The effect of training and duration of surgery on adhesion formation in the rabbit model

Autores
Ordoñez, J.L.; Domínguez, J.; Evrard, V.; Koninckx, P.R.
Año de publicación
1997
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión aceptada
Descripción
In order to evaluate the effect of training upon postoperative adhesions, standard bipolar and mechanical, nonopposing injuries were performed in the uterine horns and side walls of 52 mature female rabbits using a conventional three-puncture laparoscopy, by an endoscopic surgeon with limited experience. An additional injury, either bipolar or mechanical or both, was performed in the retro-uterine space. With experience, the duration of surgery decreased progressively from 12 K 2 to 8 K 1 min in the first and last 10 animals respectively. The amount of perioperative bleeding was not affected by experience. With experience the postoperative adhesions decreased in extent (P J 0.0001), tenacity (P J 0.004), type (P J 0.002) and inflammation (P J 0.003) and for total score (P J 0.0002). These changes were correlated with the briefer duration of surgery but not with the amount of perioperative bleeding. The strong correlations of adhesion scores in the pouch of Douglas, and around both uterine horns confirmed the importance of the inter-animal variability in making adhesions. By logistic regression, the adhesions in the pouch of Douglas were explained simultaneously by the adhesions on the uterine horns (P J 0.0004, thus correcting for interanimal variability) by the amount of bleeding (P J 0.01) and the duration of surgery (P J 0.05). No major differences were found in adhesions following a mechanical or a bipolar injury or following such a lesion in the pouch of Douglas or at the uterine horns. In conclusion, experience, expressed by the duration of surgery and to a lesser extent perioperative bleeding, is a major co-factor in postoperative adhesions, suggesting that duration of surgery should be strictly standardized in endoscopic adhesion studies. The important inter-animal variability can be circumvented by using a standard control lesion, making each animal its own control.
Fil: Ordoñez, J.L. Centre for Surgical Technologies; Belgium
Fil: Domínguez, J. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
Fil: Evrard, V. Centre for Surgical Technologies; Belgium
Fil: Koninckx, P.R. Centre for Surgical Technologies; Belgium
Fuente
Ordoñez, J.L., Domínguez, J., Evrard, V. and Koninckx, P.R. (1997) The effect of training and duration of surgery on adhesion formation in the rabbit model. Human Reproduction, 12 (12). pp. 2654-2657. ISSN 0268-1161
Materia
R Medicina (General)
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Repositorio
Producción Académica (UCC)
Institución
Universidad Católica de Córdoba
OAI Identificador
oai:pa.bibdigital.uccor.edu.ar:3723

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spelling The effect of training and duration of surgery on adhesion formation in the rabbit modelOrdoñez, J.L.Domínguez, J.Evrard, V.Koninckx, P.R.R Medicina (General)In order to evaluate the effect of training upon postoperative adhesions, standard bipolar and mechanical, nonopposing injuries were performed in the uterine horns and side walls of 52 mature female rabbits using a conventional three-puncture laparoscopy, by an endoscopic surgeon with limited experience. An additional injury, either bipolar or mechanical or both, was performed in the retro-uterine space. With experience, the duration of surgery decreased progressively from 12 K 2 to 8 K 1 min in the first and last 10 animals respectively. The amount of perioperative bleeding was not affected by experience. With experience the postoperative adhesions decreased in extent (P J 0.0001), tenacity (P J 0.004), type (P J 0.002) and inflammation (P J 0.003) and for total score (P J 0.0002). These changes were correlated with the briefer duration of surgery but not with the amount of perioperative bleeding. The strong correlations of adhesion scores in the pouch of Douglas, and around both uterine horns confirmed the importance of the inter-animal variability in making adhesions. By logistic regression, the adhesions in the pouch of Douglas were explained simultaneously by the adhesions on the uterine horns (P J 0.0004, thus correcting for interanimal variability) by the amount of bleeding (P J 0.01) and the duration of surgery (P J 0.05). No major differences were found in adhesions following a mechanical or a bipolar injury or following such a lesion in the pouch of Douglas or at the uterine horns. In conclusion, experience, expressed by the duration of surgery and to a lesser extent perioperative bleeding, is a major co-factor in postoperative adhesions, suggesting that duration of surgery should be strictly standardized in endoscopic adhesion studies. The important inter-animal variability can be circumvented by using a standard control lesion, making each animal its own control.Fil: Ordoñez, J.L. Centre for Surgical Technologies; BelgiumFil: Domínguez, J. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; ArgentinaFil: Evrard, V. Centre for Surgical Technologies; BelgiumFil: Koninckx, P.R. Centre for Surgical Technologies; Belgium1997-12-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://pa.bibdigital.ucc.edu.ar/3723/1/A_Ordo%C3%B1ez_Dom%C3%ADnguez_Evrard_Koninckx.pdf Ordoñez, J.L., Domínguez, J., Evrard, V. and Koninckx, P.R. (1997) The effect of training and duration of surgery on adhesion formation in the rabbit model. Human Reproduction, 12 (12). pp. 2654-2657. ISSN 0268-1161 reponame:Producción Académica (UCC)instname:Universidad Católica de Córdobaspahttp://pa.bibdigital.ucc.edu.ar/3723/info:eu-repo/semantics/altIdentifier/doi/10.1093/humrep/12.12.2654info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es2025-09-29T14:29:39Zoai:pa.bibdigital.uccor.edu.ar:3723instacron:UCCInstitucionalhttp://pa.bibdigital.uccor.edu.ar/Universidad privadaNo correspondehttp://pa.bibdigital.uccor.edu.ar/cgi/oai2bibdir@uccor.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:27182025-09-29 14:29:39.569Producción Académica (UCC) - Universidad Católica de Córdobafalse
dc.title.none.fl_str_mv The effect of training and duration of surgery on adhesion formation in the rabbit model
title The effect of training and duration of surgery on adhesion formation in the rabbit model
spellingShingle The effect of training and duration of surgery on adhesion formation in the rabbit model
Ordoñez, J.L.
R Medicina (General)
title_short The effect of training and duration of surgery on adhesion formation in the rabbit model
title_full The effect of training and duration of surgery on adhesion formation in the rabbit model
title_fullStr The effect of training and duration of surgery on adhesion formation in the rabbit model
title_full_unstemmed The effect of training and duration of surgery on adhesion formation in the rabbit model
title_sort The effect of training and duration of surgery on adhesion formation in the rabbit model
dc.creator.none.fl_str_mv Ordoñez, J.L.
Domínguez, J.
Evrard, V.
Koninckx, P.R.
author Ordoñez, J.L.
author_facet Ordoñez, J.L.
Domínguez, J.
Evrard, V.
Koninckx, P.R.
author_role author
author2 Domínguez, J.
Evrard, V.
Koninckx, P.R.
author2_role author
author
author
dc.subject.none.fl_str_mv R Medicina (General)
topic R Medicina (General)
dc.description.none.fl_txt_mv In order to evaluate the effect of training upon postoperative adhesions, standard bipolar and mechanical, nonopposing injuries were performed in the uterine horns and side walls of 52 mature female rabbits using a conventional three-puncture laparoscopy, by an endoscopic surgeon with limited experience. An additional injury, either bipolar or mechanical or both, was performed in the retro-uterine space. With experience, the duration of surgery decreased progressively from 12 K 2 to 8 K 1 min in the first and last 10 animals respectively. The amount of perioperative bleeding was not affected by experience. With experience the postoperative adhesions decreased in extent (P J 0.0001), tenacity (P J 0.004), type (P J 0.002) and inflammation (P J 0.003) and for total score (P J 0.0002). These changes were correlated with the briefer duration of surgery but not with the amount of perioperative bleeding. The strong correlations of adhesion scores in the pouch of Douglas, and around both uterine horns confirmed the importance of the inter-animal variability in making adhesions. By logistic regression, the adhesions in the pouch of Douglas were explained simultaneously by the adhesions on the uterine horns (P J 0.0004, thus correcting for interanimal variability) by the amount of bleeding (P J 0.01) and the duration of surgery (P J 0.05). No major differences were found in adhesions following a mechanical or a bipolar injury or following such a lesion in the pouch of Douglas or at the uterine horns. In conclusion, experience, expressed by the duration of surgery and to a lesser extent perioperative bleeding, is a major co-factor in postoperative adhesions, suggesting that duration of surgery should be strictly standardized in endoscopic adhesion studies. The important inter-animal variability can be circumvented by using a standard control lesion, making each animal its own control.
Fil: Ordoñez, J.L. Centre for Surgical Technologies; Belgium
Fil: Domínguez, J. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
Fil: Evrard, V. Centre for Surgical Technologies; Belgium
Fil: Koninckx, P.R. Centre for Surgical Technologies; Belgium
description In order to evaluate the effect of training upon postoperative adhesions, standard bipolar and mechanical, nonopposing injuries were performed in the uterine horns and side walls of 52 mature female rabbits using a conventional three-puncture laparoscopy, by an endoscopic surgeon with limited experience. An additional injury, either bipolar or mechanical or both, was performed in the retro-uterine space. With experience, the duration of surgery decreased progressively from 12 K 2 to 8 K 1 min in the first and last 10 animals respectively. The amount of perioperative bleeding was not affected by experience. With experience the postoperative adhesions decreased in extent (P J 0.0001), tenacity (P J 0.004), type (P J 0.002) and inflammation (P J 0.003) and for total score (P J 0.0002). These changes were correlated with the briefer duration of surgery but not with the amount of perioperative bleeding. The strong correlations of adhesion scores in the pouch of Douglas, and around both uterine horns confirmed the importance of the inter-animal variability in making adhesions. By logistic regression, the adhesions in the pouch of Douglas were explained simultaneously by the adhesions on the uterine horns (P J 0.0004, thus correcting for interanimal variability) by the amount of bleeding (P J 0.01) and the duration of surgery (P J 0.05). No major differences were found in adhesions following a mechanical or a bipolar injury or following such a lesion in the pouch of Douglas or at the uterine horns. In conclusion, experience, expressed by the duration of surgery and to a lesser extent perioperative bleeding, is a major co-factor in postoperative adhesions, suggesting that duration of surgery should be strictly standardized in endoscopic adhesion studies. The important inter-animal variability can be circumvented by using a standard control lesion, making each animal its own control.
publishDate 1997
dc.date.none.fl_str_mv 1997-12-31
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
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info:ar-repo/semantics/articulo
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status_str acceptedVersion
dc.identifier.none.fl_str_mv http://pa.bibdigital.ucc.edu.ar/3723/1/A_Ordo%C3%B1ez_Dom%C3%ADnguez_Evrard_Koninckx.pdf
url http://pa.bibdigital.ucc.edu.ar/3723/1/A_Ordo%C3%B1ez_Dom%C3%ADnguez_Evrard_Koninckx.pdf
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language spa
dc.relation.none.fl_str_mv http://pa.bibdigital.ucc.edu.ar/3723/
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dc.source.none.fl_str_mv Ordoñez, J.L., Domínguez, J., Evrard, V. and Koninckx, P.R. (1997) The effect of training and duration of surgery on adhesion formation in the rabbit model. Human Reproduction, 12 (12). pp. 2654-2657. ISSN 0268-1161
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instname_str Universidad Católica de Córdoba
repository.name.fl_str_mv Producción Académica (UCC) - Universidad Católica de Córdoba
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