Mitochondrial characterization and redox state in submandibular glands of rats exposed to environmental hypoxia

• Autores: Terrizzi, Antonela Romina
• Año de publicación: 2017
• Idioma: inglés
• Tipo de recurso: tesis de maestría
• Colaborador/a o director/a de tesis: Fisch, Paul; Martinez, María del Pilar; Zaobornyj, Tamara; Valdez, Laura; La Padula, Pablo; Borner, Christoph
• Materia: Hipoxia; Mitocondrias; Glándulas submaxilar; Hypoxia; Mitochondrial; Submandibular glands; Ciencias de la vida
• Institución: Universidad de Buenos Aires

Hypobaric hypoxia (HX) can be defined as a decrease in the partial pressure of oxygen (O2) leading to less levels of this gas in the tissues. HX evokes highly coordinated cellular responses in order to preserve cell viability and they differ from those populations that live permanently at high altitude (chronic continuous hypoxia, CCH) compared to those who work in HX conditions and then return to normoxic environments (chronic intermittent HX, CIH). Despite the fact that the effects of HX in the organism are well established, its role on oral health is still not clear. It has been reported salivary dysfunction in rats exposed to HX, but the mechanisms are still unknown, especially under these two types of HX conditions. In this sense, exposure to HX is known to increase cellular oxidative stress with consequent damage to lipids, proteins and DNA. As mitochondria are the most important organelle related with reactive oxygen species production, it is the aim of this master thesis to evaluate mitochondrial function in submandibular glands in a model of rats submitted to chronic hypobaric hypoxia during 3 months, in order to elucidate the mechanisms involved in glandular secretion at high altitude.
Fil: Terrizzi, Antonela Romina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Buenos Aires, Argentina
Magíster de la Universidad de Buenos Aires en Ciencias Biomédicas