Effects Of The L-Arginine Supplementation In The Fetal Development Alterations In A Congenital Chagas Disease Mouse Model

Autores
Díaz Luján, Cintia; Piegari, Mariana; Glocker, Mónica; Triquell, María Fernanda; Mezzano, Luciana; Fretes, Ricardo
Año de publicación
2013
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
3 p.
Fil: Diaz Luján, Cintia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; Argentina
Fil: Piegari, Mariana. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; Argentina
Fil: Glocker, Mónica. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; Argentina
Fil: Triquell, María Fernanda. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; Argentina
Fil: Mezzano, Luciana. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; Argentina
Fil: Fretes, Ricardo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; Argentina
A nutritional protein deficit would induce modifications in fetal development, parasitemia and congenital Chagas transmission, while arginine suministration would improve this situation. Female mice (C3H strain) were fed with hypoproteic (H), and normoproteic (N) diets during a month, some of them were provided also with 0.1% of arginine (Arg). They were infected with Trypanosoma cruzi trypomastigotes and were sacrificed at 14th day of gestation. It was evaluated maternal parasitemia, uterine horns infection, embryos and absorptions quantity; embryos and placentae size, and horns uterine weight. In serum arginine, urea and nitrites was measured. Infection reduces the fetal size independently of diet (HTC=1,092±0,74 mm; NTC=4,81±1,02mm) with respect to the controls (N=7,56±0,42 mm; H=2,72±0,86) (HTC p<0,05; NTC p=0,015). The H diet emphasizes infection effects, affecting fetal development and maternal parasitemia. (HTC=725.000±567.890p; NTC=87.500±88.987p) (p<0.05). Arginine supplementation of low-protein diet had a more marked effect. To decrease significantly from the maternal parasitemia (HTCarg = 300.000 ± 282.842p) (p <0.05) and infection of the uterus (HTCarg=70% PCR+; NTCarg=100% PCR+), plus an increase in the size of the fetuses (HTCarg = 5,75 ± 0,5 mm) (p <0,05) with a tendency to decrease resorption, which were associated with significative increased levels (p<0,05) of nitrite (HTC= 12,66 3,2uM; HTCarg= 26,068,03uM) in maternal serum. Usually, the pregnant women affected with Chagas disease are exposed to unfavorable socio-economic conditions, with deficient diets that would affect fetal development, and would be associated with congenital Chagas transmission. The Arginine supplementation, that was employed in others pregnancy pathologies, would improve fetal development in chagasic pregnancies in the acute phase of infection, possible due to an increment of Nitric Oxide production.
http://www.revista2.fcm.unc.edu.ar/jornadas.pdf
Fil: Diaz Luján, Cintia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; Argentina
Fil: Piegari, Mariana. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; Argentina
Fil: Glocker, Mónica. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; Argentina
Fil: Triquell, María Fernanda. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; Argentina
Fil: Mezzano, Luciana. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; Argentina
Fil: Fretes, Ricardo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; Argentina
Patología
Materia
Chagas
Congénito
Nutrición
L-Arginina
Modelo murino
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Repositorio Digital Universitario (UNC)
Institución
Universidad Nacional de Córdoba
OAI Identificador
oai:rdu.unc.edu.ar:11086/18150
Acceder
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oai_identifier_str oai:rdu.unc.edu.ar:11086/18150
network_acronym_str RDUUNC
repository_id_str 2572
network_name_str Repositorio Digital Universitario (UNC)
spelling Effects Of The L-Arginine Supplementation In The Fetal Development Alterations In A Congenital Chagas Disease Mouse ModelEfecto de la suplementación con L-Arginina en las alteraciones del desarrollo fetal en un modelo de enfermedad de Chagas congénito en ratonesDíaz Luján, CintiaPiegari, MarianaGlocker, MónicaTriquell, María FernandaMezzano, LucianaFretes, RicardoChagasCongénitoNutriciónL-ArgininaModelo murino3 p.Fil: Diaz Luján, Cintia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; ArgentinaFil: Piegari, Mariana. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; ArgentinaFil: Glocker, Mónica. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; ArgentinaFil: Triquell, María Fernanda. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; ArgentinaFil: Mezzano, Luciana. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; ArgentinaFil: Fretes, Ricardo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; ArgentinaA nutritional protein deficit would induce modifications in fetal development, parasitemia and congenital Chagas transmission, while arginine suministration would improve this situation. Female mice (C3H strain) were fed with hypoproteic (H), and normoproteic (N) diets during a month, some of them were provided also with 0.1% of arginine (Arg). They were infected with Trypanosoma cruzi trypomastigotes and were sacrificed at 14th day of gestation. It was evaluated maternal parasitemia, uterine horns infection, embryos and absorptions quantity; embryos and placentae size, and horns uterine weight. In serum arginine, urea and nitrites was measured. Infection reduces the fetal size independently of diet (HTC=1,092±0,74 mm; NTC=4,81±1,02mm) with respect to the controls (N=7,56±0,42 mm; H=2,72±0,86) (HTC p<0,05; NTC p=0,015). The H diet emphasizes infection effects, affecting fetal development and maternal parasitemia. (HTC=725.000±567.890p; NTC=87.500±88.987p) (p<0.05). Arginine supplementation of low-protein diet had a more marked effect. To decrease significantly from the maternal parasitemia (HTCarg = 300.000 ± 282.842p) (p <0.05) and infection of the uterus (HTCarg=70% PCR+; NTCarg=100% PCR+), plus an increase in the size of the fetuses (HTCarg = 5,75 ± 0,5 mm) (p <0,05) with a tendency to decrease resorption, which were associated with significative increased levels (p<0,05) of nitrite (HTC= 12,66 3,2uM; HTCarg= 26,068,03uM) in maternal serum. Usually, the pregnant women affected with Chagas disease are exposed to unfavorable socio-economic conditions, with deficient diets that would affect fetal development, and would be associated with congenital Chagas transmission. The Arginine supplementation, that was employed in others pregnancy pathologies, would improve fetal development in chagasic pregnancies in the acute phase of infection, possible due to an increment of Nitric Oxide production.http://www.revista2.fcm.unc.edu.ar/jornadas.pdfFil: Diaz Luján, Cintia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; ArgentinaFil: Piegari, Mariana. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; ArgentinaFil: Glocker, Mónica. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; ArgentinaFil: Triquell, María Fernanda. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; ArgentinaFil: Mezzano, Luciana. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; ArgentinaFil: Fretes, Ricardo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; ArgentinaPatologíaUniversidad Nacional de Córdoba. Facultad de Ciencias Médicas2013info:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfhttp://hdl.handle.net/11086/18150eng11086/14404info:eu-repo/semantics/openAccessreponame:Repositorio Digital Universitario (UNC)instname:Universidad Nacional de Córdobainstacron:UNC2025-11-06T09:40:26Zoai:rdu.unc.edu.ar:11086/18150Institucionalhttps://rdu.unc.edu.ar/Universidad públicaNo correspondehttp://rdu.unc.edu.ar/oai/snrdoca.unc@gmail.comArgentinaNo correspondeNo correspondeNo correspondeopendoar:25722025-11-06 09:40:27.171Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdobafalse
dc.title.none.fl_str_mv Effects Of The L-Arginine Supplementation In The Fetal Development Alterations In A Congenital Chagas Disease Mouse Model
Efecto de la suplementación con L-Arginina en las alteraciones del desarrollo fetal en un modelo de enfermedad de Chagas congénito en ratones
title Effects Of The L-Arginine Supplementation In The Fetal Development Alterations In A Congenital Chagas Disease Mouse Model
spellingShingle Effects Of The L-Arginine Supplementation In The Fetal Development Alterations In A Congenital Chagas Disease Mouse Model
Díaz Luján, Cintia
Chagas
Congénito
Nutrición
L-Arginina
Modelo murino
title_short Effects Of The L-Arginine Supplementation In The Fetal Development Alterations In A Congenital Chagas Disease Mouse Model
title_full Effects Of The L-Arginine Supplementation In The Fetal Development Alterations In A Congenital Chagas Disease Mouse Model
title_fullStr Effects Of The L-Arginine Supplementation In The Fetal Development Alterations In A Congenital Chagas Disease Mouse Model
title_full_unstemmed Effects Of The L-Arginine Supplementation In The Fetal Development Alterations In A Congenital Chagas Disease Mouse Model
title_sort Effects Of The L-Arginine Supplementation In The Fetal Development Alterations In A Congenital Chagas Disease Mouse Model
dc.creator.none.fl_str_mv Díaz Luján, Cintia
Piegari, Mariana
Glocker, Mónica
Triquell, María Fernanda
Mezzano, Luciana
Fretes, Ricardo
author Díaz Luján, Cintia
author_facet Díaz Luján, Cintia
Piegari, Mariana
Glocker, Mónica
Triquell, María Fernanda
Mezzano, Luciana
Fretes, Ricardo
author_role author
author2 Piegari, Mariana
Glocker, Mónica
Triquell, María Fernanda
Mezzano, Luciana
Fretes, Ricardo
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Chagas
Congénito
Nutrición
L-Arginina
Modelo murino
topic Chagas
Congénito
Nutrición
L-Arginina
Modelo murino
dc.description.none.fl_txt_mv 3 p.
Fil: Diaz Luján, Cintia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; Argentina
Fil: Piegari, Mariana. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; Argentina
Fil: Glocker, Mónica. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; Argentina
Fil: Triquell, María Fernanda. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; Argentina
Fil: Mezzano, Luciana. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; Argentina
Fil: Fretes, Ricardo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; Argentina
A nutritional protein deficit would induce modifications in fetal development, parasitemia and congenital Chagas transmission, while arginine suministration would improve this situation. Female mice (C3H strain) were fed with hypoproteic (H), and normoproteic (N) diets during a month, some of them were provided also with 0.1% of arginine (Arg). They were infected with Trypanosoma cruzi trypomastigotes and were sacrificed at 14th day of gestation. It was evaluated maternal parasitemia, uterine horns infection, embryos and absorptions quantity; embryos and placentae size, and horns uterine weight. In serum arginine, urea and nitrites was measured. Infection reduces the fetal size independently of diet (HTC=1,092±0,74 mm; NTC=4,81±1,02mm) with respect to the controls (N=7,56±0,42 mm; H=2,72±0,86) (HTC p<0,05; NTC p=0,015). The H diet emphasizes infection effects, affecting fetal development and maternal parasitemia. (HTC=725.000±567.890p; NTC=87.500±88.987p) (p<0.05). Arginine supplementation of low-protein diet had a more marked effect. To decrease significantly from the maternal parasitemia (HTCarg = 300.000 ± 282.842p) (p <0.05) and infection of the uterus (HTCarg=70% PCR+; NTCarg=100% PCR+), plus an increase in the size of the fetuses (HTCarg = 5,75 ± 0,5 mm) (p <0,05) with a tendency to decrease resorption, which were associated with significative increased levels (p<0,05) of nitrite (HTC= 12,66 3,2uM; HTCarg= 26,068,03uM) in maternal serum. Usually, the pregnant women affected with Chagas disease are exposed to unfavorable socio-economic conditions, with deficient diets that would affect fetal development, and would be associated with congenital Chagas transmission. The Arginine supplementation, that was employed in others pregnancy pathologies, would improve fetal development in chagasic pregnancies in the acute phase of infection, possible due to an increment of Nitric Oxide production.
http://www.revista2.fcm.unc.edu.ar/jornadas.pdf
Fil: Diaz Luján, Cintia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; Argentina
Fil: Piegari, Mariana. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; Argentina
Fil: Glocker, Mónica. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; Argentina
Fil: Triquell, María Fernanda. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; Argentina
Fil: Mezzano, Luciana. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; Argentina
Fil: Fretes, Ricardo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Biología Celular, Histología y Embriología; Argentina
Patología
description 3 p.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/conferenceObject
info:eu-repo/semantics/publishedVersion
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format conferenceObject
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11086/18150
url http://hdl.handle.net/11086/18150
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 11086/14404
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Nacional de Córdoba. Facultad de Ciencias Médicas
publisher.none.fl_str_mv Universidad Nacional de Córdoba. Facultad de Ciencias Médicas
dc.source.none.fl_str_mv reponame:Repositorio Digital Universitario (UNC)
instname:Universidad Nacional de Córdoba
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reponame_str Repositorio Digital Universitario (UNC)
collection Repositorio Digital Universitario (UNC)
instname_str Universidad Nacional de Córdoba
instacron_str UNC
institution UNC
repository.name.fl_str_mv Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdoba
repository.mail.fl_str_mv oca.unc@gmail.com
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