The effect of training and duration of surgery on adhesion formation in the rabbit model
- Autores
- Ordoñez, J.L.; Domínguez, J.; Evrard, V.; Koninckx, P.R.
- Año de publicación
- 1997
- Idioma
- español castellano
- Tipo de recurso
- artículo
- Estado
- versión aceptada
- Descripción
- In order to evaluate the effect of training upon postoperative adhesions, standard bipolar and mechanical, nonopposing injuries were performed in the uterine horns and side walls of 52 mature female rabbits using a conventional three-puncture laparoscopy, by an endoscopic surgeon with limited experience. An additional injury, either bipolar or mechanical or both, was performed in the retro-uterine space. With experience, the duration of surgery decreased progressively from 12 K 2 to 8 K 1 min in the first and last 10 animals respectively. The amount of perioperative bleeding was not affected by experience. With experience the postoperative adhesions decreased in extent (P J 0.0001), tenacity (P J 0.004), type (P J 0.002) and inflammation (P J 0.003) and for total score (P J 0.0002). These changes were correlated with the briefer duration of surgery but not with the amount of perioperative bleeding. The strong correlations of adhesion scores in the pouch of Douglas, and around both uterine horns confirmed the importance of the inter-animal variability in making adhesions. By logistic regression, the adhesions in the pouch of Douglas were explained simultaneously by the adhesions on the uterine horns (P J 0.0004, thus correcting for interanimal variability) by the amount of bleeding (P J 0.01) and the duration of surgery (P J 0.05). No major differences were found in adhesions following a mechanical or a bipolar injury or following such a lesion in the pouch of Douglas or at the uterine horns. In conclusion, experience, expressed by the duration of surgery and to a lesser extent perioperative bleeding, is a major co-factor in postoperative adhesions, suggesting that duration of surgery should be strictly standardized in endoscopic adhesion studies. The important inter-animal variability can be circumvented by using a standard control lesion, making each animal its own control.
Fil: Ordoñez, J.L. Centre for Surgical Technologies; Belgium
Fil: Domínguez, J. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
Fil: Evrard, V. Centre for Surgical Technologies; Belgium
Fil: Koninckx, P.R. Centre for Surgical Technologies; Belgium - Fuente
- Ordoñez, J.L., Domínguez, J., Evrard, V. and Koninckx, P.R. (1997) The effect of training and duration of surgery on adhesion formation in the rabbit model. Human Reproduction, 12 (12). pp. 2654-2657. ISSN 0268-1161
- Materia
- R Medicina (General)
- Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
- Repositorio
- Institución
- Universidad Católica de Córdoba
- OAI Identificador
- oai:pa.bibdigital.uccor.edu.ar:3723
Ver los metadatos del registro completo
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The effect of training and duration of surgery on adhesion formation in the rabbit modelOrdoñez, J.L.Domínguez, J.Evrard, V.Koninckx, P.R.R Medicina (General)In order to evaluate the effect of training upon postoperative adhesions, standard bipolar and mechanical, nonopposing injuries were performed in the uterine horns and side walls of 52 mature female rabbits using a conventional three-puncture laparoscopy, by an endoscopic surgeon with limited experience. An additional injury, either bipolar or mechanical or both, was performed in the retro-uterine space. With experience, the duration of surgery decreased progressively from 12 K 2 to 8 K 1 min in the first and last 10 animals respectively. The amount of perioperative bleeding was not affected by experience. With experience the postoperative adhesions decreased in extent (P J 0.0001), tenacity (P J 0.004), type (P J 0.002) and inflammation (P J 0.003) and for total score (P J 0.0002). These changes were correlated with the briefer duration of surgery but not with the amount of perioperative bleeding. The strong correlations of adhesion scores in the pouch of Douglas, and around both uterine horns confirmed the importance of the inter-animal variability in making adhesions. By logistic regression, the adhesions in the pouch of Douglas were explained simultaneously by the adhesions on the uterine horns (P J 0.0004, thus correcting for interanimal variability) by the amount of bleeding (P J 0.01) and the duration of surgery (P J 0.05). No major differences were found in adhesions following a mechanical or a bipolar injury or following such a lesion in the pouch of Douglas or at the uterine horns. In conclusion, experience, expressed by the duration of surgery and to a lesser extent perioperative bleeding, is a major co-factor in postoperative adhesions, suggesting that duration of surgery should be strictly standardized in endoscopic adhesion studies. The important inter-animal variability can be circumvented by using a standard control lesion, making each animal its own control.Fil: Ordoñez, J.L. Centre for Surgical Technologies; BelgiumFil: Domínguez, J. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; ArgentinaFil: Evrard, V. Centre for Surgical Technologies; BelgiumFil: Koninckx, P.R. Centre for Surgical Technologies; Belgium1997-12-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://pa.bibdigital.ucc.edu.ar/3723/1/A_Ordo%C3%B1ez_Dom%C3%ADnguez_Evrard_Koninckx.pdf Ordoñez, J.L., Domínguez, J., Evrard, V. and Koninckx, P.R. (1997) The effect of training and duration of surgery on adhesion formation in the rabbit model. Human Reproduction, 12 (12). pp. 2654-2657. ISSN 0268-1161 reponame:Producción Académica (UCC)instname:Universidad Católica de Córdobaspahttp://pa.bibdigital.ucc.edu.ar/3723/info:eu-repo/semantics/altIdentifier/doi/10.1093/humrep/12.12.2654info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es2025-09-29T14:29:39Zoai:pa.bibdigital.uccor.edu.ar:3723instacron:UCCInstitucionalhttp://pa.bibdigital.uccor.edu.ar/Universidad privadaNo correspondehttp://pa.bibdigital.uccor.edu.ar/cgi/oai2bibdir@uccor.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:27182025-09-29 14:29:39.569Producción Académica (UCC) - Universidad Católica de Córdobafalse |
dc.title.none.fl_str_mv |
The effect of training and duration of surgery on adhesion formation in the rabbit model |
title |
The effect of training and duration of surgery on adhesion formation in the rabbit model |
spellingShingle |
The effect of training and duration of surgery on adhesion formation in the rabbit model Ordoñez, J.L. R Medicina (General) |
title_short |
The effect of training and duration of surgery on adhesion formation in the rabbit model |
title_full |
The effect of training and duration of surgery on adhesion formation in the rabbit model |
title_fullStr |
The effect of training and duration of surgery on adhesion formation in the rabbit model |
title_full_unstemmed |
The effect of training and duration of surgery on adhesion formation in the rabbit model |
title_sort |
The effect of training and duration of surgery on adhesion formation in the rabbit model |
dc.creator.none.fl_str_mv |
Ordoñez, J.L. Domínguez, J. Evrard, V. Koninckx, P.R. |
author |
Ordoñez, J.L. |
author_facet |
Ordoñez, J.L. Domínguez, J. Evrard, V. Koninckx, P.R. |
author_role |
author |
author2 |
Domínguez, J. Evrard, V. Koninckx, P.R. |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
R Medicina (General) |
topic |
R Medicina (General) |
dc.description.none.fl_txt_mv |
In order to evaluate the effect of training upon postoperative adhesions, standard bipolar and mechanical, nonopposing injuries were performed in the uterine horns and side walls of 52 mature female rabbits using a conventional three-puncture laparoscopy, by an endoscopic surgeon with limited experience. An additional injury, either bipolar or mechanical or both, was performed in the retro-uterine space. With experience, the duration of surgery decreased progressively from 12 K 2 to 8 K 1 min in the first and last 10 animals respectively. The amount of perioperative bleeding was not affected by experience. With experience the postoperative adhesions decreased in extent (P J 0.0001), tenacity (P J 0.004), type (P J 0.002) and inflammation (P J 0.003) and for total score (P J 0.0002). These changes were correlated with the briefer duration of surgery but not with the amount of perioperative bleeding. The strong correlations of adhesion scores in the pouch of Douglas, and around both uterine horns confirmed the importance of the inter-animal variability in making adhesions. By logistic regression, the adhesions in the pouch of Douglas were explained simultaneously by the adhesions on the uterine horns (P J 0.0004, thus correcting for interanimal variability) by the amount of bleeding (P J 0.01) and the duration of surgery (P J 0.05). No major differences were found in adhesions following a mechanical or a bipolar injury or following such a lesion in the pouch of Douglas or at the uterine horns. In conclusion, experience, expressed by the duration of surgery and to a lesser extent perioperative bleeding, is a major co-factor in postoperative adhesions, suggesting that duration of surgery should be strictly standardized in endoscopic adhesion studies. The important inter-animal variability can be circumvented by using a standard control lesion, making each animal its own control. Fil: Ordoñez, J.L. Centre for Surgical Technologies; Belgium Fil: Domínguez, J. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina Fil: Evrard, V. Centre for Surgical Technologies; Belgium Fil: Koninckx, P.R. Centre for Surgical Technologies; Belgium |
description |
In order to evaluate the effect of training upon postoperative adhesions, standard bipolar and mechanical, nonopposing injuries were performed in the uterine horns and side walls of 52 mature female rabbits using a conventional three-puncture laparoscopy, by an endoscopic surgeon with limited experience. An additional injury, either bipolar or mechanical or both, was performed in the retro-uterine space. With experience, the duration of surgery decreased progressively from 12 K 2 to 8 K 1 min in the first and last 10 animals respectively. The amount of perioperative bleeding was not affected by experience. With experience the postoperative adhesions decreased in extent (P J 0.0001), tenacity (P J 0.004), type (P J 0.002) and inflammation (P J 0.003) and for total score (P J 0.0002). These changes were correlated with the briefer duration of surgery but not with the amount of perioperative bleeding. The strong correlations of adhesion scores in the pouch of Douglas, and around both uterine horns confirmed the importance of the inter-animal variability in making adhesions. By logistic regression, the adhesions in the pouch of Douglas were explained simultaneously by the adhesions on the uterine horns (P J 0.0004, thus correcting for interanimal variability) by the amount of bleeding (P J 0.01) and the duration of surgery (P J 0.05). No major differences were found in adhesions following a mechanical or a bipolar injury or following such a lesion in the pouch of Douglas or at the uterine horns. In conclusion, experience, expressed by the duration of surgery and to a lesser extent perioperative bleeding, is a major co-factor in postoperative adhesions, suggesting that duration of surgery should be strictly standardized in endoscopic adhesion studies. The important inter-animal variability can be circumvented by using a standard control lesion, making each animal its own control. |
publishDate |
1997 |
dc.date.none.fl_str_mv |
1997-12-31 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
acceptedVersion |
dc.identifier.none.fl_str_mv |
http://pa.bibdigital.ucc.edu.ar/3723/1/A_Ordo%C3%B1ez_Dom%C3%ADnguez_Evrard_Koninckx.pdf |
url |
http://pa.bibdigital.ucc.edu.ar/3723/1/A_Ordo%C3%B1ez_Dom%C3%ADnguez_Evrard_Koninckx.pdf |
dc.language.none.fl_str_mv |
spa |
language |
spa |
dc.relation.none.fl_str_mv |
http://pa.bibdigital.ucc.edu.ar/3723/ info:eu-repo/semantics/altIdentifier/doi/10.1093/humrep/12.12.2654 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Ordoñez, J.L., Domínguez, J., Evrard, V. and Koninckx, P.R. (1997) The effect of training and duration of surgery on adhesion formation in the rabbit model. Human Reproduction, 12 (12). pp. 2654-2657. ISSN 0268-1161 reponame:Producción Académica (UCC) instname:Universidad Católica de Córdoba |
reponame_str |
Producción Académica (UCC) |
collection |
Producción Académica (UCC) |
instname_str |
Universidad Católica de Córdoba |
repository.name.fl_str_mv |
Producción Académica (UCC) - Universidad Católica de Córdoba |
repository.mail.fl_str_mv |
bibdir@uccor.edu.ar |
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12.559606 |