The Parkinson`s disease pain classification system (PDPCS): results from an international mechanism-based classification approach

• Autores: Mylius, Veit; Pérez Lloret, Santiago; Gisbert Cury, Rubens; Teixeira, Manoel J.; Rossetto Barbosa, Victor; Barbosa, Egberto R.; Moreira, Larissa Iulle; Listik, Clarice; Mercia Fernandes, Ana; Veiga, Diogo de Lacera; Barbour, Julio; Hollenstein, Nathalie; Oechsner, Matthias; Walch, Julia; Brugger, Florian; Hägele Link, Stefan; Beer, Serafin; Rizos, Alexandra; Ray Chaudhuri, K.; Bouhassira, Didier; Lefaucheur, Jean-Pascal; Timmermann, Lars; Gonzenbach, Roman; Kägi, Georg; Carsten Möller, Jens; Ciampi de Andrade, Daniel
• Año de publicación: 2021
• Idioma: inglés
• Tipo de recurso: artículo
• Fuente: PAIN. 2021, 162 (4)
• Materia: DOLOR; ENFERMEDAD DE PARKINSON; CLASIFICACION; ENFERMEDADES NEURODEGENERATIVAS
• Institución: Pontificia Universidad Católica Argentina

Fil: Mylius, Veit. Center for Neurorehabilitation. Department of Neurology; Suiza
Fil: Mylius, Veit. Kantonsspital St, Gallen. Department of Neurology; Suiza
Fil: Mylius, Veit. Philipps University. Department of Neurology; Alemania
Fil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina; Argentina
Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; Argentina
Fil: Pérez Lloret, Santiago. Universidad Abierta Interamericana. Centro de Altos Estudios en Ciencias Humanas y de La Salud; Argentina
Fil: Gisbert Cury, Rubens. Universidade de Sao Paulo. Faculdade de Medicina. Departamento de Neurologia. Pain Center, LIM-62; Brasil
Fil: Gisbert Cury, Rubens. Hospital das Clínicas; Brasil
Fil: Teixeira, Manoel J. Universidade de Sao Paulo. Faculdade de Medicina. Departamento de Neurologia. Pain Center, LIM-62; Brasil
Fil: Teixeira, Manoel J. Hospital das Clínicas; Brasil
Fil: Rossetto Barbosa, Victor. Universidade de Sao Paulo. Faculdade de Medicina. Departamento de Neurologia. Pain Center, LIM-62; Brasil
Fil: Rossetto Barbosa, Victor. Hospital das Clínicas; Brasil
Fil: Barbosa, Egberto R. Universidade de Sao Paulo. Faculdade de Medicina. Departamento de Neurologia. Pain Center, LIM-62; Brasil
Fil: Barbosa, Egberto R. Hospital das Clínicas; Brasil
Fil: Moreira, Larissa Iulle. Universidade de Sao Paulo. Faculdade de Medicina. Departamento de Neurologia. Pain Center, LIM-62; Brasil
Fil: Moreira, Larissa Iulle. Hospital das Clínicas; Brasil
Fil: Listik, Clarice. Universidade de Sao Paulo. Faculdade de Medicina. Departamento de Neurologia. Pain Center, LIM-62; Brasil
Fil: Listik, Clarice. Hospital das Clínicas; Brasil
Fil: Mercia Fernandes, Ana. Universidade de Sao Paulo. Faculdade de Medicina. Departamento de Neurologia. Pain Center, LIM-62; Brasil
Fil: Mercia Fernandes, Ana. Hospital das Clínicas; Brasil
Fil: Veiga, Diogo de Lacera. Universidade de Sao Paulo. Faculdade de Medicina. Departamento de Neurologia. Pain Center, LIM-62; Brasil
Fil: Veiga, Diogo de Lacera. Hospital das Clínicas; Brasil
Fil: Barbour, Julio. Universidade de Sao Paulo. Faculdade de Medicina. Departamento de Neurologia. Pain Center, LIM-62; Brasil
Fil: Barbour, Julio. Hospital das Clínicas; Brasil
Fil: Hollenstein, Nathalie. Center for Neurorehabilitation. Department of Neurology; Suiza
Fil: Oechsner, Matthias. Parkinson Center. Center for Neurological Rehabilitation; Suiza
Fil: Walch, Julia. Kantonsspital St, Gallen. Department of Neurology; Suiza
Fil: Brugger, Florian. Kantonsspital St, Gallen. Department of Neurology; Suiza
Fil: Hägele-Link, Stefan. Kantonsspital St, Gallen. Department of Neurology; Suiza
Fil: Beer, Serafin. Center for Neurorehabilitation. Department of Neurology; Suiza
Fil: Rizos, Alexandra. King's College Hospital. Parkinson Foundation Centre of Excellence; Reino Unido
Fil: Ray Chaudhuri, K. King's College Hospital. Parkinson Foundation Centre of Excellence; Reino Unido
Fil: Ray Chaudhuri, K. King's College London, Department Basic, Reino Unido
Fil: Ray Chaudhuri, K. Maurice Wohl Clinical Neuroscience Institute; Reino Unido
Fil: Bouhassira, Didier. Hôpital Ambroise Paré. Centre d'Evaluation et de Traitement de la Douleur, Francia
Fil: Bouhassira, Didier. Assistance Publique-Hôpitaux de Paris, Boulogne-Billancourt; Francia
Fil: Bouhassira, Didier. Université de Versailles Saint-Quentin; Francia
Fil: Lefaucheur, Jean-Pascal. Unité de Neurophysiologie Clinique; Francia
Fil: Lefaucheur, Jean-Pascal. Hôpital Henri Mondor; Francia
Fil: Lefaucheur, Jean-Pascal. Assistance Publique-Hôpitaux de Paris; Francia
Fil: Lefaucheur, Jean-Pascal. Université Paris-Est-Créteil. Faculté de Médecine de Créteil; Francia
Fil: Timmermann, Lars. Philipps University. Department of Neurology; Alemania
Fil: Gonzenbach, Roman. Center for Neurorehabilitation. Department of Neurology; Suiza
Fil: Kägi, Georg. Kantonsspital St, Gallen. Department of Neurology; Suiza
Fil: Carsten Möller, Jens. Philipps University. Department of Neurology; Alemania
Fil: Carsten Möller, Jens. Parkinson Center, Center for Neurological Rehabilitation; Suiza
Fil: Ciampi de Andrade, Daniel. Universidade de Sao Paulo. Faculdade de Medicina. Departamento de Neurologia. Pain Center, LIM-62; Brasil
Fil: Ciampi de Andrade, Daniel. Hospital das Clínicas, Sao Paulo; Brasil.
Abstract: Pain is a common non-motor symptom in patients with Parkinson’s disease (PD) but the correct diagnosis of the respective cause remains difficult because suitable tools are lacking, so far. We developed a framework to differentiate PD- from non-PD-related pain and classify PD-related pain into three groups based on validated mechanistic pain descriptors (nociceptive, neuropathic, or nociplastic), which encompasses the previously described PD pain types. Severity of PD-related pain syndromes was scored by ratings of intensity, frequency, and interference with daily living activities. The PD-Pain Classification System (PD-PCS) was compared with classic pain measures (ie, brief pain inventory (BPI) and McGill pain questionnaire (MPQ), PDQ-8 quality of life score, MDS-UPDRS scores, and non-motor symptoms). 159 non-demented PD patients (disease duration 10.2±7.6 years) and 37 healthy controls were recruited in four centers. PD-related pain was present in 122 patients (77%), with 24 (15%) suffering one or more syndromes at the same time. PD-related nociceptive, neuropathic, or nociplastic pain was diagnosed in 87 (55%), 25 (16%), or 35 (22%), respectively. Pain unrelated to PD was present in 35 (22%) patients. Overall, PD-PCS severity score significantly correlated with pain’s BPI and MPQ ratings, presence of dyskinesia and motor fluctuations, PDQ-8 scores, depression and anxiety measures. Moderate intra- and inter-rater reliability were observed. The PD-PCS is a valid and reliable tool for differentiating PD-related pain from PD-unrelated pain. It detects and scores mechanistic pain subtypes in a pragmatic and treatment-oriented approach, unifying previous classifications of PD-pain.