Recovery of fenbendazole efficacy on resistant Haemonchus contortus by management of parasite refugia and population replacement

Autores
Muchiut, Sebastian; Fernandez, Alicia Silvina; Lloberas, María Mercedes; Steffan, Pedro Eduard; Luque, Sonia; Cardozo, Patricia Alejandra; Bernat, Gisele Anahí; Riva, Eliana; Fiel, César Alberto
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The recovery of fenbendazole efficacy against Haemonchus contortus was attempted in a sheep intensive production system, using a strategy of population replacement in which the initial absolute efficacy of fenbendazole was 0%. The strategy was based on managing the parasite populations in refugia. Firstly, the resistant parasite population was reduced by means of anthelmintic treatments with efficacious drugs (Phase I), then a new, susceptible population was introduced in summer by way of artificially infected lambs at weaning, which were left to graze on the experimental pasture for eleven months (Phase II). Lastly, the impact of the replacement strategy, in terms of benzimidazole efficacy, was measured (Phase III). Faecal egg counts from permanent lambs and worm burdens as a measure of pasture infectivity from tracer lambs were determined throughout the study. During Phase I, faecal egg counts diminished from a peak of 2968 (300–7740) epg to 0 epg at the end, while adult worm burdens of H. contortus were reduced from 2625 (800–5100) to 0, which showed that the treatment strategy used in Phase I was effective in reducing the resistant population. These parameters also showed that good levels of pasture contamination and infectivity were achieved in Phase II, as faecal egg counts of up to 7275 (3240–13080) epg and adult worm burdens of 500 (200–800) H. contortus were reached. The absolute benzimidazole efficacy on H. contortus estimated at 16 months post-population replacement (Phase III) was 97.58%. The results lead to the conclusion that the recovery of anthelmintic efficacy of fenbendazole against a resistant population of H. contortus may be achieved by means of a strategy based on management of refugia and a subsequent introduction of a susceptible population. This strategy might be translatable to other resistant nematode genera.
EEA Balcarce
Fil: Muchiut, Sebastian. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Área de Parasitología y Enfermedades Parasitarias; Argentina
Fil: Fernandez, Alicia Silvina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Área de Parasitología y Enfermedades Parasitarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lloberas, María Mercedes. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Steffan, Pedro Eduardo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Área de Parasitología y Enfermedades Parasitarias; Argentina
Fil: Luque, Sonia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cardozo, Patricia Alejandra. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Bernat, Gisele Anahí. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Área de Parasitología y Enfermedades Parasitarias; Argentina. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires; Argentina
Fil: Riva, Elina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Área de Parasitología y Enfermedades Parasitarias; Argentina. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires; Argentina
Fil: Fiel, César Alberto. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Área de Parasitología y Enfermedades Parasitarias; Argentina
Fuente
Veterinary Parasitology 271 : 31-37 (2019)
Materia
Oveja
Parásitos
Haemonchus Contortus
Resistencia a los Antihelmínticos
Medicamentos
Ewes
Parasites
Resistence to Anthelmintics
Drugs
Benzimidazoles
Fenbendazole
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/8820
Acceder
id INTADig_f48055e320601743c0c53f2c91343b56
oai_identifier_str oai:localhost:20.500.12123/8820
network_acronym_str INTADig
repository_id_str l
network_name_str INTA Digital (INTA)
spelling Recovery of fenbendazole efficacy on resistant Haemonchus contortus by management of parasite refugia and population replacementMuchiut, SebastianFernandez, Alicia SilvinaLloberas, María MercedesSteffan, Pedro EduardLuque, SoniaCardozo, Patricia AlejandraBernat, Gisele AnahíRiva, ElianaFiel, César AlbertoOvejaParásitosHaemonchus ContortusResistencia a los AntihelmínticosMedicamentosEwesParasitesResistence to AnthelminticsDrugsBenzimidazolesFenbendazoleThe recovery of fenbendazole efficacy against Haemonchus contortus was attempted in a sheep intensive production system, using a strategy of population replacement in which the initial absolute efficacy of fenbendazole was 0%. The strategy was based on managing the parasite populations in refugia. Firstly, the resistant parasite population was reduced by means of anthelmintic treatments with efficacious drugs (Phase I), then a new, susceptible population was introduced in summer by way of artificially infected lambs at weaning, which were left to graze on the experimental pasture for eleven months (Phase II). Lastly, the impact of the replacement strategy, in terms of benzimidazole efficacy, was measured (Phase III). Faecal egg counts from permanent lambs and worm burdens as a measure of pasture infectivity from tracer lambs were determined throughout the study. During Phase I, faecal egg counts diminished from a peak of 2968 (300–7740) epg to 0 epg at the end, while adult worm burdens of H. contortus were reduced from 2625 (800–5100) to 0, which showed that the treatment strategy used in Phase I was effective in reducing the resistant population. These parameters also showed that good levels of pasture contamination and infectivity were achieved in Phase II, as faecal egg counts of up to 7275 (3240–13080) epg and adult worm burdens of 500 (200–800) H. contortus were reached. The absolute benzimidazole efficacy on H. contortus estimated at 16 months post-population replacement (Phase III) was 97.58%. The results lead to the conclusion that the recovery of anthelmintic efficacy of fenbendazole against a resistant population of H. contortus may be achieved by means of a strategy based on management of refugia and a subsequent introduction of a susceptible population. This strategy might be translatable to other resistant nematode genera.EEA BalcarceFil: Muchiut, Sebastian. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Área de Parasitología y Enfermedades Parasitarias; ArgentinaFil: Fernandez, Alicia Silvina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Área de Parasitología y Enfermedades Parasitarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lloberas, María Mercedes. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; ArgentinaFil: Steffan, Pedro Eduardo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Área de Parasitología y Enfermedades Parasitarias; ArgentinaFil: Luque, Sonia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cardozo, Patricia Alejandra. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; ArgentinaFil: Bernat, Gisele Anahí. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Área de Parasitología y Enfermedades Parasitarias; Argentina. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires; ArgentinaFil: Riva, Elina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Área de Parasitología y Enfermedades Parasitarias; Argentina. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires; ArgentinaFil: Fiel, César Alberto. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Área de Parasitología y Enfermedades Parasitarias; ArgentinaElsevier2021-03-05T11:30:58Z2021-03-05T11:30:58Z2020-06-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/8820https://www.sciencedirect.com/science/article/abs/pii/S03044017193013590304-4017https://doi.org/10.1016/j.vetpar.2019.06.003Veterinary Parasitology 271 : 31-37 (2019)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-09-29T13:45:09Zoai:localhost:20.500.12123/8820instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:45:09.391INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Recovery of fenbendazole efficacy on resistant Haemonchus contortus by management of parasite refugia and population replacement
title Recovery of fenbendazole efficacy on resistant Haemonchus contortus by management of parasite refugia and population replacement
spellingShingle Recovery of fenbendazole efficacy on resistant Haemonchus contortus by management of parasite refugia and population replacement
Muchiut, Sebastian
Oveja
Parásitos
Haemonchus Contortus
Resistencia a los Antihelmínticos
Medicamentos
Ewes
Parasites
Resistence to Anthelmintics
Drugs
Benzimidazoles
Fenbendazole
title_short Recovery of fenbendazole efficacy on resistant Haemonchus contortus by management of parasite refugia and population replacement
title_full Recovery of fenbendazole efficacy on resistant Haemonchus contortus by management of parasite refugia and population replacement
title_fullStr Recovery of fenbendazole efficacy on resistant Haemonchus contortus by management of parasite refugia and population replacement
title_full_unstemmed Recovery of fenbendazole efficacy on resistant Haemonchus contortus by management of parasite refugia and population replacement
title_sort Recovery of fenbendazole efficacy on resistant Haemonchus contortus by management of parasite refugia and population replacement
dc.creator.none.fl_str_mv Muchiut, Sebastian
Fernandez, Alicia Silvina
Lloberas, María Mercedes
Steffan, Pedro Eduard
Luque, Sonia
Cardozo, Patricia Alejandra
Bernat, Gisele Anahí
Riva, Eliana
Fiel, César Alberto
author Muchiut, Sebastian
author_facet Muchiut, Sebastian
Fernandez, Alicia Silvina
Lloberas, María Mercedes
Steffan, Pedro Eduard
Luque, Sonia
Cardozo, Patricia Alejandra
Bernat, Gisele Anahí
Riva, Eliana
Fiel, César Alberto
author_role author
author2 Fernandez, Alicia Silvina
Lloberas, María Mercedes
Steffan, Pedro Eduard
Luque, Sonia
Cardozo, Patricia Alejandra
Bernat, Gisele Anahí
Riva, Eliana
Fiel, César Alberto
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Oveja
Parásitos
Haemonchus Contortus
Resistencia a los Antihelmínticos
Medicamentos
Ewes
Parasites
Resistence to Anthelmintics
Drugs
Benzimidazoles
Fenbendazole
topic Oveja
Parásitos
Haemonchus Contortus
Resistencia a los Antihelmínticos
Medicamentos
Ewes
Parasites
Resistence to Anthelmintics
Drugs
Benzimidazoles
Fenbendazole
dc.description.none.fl_txt_mv The recovery of fenbendazole efficacy against Haemonchus contortus was attempted in a sheep intensive production system, using a strategy of population replacement in which the initial absolute efficacy of fenbendazole was 0%. The strategy was based on managing the parasite populations in refugia. Firstly, the resistant parasite population was reduced by means of anthelmintic treatments with efficacious drugs (Phase I), then a new, susceptible population was introduced in summer by way of artificially infected lambs at weaning, which were left to graze on the experimental pasture for eleven months (Phase II). Lastly, the impact of the replacement strategy, in terms of benzimidazole efficacy, was measured (Phase III). Faecal egg counts from permanent lambs and worm burdens as a measure of pasture infectivity from tracer lambs were determined throughout the study. During Phase I, faecal egg counts diminished from a peak of 2968 (300–7740) epg to 0 epg at the end, while adult worm burdens of H. contortus were reduced from 2625 (800–5100) to 0, which showed that the treatment strategy used in Phase I was effective in reducing the resistant population. These parameters also showed that good levels of pasture contamination and infectivity were achieved in Phase II, as faecal egg counts of up to 7275 (3240–13080) epg and adult worm burdens of 500 (200–800) H. contortus were reached. The absolute benzimidazole efficacy on H. contortus estimated at 16 months post-population replacement (Phase III) was 97.58%. The results lead to the conclusion that the recovery of anthelmintic efficacy of fenbendazole against a resistant population of H. contortus may be achieved by means of a strategy based on management of refugia and a subsequent introduction of a susceptible population. This strategy might be translatable to other resistant nematode genera.
EEA Balcarce
Fil: Muchiut, Sebastian. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Área de Parasitología y Enfermedades Parasitarias; Argentina
Fil: Fernandez, Alicia Silvina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Área de Parasitología y Enfermedades Parasitarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lloberas, María Mercedes. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Steffan, Pedro Eduardo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Área de Parasitología y Enfermedades Parasitarias; Argentina
Fil: Luque, Sonia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cardozo, Patricia Alejandra. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Bernat, Gisele Anahí. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Área de Parasitología y Enfermedades Parasitarias; Argentina. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires; Argentina
Fil: Riva, Elina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Área de Parasitología y Enfermedades Parasitarias; Argentina. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires; Argentina
Fil: Fiel, César Alberto. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Área de Parasitología y Enfermedades Parasitarias; Argentina
description The recovery of fenbendazole efficacy against Haemonchus contortus was attempted in a sheep intensive production system, using a strategy of population replacement in which the initial absolute efficacy of fenbendazole was 0%. The strategy was based on managing the parasite populations in refugia. Firstly, the resistant parasite population was reduced by means of anthelmintic treatments with efficacious drugs (Phase I), then a new, susceptible population was introduced in summer by way of artificially infected lambs at weaning, which were left to graze on the experimental pasture for eleven months (Phase II). Lastly, the impact of the replacement strategy, in terms of benzimidazole efficacy, was measured (Phase III). Faecal egg counts from permanent lambs and worm burdens as a measure of pasture infectivity from tracer lambs were determined throughout the study. During Phase I, faecal egg counts diminished from a peak of 2968 (300–7740) epg to 0 epg at the end, while adult worm burdens of H. contortus were reduced from 2625 (800–5100) to 0, which showed that the treatment strategy used in Phase I was effective in reducing the resistant population. These parameters also showed that good levels of pasture contamination and infectivity were achieved in Phase II, as faecal egg counts of up to 7275 (3240–13080) epg and adult worm burdens of 500 (200–800) H. contortus were reached. The absolute benzimidazole efficacy on H. contortus estimated at 16 months post-population replacement (Phase III) was 97.58%. The results lead to the conclusion that the recovery of anthelmintic efficacy of fenbendazole against a resistant population of H. contortus may be achieved by means of a strategy based on management of refugia and a subsequent introduction of a susceptible population. This strategy might be translatable to other resistant nematode genera.
publishDate 2020
dc.date.none.fl_str_mv 2020-06-05
2021-03-05T11:30:58Z
2021-03-05T11:30:58Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/8820
https://www.sciencedirect.com/science/article/abs/pii/S0304401719301359
0304-4017
https://doi.org/10.1016/j.vetpar.2019.06.003
url http://hdl.handle.net/20.500.12123/8820
https://www.sciencedirect.com/science/article/abs/pii/S0304401719301359
https://doi.org/10.1016/j.vetpar.2019.06.003
identifier_str_mv 0304-4017
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Veterinary Parasitology 271 : 31-37 (2019)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.559606

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