Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina

Autores
Zamponi, Hernan P.; Juarez Aguaysol, Leonardo; Kukoc, Gabriela; Domínguez, María Eugenia; Pini, Belén; Padilla, Eduardo G.; Calvó, María; Molina-Rangeon, Silvia Beatriz; Guerrero, Gonzalo; Figueredo Aguiar, Mariana; Fumagalli, Emiliano; Yécora, Agustín; Brugha, Traolach S.; Seshadri, Sudha; Snyder, Heather M.; Erausquin, Gabriel A. de; Gonzalez Aleman, Gabriela
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Zamponi, Hernan P. Ministerio de Salud de Jujuy; Argentina
Fil: Juarez-Aguayso, Leonardo. Ministerio de Salud de Jujuy; Argentina
Fil: Kukoc, Gabriela. Ministerio de Salud de Jujuy; Argentina
Fil: Domínguez, María Eugenia. Ministerio de Salud de Jujuy; Argentina
Fil: Pini, Belén. Ministerio de Salud de Jujuy; Argentina
Fil: Padilla, Eduardo G. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina
Fil: Calvó, María. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina
Fil: Molina-Rangeon, Silvia Beatriz. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina
Fil: Guerrero, Gonzalo. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina
Fil: Figueredo-Aguiar, Mariana. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina
Fil: Fumagalli, Emiliano. Universidad Nacional de Jujuy; Argentina
Fil: Yécora, Agustín. Ministerio de Salud de Jujuy; Argentina
Fil: Brugha, Traolach S. University of Leicester; Reino Unido
Fil: Seshadri, Sudha. University of Texas Health Science Center at San Antonio; Estados Unidos
Fil: Seshadri, Sudha. Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases; Estados Unidos
Fil: Snyder, Heather M. Alzheimer’s Association; Argentina
Fil: Erausquin, Gabriel A. de. Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases; Estados Unidos
Fil: Erausquin, Gabriel A. de. University of Texas Health Science Center at San Antonio; Estados Unidos
Fil: Gonzalez-Aleman, Gabriela. Pontificia Universidad Católica Argentina; Argentina
Abstract: Background: COVID-19 has affected more than 150 million people. The causal coronavirus, SARS-CoV-2 has infected twice as many individuals who have remained asymptomatic. COVID-19 includes central nervous system (CNS) manifestations and may result in chronic neuropsychiatric sequelae. Risk factors for COVID-19 sequelae overlap with those for Alzheimer’s disease (AD), particularly older age and ApoE4 status. The Alzheimer’s Association Consortium on Chronic Neuropsychiatric Sequelae of SARS-CoV-2 infection (CNS SC2) established harmonized definitions, ascertainment and assessment methodologies to evaluate and longitudinally follow up cohorts of older adults with variable exposure to COVID-19. We present preliminary data from CNS SC2 in a prospective cohort of 234 older adult Amerindians from Argentina. Method: Participants are ≥ 60 years recruited from the health registry of the Province of Jujuy containing all SARS-CoV-2 testing data (regardless of clinical status and of the result of the testing). We randomly invite older adults stratified by testing status regardless of symptom severity, a minimum of 3 months after clinical recovery (maximum 6 months); refusal to participate is <45%. Assessment includes interview with the Schedules for Clinical Assessment in Neuropsychiatry (SCAN) and Clinical Dementia Rating scale; neurocognitive assessment; emotional reactivity scale; and neurological assessment including semiquantitative olfactory function test, motor function, coordination and gait. We present here the results of olfactory testing and cognitive assessments. Result: We assessed 233 infected participants and 64 controls. Average duration of formal learning is 9.35 ± 2.6 years and mean age is 66.7 ± 5.13 years. Normative data for the local population were available for Word list, Corsi Blocks, Oral Trails and Five Digit Tests and were used to normalize Z-scores and categorize the sample in 3 groups: normal cognition (NC,44.6%); memory only impairment (MOI,21%); and multiple domain impairment (MDI,34.4%). Individuals with MDI presented severe alterations in short-term memory; semantic memory; naming; executive function and attention compared to NC or MO groups (Table 1). Severity of cognitive impairment was significantly correlated with severity of olfactory dysfunction (χ2 = 13.82; p= 0.003) but not severity of acute COVID-19. Conclusion: Older adults frequently suffer persistent cognitive impairment after recovery from SARS-CoV-2 infection; cognitive impairment is correlated with persistent anosmia.
Fuente
Alzheimer y dementia Vol.17, S6, e057897, 2021
Materia
COVID-19
SARS-CoV-2
DETERIORO COGNITIVO
ADULTOS MAYORES
DISFUNCION OLFATORIA
ANOSMIA PERSISTENTE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/13711

id RIUCA_2062d2219c3d7df2442696d22e289187
oai_identifier_str oai:ucacris:123456789/13711
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of ArgentinaZamponi, Hernan P.Juarez Aguaysol, LeonardoKukoc, GabrielaDomínguez, María EugeniaPini, BelénPadilla, Eduardo G.Calvó, MaríaMolina-Rangeon, Silvia BeatrizGuerrero, GonzaloFigueredo Aguiar, MarianaFumagalli, EmilianoYécora, AgustínBrugha, Traolach S.Seshadri, SudhaSnyder, Heather M.Erausquin, Gabriel A. deGonzalez Aleman, GabrielaCOVID-19SARS-CoV-2DETERIORO COGNITIVOADULTOS MAYORESDISFUNCION OLFATORIAANOSMIA PERSISTENTEFil: Zamponi, Hernan P. Ministerio de Salud de Jujuy; ArgentinaFil: Juarez-Aguayso, Leonardo. Ministerio de Salud de Jujuy; ArgentinaFil: Kukoc, Gabriela. Ministerio de Salud de Jujuy; ArgentinaFil: Domínguez, María Eugenia. Ministerio de Salud de Jujuy; ArgentinaFil: Pini, Belén. Ministerio de Salud de Jujuy; ArgentinaFil: Padilla, Eduardo G. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; ArgentinaFil: Calvó, María. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; ArgentinaFil: Molina-Rangeon, Silvia Beatriz. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; ArgentinaFil: Guerrero, Gonzalo. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; ArgentinaFil: Figueredo-Aguiar, Mariana. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; ArgentinaFil: Fumagalli, Emiliano. Universidad Nacional de Jujuy; ArgentinaFil: Yécora, Agustín. Ministerio de Salud de Jujuy; ArgentinaFil: Brugha, Traolach S. University of Leicester; Reino UnidoFil: Seshadri, Sudha. University of Texas Health Science Center at San Antonio; Estados UnidosFil: Seshadri, Sudha. Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases; Estados UnidosFil: Snyder, Heather M. Alzheimer’s Association; ArgentinaFil: Erausquin, Gabriel A. de. Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases; Estados UnidosFil: Erausquin, Gabriel A. de. University of Texas Health Science Center at San Antonio; Estados UnidosFil: Gonzalez-Aleman, Gabriela. Pontificia Universidad Católica Argentina; ArgentinaAbstract: Background: COVID-19 has affected more than 150 million people. The causal coronavirus, SARS-CoV-2 has infected twice as many individuals who have remained asymptomatic. COVID-19 includes central nervous system (CNS) manifestations and may result in chronic neuropsychiatric sequelae. Risk factors for COVID-19 sequelae overlap with those for Alzheimer’s disease (AD), particularly older age and ApoE4 status. The Alzheimer’s Association Consortium on Chronic Neuropsychiatric Sequelae of SARS-CoV-2 infection (CNS SC2) established harmonized definitions, ascertainment and assessment methodologies to evaluate and longitudinally follow up cohorts of older adults with variable exposure to COVID-19. We present preliminary data from CNS SC2 in a prospective cohort of 234 older adult Amerindians from Argentina. Method: Participants are ≥ 60 years recruited from the health registry of the Province of Jujuy containing all SARS-CoV-2 testing data (regardless of clinical status and of the result of the testing). We randomly invite older adults stratified by testing status regardless of symptom severity, a minimum of 3 months after clinical recovery (maximum 6 months); refusal to participate is <45%. Assessment includes interview with the Schedules for Clinical Assessment in Neuropsychiatry (SCAN) and Clinical Dementia Rating scale; neurocognitive assessment; emotional reactivity scale; and neurological assessment including semiquantitative olfactory function test, motor function, coordination and gait. We present here the results of olfactory testing and cognitive assessments. Result: We assessed 233 infected participants and 64 controls. Average duration of formal learning is 9.35 ± 2.6 years and mean age is 66.7 ± 5.13 years. Normative data for the local population were available for Word list, Corsi Blocks, Oral Trails and Five Digit Tests and were used to normalize Z-scores and categorize the sample in 3 groups: normal cognition (NC,44.6%); memory only impairment (MOI,21%); and multiple domain impairment (MDI,34.4%). Individuals with MDI presented severe alterations in short-term memory; semantic memory; naming; executive function and attention compared to NC or MO groups (Table 1). Severity of cognitive impairment was significantly correlated with severity of olfactory dysfunction (χ2 = 13.82; p= 0.003) but not severity of acute COVID-19. Conclusion: Older adults frequently suffer persistent cognitive impairment after recovery from SARS-CoV-2 infection; cognitive impairment is correlated with persistent anosmia.John Wiley & Sons2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/137111552-527910.1002/alz.057897Zamponi, H. P. et al. Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina [en línea]. Alzheimer y dementia. 2021, 17, S6, e057897. doi: 10.1002/alz.057897. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13711Alzheimer y dementia Vol.17, S6, e057897, 2021reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica ArgentinaengArgentinainfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:58:30Zoai:ucacris:123456789/13711instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:58:30.485Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina
title Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina
spellingShingle Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina
Zamponi, Hernan P.
COVID-19
SARS-CoV-2
DETERIORO COGNITIVO
ADULTOS MAYORES
DISFUNCION OLFATORIA
ANOSMIA PERSISTENTE
title_short Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina
title_full Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina
title_fullStr Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina
title_full_unstemmed Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina
title_sort Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina
dc.creator.none.fl_str_mv Zamponi, Hernan P.
Juarez Aguaysol, Leonardo
Kukoc, Gabriela
Domínguez, María Eugenia
Pini, Belén
Padilla, Eduardo G.
Calvó, María
Molina-Rangeon, Silvia Beatriz
Guerrero, Gonzalo
Figueredo Aguiar, Mariana
Fumagalli, Emiliano
Yécora, Agustín
Brugha, Traolach S.
Seshadri, Sudha
Snyder, Heather M.
Erausquin, Gabriel A. de
Gonzalez Aleman, Gabriela
author Zamponi, Hernan P.
author_facet Zamponi, Hernan P.
Juarez Aguaysol, Leonardo
Kukoc, Gabriela
Domínguez, María Eugenia
Pini, Belén
Padilla, Eduardo G.
Calvó, María
Molina-Rangeon, Silvia Beatriz
Guerrero, Gonzalo
Figueredo Aguiar, Mariana
Fumagalli, Emiliano
Yécora, Agustín
Brugha, Traolach S.
Seshadri, Sudha
Snyder, Heather M.
Erausquin, Gabriel A. de
Gonzalez Aleman, Gabriela
author_role author
author2 Juarez Aguaysol, Leonardo
Kukoc, Gabriela
Domínguez, María Eugenia
Pini, Belén
Padilla, Eduardo G.
Calvó, María
Molina-Rangeon, Silvia Beatriz
Guerrero, Gonzalo
Figueredo Aguiar, Mariana
Fumagalli, Emiliano
Yécora, Agustín
Brugha, Traolach S.
Seshadri, Sudha
Snyder, Heather M.
Erausquin, Gabriel A. de
Gonzalez Aleman, Gabriela
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv COVID-19
SARS-CoV-2
DETERIORO COGNITIVO
ADULTOS MAYORES
DISFUNCION OLFATORIA
ANOSMIA PERSISTENTE
topic COVID-19
SARS-CoV-2
DETERIORO COGNITIVO
ADULTOS MAYORES
DISFUNCION OLFATORIA
ANOSMIA PERSISTENTE
dc.description.none.fl_txt_mv Fil: Zamponi, Hernan P. Ministerio de Salud de Jujuy; Argentina
Fil: Juarez-Aguayso, Leonardo. Ministerio de Salud de Jujuy; Argentina
Fil: Kukoc, Gabriela. Ministerio de Salud de Jujuy; Argentina
Fil: Domínguez, María Eugenia. Ministerio de Salud de Jujuy; Argentina
Fil: Pini, Belén. Ministerio de Salud de Jujuy; Argentina
Fil: Padilla, Eduardo G. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina
Fil: Calvó, María. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina
Fil: Molina-Rangeon, Silvia Beatriz. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina
Fil: Guerrero, Gonzalo. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina
Fil: Figueredo-Aguiar, Mariana. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina
Fil: Fumagalli, Emiliano. Universidad Nacional de Jujuy; Argentina
Fil: Yécora, Agustín. Ministerio de Salud de Jujuy; Argentina
Fil: Brugha, Traolach S. University of Leicester; Reino Unido
Fil: Seshadri, Sudha. University of Texas Health Science Center at San Antonio; Estados Unidos
Fil: Seshadri, Sudha. Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases; Estados Unidos
Fil: Snyder, Heather M. Alzheimer’s Association; Argentina
Fil: Erausquin, Gabriel A. de. Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases; Estados Unidos
Fil: Erausquin, Gabriel A. de. University of Texas Health Science Center at San Antonio; Estados Unidos
Fil: Gonzalez-Aleman, Gabriela. Pontificia Universidad Católica Argentina; Argentina
Abstract: Background: COVID-19 has affected more than 150 million people. The causal coronavirus, SARS-CoV-2 has infected twice as many individuals who have remained asymptomatic. COVID-19 includes central nervous system (CNS) manifestations and may result in chronic neuropsychiatric sequelae. Risk factors for COVID-19 sequelae overlap with those for Alzheimer’s disease (AD), particularly older age and ApoE4 status. The Alzheimer’s Association Consortium on Chronic Neuropsychiatric Sequelae of SARS-CoV-2 infection (CNS SC2) established harmonized definitions, ascertainment and assessment methodologies to evaluate and longitudinally follow up cohorts of older adults with variable exposure to COVID-19. We present preliminary data from CNS SC2 in a prospective cohort of 234 older adult Amerindians from Argentina. Method: Participants are ≥ 60 years recruited from the health registry of the Province of Jujuy containing all SARS-CoV-2 testing data (regardless of clinical status and of the result of the testing). We randomly invite older adults stratified by testing status regardless of symptom severity, a minimum of 3 months after clinical recovery (maximum 6 months); refusal to participate is <45%. Assessment includes interview with the Schedules for Clinical Assessment in Neuropsychiatry (SCAN) and Clinical Dementia Rating scale; neurocognitive assessment; emotional reactivity scale; and neurological assessment including semiquantitative olfactory function test, motor function, coordination and gait. We present here the results of olfactory testing and cognitive assessments. Result: We assessed 233 infected participants and 64 controls. Average duration of formal learning is 9.35 ± 2.6 years and mean age is 66.7 ± 5.13 years. Normative data for the local population were available for Word list, Corsi Blocks, Oral Trails and Five Digit Tests and were used to normalize Z-scores and categorize the sample in 3 groups: normal cognition (NC,44.6%); memory only impairment (MOI,21%); and multiple domain impairment (MDI,34.4%). Individuals with MDI presented severe alterations in short-term memory; semantic memory; naming; executive function and attention compared to NC or MO groups (Table 1). Severity of cognitive impairment was significantly correlated with severity of olfactory dysfunction (χ2 = 13.82; p= 0.003) but not severity of acute COVID-19. Conclusion: Older adults frequently suffer persistent cognitive impairment after recovery from SARS-CoV-2 infection; cognitive impairment is correlated with persistent anosmia.
description Fil: Zamponi, Hernan P. Ministerio de Salud de Jujuy; Argentina
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/13711
1552-5279
10.1002/alz.057897
Zamponi, H. P. et al. Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina [en línea]. Alzheimer y dementia. 2021, 17, S6, e057897. doi: 10.1002/alz.057897. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13711
url https://repositorio.uca.edu.ar/handle/123456789/13711
identifier_str_mv 1552-5279
10.1002/alz.057897
Zamponi, H. P. et al. Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina [en línea]. Alzheimer y dementia. 2021, 17, S6, e057897. doi: 10.1002/alz.057897. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13711
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv Argentina
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv Alzheimer y dementia Vol.17, S6, e057897, 2021
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 13.22299