An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccination

Autores
Cardinali, Daniel Pedro; Brown, Gregory M.; Pandi Perumal, Seithikurippu R.
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Medicina; Argentina
Fil: Brown, Gregory M. University of Toronto. Department of Psychiatry. Centre for Addiction and Mental Health; Canada
Fil: Pandi Perumal, Seithikurippu R. Somnogen Canada Inc; Canada
Abstract: Competition among pharmaceutical companies to develop safe and effective vaccines against SARS-CoV-2 is high. However, based on the prior experience with the influenza vaccine, up to 50% in lack of effectiveness would be found among healthy adults receiving effective vaccines against SARS-CoV-2. There is growing evidence that insufficient sleep may potentially be a pervasive and prominent factor accounting for this variability. Individuals experiencing total or partial sleep loss exhibit markedly reduced antigen-specific antibodies as compared to healthy sleepers. Besides, pre-vaccination sleep quality is also an important contributing factor. Several meta-analyses and expert consensus reports support the view that the chronobiotic/hypnotic properties of melatonin are useful in patients with primary sleep disorders to decrease sleep onset latency and to increase total sleep time. Hence, the prescription of melatonin for at least 2 weeks prior to vaccination can be a useful approach to improve sleep quality and to ensure that the vaccination is performed at a moment of optimal sleep conditions. Moreover, melatonin enhances the immune response to vaccines by increasing peripheral blood CD4+ T cells and IgG-expressing B cells. Administration of exogenous melatonin could increase the potency of the immune response and the duration of the immunity induced by the vaccine. Besides, melatonin could also prevent adverse effects of the vaccination due to its antioxidant and immunomodulatory properties. Therefore, the administration of melatonin from 2 weeks to at least 4 weeks after vaccination may constitute an effective means to enhance the efficacy of vaccination against SARS-CoV-2.
Fuente
Melatonin Research Vol. 4, No.1, 2021
Materia
COVID-19
SARS-CoV-2
MELATONINA
INSOMNIO
SUEÑO
VACUNACION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/13669

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oai_identifier_str oai:ucacris:123456789/13669
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccinationCardinali, Daniel PedroBrown, Gregory M.Pandi Perumal, Seithikurippu R.COVID-19SARS-CoV-2MELATONINAINSOMNIOSUEÑOVACUNACIONFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Medicina; ArgentinaFil: Brown, Gregory M. University of Toronto. Department of Psychiatry. Centre for Addiction and Mental Health; CanadaFil: Pandi Perumal, Seithikurippu R. Somnogen Canada Inc; CanadaAbstract: Competition among pharmaceutical companies to develop safe and effective vaccines against SARS-CoV-2 is high. However, based on the prior experience with the influenza vaccine, up to 50% in lack of effectiveness would be found among healthy adults receiving effective vaccines against SARS-CoV-2. There is growing evidence that insufficient sleep may potentially be a pervasive and prominent factor accounting for this variability. Individuals experiencing total or partial sleep loss exhibit markedly reduced antigen-specific antibodies as compared to healthy sleepers. Besides, pre-vaccination sleep quality is also an important contributing factor. Several meta-analyses and expert consensus reports support the view that the chronobiotic/hypnotic properties of melatonin are useful in patients with primary sleep disorders to decrease sleep onset latency and to increase total sleep time. Hence, the prescription of melatonin for at least 2 weeks prior to vaccination can be a useful approach to improve sleep quality and to ensure that the vaccination is performed at a moment of optimal sleep conditions. Moreover, melatonin enhances the immune response to vaccines by increasing peripheral blood CD4+ T cells and IgG-expressing B cells. Administration of exogenous melatonin could increase the potency of the immune response and the duration of the immunity induced by the vaccine. Besides, melatonin could also prevent adverse effects of the vaccination due to its antioxidant and immunomodulatory properties. Therefore, the administration of melatonin from 2 weeks to at least 4 weeks after vaccination may constitute an effective means to enhance the efficacy of vaccination against SARS-CoV-2.ST-Bio-Life LLC2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/136692641-0281 (online)10.32794/mr11250091Cardinali, D. P., Brown, G. M., Pandi Perumal, S. R. An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccination [en línea]. Melatonin Research. 2021, 4 (1). doi: 10.32794/mr11250091. doi: 10.32794/mr11250091. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13669Melatonin Research Vol. 4, No.1, 2021reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:58:30Zoai:ucacris:123456789/13669instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:58:30.371Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccination
title An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccination
spellingShingle An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccination
Cardinali, Daniel Pedro
COVID-19
SARS-CoV-2
MELATONINA
INSOMNIO
SUEÑO
VACUNACION
title_short An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccination
title_full An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccination
title_fullStr An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccination
title_full_unstemmed An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccination
title_sort An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccination
dc.creator.none.fl_str_mv Cardinali, Daniel Pedro
Brown, Gregory M.
Pandi Perumal, Seithikurippu R.
author Cardinali, Daniel Pedro
author_facet Cardinali, Daniel Pedro
Brown, Gregory M.
Pandi Perumal, Seithikurippu R.
author_role author
author2 Brown, Gregory M.
Pandi Perumal, Seithikurippu R.
author2_role author
author
dc.subject.none.fl_str_mv COVID-19
SARS-CoV-2
MELATONINA
INSOMNIO
SUEÑO
VACUNACION
topic COVID-19
SARS-CoV-2
MELATONINA
INSOMNIO
SUEÑO
VACUNACION
dc.description.none.fl_txt_mv Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Medicina; Argentina
Fil: Brown, Gregory M. University of Toronto. Department of Psychiatry. Centre for Addiction and Mental Health; Canada
Fil: Pandi Perumal, Seithikurippu R. Somnogen Canada Inc; Canada
Abstract: Competition among pharmaceutical companies to develop safe and effective vaccines against SARS-CoV-2 is high. However, based on the prior experience with the influenza vaccine, up to 50% in lack of effectiveness would be found among healthy adults receiving effective vaccines against SARS-CoV-2. There is growing evidence that insufficient sleep may potentially be a pervasive and prominent factor accounting for this variability. Individuals experiencing total or partial sleep loss exhibit markedly reduced antigen-specific antibodies as compared to healthy sleepers. Besides, pre-vaccination sleep quality is also an important contributing factor. Several meta-analyses and expert consensus reports support the view that the chronobiotic/hypnotic properties of melatonin are useful in patients with primary sleep disorders to decrease sleep onset latency and to increase total sleep time. Hence, the prescription of melatonin for at least 2 weeks prior to vaccination can be a useful approach to improve sleep quality and to ensure that the vaccination is performed at a moment of optimal sleep conditions. Moreover, melatonin enhances the immune response to vaccines by increasing peripheral blood CD4+ T cells and IgG-expressing B cells. Administration of exogenous melatonin could increase the potency of the immune response and the duration of the immunity induced by the vaccine. Besides, melatonin could also prevent adverse effects of the vaccination due to its antioxidant and immunomodulatory properties. Therefore, the administration of melatonin from 2 weeks to at least 4 weeks after vaccination may constitute an effective means to enhance the efficacy of vaccination against SARS-CoV-2.
description Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Medicina; Argentina
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/13669
2641-0281 (online)
10.32794/mr11250091
Cardinali, D. P., Brown, G. M., Pandi Perumal, S. R. An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccination [en línea]. Melatonin Research. 2021, 4 (1). doi: 10.32794/mr11250091. doi: 10.32794/mr11250091. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13669
url https://repositorio.uca.edu.ar/handle/123456789/13669
identifier_str_mv 2641-0281 (online)
10.32794/mr11250091
Cardinali, D. P., Brown, G. M., Pandi Perumal, S. R. An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccination [en línea]. Melatonin Research. 2021, 4 (1). doi: 10.32794/mr11250091. doi: 10.32794/mr11250091. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13669
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv ST-Bio-Life LLC
publisher.none.fl_str_mv ST-Bio-Life LLC
dc.source.none.fl_str_mv Melatonin Research Vol. 4, No.1, 2021
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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