of 20 to 50 new cases per 100,000 inhabitants per year with a considerably higher frequency in women than in men. In addition to hyperthyroidism, extrathyroidal manifestations including orbitopathy, thyroid dermopathy, and acropachy are frequently associated with GD. Genetic factors (such as HLA-DR3, CD40, CTLA-4, PTPN22, FOXP3, and CD25) and environmental and endogenous factors (such as age, emotional stress, smoking, female sex, pregnancy, bacterial and viral infections, and some drugs) contribute to the development of GD. Although the pathogenesis of GD has been better understood, directed treatments against the molecular mechanisms are lacking. Therapies for GD are presently based upon antithyroid drugs, but due to the high rate of recurrence in hyperthyroidism, ablation of the thyroid by either radioiodine treatment or surgical thyroidectomy is the only treatment available. In the present chapter, we provide updated knowledge on the epidemiology and etiopathogenesis of GD.
Fuente
Karunakaran, P. Understanding and Managing Hyperthyroidism. Nueva York : Nova Science. 2023
Materia
ENFERMEDAD DE GRAVES
AUTOINMUNIDAD
GLANDULA TIROIDES
HORMONA TIROIDEA
OFTALMOPATIA DE GRAVES
EPIDEMIOLOGIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/16519

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oai_identifier_str oai:ucacris:123456789/16519
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repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling The epidemiology and etiopathogenesis of graves’ diseaseSaban, MelinaCurriá, Marina InésRomeo, HoracioBarreiro Arcos, María LauraENFERMEDAD DE GRAVESAUTOINMUNIDADGLANDULA TIROIDESHORMONA TIROIDEAOFTALMOPATIA DE GRAVESEPIDEMIOLOGIAFil: Saban, Melina. Hospital Británico de Buenos Aires. División de Endocrinología, Metabolismo, Nutrición y Diabetes; ArgentinaFil: Curriá, Marina Inés. Hospital Británico de Buenos Aires. División de Endocrinología, Metabolismo, Nutrición y Diabetes; ArgentinaFil: Romeo, Horacio. Pontificia Universidad Católica Argentina. Facultad de Ingeniería y Ciencias Agrarias. Instituto de Investigaciones Biomédicas; ArgentinaFil: Barreiro Arcos, María Laura. Pontificia Universidad Católica Argentina. Facultad de Ingeniería y Ciencias Agrarias. Instituto de Investigaciones Biomédicas; ArgentinaAbstract: Graves' disease (GD) is the most common cause of hyperthyroidism. GD is an endocrine autoimmune disorder caused by the presence in serum of TSH receptor-stimulating autoantibodies (TRAb) that induce the overproduction of 3,3',5'-triiodo-L-thyronine (T3) and L-thyroxine (T4) and enlargement of the thyroid gland. GD is also often accompanied by autoantibodies against other thyroid antigens such as thyroglobulin and thyroid peroxidase. The prevalence of GD is around 1-1.5 % worldwide, with an incidence of 20 to 50 new cases per 100,000 inhabitants per year with a considerably higher frequency in women than in men. In addition to hyperthyroidism, extrathyroidal manifestations including orbitopathy, thyroid dermopathy, and acropachy are frequently associated with GD. Genetic factors (such as HLA-DR3, CD40, CTLA-4, PTPN22, FOXP3, and CD25) and environmental and endogenous factors (such as age, emotional stress, smoking, female sex, pregnancy, bacterial and viral infections, and some drugs) contribute to the development of GD. Although the pathogenesis of GD has been better understood, directed treatments against the molecular mechanisms are lacking. Therapies for GD are presently based upon antithyroid drugs, but due to the high rate of recurrence in hyperthyroidism, ablation of the thyroid by either radioiodine treatment or surgical thyroidectomy is the only treatment available. In the present chapter, we provide updated knowledge on the epidemiology and etiopathogenesis of GD.Nova Science2023info:eu-repo/semantics/bookPartinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_3248info:ar-repo/semantics/parteDeLibroapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/16519979888697636610.52305/HCEE6098Saban, M. et al. The epidemiology and etiopathogenesis of graves’ disease [en línea]. En: Karunakaran, P. Understanding and Managing Hyperthyroidism. Nueva York : Nova Science. 2023. doi: 10.52305/HCEE6098. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16519Karunakaran, P. Understanding and Managing Hyperthyroidism. Nueva York : Nova Science. 2023reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:59:20Zoai:ucacris:123456789/16519instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:59:20.503Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv The epidemiology and etiopathogenesis of graves’ disease
title The epidemiology and etiopathogenesis of graves’ disease
spellingShingle The epidemiology and etiopathogenesis of graves’ disease
Saban, Melina
ENFERMEDAD DE GRAVES
AUTOINMUNIDAD
GLANDULA TIROIDES
HORMONA TIROIDEA
OFTALMOPATIA DE GRAVES
EPIDEMIOLOGIA
title_short The epidemiology and etiopathogenesis of graves’ disease
title_full The epidemiology and etiopathogenesis of graves’ disease
title_fullStr The epidemiology and etiopathogenesis of graves’ disease
title_full_unstemmed The epidemiology and etiopathogenesis of graves’ disease
title_sort The epidemiology and etiopathogenesis of graves’ disease
dc.creator.none.fl_str_mv Saban, Melina
Curriá, Marina Inés
Romeo, Horacio
Barreiro Arcos, María Laura
author Saban, Melina
author_facet Saban, Melina
Curriá, Marina Inés
Romeo, Horacio
Barreiro Arcos, María Laura
author_role author
author2 Curriá, Marina Inés
Romeo, Horacio
Barreiro Arcos, María Laura
author2_role author
author
author
dc.subject.none.fl_str_mv ENFERMEDAD DE GRAVES
AUTOINMUNIDAD
GLANDULA TIROIDES
HORMONA TIROIDEA
OFTALMOPATIA DE GRAVES
EPIDEMIOLOGIA
topic ENFERMEDAD DE GRAVES
AUTOINMUNIDAD
GLANDULA TIROIDES
HORMONA TIROIDEA
OFTALMOPATIA DE GRAVES
EPIDEMIOLOGIA
dc.description.none.fl_txt_mv Fil: Saban, Melina. Hospital Británico de Buenos Aires. División de Endocrinología, Metabolismo, Nutrición y Diabetes; Argentina
Fil: Curriá, Marina Inés. Hospital Británico de Buenos Aires. División de Endocrinología, Metabolismo, Nutrición y Diabetes; Argentina
Fil: Romeo, Horacio. Pontificia Universidad Católica Argentina. Facultad de Ingeniería y Ciencias Agrarias. Instituto de Investigaciones Biomédicas; Argentina
Fil: Barreiro Arcos, María Laura. Pontificia Universidad Católica Argentina. Facultad de Ingeniería y Ciencias Agrarias. Instituto de Investigaciones Biomédicas; Argentina
Abstract: Graves' disease (GD) is the most common cause of hyperthyroidism. GD is an endocrine autoimmune disorder caused by the presence in serum of TSH receptor-stimulating autoantibodies (TRAb) that induce the overproduction of 3,3',5'-triiodo-L-thyronine (T3) and L-thyroxine (T4) and enlargement of the thyroid gland. GD is also often accompanied by autoantibodies against other thyroid antigens such as thyroglobulin and thyroid peroxidase. The prevalence of GD is around 1-1.5 % worldwide, with an incidence of 20 to 50 new cases per 100,000 inhabitants per year with a considerably higher frequency in women than in men. In addition to hyperthyroidism, extrathyroidal manifestations including orbitopathy, thyroid dermopathy, and acropachy are frequently associated with GD. Genetic factors (such as HLA-DR3, CD40, CTLA-4, PTPN22, FOXP3, and CD25) and environmental and endogenous factors (such as age, emotional stress, smoking, female sex, pregnancy, bacterial and viral infections, and some drugs) contribute to the development of GD. Although the pathogenesis of GD has been better understood, directed treatments against the molecular mechanisms are lacking. Therapies for GD are presently based upon antithyroid drugs, but due to the high rate of recurrence in hyperthyroidism, ablation of the thyroid by either radioiodine treatment or surgical thyroidectomy is the only treatment available. In the present chapter, we provide updated knowledge on the epidemiology and etiopathogenesis of GD.
description Fil: Saban, Melina. Hospital Británico de Buenos Aires. División de Endocrinología, Metabolismo, Nutrición y Diabetes; Argentina
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/bookPart
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_3248
info:ar-repo/semantics/parteDeLibro
format bookPart
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/16519
9798886976366
10.52305/HCEE6098
Saban, M. et al. The epidemiology and etiopathogenesis of graves’ disease [en línea]. En: Karunakaran, P. Understanding and Managing Hyperthyroidism. Nueva York : Nova Science. 2023. doi: 10.52305/HCEE6098. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16519
url https://repositorio.uca.edu.ar/handle/123456789/16519
identifier_str_mv 9798886976366
10.52305/HCEE6098
Saban, M. et al. The epidemiology and etiopathogenesis of graves’ disease [en línea]. En: Karunakaran, P. Understanding and Managing Hyperthyroidism. Nueva York : Nova Science. 2023. doi: 10.52305/HCEE6098. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16519
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nova Science
publisher.none.fl_str_mv Nova Science
dc.source.none.fl_str_mv Karunakaran, P. Understanding and Managing Hyperthyroidism. Nueva York : Nova Science. 2023
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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