Prevalence, risk factors and molecular characterization of Chlamydia trachomatis in pregnant women from Córdoba, Argentina: A prospective study

Autores
Kiguen, Ana Ximena; Marramá, Marcela; Ruiz, Susana; Estofan, Patricia; Venezuela, Raúl Fernando; Mosmann, Jessica Paola; Monetti, Marina Soledad; Rivero, Virginia; Cuffini, Cecilia Gabriela
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
10 p.
Fil: Kiguen, Ana Ximena. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología “Dr. J.M. Vanella”; Argentina.
Fil: Marramá, Marcela. Municipalidad de Córdoba. Dirección de Especialidades Médicas; Argentina.
Fil: Ruiz, Susana. Laboratorios LACE; Argentina.
Fil: Estofan, Patricia. Centro Integral de Ginecología (CIGOR); Argentina.
Fil: Venezuela, Raúl Fernando. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J. M. Vanella"; Argentina.
Fil: Mosmann, Jessica Paola. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J. M. Vanella"; Argentina.
Fil: Monetti, Marina Soledad. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J. M. Vanella"; Argentina.
Fil: Rivero, Virginia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica; Argentina.
Fil: Rivero, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina.
Fil: Cuffini, Cecilia Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J. M. Vanella"; Argentina.
Chlamydia trachomatis causes the most prevalent bacterial Sexual Transmitted Infection. In pregnant women, untreated chlamydial infections are associated with abortions, premature rupture of membranes, postpartum endometritis, low birth weight and transmission to the newborn. In Córdoba, Argentina, there is little knowledge about the prevalence of Chlamydia trachomatis in women in their third trimester of pregnancy, so, the aim of this study was to evaluate Chlamydia trachomatis prevalence and genotypes present in Cordovan pregnant women with different age and socioeconomic status. Methods and findings Design: prospective study. Settings: Women population from Cordoba city, Argentina. Population: Pregnant women having 35 to 37 weeks of gestation. Methods: Five hundred and nine cervical swabs were collected. Each sample was subjected to DNA extraction and PCR for Chlamydia trachomatis using primers NRO/NLO and CTP1/CTP2. Positives samples were sequenced to determine genotype. Main outcome measures: Demographic data of the patients were collected to detect a population at risk for this infection. Results A prevalence of 6.9% (35/509) for Chlamydia trachomatis infection was detected, with 32/ 295 and 3/214 from pregnant women with low or better economic resources respectively (p = 0,0001). Results showed a significantly increased rate of 11.6% (30/258) in women under 25 years compared with 2% (5/251) in patients over that age (p = 0,00003). Genotype E was the most prevalent. Conclusions With these results, we can say that pregnant women under 25 years old and low economic resources are one of the populations in which the screening programs of Chlamydia trachomatis should focus.
publishedVersion
Fil: Kiguen, Ana Ximena. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología “Dr. J.M. Vanella”; Argentina.
Fil: Marramá, Marcela. Municipalidad de Córdoba. Dirección de Especialidades Médicas; Argentina.
Fil: Ruiz, Susana. Laboratorios LACE; Argentina.
Fil: Estofan, Patricia. Centro Integral de Ginecología (CIGOR); Argentina.
Fil: Venezuela, Raúl Fernando. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J. M. Vanella"; Argentina.
Fil: Mosmann, Jessica Paola. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J. M. Vanella"; Argentina.
Fil: Monetti, Marina Soledad. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J. M. Vanella"; Argentina.
Fil: Rivero, Virginia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica; Argentina.
Fil: Rivero, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina.
Fil: Cuffini, Cecilia Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J. M. Vanella"; Argentina.
Biología Celular, Microbiología
Materia
Chlamydia Trachomatis
Pregnant People
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Repositorio Digital Universitario (UNC)
Institución
Universidad Nacional de Córdoba
OAI Identificador
oai:rdu.unc.edu.ar:11086/556753
Acceder
id RDUUNC_d297cbcd607e011765e0225e61b86891
oai_identifier_str oai:rdu.unc.edu.ar:11086/556753
network_acronym_str RDUUNC
repository_id_str 2572
network_name_str Repositorio Digital Universitario (UNC)
spelling Prevalence, risk factors and molecular characterization of Chlamydia trachomatis in pregnant women from Córdoba, Argentina: A prospective studyKiguen, Ana XimenaMarramá, MarcelaRuiz, SusanaEstofan, PatriciaVenezuela, Raúl FernandoMosmann, Jessica PaolaMonetti, Marina SoledadRivero, VirginiaCuffini, Cecilia GabrielaChlamydia TrachomatisPregnant People10 p.Fil: Kiguen, Ana Ximena. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología “Dr. J.M. Vanella”; Argentina.Fil: Marramá, Marcela. Municipalidad de Córdoba. Dirección de Especialidades Médicas; Argentina.Fil: Ruiz, Susana. Laboratorios LACE; Argentina.Fil: Estofan, Patricia. Centro Integral de Ginecología (CIGOR); Argentina.Fil: Venezuela, Raúl Fernando. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J. M. Vanella"; Argentina.Fil: Mosmann, Jessica Paola. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J. M. Vanella"; Argentina.Fil: Monetti, Marina Soledad. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J. M. Vanella"; Argentina.Fil: Rivero, Virginia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica; Argentina.Fil: Rivero, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina.Fil: Cuffini, Cecilia Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J. M. Vanella"; Argentina.Chlamydia trachomatis causes the most prevalent bacterial Sexual Transmitted Infection. In pregnant women, untreated chlamydial infections are associated with abortions, premature rupture of membranes, postpartum endometritis, low birth weight and transmission to the newborn. In Córdoba, Argentina, there is little knowledge about the prevalence of Chlamydia trachomatis in women in their third trimester of pregnancy, so, the aim of this study was to evaluate Chlamydia trachomatis prevalence and genotypes present in Cordovan pregnant women with different age and socioeconomic status. Methods and findings Design: prospective study. Settings: Women population from Cordoba city, Argentina. Population: Pregnant women having 35 to 37 weeks of gestation. Methods: Five hundred and nine cervical swabs were collected. Each sample was subjected to DNA extraction and PCR for Chlamydia trachomatis using primers NRO/NLO and CTP1/CTP2. Positives samples were sequenced to determine genotype. Main outcome measures: Demographic data of the patients were collected to detect a population at risk for this infection. Results A prevalence of 6.9% (35/509) for Chlamydia trachomatis infection was detected, with 32/ 295 and 3/214 from pregnant women with low or better economic resources respectively (p = 0,0001). Results showed a significantly increased rate of 11.6% (30/258) in women under 25 years compared with 2% (5/251) in patients over that age (p = 0,00003). Genotype E was the most prevalent. Conclusions With these results, we can say that pregnant women under 25 years old and low economic resources are one of the populations in which the screening programs of Chlamydia trachomatis should focus.publishedVersionFil: Kiguen, Ana Ximena. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología “Dr. J.M. Vanella”; Argentina.Fil: Marramá, Marcela. Municipalidad de Córdoba. Dirección de Especialidades Médicas; Argentina.Fil: Ruiz, Susana. Laboratorios LACE; Argentina.Fil: Estofan, Patricia. Centro Integral de Ginecología (CIGOR); Argentina.Fil: Venezuela, Raúl Fernando. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J. M. Vanella"; Argentina.Fil: Mosmann, Jessica Paola. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J. M. Vanella"; Argentina.Fil: Monetti, Marina Soledad. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J. M. Vanella"; Argentina.Fil: Rivero, Virginia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica; Argentina.Fil: Rivero, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina.Fil: Cuffini, Cecilia Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J. M. Vanella"; Argentina.Biología Celular, Microbiologíahttps://orcid.org/0000-0002-8304-840Xhttps://orcid.org/0000-0002-0839-63242019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfKiguen, Ana Ximena; Marramá, Marcela; Ruiz, Susana; Estofan, Patricia; Venezuela, Raul Fernando; et al.; Prevalence, risk factors and molecular characterization of Chlamydia trachomatis in pregnant women from Córdoba, Argentina: A prospective study; Public Library of Science; Plos One; 14; 5; 5-20191932-6203http://hdl.handle.net/11086/556753https://doi.org/10.1371/journal.pone.0217245enginfo:eu-repo/semantics/openAccessreponame:Repositorio Digital Universitario (UNC)instname:Universidad Nacional de Córdobainstacron:UNC2025-09-04T12:33:53Zoai:rdu.unc.edu.ar:11086/556753Institucionalhttps://rdu.unc.edu.ar/Universidad públicaNo correspondehttp://rdu.unc.edu.ar/oai/snrdoca.unc@gmail.comArgentinaNo correspondeNo correspondeNo correspondeopendoar:25722025-09-04 12:33:53.824Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdobafalse
dc.title.none.fl_str_mv Prevalence, risk factors and molecular characterization of Chlamydia trachomatis in pregnant women from Córdoba, Argentina: A prospective study
title Prevalence, risk factors and molecular characterization of Chlamydia trachomatis in pregnant women from Córdoba, Argentina: A prospective study
spellingShingle Prevalence, risk factors and molecular characterization of Chlamydia trachomatis in pregnant women from Córdoba, Argentina: A prospective study
Kiguen, Ana Ximena
Chlamydia Trachomatis
Pregnant People
title_short Prevalence, risk factors and molecular characterization of Chlamydia trachomatis in pregnant women from Córdoba, Argentina: A prospective study
title_full Prevalence, risk factors and molecular characterization of Chlamydia trachomatis in pregnant women from Córdoba, Argentina: A prospective study
title_fullStr Prevalence, risk factors and molecular characterization of Chlamydia trachomatis in pregnant women from Córdoba, Argentina: A prospective study
title_full_unstemmed Prevalence, risk factors and molecular characterization of Chlamydia trachomatis in pregnant women from Córdoba, Argentina: A prospective study
title_sort Prevalence, risk factors and molecular characterization of Chlamydia trachomatis in pregnant women from Córdoba, Argentina: A prospective study
dc.creator.none.fl_str_mv Kiguen, Ana Ximena
Marramá, Marcela
Ruiz, Susana
Estofan, Patricia
Venezuela, Raúl Fernando
Mosmann, Jessica Paola
Monetti, Marina Soledad
Rivero, Virginia
Cuffini, Cecilia Gabriela
author Kiguen, Ana Ximena
author_facet Kiguen, Ana Ximena
Marramá, Marcela
Ruiz, Susana
Estofan, Patricia
Venezuela, Raúl Fernando
Mosmann, Jessica Paola
Monetti, Marina Soledad
Rivero, Virginia
Cuffini, Cecilia Gabriela
author_role author
author2 Marramá, Marcela
Ruiz, Susana
Estofan, Patricia
Venezuela, Raúl Fernando
Mosmann, Jessica Paola
Monetti, Marina Soledad
Rivero, Virginia
Cuffini, Cecilia Gabriela
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv https://orcid.org/0000-0002-8304-840X
https://orcid.org/0000-0002-0839-6324
dc.subject.none.fl_str_mv Chlamydia Trachomatis
Pregnant People
topic Chlamydia Trachomatis
Pregnant People
dc.description.none.fl_txt_mv 10 p.
Fil: Kiguen, Ana Ximena. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología “Dr. J.M. Vanella”; Argentina.
Fil: Marramá, Marcela. Municipalidad de Córdoba. Dirección de Especialidades Médicas; Argentina.
Fil: Ruiz, Susana. Laboratorios LACE; Argentina.
Fil: Estofan, Patricia. Centro Integral de Ginecología (CIGOR); Argentina.
Fil: Venezuela, Raúl Fernando. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J. M. Vanella"; Argentina.
Fil: Mosmann, Jessica Paola. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J. M. Vanella"; Argentina.
Fil: Monetti, Marina Soledad. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J. M. Vanella"; Argentina.
Fil: Rivero, Virginia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica; Argentina.
Fil: Rivero, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina.
Fil: Cuffini, Cecilia Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J. M. Vanella"; Argentina.
Chlamydia trachomatis causes the most prevalent bacterial Sexual Transmitted Infection. In pregnant women, untreated chlamydial infections are associated with abortions, premature rupture of membranes, postpartum endometritis, low birth weight and transmission to the newborn. In Córdoba, Argentina, there is little knowledge about the prevalence of Chlamydia trachomatis in women in their third trimester of pregnancy, so, the aim of this study was to evaluate Chlamydia trachomatis prevalence and genotypes present in Cordovan pregnant women with different age and socioeconomic status. Methods and findings Design: prospective study. Settings: Women population from Cordoba city, Argentina. Population: Pregnant women having 35 to 37 weeks of gestation. Methods: Five hundred and nine cervical swabs were collected. Each sample was subjected to DNA extraction and PCR for Chlamydia trachomatis using primers NRO/NLO and CTP1/CTP2. Positives samples were sequenced to determine genotype. Main outcome measures: Demographic data of the patients were collected to detect a population at risk for this infection. Results A prevalence of 6.9% (35/509) for Chlamydia trachomatis infection was detected, with 32/ 295 and 3/214 from pregnant women with low or better economic resources respectively (p = 0,0001). Results showed a significantly increased rate of 11.6% (30/258) in women under 25 years compared with 2% (5/251) in patients over that age (p = 0,00003). Genotype E was the most prevalent. Conclusions With these results, we can say that pregnant women under 25 years old and low economic resources are one of the populations in which the screening programs of Chlamydia trachomatis should focus.
publishedVersion
Fil: Kiguen, Ana Ximena. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología “Dr. J.M. Vanella”; Argentina.
Fil: Marramá, Marcela. Municipalidad de Córdoba. Dirección de Especialidades Médicas; Argentina.
Fil: Ruiz, Susana. Laboratorios LACE; Argentina.
Fil: Estofan, Patricia. Centro Integral de Ginecología (CIGOR); Argentina.
Fil: Venezuela, Raúl Fernando. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J. M. Vanella"; Argentina.
Fil: Mosmann, Jessica Paola. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J. M. Vanella"; Argentina.
Fil: Monetti, Marina Soledad. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J. M. Vanella"; Argentina.
Fil: Rivero, Virginia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica; Argentina.
Fil: Rivero, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina.
Fil: Cuffini, Cecilia Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J. M. Vanella"; Argentina.
Biología Celular, Microbiología
description 10 p.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv Kiguen, Ana Ximena; Marramá, Marcela; Ruiz, Susana; Estofan, Patricia; Venezuela, Raul Fernando; et al.; Prevalence, risk factors and molecular characterization of Chlamydia trachomatis in pregnant women from Córdoba, Argentina: A prospective study; Public Library of Science; Plos One; 14; 5; 5-2019
1932-6203
http://hdl.handle.net/11086/556753
https://doi.org/10.1371/journal.pone.0217245
identifier_str_mv Kiguen, Ana Ximena; Marramá, Marcela; Ruiz, Susana; Estofan, Patricia; Venezuela, Raul Fernando; et al.; Prevalence, risk factors and molecular characterization of Chlamydia trachomatis in pregnant women from Córdoba, Argentina: A prospective study; Public Library of Science; Plos One; 14; 5; 5-2019
1932-6203
url http://hdl.handle.net/11086/556753
https://doi.org/10.1371/journal.pone.0217245
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
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reponame_str Repositorio Digital Universitario (UNC)
collection Repositorio Digital Universitario (UNC)
instname_str Universidad Nacional de Córdoba
instacron_str UNC
institution UNC
repository.name.fl_str_mv Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdoba
repository.mail.fl_str_mv oca.unc@gmail.com
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