Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice
- Autores
- Dieguez, Hernán H.; Romeo, Horacio; González Fleitas, María F.; Aranda, Marcos L.; Milne, Georgia A.; Rosenstein, Ruth E.; Dorfman, Damián
- Año de publicación
- 2018
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Dieguez, Hernán H. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina
Fil: Dieguez, Hernán H. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Romeo, Horacio E. Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Romeo, Horacio E. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: González Fleitas, María F. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina
Fil: González Fleitas, María F. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Aranda, Marcos L. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina
Fil: Aranda, Marcos L. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Milne, Georgia A. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina
Fil: Milne, Georgia A. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Rosenstein, Ruth E. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina
Fil: Rosenstein, Ruth E. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina
Fil: Dorfman, Damián. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina
Fil: Dorfman, Damián. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina
Abstract: Non-exudative age-related macular degeneration, a prevalent cause of blindness, is a progressive and degenerative disease characterized by alterations in Bruch's membrane, retinal pigment epithelium, and photoreceptors exclusively localized in the macula. Although experimental murine models exist, the vast majority take a long time to develop retinal alterations and, in general, these alterations are ubiquitous, with many resulting from non-eye-specific genetic manipulations; additionally, most do not always reproduce the hallmarks of human age-related macular degeneration. Choroid vessels receive sympathetic innervation from the superior cervical ganglion, which, together with the parasympathetic system, regulates blood flow into the choroid. Choroid blood flow changes have been involved in age-related macular degeneration development and progression. At present, no experimental models take this factor into account. The aim of this work was to analyze the effect of superior cervical gangliectomy (also known as ganglionectomy) on the choroid, Bruch's membrane, retinal pigment epithelium and retina. Adult male C57BL/6J mice underwent unilateral superior cervical gangliectomy and a contralateral sham procedure. Although superior cervical gangliectomy induced ubiquitous choroid and choriocapillaris changes, it induced Bruch's membrane thickening, loss of retinal pigment epithelium melanin content and retinoid isomerohydrolase, the appearance of drusen-like deposits, and retinal pigment epithelium and photoreceptor atrophy, exclusively localized in the temporal side. Moreover, superior cervical gangliectomy provoked a localized increase in retinal pigment epithelium and photoreceptor apoptosis, and a decline in photoreceptor electroretinographic function. Therefore, superior cervical gangliectomy recapitulated the main features of human non-exudative age-related macular degeneration, and could become a new experimental model of dry age-related macular degeneration, and a useful platform for developing new therapies. - Fuente
- Disease Models & Mechanisms. 2018;11(2):dmm031641
- Materia
-
DEGENERACION MACULAR
GANGLIOS
RETINA - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Pontificia Universidad Católica Argentina
- OAI Identificador
- oai:ucacris:123456789/8621
Ver los metadatos del registro completo
id |
RIUCA_05af16881d1491a7798b0f8cd222832c |
---|---|
oai_identifier_str |
oai:ucacris:123456789/8621 |
network_acronym_str |
RIUCA |
repository_id_str |
2585 |
network_name_str |
Repositorio Institucional (UCA) |
spelling |
Superior cervical gangliectomy induces non-exudative age-related macular degeneration in miceDieguez, Hernán H.Romeo, HoracioGonzález Fleitas, María F.Aranda, Marcos L.Milne, Georgia A.Rosenstein, Ruth E.Dorfman, DamiánDEGENERACION MACULARGANGLIOSRETINAFil: Dieguez, Hernán H. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; ArgentinaFil: Dieguez, Hernán H. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Romeo, Horacio E. Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Romeo, Horacio E. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: González Fleitas, María F. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; ArgentinaFil: González Fleitas, María F. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Aranda, Marcos L. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; ArgentinaFil: Aranda, Marcos L. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Milne, Georgia A. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; ArgentinaFil: Milne, Georgia A. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Rosenstein, Ruth E. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; ArgentinaFil: Rosenstein, Ruth E. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; ArgentinaFil: Dorfman, Damián. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; ArgentinaFil: Dorfman, Damián. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; ArgentinaAbstract: Non-exudative age-related macular degeneration, a prevalent cause of blindness, is a progressive and degenerative disease characterized by alterations in Bruch's membrane, retinal pigment epithelium, and photoreceptors exclusively localized in the macula. Although experimental murine models exist, the vast majority take a long time to develop retinal alterations and, in general, these alterations are ubiquitous, with many resulting from non-eye-specific genetic manipulations; additionally, most do not always reproduce the hallmarks of human age-related macular degeneration. Choroid vessels receive sympathetic innervation from the superior cervical ganglion, which, together with the parasympathetic system, regulates blood flow into the choroid. Choroid blood flow changes have been involved in age-related macular degeneration development and progression. At present, no experimental models take this factor into account. The aim of this work was to analyze the effect of superior cervical gangliectomy (also known as ganglionectomy) on the choroid, Bruch's membrane, retinal pigment epithelium and retina. Adult male C57BL/6J mice underwent unilateral superior cervical gangliectomy and a contralateral sham procedure. Although superior cervical gangliectomy induced ubiquitous choroid and choriocapillaris changes, it induced Bruch's membrane thickening, loss of retinal pigment epithelium melanin content and retinoid isomerohydrolase, the appearance of drusen-like deposits, and retinal pigment epithelium and photoreceptor atrophy, exclusively localized in the temporal side. Moreover, superior cervical gangliectomy provoked a localized increase in retinal pigment epithelium and photoreceptor apoptosis, and a decline in photoreceptor electroretinographic function. Therefore, superior cervical gangliectomy recapitulated the main features of human non-exudative age-related macular degeneration, and could become a new experimental model of dry age-related macular degeneration, and a useful platform for developing new therapies.Company of Biologists2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/86211754-8403 (print)1754-8411 (online)10.1242/dmm.03164129361515Dieguez HH, Romeo HE, Fleitas MFG, et al. Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice [en línea]. Disease Models & Mechanisms. 2018;11(2):dmm031641. doi:10.1242/dmm.031641 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8621Disease Models & Mechanisms. 2018;11(2):dmm031641reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:56:52Zoai:ucacris:123456789/8621instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:56:52.527Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse |
dc.title.none.fl_str_mv |
Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice |
title |
Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice |
spellingShingle |
Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice Dieguez, Hernán H. DEGENERACION MACULAR GANGLIOS RETINA |
title_short |
Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice |
title_full |
Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice |
title_fullStr |
Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice |
title_full_unstemmed |
Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice |
title_sort |
Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice |
dc.creator.none.fl_str_mv |
Dieguez, Hernán H. Romeo, Horacio González Fleitas, María F. Aranda, Marcos L. Milne, Georgia A. Rosenstein, Ruth E. Dorfman, Damián |
author |
Dieguez, Hernán H. |
author_facet |
Dieguez, Hernán H. Romeo, Horacio González Fleitas, María F. Aranda, Marcos L. Milne, Georgia A. Rosenstein, Ruth E. Dorfman, Damián |
author_role |
author |
author2 |
Romeo, Horacio González Fleitas, María F. Aranda, Marcos L. Milne, Georgia A. Rosenstein, Ruth E. Dorfman, Damián |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
DEGENERACION MACULAR GANGLIOS RETINA |
topic |
DEGENERACION MACULAR GANGLIOS RETINA |
dc.description.none.fl_txt_mv |
Fil: Dieguez, Hernán H. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina Fil: Dieguez, Hernán H. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Farmacológicos y Botánicos; Argentina Fil: Romeo, Horacio E. Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina Fil: Romeo, Horacio E. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: González Fleitas, María F. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina Fil: González Fleitas, María F. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Farmacológicos y Botánicos; Argentina Fil: Aranda, Marcos L. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina Fil: Aranda, Marcos L. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Farmacológicos y Botánicos; Argentina Fil: Milne, Georgia A. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina Fil: Milne, Georgia A. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Farmacológicos y Botánicos; Argentina Fil: Rosenstein, Ruth E. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina Fil: Rosenstein, Ruth E. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina Fil: Dorfman, Damián. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina Fil: Dorfman, Damián. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina Abstract: Non-exudative age-related macular degeneration, a prevalent cause of blindness, is a progressive and degenerative disease characterized by alterations in Bruch's membrane, retinal pigment epithelium, and photoreceptors exclusively localized in the macula. Although experimental murine models exist, the vast majority take a long time to develop retinal alterations and, in general, these alterations are ubiquitous, with many resulting from non-eye-specific genetic manipulations; additionally, most do not always reproduce the hallmarks of human age-related macular degeneration. Choroid vessels receive sympathetic innervation from the superior cervical ganglion, which, together with the parasympathetic system, regulates blood flow into the choroid. Choroid blood flow changes have been involved in age-related macular degeneration development and progression. At present, no experimental models take this factor into account. The aim of this work was to analyze the effect of superior cervical gangliectomy (also known as ganglionectomy) on the choroid, Bruch's membrane, retinal pigment epithelium and retina. Adult male C57BL/6J mice underwent unilateral superior cervical gangliectomy and a contralateral sham procedure. Although superior cervical gangliectomy induced ubiquitous choroid and choriocapillaris changes, it induced Bruch's membrane thickening, loss of retinal pigment epithelium melanin content and retinoid isomerohydrolase, the appearance of drusen-like deposits, and retinal pigment epithelium and photoreceptor atrophy, exclusively localized in the temporal side. Moreover, superior cervical gangliectomy provoked a localized increase in retinal pigment epithelium and photoreceptor apoptosis, and a decline in photoreceptor electroretinographic function. Therefore, superior cervical gangliectomy recapitulated the main features of human non-exudative age-related macular degeneration, and could become a new experimental model of dry age-related macular degeneration, and a useful platform for developing new therapies. |
description |
Fil: Dieguez, Hernán H. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana. Laboratorio de Neuroquímica Retinal y Oftamología Experimental; Argentina |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://repositorio.uca.edu.ar/handle/123456789/8621 1754-8403 (print) 1754-8411 (online) 10.1242/dmm.031641 29361515 Dieguez HH, Romeo HE, Fleitas MFG, et al. Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice [en línea]. Disease Models & Mechanisms. 2018;11(2):dmm031641. doi:10.1242/dmm.031641 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8621 |
url |
https://repositorio.uca.edu.ar/handle/123456789/8621 |
identifier_str_mv |
1754-8403 (print) 1754-8411 (online) 10.1242/dmm.031641 29361515 Dieguez HH, Romeo HE, Fleitas MFG, et al. Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice [en línea]. Disease Models & Mechanisms. 2018;11(2):dmm031641. doi:10.1242/dmm.031641 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8621 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Company of Biologists |
publisher.none.fl_str_mv |
Company of Biologists |
dc.source.none.fl_str_mv |
Disease Models & Mechanisms. 2018;11(2):dmm031641 reponame:Repositorio Institucional (UCA) instname:Pontificia Universidad Católica Argentina |
reponame_str |
Repositorio Institucional (UCA) |
collection |
Repositorio Institucional (UCA) |
instname_str |
Pontificia Universidad Católica Argentina |
repository.name.fl_str_mv |
Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina |
repository.mail.fl_str_mv |
claudia_fernandez@uca.edu.ar |
_version_ |
1836638347402936320 |
score |
13.070432 |