Fatty acid regulation of voltage-and-ligand-gated ion channel function
- Autores
- Antollini, Silvia S.; Barrantes, Francisco José
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Antollini, Silvia S. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; Argentina
Fil: Barrantes, Franacisco José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Antollini, Silvia S. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Abstract: Free fatty acids (FFA) are essential components of the cell, where they play a key role in lipid and carbohydrate metabolism, and most particularly in cell membranes, where they are central actors in shaping the physicochemical properties of the lipid bilayer and the cellular adaptation to the environment. FFA are continuously being produced and degraded, and a feedback regulatory function has been attributed to their turnover. The massive increase observed under some pathological conditions, especially in brain, has been interpreted as a protective mechanism possibly operative on ion channels, which in some cases is of stimulatory nature and in other cases inhibitory. Here we discuss the correlation between the structure of FFA and their ability to modulate protein function, evaluating the influence of saturation/unsaturation, number of double bonds, and cis vs. trans isomerism. We further focus on the mechanisms of FFA modulation operating on voltage-gated and ligand-gated ion channel function, contrasting the still conflicting evidence on direct vs. indirect mechanisms of action. - Fuente
- Frontiers in Physiology Vol. 7, 2016
- Materia
-
MEDICINA
ACIDOS GRASOS LIBRES
MEMBRANAS CELULARES
PROTEINAS
CANALES IONICOS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Pontificia Universidad Católica Argentina
- OAI Identificador
- oai:ucacris:123456789/8689
Ver los metadatos del registro completo
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oai:ucacris:123456789/8689 |
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Fatty acid regulation of voltage-and-ligand-gated ion channel functionAntollini, Silvia S.Barrantes, Francisco JoséMEDICINAACIDOS GRASOS LIBRESMEMBRANAS CELULARESPROTEINASCANALES IONICOSFil: Antollini, Silvia S. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; ArgentinaFil: Barrantes, Franacisco José. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Antollini, Silvia S. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaAbstract: Free fatty acids (FFA) are essential components of the cell, where they play a key role in lipid and carbohydrate metabolism, and most particularly in cell membranes, where they are central actors in shaping the physicochemical properties of the lipid bilayer and the cellular adaptation to the environment. FFA are continuously being produced and degraded, and a feedback regulatory function has been attributed to their turnover. The massive increase observed under some pathological conditions, especially in brain, has been interpreted as a protective mechanism possibly operative on ion channels, which in some cases is of stimulatory nature and in other cases inhibitory. Here we discuss the correlation between the structure of FFA and their ability to modulate protein function, evaluating the influence of saturation/unsaturation, number of double bonds, and cis vs. trans isomerism. We further focus on the mechanisms of FFA modulation operating on voltage-gated and ligand-gated ion channel function, contrasting the still conflicting evidence on direct vs. indirect mechanisms of action.Frontiers2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/86891664-042X10.3389/fphys.2016.00573Antollini SS, Barrantes FJ(2016) Fatty acid regulation of voltage-and ligand-gated ion channel function. Front. Physiol.7:573. doi: 10.3389/fphys.2016.00573. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8689Frontiers in Physiology Vol. 7, 2016reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:56:54Zoai:ucacris:123456789/8689instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:56:55.016Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse |
dc.title.none.fl_str_mv |
Fatty acid regulation of voltage-and-ligand-gated ion channel function |
title |
Fatty acid regulation of voltage-and-ligand-gated ion channel function |
spellingShingle |
Fatty acid regulation of voltage-and-ligand-gated ion channel function Antollini, Silvia S. MEDICINA ACIDOS GRASOS LIBRES MEMBRANAS CELULARES PROTEINAS CANALES IONICOS |
title_short |
Fatty acid regulation of voltage-and-ligand-gated ion channel function |
title_full |
Fatty acid regulation of voltage-and-ligand-gated ion channel function |
title_fullStr |
Fatty acid regulation of voltage-and-ligand-gated ion channel function |
title_full_unstemmed |
Fatty acid regulation of voltage-and-ligand-gated ion channel function |
title_sort |
Fatty acid regulation of voltage-and-ligand-gated ion channel function |
dc.creator.none.fl_str_mv |
Antollini, Silvia S. Barrantes, Francisco José |
author |
Antollini, Silvia S. |
author_facet |
Antollini, Silvia S. Barrantes, Francisco José |
author_role |
author |
author2 |
Barrantes, Francisco José |
author2_role |
author |
dc.subject.none.fl_str_mv |
MEDICINA ACIDOS GRASOS LIBRES MEMBRANAS CELULARES PROTEINAS CANALES IONICOS |
topic |
MEDICINA ACIDOS GRASOS LIBRES MEMBRANAS CELULARES PROTEINAS CANALES IONICOS |
dc.description.none.fl_txt_mv |
Fil: Antollini, Silvia S. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina Fil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; Argentina Fil: Barrantes, Franacisco José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Antollini, Silvia S. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina Abstract: Free fatty acids (FFA) are essential components of the cell, where they play a key role in lipid and carbohydrate metabolism, and most particularly in cell membranes, where they are central actors in shaping the physicochemical properties of the lipid bilayer and the cellular adaptation to the environment. FFA are continuously being produced and degraded, and a feedback regulatory function has been attributed to their turnover. The massive increase observed under some pathological conditions, especially in brain, has been interpreted as a protective mechanism possibly operative on ion channels, which in some cases is of stimulatory nature and in other cases inhibitory. Here we discuss the correlation between the structure of FFA and their ability to modulate protein function, evaluating the influence of saturation/unsaturation, number of double bonds, and cis vs. trans isomerism. We further focus on the mechanisms of FFA modulation operating on voltage-gated and ligand-gated ion channel function, contrasting the still conflicting evidence on direct vs. indirect mechanisms of action. |
description |
Fil: Antollini, Silvia S. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://repositorio.uca.edu.ar/handle/123456789/8689 1664-042X 10.3389/fphys.2016.00573 Antollini SS, Barrantes FJ(2016) Fatty acid regulation of voltage-and ligand-gated ion channel function. Front. Physiol.7:573. doi: 10.3389/fphys.2016.00573. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8689 |
url |
https://repositorio.uca.edu.ar/handle/123456789/8689 |
identifier_str_mv |
1664-042X 10.3389/fphys.2016.00573 Antollini SS, Barrantes FJ(2016) Fatty acid regulation of voltage-and ligand-gated ion channel function. Front. Physiol.7:573. doi: 10.3389/fphys.2016.00573. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8689 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers |
publisher.none.fl_str_mv |
Frontiers |
dc.source.none.fl_str_mv |
Frontiers in Physiology Vol. 7, 2016 reponame:Repositorio Institucional (UCA) instname:Pontificia Universidad Católica Argentina |
reponame_str |
Repositorio Institucional (UCA) |
collection |
Repositorio Institucional (UCA) |
instname_str |
Pontificia Universidad Católica Argentina |
repository.name.fl_str_mv |
Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina |
repository.mail.fl_str_mv |
claudia_fernandez@uca.edu.ar |
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1836638347498356736 |
score |
13.22299 |