Development and validation of the dystonia-pain classification System : a multicenter study

• Autores: Listik, Clarice; Listik, Eduardo; Santos Rolim, Flavia de Paiva; Cury Portela, Denise Maria Meneses; Pérez Lloret, Santiago; Araújo, Natalia Rebeca de Alves; Carvalho, Pedro Rubens Araújo; Santos, Graziele Costa; Limongi, João Carlos Papaterra; Cardoso, Francisco; Mylius, Veit; Brugger, Florian; Mercia Fernandes, Ana; Barbosa, Egberto R.; Teixeira, Manoel J.; Ferraz, Henrique Ballalai; Camargos, Sarah Teixeira; Gisbert Cury, Rubens; Ciampi de Andrade, Daniel
• Año de publicación: 2023
• Idioma: inglés
• Tipo de recurso: artículo
• Fuente: Movement Disorders. 2023, 38(7)
• Materia: DOLOR; DISTONÍA; TRASTORNOS DEL MOVIMIENTO; SINTOMAS NO MOTORES
• Institución: Pontificia Universidad Católica Argentina

Fil: Listik, Clarice. Universidad de São Paulo. Facultad de Medicina. Centro de Trastornos del Movimiento. Departamento de Neurología; Brasil
Fil: Listik, Eduardo. University of Alabama. Department of Neurology; Estados Unidos
Fil: Santos Rolim, Flavia de Paiva. Hospital Geral de Fortaleza. Department of Neurology; Brasil
Fil: Cury Portela, Denise Maria Meneses. Instituto de Ensino Superior do Piaui. Department of Neurology; Brasil
Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Observatorio de Salud Pública; Argentina
Fil: Pérez Lloret, Santiago. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; Argentina
Fil: Araújo, Natalia Rebeca de Alves. Instituto de Ensino Superior do Piaui. Department of Neurology; Brasil
Fil: Carvalho, Pedro Rubens Araújo. Hospital Geral de Fortaleza. Department of Neurology; Brasil
Fil: Santos, Graziele Costa. Universidade Federal de Sao Paulo. Department of Neurology; Brasil
Fil: Limongi, João Carlos Papaterra. Universidad de São Paulo. Facultad de Medicina. Centro de Trastornos del Movimiento. Departamento de Neurología; Brasil
Fil: Cardoso, Francisco. Hospital das Clínicas da Universidade Federal de Minas Gerais. Department of Neurology; Brasil
Fil: Mylius, Veit. Centro de Neurorrehabilitación. Departamento de Neurología; Suiza
Fil: Mylius, Veit. Universidad Philipps. Departamento de Neurología; Alemania
Fil: Brugger, Florian. Kantonsspital St. Gallen. Departamento de Neurología; Suiza
Fil: Mercia Fernandes, Ana. Universidad de São Paulo. Facultad de Medicina. Centro de Trastornos del Movimiento. Departamento de Neurología; Brasil
Fil: Barbosa, Egberto R. Universidad de São Paulo. Facultad de Medicina. Centro de Trastornos del Movimiento. Departamento de Neurología; Brasil
Fil: Teixeira, Manoel J. Universidad de São Paulo. Facultad de Medicina. Centro de Trastornos del Movimiento. Departamento de Neurología; Brasil
Fil: Ferraz, Henrique Ballalai. Universidade Federal de Sao Paulo. Department of Neurology; Brasil
Fil: Camargos, Sarah Teixeira. Hospital das Clínicas da Universidade Federal de Minas Gerais. Department of Neurology; Brasil
Fil: Gisbert Cury, Rubens. Universidad de São Paulo. Facultad de Medicina. Centro de Trastornos del Movimiento. Departamento de Neurología; Brasil
Fil: Ciampi de Andrade, Daniel. Universidad de São Paulo. Facultad de Medicina. Centro de Trastornos del Movimiento. Departamento de Neurología; Brasil
Fil: Ciampi de Andrade, Daniel. Universidad de Aalborg. Facultad de Medicina. Centro de Neuroplasticidad y Dolor. Departamento de Ciencia y Tecnología de la Salud; Dinamarca
Abstract: Background: Dystonia is associated with disabling nonmotor symptoms like chronic pain (CP), which is prevalent in dystonia and significantly impacts the quality of life (QoL). There is no validated tool for assessing CP in dystonia, which substantially hampers pain management. Objective: The aim was to develop a CP classification and scoring system for dystonia. Methods: A multidisciplinary group was established to develop the Dystonia-Pain Classification System (Dystonia- PCS). The classification of CP as related or unrelated to dystonia was followed by the assessment of pain severity score, encompassing pain intensity, frequency, and impact on daily living. Then, consecutive patients with inherited/idiopathic dystonia of different spatial distribution were recruited in a cross-sectional multicenter validation study. Dystonia-PCS was compared to validated pain, mood, QoL, and dystonia scales (Brief Pain Inventory, Douleur Neuropathique-4 questionnaire, European QoL-5 Dimensions-3 Level Version, and Burke–Fahn–Marsden Dystonia Rating Scale). Results: CP was present in 81 of 123 recruited patients, being directly related to dystonia in 82.7%, aggravated by dystonia in 8.8%, and nonrelated to dystonia in 7.5%. affected by this disorder. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. Dystonia-PCS had excellent intra-rater (Intraclass Correlation Coefficient - ICC: 0.941) and inter-rater (ICC: 0.867) reliability. In addition, pain severity score correlated with European QoL-5 Dimensions-3 Level Version’s pain subscore (r = 0.635, P < 0.001) and the Brief Pain Inventory’s severity and interference scores (r = 0.553, P < 0.001 and r = 0.609, P < 0.001, respectively). Conclusions: Dystonia-PCS is a reliable tool to categorize and quantify CP impact in dystonia and will help improve clinical trial design and management of CP in patients affected by this disorder.