Failure of Dental Implants and its Association with IL-10 A/G rs1800896 and TNF-α G308A rs1800629308 Polymorphisms, Systematic Review, and Meta-Analysis of Clinical Trials
- Autores
- Bono, Alejandra; Brunotto, Mabel Noemí; Ibañez, Juan Carlos; Murúa, María Julia; Ghirardi, Federico; García, Lucrecia; Dantur, Andrea
- Año de publicación
- 2025
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Bono, Alejandra, Liliana. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de patología oral; Argentina.
Fil: Brunotto, Mabel Noemí. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de biología oral; Argentina.
Fil: Ibañez, Juan Carlos. Universidad Católica de Córdoba. Especialización en Implantología Oral; Argentina.
Fil: Murúa, María Julia. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de patología oral; Argentina.
Fil: Ghirardi, Federico. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de patología oral; Argentina.
Fil: García, Lucrecia. Universidad Nacional de Córdoba. Facultad de Odontología. Biblioteca Dr. Agustín Larrauri; Argentina.
Fil: Dantur, Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de patología oral; Argentina.
The general objective of this work was to evaluate the IL-10 A/G rs1800896 and TNF-α G308A rs1800629308 polymorphisms with the loss of one or more dental implants through a systematic review and meta-analysis of clinical trials. The PRISMA guidelines established for systematic reviews and meta-analyses were followed. It was carried out on randomized controlled clinical trials, epidemiological studies obtained from the MEDLINE, EMBASE, LILACS, IBECS and Cochrane databases. The initial search returned 593 results. 28 articles were selected, and we excluded 12 studies that did not describe the genetic polymorphism we were looking for related to dental implant survival. Therefore, we included 4 articles in this review. We analyzed all these different categories of genes with their respective polymorphisms (IL-1A [-889], IL-1B [+3954], IL-1B [+3953], IL-1B [-511], IL-4 [+33 ], IL-4 [-590], IL-6 [-174], IL-10 [-1082], IL-10 [-819], IL-10 [-592], IL-1 receptor antagonist [IL-1ra]), tumor necrosis factor (TNF-α [-308]). There are very few comprehensive studies that have the same methodologies and similar data analyzes to be able to compare them that include the types of SNPs altered in the gene related to reduced implant survival to perform the meta-analysis. This systematic review confirms results that are still controversial due to the limited sample size, the definition in the terminology dental implant failure not yet defined equally in all studies, and the non-homogeneous inclusion and exclusion criteria, which include race, age, smoking, occlusion trauma, and periodontal disease.
info:eu-repo/semantics/publishedVersion
Fil: Bono, Alejandra, Liliana. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de patología oral; Argentina.
Fil: Brunotto, Mabel Noemí. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de biología oral; Argentina.
Fil: Ibañez, Juan Carlos. Universidad Católica de Córdoba. Especialización en Implantología Oral; Argentina.
Fil: Murúa, María Julia. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de patología oral; Argentina.
Fil: Ghirardi, Federico. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de patología oral; Argentina.
Fil: García, Lucrecia. Universidad Nacional de Córdoba. Facultad de Odontología. Biblioteca Dr. Agustín Larrauri; Argentina.
Fil: Dantur, Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de patología oral; Argentina. - Materia
-
Dental implants
Implant failure
Polymorphisms
Systematic review - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- Repositorio
.jpg)
- Institución
- Universidad Nacional de Córdoba
- OAI Identificador
- oai:rdu.unc.edu.ar:11086/555984
Ver los metadatos del registro completo
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Failure of Dental Implants and its Association with IL-10 A/G rs1800896 and TNF-α G308A rs1800629308 Polymorphisms, Systematic Review, and Meta-Analysis of Clinical TrialsBono, AlejandraBrunotto, Mabel NoemíIbañez, Juan CarlosMurúa, María JuliaGhirardi, FedericoGarcía, LucreciaDantur, AndreaDental implantsImplant failurePolymorphismsSystematic reviewFil: Bono, Alejandra, Liliana. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de patología oral; Argentina.Fil: Brunotto, Mabel Noemí. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de biología oral; Argentina.Fil: Ibañez, Juan Carlos. Universidad Católica de Córdoba. Especialización en Implantología Oral; Argentina.Fil: Murúa, María Julia. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de patología oral; Argentina.Fil: Ghirardi, Federico. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de patología oral; Argentina.Fil: García, Lucrecia. Universidad Nacional de Córdoba. Facultad de Odontología. Biblioteca Dr. Agustín Larrauri; Argentina.Fil: Dantur, Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de patología oral; Argentina.The general objective of this work was to evaluate the IL-10 A/G rs1800896 and TNF-α G308A rs1800629308 polymorphisms with the loss of one or more dental implants through a systematic review and meta-analysis of clinical trials. The PRISMA guidelines established for systematic reviews and meta-analyses were followed. It was carried out on randomized controlled clinical trials, epidemiological studies obtained from the MEDLINE, EMBASE, LILACS, IBECS and Cochrane databases. The initial search returned 593 results. 28 articles were selected, and we excluded 12 studies that did not describe the genetic polymorphism we were looking for related to dental implant survival. Therefore, we included 4 articles in this review. We analyzed all these different categories of genes with their respective polymorphisms (IL-1A [-889], IL-1B [+3954], IL-1B [+3953], IL-1B [-511], IL-4 [+33 ], IL-4 [-590], IL-6 [-174], IL-10 [-1082], IL-10 [-819], IL-10 [-592], IL-1 receptor antagonist [IL-1ra]), tumor necrosis factor (TNF-α [-308]). There are very few comprehensive studies that have the same methodologies and similar data analyzes to be able to compare them that include the types of SNPs altered in the gene related to reduced implant survival to perform the meta-analysis. This systematic review confirms results that are still controversial due to the limited sample size, the definition in the terminology dental implant failure not yet defined equally in all studies, and the non-homogeneous inclusion and exclusion criteria, which include race, age, smoking, occlusion trauma, and periodontal disease.info:eu-repo/semantics/publishedVersionFil: Bono, Alejandra, Liliana. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de patología oral; Argentina.Fil: Brunotto, Mabel Noemí. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de biología oral; Argentina.Fil: Ibañez, Juan Carlos. Universidad Católica de Córdoba. Especialización en Implantología Oral; Argentina.Fil: Murúa, María Julia. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de patología oral; Argentina.Fil: Ghirardi, Federico. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de patología oral; Argentina.Fil: García, Lucrecia. Universidad Nacional de Córdoba. Facultad de Odontología. Biblioteca Dr. Agustín Larrauri; Argentina.Fil: Dantur, Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de patología oral; Argentina.https://orcid.org/0000-0003-3684-1947https://orcid.org/0000-0001-8010-1079https://orcid.org/0000-0001-6857-4818https://orcid.org/0000-0002-8111-13992025-03-25info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfBono, A., Brunotto, M. N., Ibanez, J. C., Murúa, M. J., Ghirardi, F., García, L., & Dantur, A. (2025). Failure of Dental Implants and its Association with IL-10 A/G rs1800896 and TNF-α G308A rs1800629308 Polymorphisms, Systematic Review, and Meta-Analysis of Clinical Trials. European Journal of Dental and Oral Health, 6(2), 1–7. https://doi.org/10.24018/ejdent.2025.6.2.3702684-4443http://hdl.handle.net/11086/55598410.24018/ejdent.2025.6.2.370enginfo:eu-repo/semantics/openAccessreponame:Repositorio Digital Universitario (UNC)instname:Universidad Nacional de Córdobainstacron:UNC2025-09-04T12:34:46Zoai:rdu.unc.edu.ar:11086/555984Institucionalhttps://rdu.unc.edu.ar/Universidad públicaNo correspondehttp://rdu.unc.edu.ar/oai/snrdoca.unc@gmail.comArgentinaNo correspondeNo correspondeNo correspondeopendoar:25722025-09-04 12:34:47.164Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdobafalse |
| dc.title.none.fl_str_mv |
Failure of Dental Implants and its Association with IL-10 A/G rs1800896 and TNF-α G308A rs1800629308 Polymorphisms, Systematic Review, and Meta-Analysis of Clinical Trials |
| title |
Failure of Dental Implants and its Association with IL-10 A/G rs1800896 and TNF-α G308A rs1800629308 Polymorphisms, Systematic Review, and Meta-Analysis of Clinical Trials |
| spellingShingle |
Failure of Dental Implants and its Association with IL-10 A/G rs1800896 and TNF-α G308A rs1800629308 Polymorphisms, Systematic Review, and Meta-Analysis of Clinical Trials Bono, Alejandra Dental implants Implant failure Polymorphisms Systematic review |
| title_short |
Failure of Dental Implants and its Association with IL-10 A/G rs1800896 and TNF-α G308A rs1800629308 Polymorphisms, Systematic Review, and Meta-Analysis of Clinical Trials |
| title_full |
Failure of Dental Implants and its Association with IL-10 A/G rs1800896 and TNF-α G308A rs1800629308 Polymorphisms, Systematic Review, and Meta-Analysis of Clinical Trials |
| title_fullStr |
Failure of Dental Implants and its Association with IL-10 A/G rs1800896 and TNF-α G308A rs1800629308 Polymorphisms, Systematic Review, and Meta-Analysis of Clinical Trials |
| title_full_unstemmed |
Failure of Dental Implants and its Association with IL-10 A/G rs1800896 and TNF-α G308A rs1800629308 Polymorphisms, Systematic Review, and Meta-Analysis of Clinical Trials |
| title_sort |
Failure of Dental Implants and its Association with IL-10 A/G rs1800896 and TNF-α G308A rs1800629308 Polymorphisms, Systematic Review, and Meta-Analysis of Clinical Trials |
| dc.creator.none.fl_str_mv |
Bono, Alejandra Brunotto, Mabel Noemí Ibañez, Juan Carlos Murúa, María Julia Ghirardi, Federico García, Lucrecia Dantur, Andrea |
| author |
Bono, Alejandra |
| author_facet |
Bono, Alejandra Brunotto, Mabel Noemí Ibañez, Juan Carlos Murúa, María Julia Ghirardi, Federico García, Lucrecia Dantur, Andrea |
| author_role |
author |
| author2 |
Brunotto, Mabel Noemí Ibañez, Juan Carlos Murúa, María Julia Ghirardi, Federico García, Lucrecia Dantur, Andrea |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
https://orcid.org/0000-0003-3684-1947 https://orcid.org/0000-0001-8010-1079 https://orcid.org/0000-0001-6857-4818 https://orcid.org/0000-0002-8111-1399 |
| dc.subject.none.fl_str_mv |
Dental implants Implant failure Polymorphisms Systematic review |
| topic |
Dental implants Implant failure Polymorphisms Systematic review |
| dc.description.none.fl_txt_mv |
Fil: Bono, Alejandra, Liliana. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de patología oral; Argentina. Fil: Brunotto, Mabel Noemí. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de biología oral; Argentina. Fil: Ibañez, Juan Carlos. Universidad Católica de Córdoba. Especialización en Implantología Oral; Argentina. Fil: Murúa, María Julia. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de patología oral; Argentina. Fil: Ghirardi, Federico. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de patología oral; Argentina. Fil: García, Lucrecia. Universidad Nacional de Córdoba. Facultad de Odontología. Biblioteca Dr. Agustín Larrauri; Argentina. Fil: Dantur, Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de patología oral; Argentina. The general objective of this work was to evaluate the IL-10 A/G rs1800896 and TNF-α G308A rs1800629308 polymorphisms with the loss of one or more dental implants through a systematic review and meta-analysis of clinical trials. The PRISMA guidelines established for systematic reviews and meta-analyses were followed. It was carried out on randomized controlled clinical trials, epidemiological studies obtained from the MEDLINE, EMBASE, LILACS, IBECS and Cochrane databases. The initial search returned 593 results. 28 articles were selected, and we excluded 12 studies that did not describe the genetic polymorphism we were looking for related to dental implant survival. Therefore, we included 4 articles in this review. We analyzed all these different categories of genes with their respective polymorphisms (IL-1A [-889], IL-1B [+3954], IL-1B [+3953], IL-1B [-511], IL-4 [+33 ], IL-4 [-590], IL-6 [-174], IL-10 [-1082], IL-10 [-819], IL-10 [-592], IL-1 receptor antagonist [IL-1ra]), tumor necrosis factor (TNF-α [-308]). There are very few comprehensive studies that have the same methodologies and similar data analyzes to be able to compare them that include the types of SNPs altered in the gene related to reduced implant survival to perform the meta-analysis. This systematic review confirms results that are still controversial due to the limited sample size, the definition in the terminology dental implant failure not yet defined equally in all studies, and the non-homogeneous inclusion and exclusion criteria, which include race, age, smoking, occlusion trauma, and periodontal disease. info:eu-repo/semantics/publishedVersion Fil: Bono, Alejandra, Liliana. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de patología oral; Argentina. Fil: Brunotto, Mabel Noemí. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de biología oral; Argentina. Fil: Ibañez, Juan Carlos. Universidad Católica de Córdoba. Especialización en Implantología Oral; Argentina. Fil: Murúa, María Julia. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de patología oral; Argentina. Fil: Ghirardi, Federico. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de patología oral; Argentina. Fil: García, Lucrecia. Universidad Nacional de Córdoba. Facultad de Odontología. Biblioteca Dr. Agustín Larrauri; Argentina. Fil: Dantur, Andrea. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de patología oral; Argentina. |
| description |
Fil: Bono, Alejandra, Liliana. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de patología oral; Argentina. |
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2025 |
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2025-03-25 |
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Bono, A., Brunotto, M. N., Ibanez, J. C., Murúa, M. J., Ghirardi, F., García, L., & Dantur, A. (2025). Failure of Dental Implants and its Association with IL-10 A/G rs1800896 and TNF-α G308A rs1800629308 Polymorphisms, Systematic Review, and Meta-Analysis of Clinical Trials. European Journal of Dental and Oral Health, 6(2), 1–7. https://doi.org/10.24018/ejdent.2025.6.2.370 2684-4443 http://hdl.handle.net/11086/555984 10.24018/ejdent.2025.6.2.370 |
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Bono, A., Brunotto, M. N., Ibanez, J. C., Murúa, M. J., Ghirardi, F., García, L., & Dantur, A. (2025). Failure of Dental Implants and its Association with IL-10 A/G rs1800896 and TNF-α G308A rs1800629308 Polymorphisms, Systematic Review, and Meta-Analysis of Clinical Trials. European Journal of Dental and Oral Health, 6(2), 1–7. https://doi.org/10.24018/ejdent.2025.6.2.370 2684-4443 10.24018/ejdent.2025.6.2.370 |
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