Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice

Autores
Dieguez, Hernán H.; Romeo, Horacio; González Fleitas, María F.; Aranda, Marcos L.; Milne, Georgia A.; Rosenstein, Ruth E.; Dorfman, Damián
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Dieguez, Hernán H. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina
Fil: Dieguez, Hernán H. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Romeo, Horacio E. Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Romeo, Horacio E. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: González Fleitas, María F. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina
Fil: González Fleitas, María F. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Aranda, Marcos L. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina
Fil: Aranda, Marcos L. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Milne, Georgia A. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina
Fil: Milne, Georgia A. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Rosenstein, Ruth E. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina
Fil: Rosenstein, Ruth E. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina
Fil: Dorfman, Damián. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina
Fil: Dorfman, Damián. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina
Abstract: Non-exudative age-related macular degeneration, a prevalent cause of blindness, is a progressive and degenerative disease characterized by alterations in Bruch's membrane, retinal pigment epithelium, and photoreceptors exclusively localized in the macula. Although experimental murine models exist, the vast majority take a long time to develop retinal alterations and, in general, these alterations are ubiquitous, with many resulting from non-eye-specific genetic manipulations; additionally, most do not always reproduce the hallmarks of human age-related macular degeneration. Choroid vessels receive sympathetic innervation from the superior cervical ganglion, which, together with the parasympathetic system, regulates blood flow into the choroid. Choroid blood flow changes have been involved in age-related macular degeneration development and progression. At present, no experimental models take this factor into account. The aim of this work was to analyze the effect of superior cervical gangliectomy (also known as ganglionectomy) on the choroid, Bruch's membrane, retinal pigment epithelium and retina. Adult male C57BL/6J mice underwent unilateral superior cervical gangliectomy and a contralateral sham procedure. Although superior cervical gangliectomy induced ubiquitous choroid and choriocapillaris changes, it induced Bruch's membrane thickening, loss of retinal pigment epithelium melanin content and retinoid isomerohydrolase, the appearance of drusen-like deposits, and retinal pigment epithelium and photoreceptor atrophy, exclusively localized in the temporal side. Moreover, superior cervical gangliectomy provoked a localized increase in retinal pigment epithelium and photoreceptor apoptosis, and a decline in photoreceptor electroretinographic function. Therefore, superior cervical gangliectomy recapitulated the main features of human non-exudative age-related macular degeneration, and could become a new experimental model of dry age-related macular degeneration, and a useful platform for developing new therapies.
Fuente
Disease Models & Mechanisms. 2018;11(2):dmm031641
Materia
DEGENERACION MACULAR
GANGLIOS
RETINA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/8621

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oai_identifier_str oai:ucacris:123456789/8621
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Superior cervical gangliectomy induces non-exudative age-related macular degeneration in miceDieguez, Hernán H.Romeo, HoracioGonzález Fleitas, María F.Aranda, Marcos L.Milne, Georgia A.Rosenstein, Ruth E.Dorfman, DamiánDEGENERACION MACULARGANGLIOSRETINAFil: Dieguez, Hernán H. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; ArgentinaFil: Dieguez, Hernán H. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Romeo, Horacio E. Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Romeo, Horacio E. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: González Fleitas, María F. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; ArgentinaFil: González Fleitas, María F. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Aranda, Marcos L. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; ArgentinaFil: Aranda, Marcos L. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Milne, Georgia A. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; ArgentinaFil: Milne, Georgia A. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Rosenstein, Ruth E. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; ArgentinaFil: Rosenstein, Ruth E. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; ArgentinaFil: Dorfman, Damián. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; ArgentinaFil: Dorfman, Damián. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; ArgentinaAbstract: Non-exudative age-related macular degeneration, a prevalent cause of blindness, is a progressive and degenerative disease characterized by alterations in Bruch's membrane, retinal pigment epithelium, and photoreceptors exclusively localized in the macula. Although experimental murine models exist, the vast majority take a long time to develop retinal alterations and, in general, these alterations are ubiquitous, with many resulting from non-eye-specific genetic manipulations; additionally, most do not always reproduce the hallmarks of human age-related macular degeneration. Choroid vessels receive sympathetic innervation from the superior cervical ganglion, which, together with the parasympathetic system, regulates blood flow into the choroid. Choroid blood flow changes have been involved in age-related macular degeneration development and progression. At present, no experimental models take this factor into account. The aim of this work was to analyze the effect of superior cervical gangliectomy (also known as ganglionectomy) on the choroid, Bruch's membrane, retinal pigment epithelium and retina. Adult male C57BL/6J mice underwent unilateral superior cervical gangliectomy and a contralateral sham procedure. Although superior cervical gangliectomy induced ubiquitous choroid and choriocapillaris changes, it induced Bruch's membrane thickening, loss of retinal pigment epithelium melanin content and retinoid isomerohydrolase, the appearance of drusen-like deposits, and retinal pigment epithelium and photoreceptor atrophy, exclusively localized in the temporal side. Moreover, superior cervical gangliectomy provoked a localized increase in retinal pigment epithelium and photoreceptor apoptosis, and a decline in photoreceptor electroretinographic function. Therefore, superior cervical gangliectomy recapitulated the main features of human non-exudative age-related macular degeneration, and could become a new experimental model of dry age-related macular degeneration, and a useful platform for developing new therapies.Company of Biologists2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/86211754-8403 (print)1754-8411 (online)10.1242/dmm.03164129361515Dieguez HH, Romeo HE, Fleitas MFG, et al. Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice [en línea]. Disease Models & Mechanisms. 2018;11(2):dmm031641. doi:10.1242/dmm.031641 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8621Disease Models & Mechanisms. 2018;11(2):dmm031641reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:56:52Zoai:ucacris:123456789/8621instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:56:52.527Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice
title Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice
spellingShingle Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice
Dieguez, Hernán H.
DEGENERACION MACULAR
GANGLIOS
RETINA
title_short Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice
title_full Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice
title_fullStr Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice
title_full_unstemmed Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice
title_sort Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice
dc.creator.none.fl_str_mv Dieguez, Hernán H.
Romeo, Horacio
González Fleitas, María F.
Aranda, Marcos L.
Milne, Georgia A.
Rosenstein, Ruth E.
Dorfman, Damián
author Dieguez, Hernán H.
author_facet Dieguez, Hernán H.
Romeo, Horacio
González Fleitas, María F.
Aranda, Marcos L.
Milne, Georgia A.
Rosenstein, Ruth E.
Dorfman, Damián
author_role author
author2 Romeo, Horacio
González Fleitas, María F.
Aranda, Marcos L.
Milne, Georgia A.
Rosenstein, Ruth E.
Dorfman, Damián
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv DEGENERACION MACULAR
GANGLIOS
RETINA
topic DEGENERACION MACULAR
GANGLIOS
RETINA
dc.description.none.fl_txt_mv Fil: Dieguez, Hernán H. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina
Fil: Dieguez, Hernán H. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Romeo, Horacio E. Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Romeo, Horacio E. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: González Fleitas, María F. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina
Fil: González Fleitas, María F. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Aranda, Marcos L. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina
Fil: Aranda, Marcos L. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Milne, Georgia A. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina
Fil: Milne, Georgia A. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Rosenstein, Ruth E. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina
Fil: Rosenstein, Ruth E. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina
Fil: Dorfman, Damián. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina
Fil: Dorfman, Damián. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina
Abstract: Non-exudative age-related macular degeneration, a prevalent cause of blindness, is a progressive and degenerative disease characterized by alterations in Bruch's membrane, retinal pigment epithelium, and photoreceptors exclusively localized in the macula. Although experimental murine models exist, the vast majority take a long time to develop retinal alterations and, in general, these alterations are ubiquitous, with many resulting from non-eye-specific genetic manipulations; additionally, most do not always reproduce the hallmarks of human age-related macular degeneration. Choroid vessels receive sympathetic innervation from the superior cervical ganglion, which, together with the parasympathetic system, regulates blood flow into the choroid. Choroid blood flow changes have been involved in age-related macular degeneration development and progression. At present, no experimental models take this factor into account. The aim of this work was to analyze the effect of superior cervical gangliectomy (also known as ganglionectomy) on the choroid, Bruch's membrane, retinal pigment epithelium and retina. Adult male C57BL/6J mice underwent unilateral superior cervical gangliectomy and a contralateral sham procedure. Although superior cervical gangliectomy induced ubiquitous choroid and choriocapillaris changes, it induced Bruch's membrane thickening, loss of retinal pigment epithelium melanin content and retinoid isomerohydrolase, the appearance of drusen-like deposits, and retinal pigment epithelium and photoreceptor atrophy, exclusively localized in the temporal side. Moreover, superior cervical gangliectomy provoked a localized increase in retinal pigment epithelium and photoreceptor apoptosis, and a decline in photoreceptor electroretinographic function. Therefore, superior cervical gangliectomy recapitulated the main features of human non-exudative age-related macular degeneration, and could become a new experimental model of dry age-related macular degeneration, and a useful platform for developing new therapies.
description Fil: Dieguez, Hernán H. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/8621
1754-8403 (print)
1754-8411 (online)
10.1242/dmm.031641
29361515
Dieguez HH, Romeo HE, Fleitas MFG, et al. Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice [en línea]. Disease Models & Mechanisms. 2018;11(2):dmm031641. doi:10.1242/dmm.031641 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8621
url https://repositorio.uca.edu.ar/handle/123456789/8621
identifier_str_mv 1754-8403 (print)
1754-8411 (online)
10.1242/dmm.031641
29361515
Dieguez HH, Romeo HE, Fleitas MFG, et al. Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice [en línea]. Disease Models & Mechanisms. 2018;11(2):dmm031641. doi:10.1242/dmm.031641 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8621
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Company of Biologists
publisher.none.fl_str_mv Company of Biologists
dc.source.none.fl_str_mv Disease Models & Mechanisms. 2018;11(2):dmm031641
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 13.070432