Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides

Autores
Vera, Berta; Santa Cruz, Silvia; Magnarelli, Gladis
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión aceptada
Descripción
Blood cholinesterases and tissue carboxylesterases (CEs) are sensitive indicators of environmental organophosphate pesticides (OPs) exposure. The aim of this pilot study was to assess the impact of OP exposure on placental CE activity and lipid composition. We performed a study of 40 healthy women who live in agricultural farms. Samples were collected during the pulverization period (PP) and recess period (RP). The plasma cholinesterase and placental CE activity decreased in PP, suggesting that women were exposed to OPs and that these pesticides reached the placenta. The cardiolipin content increased and the phosphatidylethanolamine content decreased in the light mitochondrial fraction while total cholesterol and sphingomyelin increased in the nuclear fraction. These changes in lipid profiles suggest repair by hyperplasia of the cytotrophoblast. Decreased CE activity may have clinical and toxicological implications and thus entail potential risks to damage fetal growth and development.
Fil: Vera, Berta. Universidad Nacional del Comahue. Instituto Multidisciplinario de Investigación y Desarrollo de la Patagonia Norte; Argentina.
Fil: Vera, Berta. Universidad Nacional del Comahue. Facultad de Ciencias Médicas; Argentina.
Fil: Vera, Berta. Concejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
Fil: Magnarelli, Gladis. Universidad Nacional del Comahue. Facultad de Ingeniería. Instituto Multidisciplinario de Investigación y Desarrollo de la Patagonia Norte; Argentina.
Fil: Magnarelli, Gladis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
Fil: Magnarelli, Gladis. Universidad Nacional del Comahue. Facultad Ciencias Médicas; Argentina.
Fil: Santa Cruz, Silvia. Hospital Área Programa Cinco Saltos. Rio Negro; Argentina.
Fuente
ReproductiveToxicology 34 (2012)
Materia
Organophosphate pesticides
Carboxylesterase
Lipid composition
Placenta
Ciencias de la Tierra y Medio Ambiente
Ciencias Biomédicas
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
Repositorio Digital Institucional (UNCo)
Institución
Universidad Nacional del Comahue
OAI Identificador
oai:rdi.uncoma.edu.ar:uncomaid/15224
Acceder
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oai_identifier_str oai:rdi.uncoma.edu.ar:uncomaid/15224
network_acronym_str RDIUNCO
repository_id_str 7108
network_name_str Repositorio Digital Institucional (UNCo)
spelling Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticidesVera, BertaSanta Cruz, SilviaMagnarelli, GladisOrganophosphate pesticidesCarboxylesteraseLipid compositionPlacentaCiencias de la Tierra y Medio AmbienteCiencias BiomédicasBlood cholinesterases and tissue carboxylesterases (CEs) are sensitive indicators of environmental organophosphate pesticides (OPs) exposure. The aim of this pilot study was to assess the impact of OP exposure on placental CE activity and lipid composition. We performed a study of 40 healthy women who live in agricultural farms. Samples were collected during the pulverization period (PP) and recess period (RP). The plasma cholinesterase and placental CE activity decreased in PP, suggesting that women were exposed to OPs and that these pesticides reached the placenta. The cardiolipin content increased and the phosphatidylethanolamine content decreased in the light mitochondrial fraction while total cholesterol and sphingomyelin increased in the nuclear fraction. These changes in lipid profiles suggest repair by hyperplasia of the cytotrophoblast. Decreased CE activity may have clinical and toxicological implications and thus entail potential risks to damage fetal growth and development.Fil: Vera, Berta. Universidad Nacional del Comahue. Instituto Multidisciplinario de Investigación y Desarrollo de la Patagonia Norte; Argentina.Fil: Vera, Berta. Universidad Nacional del Comahue. Facultad de Ciencias Médicas; Argentina.Fil: Vera, Berta. Concejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Magnarelli, Gladis. Universidad Nacional del Comahue. Facultad de Ingeniería. Instituto Multidisciplinario de Investigación y Desarrollo de la Patagonia Norte; Argentina.Fil: Magnarelli, Gladis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Magnarelli, Gladis. Universidad Nacional del Comahue. Facultad Ciencias Médicas; Argentina.Fil: Santa Cruz, Silvia. Hospital Área Programa Cinco Saltos. Rio Negro; Argentina.ElsevierBoard2012-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfpp. 402-407application/pdfhttp://rdi.uncoma.edu.ar/handle/uncomaid/152240890-6238ReproductiveToxicology 34 (2012)reponame:Repositorio Digital Institucional (UNCo)instname:Universidad Nacional del Comahueenghttps://www.journals.elsevier.com/reproductive-toxicologyinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/2025-09-29T14:29:01Zoai:rdi.uncoma.edu.ar:uncomaid/15224instacron:UNCoInstitucionalhttp://rdi.uncoma.edu.ar/Universidad públicaNo correspondehttp://rdi.uncoma.edu.ar/oaimirtha.mateo@biblioteca.uncoma.edu.ar; adriana.acuna@biblioteca.uncoma.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:71082025-09-29 14:29:02.247Repositorio Digital Institucional (UNCo) - Universidad Nacional del Comahuefalse
dc.title.none.fl_str_mv Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides
title Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides
spellingShingle Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides
Vera, Berta
Organophosphate pesticides
Carboxylesterase
Lipid composition
Placenta
Ciencias de la Tierra y Medio Ambiente
Ciencias Biomédicas
title_short Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides
title_full Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides
title_fullStr Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides
title_full_unstemmed Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides
title_sort Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides
dc.creator.none.fl_str_mv Vera, Berta
Santa Cruz, Silvia
Magnarelli, Gladis
author Vera, Berta
author_facet Vera, Berta
Santa Cruz, Silvia
Magnarelli, Gladis
author_role author
author2 Santa Cruz, Silvia
Magnarelli, Gladis
author2_role author
author
dc.subject.none.fl_str_mv Organophosphate pesticides
Carboxylesterase
Lipid composition
Placenta
Ciencias de la Tierra y Medio Ambiente
Ciencias Biomédicas
topic Organophosphate pesticides
Carboxylesterase
Lipid composition
Placenta
Ciencias de la Tierra y Medio Ambiente
Ciencias Biomédicas
dc.description.none.fl_txt_mv Blood cholinesterases and tissue carboxylesterases (CEs) are sensitive indicators of environmental organophosphate pesticides (OPs) exposure. The aim of this pilot study was to assess the impact of OP exposure on placental CE activity and lipid composition. We performed a study of 40 healthy women who live in agricultural farms. Samples were collected during the pulverization period (PP) and recess period (RP). The plasma cholinesterase and placental CE activity decreased in PP, suggesting that women were exposed to OPs and that these pesticides reached the placenta. The cardiolipin content increased and the phosphatidylethanolamine content decreased in the light mitochondrial fraction while total cholesterol and sphingomyelin increased in the nuclear fraction. These changes in lipid profiles suggest repair by hyperplasia of the cytotrophoblast. Decreased CE activity may have clinical and toxicological implications and thus entail potential risks to damage fetal growth and development.
Fil: Vera, Berta. Universidad Nacional del Comahue. Instituto Multidisciplinario de Investigación y Desarrollo de la Patagonia Norte; Argentina.
Fil: Vera, Berta. Universidad Nacional del Comahue. Facultad de Ciencias Médicas; Argentina.
Fil: Vera, Berta. Concejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
Fil: Magnarelli, Gladis. Universidad Nacional del Comahue. Facultad de Ingeniería. Instituto Multidisciplinario de Investigación y Desarrollo de la Patagonia Norte; Argentina.
Fil: Magnarelli, Gladis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
Fil: Magnarelli, Gladis. Universidad Nacional del Comahue. Facultad Ciencias Médicas; Argentina.
Fil: Santa Cruz, Silvia. Hospital Área Programa Cinco Saltos. Rio Negro; Argentina.
description Blood cholinesterases and tissue carboxylesterases (CEs) are sensitive indicators of environmental organophosphate pesticides (OPs) exposure. The aim of this pilot study was to assess the impact of OP exposure on placental CE activity and lipid composition. We performed a study of 40 healthy women who live in agricultural farms. Samples were collected during the pulverization period (PP) and recess period (RP). The plasma cholinesterase and placental CE activity decreased in PP, suggesting that women were exposed to OPs and that these pesticides reached the placenta. The cardiolipin content increased and the phosphatidylethanolamine content decreased in the light mitochondrial fraction while total cholesterol and sphingomyelin increased in the nuclear fraction. These changes in lipid profiles suggest repair by hyperplasia of the cytotrophoblast. Decreased CE activity may have clinical and toxicological implications and thus entail potential risks to damage fetal growth and development.
publishDate 2012
dc.date.none.fl_str_mv 2012-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://rdi.uncoma.edu.ar/handle/uncomaid/15224
0890-6238
url http://rdi.uncoma.edu.ar/handle/uncomaid/15224
identifier_str_mv 0890-6238
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.journals.elsevier.com/reproductive-toxicology
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
pp. 402-407
application/pdf
dc.publisher.none.fl_str_mv Elsevier
Board
publisher.none.fl_str_mv Elsevier
Board
dc.source.none.fl_str_mv ReproductiveToxicology 34 (2012)
reponame:Repositorio Digital Institucional (UNCo)
instname:Universidad Nacional del Comahue
reponame_str Repositorio Digital Institucional (UNCo)
collection Repositorio Digital Institucional (UNCo)
instname_str Universidad Nacional del Comahue
repository.name.fl_str_mv Repositorio Digital Institucional (UNCo) - Universidad Nacional del Comahue
repository.mail.fl_str_mv mirtha.mateo@biblioteca.uncoma.edu.ar; adriana.acuna@biblioteca.uncoma.edu.ar
_version_ 1844621558712107008
score 12.559606

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