Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response
- Autores
- Gao, Xinghua; Cao, Qiuhua; Cheng, Yan; Zhao, Dandan; Wang, Zhuo; Yang, Hongbao; Wu, Qijin; You, Linjun; Wang, Yue; Lin, Yanting; Li, Xianjing; Wang, Yun; Bian, Jin-Song; Sun, Dongdong; Kong, Lingyi; Birnbaumer, Lutz; Yang, Yong
- Año de publicación
- 2018
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Gao, Xinghua. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China
Fil: Gao, Xinghua. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China
Fil: Gao, Xinghua. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; China
Fil: Cao, Qiuhua. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China
Fil: Cao, Qiuhua. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China
Fil: Cao, Qiuhua. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; China
Fil: Cheng, Yan. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China
Fil: Cheng, Yan. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China
Fil: Cheng, Yan. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China
Fil: Zhao, Dandan. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China
Fil: Zhao, Dandan. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China
Fil: Zhao, Dandan. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; China
Fil: Wang, Zhuo. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China
Fil: Wang, Zhuo. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China
Fil: Wang, Zhuo. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; China
Fil: Wang, Zhuo. Nanjing University of Chinese Medicine. Translational Medicine Center; China
Fil: Yang, Hongbao. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China
Fil: Yang, Hongbao. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China
Fil: Yang, Hongbao. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; China
Fil: Wu, Qijin. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China
Fil: Wu, Qijin. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China
Fil: Wu, Qijin. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; China
Fil: You, Linjun. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China
Fil: You, Linjun. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China
Fil: You, Linjun. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China
Fil: Wang, Yue. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China
Fil: Wang, Yue. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China
Fil: Wang, Yue. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China
Fil: Lin, Yanting. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China
Fil: Lin, Yanting. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China
Fil: Lin, Yanting. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China
Fil: Li, Xianjing. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China
Fil: Li, Xianjing. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China
Fil: Li, Xianjing. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China
Fil: Wang, Yue. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China
Fil: Wang, Yue. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China
Fil: Wang, Yue. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China
Fil: Bian, Jin-Song. National University of Singapore. Yong Loo Lin School of Medicine. Department of Pharmacology; Singapur
Fil: Sun, Dongdong. Nanjing University of Chinese Medicine. Translational Medicine Center; China
Fil: Kong, Lingyi. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China
Fil: Kong, Lingyi. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China
Fil: Kong, Lingyi. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China
Fil: Birnbaumer, Lutz. National Institute of Environmental Health Sciences. Neurobiology Laboratory; Estados Unidos
Fil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Yang, Yong. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China
Fil: Yang, Yong. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China
Fil: Yang, Yong. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China
Abstract: Chronic stress is known to promote inflammatory bowel disease (IBD), but the underlying mechanism remains largely unresolved. Here, we found chronic stress to sensitize mice to dextran sulfate sodium (DSS)-induced colitis; to increase the infiltration of B cells, neutrophils, and proinflammatory ly6Chi macrophages in colonic lamina propria; and to present with decreased thymus and mesenteric lymph node (MLN) coefficients. Circulating total white blood cells were significantly increased after stress, and the proportion of MLN-associated immune cells were largely changed. Results showed a marked activation of IL-6/STAT3 signaling by stress. The detrimental action of stress was not terminated in IL-6-/- mice. Interestingly, the composition of gut microbiota was dramatically changed after stress, with expansion of inflammation-promoting bacteria. Furthermore, results showed stress-induced deficient expression of mucin-2 and lysozyme, which may contribute to the disorder of gut microbiota. Of note is that, in the case of cohousing, the stress-induced immune reaction and decreased body weight were abrogated, and transferred gut microbiota from stressed mice to control mice was sufficient to facilitate DSS-induced colitis. The important role of gut microbiota was further reinforced by broad-spectrum antibiotic treatment. Taken together, our results reveal that chronic stress disturbs gut microbiota, triggering immune system response and facilitating DSS-induced colitis. - Fuente
- Proceedings of the National Academy of Sciences. 2018;115(13):E2960-E2969
- Materia
-
ESTRES
COLITIS
MICROORGANISMOS
SISTEMA INMUNOLOGICO - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
.jpg)
- Institución
- Pontificia Universidad Católica Argentina
- OAI Identificador
- oai:ucacris:123456789/8696
Ver los metadatos del registro completo
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Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system responseGao, XinghuaCao, QiuhuaCheng, YanZhao, DandanWang, ZhuoYang, HongbaoWu, QijinYou, LinjunWang, YueLin, YantingLi, XianjingWang, YunBian, Jin-SongSun, DongdongKong, LingyiBirnbaumer, LutzYang, YongESTRESCOLITISMICROORGANISMOSSISTEMA INMUNOLOGICOFil: Gao, Xinghua. China Pharmaceutical University. State Key Laboratory of Natural Medicines; ChinaFil: Gao, Xinghua. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; ChinaFil: Gao, Xinghua. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; ChinaFil: Cao, Qiuhua. China Pharmaceutical University. State Key Laboratory of Natural Medicines; ChinaFil: Cao, Qiuhua. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; ChinaFil: Cao, Qiuhua. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; ChinaFil: Cheng, Yan. China Pharmaceutical University. State Key Laboratory of Natural Medicines; ChinaFil: Cheng, Yan. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; ChinaFil: Cheng, Yan. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; ChinaFil: Zhao, Dandan. China Pharmaceutical University. State Key Laboratory of Natural Medicines; ChinaFil: Zhao, Dandan. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; ChinaFil: Zhao, Dandan. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; ChinaFil: Wang, Zhuo. China Pharmaceutical University. State Key Laboratory of Natural Medicines; ChinaFil: Wang, Zhuo. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; ChinaFil: Wang, Zhuo. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; ChinaFil: Wang, Zhuo. Nanjing University of Chinese Medicine. Translational Medicine Center; ChinaFil: Yang, Hongbao. China Pharmaceutical University. State Key Laboratory of Natural Medicines; ChinaFil: Yang, Hongbao. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; ChinaFil: Yang, Hongbao. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; ChinaFil: Wu, Qijin. China Pharmaceutical University. State Key Laboratory of Natural Medicines; ChinaFil: Wu, Qijin. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; ChinaFil: Wu, Qijin. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; ChinaFil: You, Linjun. China Pharmaceutical University. State Key Laboratory of Natural Medicines; ChinaFil: You, Linjun. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; ChinaFil: You, Linjun. China Pharmaceutical University. State Key Laboratory of Natural Medicines; ChinaFil: Wang, Yue. China Pharmaceutical University. State Key Laboratory of Natural Medicines; ChinaFil: Wang, Yue. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; ChinaFil: Wang, Yue. China Pharmaceutical University. State Key Laboratory of Natural Medicines; ChinaFil: Lin, Yanting. China Pharmaceutical University. State Key Laboratory of Natural Medicines; ChinaFil: Lin, Yanting. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; ChinaFil: Lin, Yanting. China Pharmaceutical University. State Key Laboratory of Natural Medicines; ChinaFil: Li, Xianjing. China Pharmaceutical University. State Key Laboratory of Natural Medicines; ChinaFil: Li, Xianjing. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; ChinaFil: Li, Xianjing. China Pharmaceutical University. State Key Laboratory of Natural Medicines; ChinaFil: Wang, Yue. China Pharmaceutical University. State Key Laboratory of Natural Medicines; ChinaFil: Wang, Yue. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; ChinaFil: Wang, Yue. China Pharmaceutical University. State Key Laboratory of Natural Medicines; ChinaFil: Bian, Jin-Song. National University of Singapore. Yong Loo Lin School of Medicine. Department of Pharmacology; SingapurFil: Sun, Dongdong. Nanjing University of Chinese Medicine. Translational Medicine Center; ChinaFil: Kong, Lingyi. China Pharmaceutical University. State Key Laboratory of Natural Medicines; ChinaFil: Kong, Lingyi. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; ChinaFil: Kong, Lingyi. China Pharmaceutical University. State Key Laboratory of Natural Medicines; ChinaFil: Birnbaumer, Lutz. National Institute of Environmental Health Sciences. Neurobiology Laboratory; Estados UnidosFil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Yang, Yong. China Pharmaceutical University. State Key Laboratory of Natural Medicines; ChinaFil: Yang, Yong. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; ChinaFil: Yang, Yong. China Pharmaceutical University. State Key Laboratory of Natural Medicines; ChinaAbstract: Chronic stress is known to promote inflammatory bowel disease (IBD), but the underlying mechanism remains largely unresolved. Here, we found chronic stress to sensitize mice to dextran sulfate sodium (DSS)-induced colitis; to increase the infiltration of B cells, neutrophils, and proinflammatory ly6Chi macrophages in colonic lamina propria; and to present with decreased thymus and mesenteric lymph node (MLN) coefficients. Circulating total white blood cells were significantly increased after stress, and the proportion of MLN-associated immune cells were largely changed. Results showed a marked activation of IL-6/STAT3 signaling by stress. The detrimental action of stress was not terminated in IL-6-/- mice. Interestingly, the composition of gut microbiota was dramatically changed after stress, with expansion of inflammation-promoting bacteria. Furthermore, results showed stress-induced deficient expression of mucin-2 and lysozyme, which may contribute to the disorder of gut microbiota. Of note is that, in the case of cohousing, the stress-induced immune reaction and decreased body weight were abrogated, and transferred gut microbiota from stressed mice to control mice was sufficient to facilitate DSS-induced colitis. The important role of gut microbiota was further reinforced by broad-spectrum antibiotic treatment. Taken together, our results reveal that chronic stress disturbs gut microbiota, triggering immune system response and facilitating DSS-induced colitis.National Academy of Sciences2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/86961091-6490 (online)10.1073/pnas.172069611529531080Gao X, Cao Q, Cheng Y, et al. Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response. Proceedings of the National Academy of Sciences. 2018;115(13):E2960-E2969. doi:10.1073/pnas.1720696115 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8696Proceedings of the National Academy of Sciences. 2018;115(13):E2960-E2969reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:56:54Zoai:ucacris:123456789/8696instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:56:55.037Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse |
| dc.title.none.fl_str_mv |
Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response |
| title |
Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response |
| spellingShingle |
Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response Gao, Xinghua ESTRES COLITIS MICROORGANISMOS SISTEMA INMUNOLOGICO |
| title_short |
Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response |
| title_full |
Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response |
| title_fullStr |
Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response |
| title_full_unstemmed |
Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response |
| title_sort |
Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response |
| dc.creator.none.fl_str_mv |
Gao, Xinghua Cao, Qiuhua Cheng, Yan Zhao, Dandan Wang, Zhuo Yang, Hongbao Wu, Qijin You, Linjun Wang, Yue Lin, Yanting Li, Xianjing Wang, Yun Bian, Jin-Song Sun, Dongdong Kong, Lingyi Birnbaumer, Lutz Yang, Yong |
| author |
Gao, Xinghua |
| author_facet |
Gao, Xinghua Cao, Qiuhua Cheng, Yan Zhao, Dandan Wang, Zhuo Yang, Hongbao Wu, Qijin You, Linjun Wang, Yue Lin, Yanting Li, Xianjing Wang, Yun Bian, Jin-Song Sun, Dongdong Kong, Lingyi Birnbaumer, Lutz Yang, Yong |
| author_role |
author |
| author2 |
Cao, Qiuhua Cheng, Yan Zhao, Dandan Wang, Zhuo Yang, Hongbao Wu, Qijin You, Linjun Wang, Yue Lin, Yanting Li, Xianjing Wang, Yun Bian, Jin-Song Sun, Dongdong Kong, Lingyi Birnbaumer, Lutz Yang, Yong |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
ESTRES COLITIS MICROORGANISMOS SISTEMA INMUNOLOGICO |
| topic |
ESTRES COLITIS MICROORGANISMOS SISTEMA INMUNOLOGICO |
| dc.description.none.fl_txt_mv |
Fil: Gao, Xinghua. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China Fil: Gao, Xinghua. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China Fil: Gao, Xinghua. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; China Fil: Cao, Qiuhua. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China Fil: Cao, Qiuhua. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China Fil: Cao, Qiuhua. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; China Fil: Cheng, Yan. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China Fil: Cheng, Yan. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China Fil: Cheng, Yan. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China Fil: Zhao, Dandan. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China Fil: Zhao, Dandan. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China Fil: Zhao, Dandan. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; China Fil: Wang, Zhuo. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China Fil: Wang, Zhuo. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China Fil: Wang, Zhuo. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; China Fil: Wang, Zhuo. Nanjing University of Chinese Medicine. Translational Medicine Center; China Fil: Yang, Hongbao. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China Fil: Yang, Hongbao. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China Fil: Yang, Hongbao. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; China Fil: Wu, Qijin. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China Fil: Wu, Qijin. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China Fil: Wu, Qijin. China Pharmaceutical University. Center for New Drug Safety Evaluation and Research; China Fil: You, Linjun. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China Fil: You, Linjun. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China Fil: You, Linjun. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China Fil: Wang, Yue. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China Fil: Wang, Yue. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China Fil: Wang, Yue. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China Fil: Lin, Yanting. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China Fil: Lin, Yanting. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China Fil: Lin, Yanting. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China Fil: Li, Xianjing. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China Fil: Li, Xianjing. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China Fil: Li, Xianjing. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China Fil: Wang, Yue. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China Fil: Wang, Yue. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China Fil: Wang, Yue. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China Fil: Bian, Jin-Song. National University of Singapore. Yong Loo Lin School of Medicine. Department of Pharmacology; Singapur Fil: Sun, Dongdong. Nanjing University of Chinese Medicine. Translational Medicine Center; China Fil: Kong, Lingyi. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China Fil: Kong, Lingyi. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China Fil: Kong, Lingyi. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China Fil: Birnbaumer, Lutz. National Institute of Environmental Health Sciences. Neurobiology Laboratory; Estados Unidos Fil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina Fil: Yang, Yong. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China Fil: Yang, Yong. China Pharmaceutical University. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease; China Fil: Yang, Yong. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China Abstract: Chronic stress is known to promote inflammatory bowel disease (IBD), but the underlying mechanism remains largely unresolved. Here, we found chronic stress to sensitize mice to dextran sulfate sodium (DSS)-induced colitis; to increase the infiltration of B cells, neutrophils, and proinflammatory ly6Chi macrophages in colonic lamina propria; and to present with decreased thymus and mesenteric lymph node (MLN) coefficients. Circulating total white blood cells were significantly increased after stress, and the proportion of MLN-associated immune cells were largely changed. Results showed a marked activation of IL-6/STAT3 signaling by stress. The detrimental action of stress was not terminated in IL-6-/- mice. Interestingly, the composition of gut microbiota was dramatically changed after stress, with expansion of inflammation-promoting bacteria. Furthermore, results showed stress-induced deficient expression of mucin-2 and lysozyme, which may contribute to the disorder of gut microbiota. Of note is that, in the case of cohousing, the stress-induced immune reaction and decreased body weight were abrogated, and transferred gut microbiota from stressed mice to control mice was sufficient to facilitate DSS-induced colitis. The important role of gut microbiota was further reinforced by broad-spectrum antibiotic treatment. Taken together, our results reveal that chronic stress disturbs gut microbiota, triggering immune system response and facilitating DSS-induced colitis. |
| description |
Fil: Gao, Xinghua. China Pharmaceutical University. State Key Laboratory of Natural Medicines; China |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://repositorio.uca.edu.ar/handle/123456789/8696 1091-6490 (online) 10.1073/pnas.1720696115 29531080 Gao X, Cao Q, Cheng Y, et al. Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response. Proceedings of the National Academy of Sciences. 2018;115(13):E2960-E2969. doi:10.1073/pnas.1720696115 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8696 |
| url |
https://repositorio.uca.edu.ar/handle/123456789/8696 |
| identifier_str_mv |
1091-6490 (online) 10.1073/pnas.1720696115 29531080 Gao X, Cao Q, Cheng Y, et al. Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response. Proceedings of the National Academy of Sciences. 2018;115(13):E2960-E2969. doi:10.1073/pnas.1720696115 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8696 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/4.0/ |
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openAccess |
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National Academy of Sciences |
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National Academy of Sciences |
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Proceedings of the National Academy of Sciences. 2018;115(13):E2960-E2969 reponame:Repositorio Institucional (UCA) instname:Pontificia Universidad Católica Argentina |
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Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina |
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