An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccination
- Autores
- Cardinali, Daniel Pedro; Brown, Gregory M.; Pandi Perumal, Seithikurippu R.
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Medicina; Argentina
Fil: Brown, Gregory M. University of Toronto. Department of Psychiatry. Centre for Addiction and Mental Health; Canada
Fil: Pandi Perumal, Seithikurippu R. Somnogen Canada Inc; Canada
Abstract: Competition among pharmaceutical companies to develop safe and effective vaccines against SARS-CoV-2 is high. However, based on the prior experience with the influenza vaccine, up to 50% in lack of effectiveness would be found among healthy adults receiving effective vaccines against SARS-CoV-2. There is growing evidence that insufficient sleep may potentially be a pervasive and prominent factor accounting for this variability. Individuals experiencing total or partial sleep loss exhibit markedly reduced antigen-specific antibodies as compared to healthy sleepers. Besides, pre-vaccination sleep quality is also an important contributing factor. Several meta-analyses and expert consensus reports support the view that the chronobiotic/hypnotic properties of melatonin are useful in patients with primary sleep disorders to decrease sleep onset latency and to increase total sleep time. Hence, the prescription of melatonin for at least 2 weeks prior to vaccination can be a useful approach to improve sleep quality and to ensure that the vaccination is performed at a moment of optimal sleep conditions. Moreover, melatonin enhances the immune response to vaccines by increasing peripheral blood CD4+ T cells and IgG-expressing B cells. Administration of exogenous melatonin could increase the potency of the immune response and the duration of the immunity induced by the vaccine. Besides, melatonin could also prevent adverse effects of the vaccination due to its antioxidant and immunomodulatory properties. Therefore, the administration of melatonin from 2 weeks to at least 4 weeks after vaccination may constitute an effective means to enhance the efficacy of vaccination against SARS-CoV-2. - Fuente
- Melatonin Research Vol. 4, No.1, 2021
- Materia
-
COVID-19
SARS-CoV-2
MELATONINA
INSOMNIO
SUEÑO
VACUNACION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Pontificia Universidad Católica Argentina
- OAI Identificador
- oai:ucacris:123456789/13669
Ver los metadatos del registro completo
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An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccinationCardinali, Daniel PedroBrown, Gregory M.Pandi Perumal, Seithikurippu R.COVID-19SARS-CoV-2MELATONINAINSOMNIOSUEÑOVACUNACIONFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Medicina; ArgentinaFil: Brown, Gregory M. University of Toronto. Department of Psychiatry. Centre for Addiction and Mental Health; CanadaFil: Pandi Perumal, Seithikurippu R. Somnogen Canada Inc; CanadaAbstract: Competition among pharmaceutical companies to develop safe and effective vaccines against SARS-CoV-2 is high. However, based on the prior experience with the influenza vaccine, up to 50% in lack of effectiveness would be found among healthy adults receiving effective vaccines against SARS-CoV-2. There is growing evidence that insufficient sleep may potentially be a pervasive and prominent factor accounting for this variability. Individuals experiencing total or partial sleep loss exhibit markedly reduced antigen-specific antibodies as compared to healthy sleepers. Besides, pre-vaccination sleep quality is also an important contributing factor. Several meta-analyses and expert consensus reports support the view that the chronobiotic/hypnotic properties of melatonin are useful in patients with primary sleep disorders to decrease sleep onset latency and to increase total sleep time. Hence, the prescription of melatonin for at least 2 weeks prior to vaccination can be a useful approach to improve sleep quality and to ensure that the vaccination is performed at a moment of optimal sleep conditions. Moreover, melatonin enhances the immune response to vaccines by increasing peripheral blood CD4+ T cells and IgG-expressing B cells. Administration of exogenous melatonin could increase the potency of the immune response and the duration of the immunity induced by the vaccine. Besides, melatonin could also prevent adverse effects of the vaccination due to its antioxidant and immunomodulatory properties. Therefore, the administration of melatonin from 2 weeks to at least 4 weeks after vaccination may constitute an effective means to enhance the efficacy of vaccination against SARS-CoV-2.ST-Bio-Life LLC2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/136692641-0281 (online)10.32794/mr11250091Cardinali, D. P., Brown, G. M., Pandi Perumal, S. R. An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccination [en línea]. Melatonin Research. 2021, 4 (1). doi: 10.32794/mr11250091. doi: 10.32794/mr11250091. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13669Melatonin Research Vol. 4, No.1, 2021reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:58:30Zoai:ucacris:123456789/13669instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:58:30.371Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse |
dc.title.none.fl_str_mv |
An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccination |
title |
An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccination |
spellingShingle |
An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccination Cardinali, Daniel Pedro COVID-19 SARS-CoV-2 MELATONINA INSOMNIO SUEÑO VACUNACION |
title_short |
An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccination |
title_full |
An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccination |
title_fullStr |
An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccination |
title_full_unstemmed |
An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccination |
title_sort |
An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccination |
dc.creator.none.fl_str_mv |
Cardinali, Daniel Pedro Brown, Gregory M. Pandi Perumal, Seithikurippu R. |
author |
Cardinali, Daniel Pedro |
author_facet |
Cardinali, Daniel Pedro Brown, Gregory M. Pandi Perumal, Seithikurippu R. |
author_role |
author |
author2 |
Brown, Gregory M. Pandi Perumal, Seithikurippu R. |
author2_role |
author author |
dc.subject.none.fl_str_mv |
COVID-19 SARS-CoV-2 MELATONINA INSOMNIO SUEÑO VACUNACION |
topic |
COVID-19 SARS-CoV-2 MELATONINA INSOMNIO SUEÑO VACUNACION |
dc.description.none.fl_txt_mv |
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Medicina; Argentina Fil: Brown, Gregory M. University of Toronto. Department of Psychiatry. Centre for Addiction and Mental Health; Canada Fil: Pandi Perumal, Seithikurippu R. Somnogen Canada Inc; Canada Abstract: Competition among pharmaceutical companies to develop safe and effective vaccines against SARS-CoV-2 is high. However, based on the prior experience with the influenza vaccine, up to 50% in lack of effectiveness would be found among healthy adults receiving effective vaccines against SARS-CoV-2. There is growing evidence that insufficient sleep may potentially be a pervasive and prominent factor accounting for this variability. Individuals experiencing total or partial sleep loss exhibit markedly reduced antigen-specific antibodies as compared to healthy sleepers. Besides, pre-vaccination sleep quality is also an important contributing factor. Several meta-analyses and expert consensus reports support the view that the chronobiotic/hypnotic properties of melatonin are useful in patients with primary sleep disorders to decrease sleep onset latency and to increase total sleep time. Hence, the prescription of melatonin for at least 2 weeks prior to vaccination can be a useful approach to improve sleep quality and to ensure that the vaccination is performed at a moment of optimal sleep conditions. Moreover, melatonin enhances the immune response to vaccines by increasing peripheral blood CD4+ T cells and IgG-expressing B cells. Administration of exogenous melatonin could increase the potency of the immune response and the duration of the immunity induced by the vaccine. Besides, melatonin could also prevent adverse effects of the vaccination due to its antioxidant and immunomodulatory properties. Therefore, the administration of melatonin from 2 weeks to at least 4 weeks after vaccination may constitute an effective means to enhance the efficacy of vaccination against SARS-CoV-2. |
description |
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Medicina; Argentina |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://repositorio.uca.edu.ar/handle/123456789/13669 2641-0281 (online) 10.32794/mr11250091 Cardinali, D. P., Brown, G. M., Pandi Perumal, S. R. An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccination [en línea]. Melatonin Research. 2021, 4 (1). doi: 10.32794/mr11250091. doi: 10.32794/mr11250091. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13669 |
url |
https://repositorio.uca.edu.ar/handle/123456789/13669 |
identifier_str_mv |
2641-0281 (online) 10.32794/mr11250091 Cardinali, D. P., Brown, G. M., Pandi Perumal, S. R. An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccination [en línea]. Melatonin Research. 2021, 4 (1). doi: 10.32794/mr11250091. doi: 10.32794/mr11250091. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13669 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
ST-Bio-Life LLC |
publisher.none.fl_str_mv |
ST-Bio-Life LLC |
dc.source.none.fl_str_mv |
Melatonin Research Vol. 4, No.1, 2021 reponame:Repositorio Institucional (UCA) instname:Pontificia Universidad Católica Argentina |
reponame_str |
Repositorio Institucional (UCA) |
collection |
Repositorio Institucional (UCA) |
instname_str |
Pontificia Universidad Católica Argentina |
repository.name.fl_str_mv |
Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina |
repository.mail.fl_str_mv |
claudia_fernandez@uca.edu.ar |
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1836638361010307072 |
score |
13.13397 |