Risk polymorphisms in oral leukoplakia: a sistematic review
- Autores
- Bono, Alejandra; Zarate, Ana María; Don, Julieta; Barra, José Luis; Brunotto, Mabel
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- Fil: Bono, Alejandra. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Patología Bucal; Argentina.
Fil: Zarate, Ana María. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Biología Bucal; Argentina.
Fil: Don, Julieta. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Biología Bucal; Argentina.
Fil: Barra, José Luis. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica; Argentina.
Fil: Brunotto, Mabel. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Biología Bucal; Argentina.
Introduction: The greatest challenge is to predict which oral leukoplakia (OL) will be able to progress to oral squamous cell carcinoma.Purpose: Generally, the systematic reviews and meta-analysis of polymorphisms are focused in genes related to unique cellular process; in this work, our goal was to identify studied genes in last decade and to know which ones are related to the risk of developing OL.Method: Eligible gene/polymorphism studies were identified by electronic searches. Individual participant data of 2054 Oral Leukoplakia and 3493 controls from 16 genetic studies were analyzed, yielding adjusted (tobacco, gender, age and alcohol) odds ratios (OR) and 95% confidence intervals (CIs) comparing cases with controls.Results: The following genes/polymorphisms were seen to have significant association with increased risk of OL: CYPA1 (m1/m2), XDP (Gln/Gln), GSTM1 (null), and P53 (intron 6). In contrast, COX-2 (exon 10), P53 (intron 3), XRCC3 (GG), and PRKDC (rs7003908) polymorphisms are associated with a diminished risk of OL. Conclusions: According to the results of this work, we conclude that all genotypes are heterozygous or homozygous for the polymorphic variants; and the people with genotypes CYP1A1 m1/m2, XDP Gln/Gln, GSTM1 null, P53 intron 6, XRCC3 rs861539, COX2 -765 have high risk of presented OL, and therefore they are more exposed to oral cancer risk.
https://doi.org/10.1002/hed.24138
Fil: Bono, Alejandra. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Patología Bucal; Argentina.
Fil: Zarate, Ana María. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Biología Bucal; Argentina.
Fil: Don, Julieta. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Biología Bucal; Argentina.
Fil: Barra, José Luis. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica; Argentina.
Fil: Brunotto, Mabel. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Biología Bucal; Argentina.
Otras Ciencias de la Salud - Materia
-
Polymorphisms
Oral cáncer
Oral cáncer - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- Repositorio
.jpg)
- Institución
- Universidad Nacional de Córdoba
- OAI Identificador
- oai:rdu.unc.edu.ar:11086/556099
Ver los metadatos del registro completo
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Risk polymorphisms in oral leukoplakia: a sistematic reviewBono, AlejandraZarate, Ana MaríaDon, JulietaBarra, José LuisBrunotto, MabelPolymorphismsOral cáncerOral cáncerFil: Bono, Alejandra. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Patología Bucal; Argentina.Fil: Zarate, Ana María. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Biología Bucal; Argentina.Fil: Don, Julieta. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Biología Bucal; Argentina.Fil: Barra, José Luis. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica; Argentina.Fil: Brunotto, Mabel. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Biología Bucal; Argentina.Introduction: The greatest challenge is to predict which oral leukoplakia (OL) will be able to progress to oral squamous cell carcinoma.Purpose: Generally, the systematic reviews and meta-analysis of polymorphisms are focused in genes related to unique cellular process; in this work, our goal was to identify studied genes in last decade and to know which ones are related to the risk of developing OL.Method: Eligible gene/polymorphism studies were identified by electronic searches. Individual participant data of 2054 Oral Leukoplakia and 3493 controls from 16 genetic studies were analyzed, yielding adjusted (tobacco, gender, age and alcohol) odds ratios (OR) and 95% confidence intervals (CIs) comparing cases with controls.Results: The following genes/polymorphisms were seen to have significant association with increased risk of OL: CYPA1 (m1/m2), XDP (Gln/Gln), GSTM1 (null), and P53 (intron 6). In contrast, COX-2 (exon 10), P53 (intron 3), XRCC3 (GG), and PRKDC (rs7003908) polymorphisms are associated with a diminished risk of OL. Conclusions: According to the results of this work, we conclude that all genotypes are heterozygous or homozygous for the polymorphic variants; and the people with genotypes CYP1A1 m1/m2, XDP Gln/Gln, GSTM1 null, P53 intron 6, XRCC3 rs861539, COX2 -765 have high risk of presented OL, and therefore they are more exposed to oral cancer risk.https://doi.org/10.1002/hed.24138Fil: Bono, Alejandra. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Patología Bucal; Argentina.Fil: Zarate, Ana María. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Biología Bucal; Argentina.Fil: Don, Julieta. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Biología Bucal; Argentina.Fil: Barra, José Luis. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica; Argentina.Fil: Brunotto, Mabel. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Biología Bucal; Argentina.Otras Ciencias de la Salud2015info:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfhttp://hdl.handle.net/11086/556099enginfo:eu-repo/semantics/openAccessreponame:Repositorio Digital Universitario (UNC)instname:Universidad Nacional de Córdobainstacron:UNC2025-09-04T12:34:35Zoai:rdu.unc.edu.ar:11086/556099Institucionalhttps://rdu.unc.edu.ar/Universidad públicaNo correspondehttp://rdu.unc.edu.ar/oai/snrdoca.unc@gmail.comArgentinaNo correspondeNo correspondeNo correspondeopendoar:25722025-09-04 12:34:35.276Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdobafalse |
| dc.title.none.fl_str_mv |
Risk polymorphisms in oral leukoplakia: a sistematic review |
| title |
Risk polymorphisms in oral leukoplakia: a sistematic review |
| spellingShingle |
Risk polymorphisms in oral leukoplakia: a sistematic review Bono, Alejandra Polymorphisms Oral cáncer Oral cáncer |
| title_short |
Risk polymorphisms in oral leukoplakia: a sistematic review |
| title_full |
Risk polymorphisms in oral leukoplakia: a sistematic review |
| title_fullStr |
Risk polymorphisms in oral leukoplakia: a sistematic review |
| title_full_unstemmed |
Risk polymorphisms in oral leukoplakia: a sistematic review |
| title_sort |
Risk polymorphisms in oral leukoplakia: a sistematic review |
| dc.creator.none.fl_str_mv |
Bono, Alejandra Zarate, Ana María Don, Julieta Barra, José Luis Brunotto, Mabel |
| author |
Bono, Alejandra |
| author_facet |
Bono, Alejandra Zarate, Ana María Don, Julieta Barra, José Luis Brunotto, Mabel |
| author_role |
author |
| author2 |
Zarate, Ana María Don, Julieta Barra, José Luis Brunotto, Mabel |
| author2_role |
author author author author |
| dc.subject.none.fl_str_mv |
Polymorphisms Oral cáncer Oral cáncer |
| topic |
Polymorphisms Oral cáncer Oral cáncer |
| dc.description.none.fl_txt_mv |
Fil: Bono, Alejandra. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Patología Bucal; Argentina. Fil: Zarate, Ana María. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Biología Bucal; Argentina. Fil: Don, Julieta. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Biología Bucal; Argentina. Fil: Barra, José Luis. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica; Argentina. Fil: Brunotto, Mabel. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Biología Bucal; Argentina. Introduction: The greatest challenge is to predict which oral leukoplakia (OL) will be able to progress to oral squamous cell carcinoma.Purpose: Generally, the systematic reviews and meta-analysis of polymorphisms are focused in genes related to unique cellular process; in this work, our goal was to identify studied genes in last decade and to know which ones are related to the risk of developing OL.Method: Eligible gene/polymorphism studies were identified by electronic searches. Individual participant data of 2054 Oral Leukoplakia and 3493 controls from 16 genetic studies were analyzed, yielding adjusted (tobacco, gender, age and alcohol) odds ratios (OR) and 95% confidence intervals (CIs) comparing cases with controls.Results: The following genes/polymorphisms were seen to have significant association with increased risk of OL: CYPA1 (m1/m2), XDP (Gln/Gln), GSTM1 (null), and P53 (intron 6). In contrast, COX-2 (exon 10), P53 (intron 3), XRCC3 (GG), and PRKDC (rs7003908) polymorphisms are associated with a diminished risk of OL. Conclusions: According to the results of this work, we conclude that all genotypes are heterozygous or homozygous for the polymorphic variants; and the people with genotypes CYP1A1 m1/m2, XDP Gln/Gln, GSTM1 null, P53 intron 6, XRCC3 rs861539, COX2 -765 have high risk of presented OL, and therefore they are more exposed to oral cancer risk. https://doi.org/10.1002/hed.24138 Fil: Bono, Alejandra. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Patología Bucal; Argentina. Fil: Zarate, Ana María. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Biología Bucal; Argentina. Fil: Don, Julieta. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Biología Bucal; Argentina. Fil: Barra, José Luis. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica; Argentina. Fil: Brunotto, Mabel. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Biología Bucal; Argentina. Otras Ciencias de la Salud |
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Fil: Bono, Alejandra. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Patología Bucal; Argentina. |
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