Fatty acid regulation of voltage-and-ligand-gated ion channel function

Autores
Antollini, Silvia S.; Barrantes, Francisco José
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Antollini, Silvia S. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; Argentina
Fil: Barrantes, Franacisco José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Antollini, Silvia S. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Abstract: Free fatty acids (FFA) are essential components of the cell, where they play a key role in lipid and carbohydrate metabolism, and most particularly in cell membranes, where they are central actors in shaping the physicochemical properties of the lipid bilayer and the cellular adaptation to the environment. FFA are continuously being produced and degraded, and a feedback regulatory function has been attributed to their turnover. The massive increase observed under some pathological conditions, especially in brain, has been interpreted as a protective mechanism possibly operative on ion channels, which in some cases is of stimulatory nature and in other cases inhibitory. Here we discuss the correlation between the structure of FFA and their ability to modulate protein function, evaluating the influence of saturation/unsaturation, number of double bonds, and cis vs. trans isomerism. We further focus on the mechanisms of FFA modulation operating on voltage-gated and ligand-gated ion channel function, contrasting the still conflicting evidence on direct vs. indirect mechanisms of action.
Fuente
Frontiers in Physiology Vol. 7, 2016
Materia
MEDICINA
ACIDOS GRASOS LIBRES
MEMBRANAS CELULARES
PROTEINAS
CANALES IONICOS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/8689

id RIUCA_01d2b54265fe784c59296fe4067d65f5
oai_identifier_str oai:ucacris:123456789/8689
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Fatty acid regulation of voltage-and-ligand-gated ion channel functionAntollini, Silvia S.Barrantes, Francisco JoséMEDICINAACIDOS GRASOS LIBRESMEMBRANAS CELULARESPROTEINASCANALES IONICOSFil: Antollini, Silvia S. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; ArgentinaFil: Barrantes, Franacisco José. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Antollini, Silvia S. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaAbstract: Free fatty acids (FFA) are essential components of the cell, where they play a key role in lipid and carbohydrate metabolism, and most particularly in cell membranes, where they are central actors in shaping the physicochemical properties of the lipid bilayer and the cellular adaptation to the environment. FFA are continuously being produced and degraded, and a feedback regulatory function has been attributed to their turnover. The massive increase observed under some pathological conditions, especially in brain, has been interpreted as a protective mechanism possibly operative on ion channels, which in some cases is of stimulatory nature and in other cases inhibitory. Here we discuss the correlation between the structure of FFA and their ability to modulate protein function, evaluating the influence of saturation/unsaturation, number of double bonds, and cis vs. trans isomerism. We further focus on the mechanisms of FFA modulation operating on voltage-gated and ligand-gated ion channel function, contrasting the still conflicting evidence on direct vs. indirect mechanisms of action.Frontiers2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/86891664-042X10.3389/fphys.2016.00573Antollini SS, Barrantes FJ(2016) Fatty acid regulation of voltage-and ligand-gated ion channel function. Front. Physiol.7:573. doi: 10.3389/fphys.2016.00573. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8689Frontiers in Physiology Vol. 7, 2016reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:56:54Zoai:ucacris:123456789/8689instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:56:55.016Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Fatty acid regulation of voltage-and-ligand-gated ion channel function
title Fatty acid regulation of voltage-and-ligand-gated ion channel function
spellingShingle Fatty acid regulation of voltage-and-ligand-gated ion channel function
Antollini, Silvia S.
MEDICINA
ACIDOS GRASOS LIBRES
MEMBRANAS CELULARES
PROTEINAS
CANALES IONICOS
title_short Fatty acid regulation of voltage-and-ligand-gated ion channel function
title_full Fatty acid regulation of voltage-and-ligand-gated ion channel function
title_fullStr Fatty acid regulation of voltage-and-ligand-gated ion channel function
title_full_unstemmed Fatty acid regulation of voltage-and-ligand-gated ion channel function
title_sort Fatty acid regulation of voltage-and-ligand-gated ion channel function
dc.creator.none.fl_str_mv Antollini, Silvia S.
Barrantes, Francisco José
author Antollini, Silvia S.
author_facet Antollini, Silvia S.
Barrantes, Francisco José
author_role author
author2 Barrantes, Francisco José
author2_role author
dc.subject.none.fl_str_mv MEDICINA
ACIDOS GRASOS LIBRES
MEMBRANAS CELULARES
PROTEINAS
CANALES IONICOS
topic MEDICINA
ACIDOS GRASOS LIBRES
MEMBRANAS CELULARES
PROTEINAS
CANALES IONICOS
dc.description.none.fl_txt_mv Fil: Antollini, Silvia S. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; Argentina
Fil: Barrantes, Franacisco José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Antollini, Silvia S. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Abstract: Free fatty acids (FFA) are essential components of the cell, where they play a key role in lipid and carbohydrate metabolism, and most particularly in cell membranes, where they are central actors in shaping the physicochemical properties of the lipid bilayer and the cellular adaptation to the environment. FFA are continuously being produced and degraded, and a feedback regulatory function has been attributed to their turnover. The massive increase observed under some pathological conditions, especially in brain, has been interpreted as a protective mechanism possibly operative on ion channels, which in some cases is of stimulatory nature and in other cases inhibitory. Here we discuss the correlation between the structure of FFA and their ability to modulate protein function, evaluating the influence of saturation/unsaturation, number of double bonds, and cis vs. trans isomerism. We further focus on the mechanisms of FFA modulation operating on voltage-gated and ligand-gated ion channel function, contrasting the still conflicting evidence on direct vs. indirect mechanisms of action.
description Fil: Antollini, Silvia S. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/8689
1664-042X
10.3389/fphys.2016.00573
Antollini SS, Barrantes FJ(2016) Fatty acid regulation of voltage-and ligand-gated ion channel function. Front. Physiol.7:573. doi: 10.3389/fphys.2016.00573. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8689
url https://repositorio.uca.edu.ar/handle/123456789/8689
identifier_str_mv 1664-042X
10.3389/fphys.2016.00573
Antollini SS, Barrantes FJ(2016) Fatty acid regulation of voltage-and ligand-gated ion channel function. Front. Physiol.7:573. doi: 10.3389/fphys.2016.00573. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8689
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv Frontiers in Physiology Vol. 7, 2016
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 13.22299