Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina
- Autores
- Zamponi, Hernan P.; Juarez Aguaysol, Leonardo; Kukoc, Gabriela; Domínguez, María Eugenia; Pini, Belén; Padilla, Eduardo G.; Calvó, María; Molina-Rangeon, Silvia Beatriz; Guerrero, Gonzalo; Figueredo Aguiar, Mariana; Fumagalli, Emiliano; Yécora, Agustín; Brugha, Traolach S.; Seshadri, Sudha; Snyder, Heather M.; Erausquin, Gabriel A. de; Gonzalez Aleman, Gabriela
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Zamponi, Hernan P. Ministerio de Salud de Jujuy; Argentina
Fil: Juarez-Aguayso, Leonardo. Ministerio de Salud de Jujuy; Argentina
Fil: Kukoc, Gabriela. Ministerio de Salud de Jujuy; Argentina
Fil: Domínguez, María Eugenia. Ministerio de Salud de Jujuy; Argentina
Fil: Pini, Belén. Ministerio de Salud de Jujuy; Argentina
Fil: Padilla, Eduardo G. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina
Fil: Calvó, María. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina
Fil: Molina-Rangeon, Silvia Beatriz. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina
Fil: Guerrero, Gonzalo. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina
Fil: Figueredo-Aguiar, Mariana. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina
Fil: Fumagalli, Emiliano. Universidad Nacional de Jujuy; Argentina
Fil: Yécora, Agustín. Ministerio de Salud de Jujuy; Argentina
Fil: Brugha, Traolach S. University of Leicester; Reino Unido
Fil: Seshadri, Sudha. University of Texas Health Science Center at San Antonio; Estados Unidos
Fil: Seshadri, Sudha. Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases; Estados Unidos
Fil: Snyder, Heather M. Alzheimer’s Association; Argentina
Fil: Erausquin, Gabriel A. de. Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases; Estados Unidos
Fil: Erausquin, Gabriel A. de. University of Texas Health Science Center at San Antonio; Estados Unidos
Fil: Gonzalez-Aleman, Gabriela. Pontificia Universidad Católica Argentina; Argentina
Abstract: Background: COVID-19 has affected more than 150 million people. The causal coronavirus, SARS-CoV-2 has infected twice as many individuals who have remained asymptomatic. COVID-19 includes central nervous system (CNS) manifestations and may result in chronic neuropsychiatric sequelae. Risk factors for COVID-19 sequelae overlap with those for Alzheimer’s disease (AD), particularly older age and ApoE4 status. The Alzheimer’s Association Consortium on Chronic Neuropsychiatric Sequelae of SARS-CoV-2 infection (CNS SC2) established harmonized definitions, ascertainment and assessment methodologies to evaluate and longitudinally follow up cohorts of older adults with variable exposure to COVID-19. We present preliminary data from CNS SC2 in a prospective cohort of 234 older adult Amerindians from Argentina. Method: Participants are ≥ 60 years recruited from the health registry of the Province of Jujuy containing all SARS-CoV-2 testing data (regardless of clinical status and of the result of the testing). We randomly invite older adults stratified by testing status regardless of symptom severity, a minimum of 3 months after clinical recovery (maximum 6 months); refusal to participate is <45%. Assessment includes interview with the Schedules for Clinical Assessment in Neuropsychiatry (SCAN) and Clinical Dementia Rating scale; neurocognitive assessment; emotional reactivity scale; and neurological assessment including semiquantitative olfactory function test, motor function, coordination and gait. We present here the results of olfactory testing and cognitive assessments. Result: We assessed 233 infected participants and 64 controls. Average duration of formal learning is 9.35 ± 2.6 years and mean age is 66.7 ± 5.13 years. Normative data for the local population were available for Word list, Corsi Blocks, Oral Trails and Five Digit Tests and were used to normalize Z-scores and categorize the sample in 3 groups: normal cognition (NC,44.6%); memory only impairment (MOI,21%); and multiple domain impairment (MDI,34.4%). Individuals with MDI presented severe alterations in short-term memory; semantic memory; naming; executive function and attention compared to NC or MO groups (Table 1). Severity of cognitive impairment was significantly correlated with severity of olfactory dysfunction (χ2 = 13.82; p= 0.003) but not severity of acute COVID-19. Conclusion: Older adults frequently suffer persistent cognitive impairment after recovery from SARS-CoV-2 infection; cognitive impairment is correlated with persistent anosmia. - Fuente
- Alzheimer y dementia Vol.17, S6, e057897, 2021
- Materia
-
COVID-19
SARS-CoV-2
DETERIORO COGNITIVO
ADULTOS MAYORES
DISFUNCION OLFATORIA
ANOSMIA PERSISTENTE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Pontificia Universidad Católica Argentina
- OAI Identificador
- oai:ucacris:123456789/13711
Ver los metadatos del registro completo
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spelling |
Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of ArgentinaZamponi, Hernan P.Juarez Aguaysol, LeonardoKukoc, GabrielaDomínguez, María EugeniaPini, BelénPadilla, Eduardo G.Calvó, MaríaMolina-Rangeon, Silvia BeatrizGuerrero, GonzaloFigueredo Aguiar, MarianaFumagalli, EmilianoYécora, AgustínBrugha, Traolach S.Seshadri, SudhaSnyder, Heather M.Erausquin, Gabriel A. deGonzalez Aleman, GabrielaCOVID-19SARS-CoV-2DETERIORO COGNITIVOADULTOS MAYORESDISFUNCION OLFATORIAANOSMIA PERSISTENTEFil: Zamponi, Hernan P. Ministerio de Salud de Jujuy; ArgentinaFil: Juarez-Aguayso, Leonardo. Ministerio de Salud de Jujuy; ArgentinaFil: Kukoc, Gabriela. Ministerio de Salud de Jujuy; ArgentinaFil: Domínguez, María Eugenia. Ministerio de Salud de Jujuy; ArgentinaFil: Pini, Belén. Ministerio de Salud de Jujuy; ArgentinaFil: Padilla, Eduardo G. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; ArgentinaFil: Calvó, María. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; ArgentinaFil: Molina-Rangeon, Silvia Beatriz. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; ArgentinaFil: Guerrero, Gonzalo. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; ArgentinaFil: Figueredo-Aguiar, Mariana. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; ArgentinaFil: Fumagalli, Emiliano. Universidad Nacional de Jujuy; ArgentinaFil: Yécora, Agustín. Ministerio de Salud de Jujuy; ArgentinaFil: Brugha, Traolach S. University of Leicester; Reino UnidoFil: Seshadri, Sudha. University of Texas Health Science Center at San Antonio; Estados UnidosFil: Seshadri, Sudha. Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases; Estados UnidosFil: Snyder, Heather M. Alzheimer’s Association; ArgentinaFil: Erausquin, Gabriel A. de. Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases; Estados UnidosFil: Erausquin, Gabriel A. de. University of Texas Health Science Center at San Antonio; Estados UnidosFil: Gonzalez-Aleman, Gabriela. Pontificia Universidad Católica Argentina; ArgentinaAbstract: Background: COVID-19 has affected more than 150 million people. The causal coronavirus, SARS-CoV-2 has infected twice as many individuals who have remained asymptomatic. COVID-19 includes central nervous system (CNS) manifestations and may result in chronic neuropsychiatric sequelae. Risk factors for COVID-19 sequelae overlap with those for Alzheimer’s disease (AD), particularly older age and ApoE4 status. The Alzheimer’s Association Consortium on Chronic Neuropsychiatric Sequelae of SARS-CoV-2 infection (CNS SC2) established harmonized definitions, ascertainment and assessment methodologies to evaluate and longitudinally follow up cohorts of older adults with variable exposure to COVID-19. We present preliminary data from CNS SC2 in a prospective cohort of 234 older adult Amerindians from Argentina. Method: Participants are ≥ 60 years recruited from the health registry of the Province of Jujuy containing all SARS-CoV-2 testing data (regardless of clinical status and of the result of the testing). We randomly invite older adults stratified by testing status regardless of symptom severity, a minimum of 3 months after clinical recovery (maximum 6 months); refusal to participate is <45%. Assessment includes interview with the Schedules for Clinical Assessment in Neuropsychiatry (SCAN) and Clinical Dementia Rating scale; neurocognitive assessment; emotional reactivity scale; and neurological assessment including semiquantitative olfactory function test, motor function, coordination and gait. We present here the results of olfactory testing and cognitive assessments. Result: We assessed 233 infected participants and 64 controls. Average duration of formal learning is 9.35 ± 2.6 years and mean age is 66.7 ± 5.13 years. Normative data for the local population were available for Word list, Corsi Blocks, Oral Trails and Five Digit Tests and were used to normalize Z-scores and categorize the sample in 3 groups: normal cognition (NC,44.6%); memory only impairment (MOI,21%); and multiple domain impairment (MDI,34.4%). Individuals with MDI presented severe alterations in short-term memory; semantic memory; naming; executive function and attention compared to NC or MO groups (Table 1). Severity of cognitive impairment was significantly correlated with severity of olfactory dysfunction (χ2 = 13.82; p= 0.003) but not severity of acute COVID-19. Conclusion: Older adults frequently suffer persistent cognitive impairment after recovery from SARS-CoV-2 infection; cognitive impairment is correlated with persistent anosmia.John Wiley & Sons2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/137111552-527910.1002/alz.057897Zamponi, H. P. et al. Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina [en línea]. Alzheimer y dementia. 2021, 17, S6, e057897. doi: 10.1002/alz.057897. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13711Alzheimer y dementia Vol.17, S6, e057897, 2021reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica ArgentinaengArgentinainfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:58:30Zoai:ucacris:123456789/13711instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:58:30.485Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse |
dc.title.none.fl_str_mv |
Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina |
title |
Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina |
spellingShingle |
Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina Zamponi, Hernan P. COVID-19 SARS-CoV-2 DETERIORO COGNITIVO ADULTOS MAYORES DISFUNCION OLFATORIA ANOSMIA PERSISTENTE |
title_short |
Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina |
title_full |
Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina |
title_fullStr |
Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina |
title_full_unstemmed |
Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina |
title_sort |
Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina |
dc.creator.none.fl_str_mv |
Zamponi, Hernan P. Juarez Aguaysol, Leonardo Kukoc, Gabriela Domínguez, María Eugenia Pini, Belén Padilla, Eduardo G. Calvó, María Molina-Rangeon, Silvia Beatriz Guerrero, Gonzalo Figueredo Aguiar, Mariana Fumagalli, Emiliano Yécora, Agustín Brugha, Traolach S. Seshadri, Sudha Snyder, Heather M. Erausquin, Gabriel A. de Gonzalez Aleman, Gabriela |
author |
Zamponi, Hernan P. |
author_facet |
Zamponi, Hernan P. Juarez Aguaysol, Leonardo Kukoc, Gabriela Domínguez, María Eugenia Pini, Belén Padilla, Eduardo G. Calvó, María Molina-Rangeon, Silvia Beatriz Guerrero, Gonzalo Figueredo Aguiar, Mariana Fumagalli, Emiliano Yécora, Agustín Brugha, Traolach S. Seshadri, Sudha Snyder, Heather M. Erausquin, Gabriel A. de Gonzalez Aleman, Gabriela |
author_role |
author |
author2 |
Juarez Aguaysol, Leonardo Kukoc, Gabriela Domínguez, María Eugenia Pini, Belén Padilla, Eduardo G. Calvó, María Molina-Rangeon, Silvia Beatriz Guerrero, Gonzalo Figueredo Aguiar, Mariana Fumagalli, Emiliano Yécora, Agustín Brugha, Traolach S. Seshadri, Sudha Snyder, Heather M. Erausquin, Gabriel A. de Gonzalez Aleman, Gabriela |
author2_role |
author author author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
COVID-19 SARS-CoV-2 DETERIORO COGNITIVO ADULTOS MAYORES DISFUNCION OLFATORIA ANOSMIA PERSISTENTE |
topic |
COVID-19 SARS-CoV-2 DETERIORO COGNITIVO ADULTOS MAYORES DISFUNCION OLFATORIA ANOSMIA PERSISTENTE |
dc.description.none.fl_txt_mv |
Fil: Zamponi, Hernan P. Ministerio de Salud de Jujuy; Argentina Fil: Juarez-Aguayso, Leonardo. Ministerio de Salud de Jujuy; Argentina Fil: Kukoc, Gabriela. Ministerio de Salud de Jujuy; Argentina Fil: Domínguez, María Eugenia. Ministerio de Salud de Jujuy; Argentina Fil: Pini, Belén. Ministerio de Salud de Jujuy; Argentina Fil: Padilla, Eduardo G. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina Fil: Calvó, María. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina Fil: Molina-Rangeon, Silvia Beatriz. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina Fil: Guerrero, Gonzalo. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina Fil: Figueredo-Aguiar, Mariana. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina Fil: Fumagalli, Emiliano. Universidad Nacional de Jujuy; Argentina Fil: Yécora, Agustín. Ministerio de Salud de Jujuy; Argentina Fil: Brugha, Traolach S. University of Leicester; Reino Unido Fil: Seshadri, Sudha. University of Texas Health Science Center at San Antonio; Estados Unidos Fil: Seshadri, Sudha. Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases; Estados Unidos Fil: Snyder, Heather M. Alzheimer’s Association; Argentina Fil: Erausquin, Gabriel A. de. Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases; Estados Unidos Fil: Erausquin, Gabriel A. de. University of Texas Health Science Center at San Antonio; Estados Unidos Fil: Gonzalez-Aleman, Gabriela. Pontificia Universidad Católica Argentina; Argentina Abstract: Background: COVID-19 has affected more than 150 million people. The causal coronavirus, SARS-CoV-2 has infected twice as many individuals who have remained asymptomatic. COVID-19 includes central nervous system (CNS) manifestations and may result in chronic neuropsychiatric sequelae. Risk factors for COVID-19 sequelae overlap with those for Alzheimer’s disease (AD), particularly older age and ApoE4 status. The Alzheimer’s Association Consortium on Chronic Neuropsychiatric Sequelae of SARS-CoV-2 infection (CNS SC2) established harmonized definitions, ascertainment and assessment methodologies to evaluate and longitudinally follow up cohorts of older adults with variable exposure to COVID-19. We present preliminary data from CNS SC2 in a prospective cohort of 234 older adult Amerindians from Argentina. Method: Participants are ≥ 60 years recruited from the health registry of the Province of Jujuy containing all SARS-CoV-2 testing data (regardless of clinical status and of the result of the testing). We randomly invite older adults stratified by testing status regardless of symptom severity, a minimum of 3 months after clinical recovery (maximum 6 months); refusal to participate is <45%. Assessment includes interview with the Schedules for Clinical Assessment in Neuropsychiatry (SCAN) and Clinical Dementia Rating scale; neurocognitive assessment; emotional reactivity scale; and neurological assessment including semiquantitative olfactory function test, motor function, coordination and gait. We present here the results of olfactory testing and cognitive assessments. Result: We assessed 233 infected participants and 64 controls. Average duration of formal learning is 9.35 ± 2.6 years and mean age is 66.7 ± 5.13 years. Normative data for the local population were available for Word list, Corsi Blocks, Oral Trails and Five Digit Tests and were used to normalize Z-scores and categorize the sample in 3 groups: normal cognition (NC,44.6%); memory only impairment (MOI,21%); and multiple domain impairment (MDI,34.4%). Individuals with MDI presented severe alterations in short-term memory; semantic memory; naming; executive function and attention compared to NC or MO groups (Table 1). Severity of cognitive impairment was significantly correlated with severity of olfactory dysfunction (χ2 = 13.82; p= 0.003) but not severity of acute COVID-19. Conclusion: Older adults frequently suffer persistent cognitive impairment after recovery from SARS-CoV-2 infection; cognitive impairment is correlated with persistent anosmia. |
description |
Fil: Zamponi, Hernan P. Ministerio de Salud de Jujuy; Argentina |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://repositorio.uca.edu.ar/handle/123456789/13711 1552-5279 10.1002/alz.057897 Zamponi, H. P. et al. Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina [en línea]. Alzheimer y dementia. 2021, 17, S6, e057897. doi: 10.1002/alz.057897. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13711 |
url |
https://repositorio.uca.edu.ar/handle/123456789/13711 |
identifier_str_mv |
1552-5279 10.1002/alz.057897 Zamponi, H. P. et al. Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina [en línea]. Alzheimer y dementia. 2021, 17, S6, e057897. doi: 10.1002/alz.057897. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13711 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
dc.format.none.fl_str_mv |
application/pdf |
dc.coverage.none.fl_str_mv |
Argentina |
dc.publisher.none.fl_str_mv |
John Wiley & Sons |
publisher.none.fl_str_mv |
John Wiley & Sons |
dc.source.none.fl_str_mv |
Alzheimer y dementia Vol.17, S6, e057897, 2021 reponame:Repositorio Institucional (UCA) instname:Pontificia Universidad Católica Argentina |
reponame_str |
Repositorio Institucional (UCA) |
collection |
Repositorio Institucional (UCA) |
instname_str |
Pontificia Universidad Católica Argentina |
repository.name.fl_str_mv |
Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina |
repository.mail.fl_str_mv |
claudia_fernandez@uca.edu.ar |
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1836638361082658816 |
score |
13.22299 |