Fasciola hepatica infection modifies IgG1 specific immune response to foot-and-mouth disease virus induced by vaccination

Autores
Costa, Monique; Mansilla, Florencia Celeste; Sala, Juan Manuel; Saravia, Anderson; Ubios, Diego; Lores, Pablo; Capozzo, Alejandra; Freire, Teresa
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fasciola hepatica, a worldwide distributed helminth, has a robust immunoregulatory effect in the host, increasing the susceptibility to secondary infections. Foot and mouth disease (FMD) is a highly contagious acute vesicular viral disease effectively controlled by vaccination in endemic regions. Despite the evidence of immunoregulatory effects, the impact of fasciolosis on the immune response induced by FMD vaccination in cattle has never been assessed. Our objective was to evaluate whether the infection by F. hepatica in cattle influences the long-term immunity elicited by the currently used commercial FMD-inactivated vaccines. Aberdeen Angus steers negative for F. hepatica were vaccinated twice against FMD virus (FMDV) during the first 6 months of age using a commercial oil vaccine formulated with A24/Cruzeiro and O1/Campos strains. When maternal antibodies against F. hepatica were weaned (18––20 months of age) animals were divided into groups of 12 and infected or mock-infected with 500 metacercariae/animal. Individual serum samples were collected at 0-, 28-, 59-, 87- and 157-days post-infection (dpi). Indirect ELISAs were used to detect A24/Cruzeiro specific bovine IgG and IgG subtypes. The total IgG antibody levels and avidity against FMDV did not show significant differences between all the groups. The commercial vaccine induced higher IgG2 than IgG1 titers in vaccinated animals. Anti-FMDV IgG1 levels significantly decreased in the infected group at 28 dpi. In addition, the avidity of IgG1 FMDV-specific antibodies at day 28 in the infected group was reduced compared to the control. These results show that F. hepatica infection modified anamnestic responses against FMDV, reducing serum IgG1 titers and avidity. To our knowledge, this is the first report of immune-regulation of F. hepatica altering the immune response of FMD vaccines, one of the most globally used animal vaccines.
Instituto de Virología
Fil: Costa, Monique. Universidad de La República. Facultad de Medicina. Departamento de Inmunobiología. Laboratorio de Inmunomodulación y Vacunas; Uruguay
Fil: Mansilla, Florencia Celeste. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina
Fil: Sala, Juan Manuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; Argentina
Fil: Saravia, Anderson. Instituto Nacional de Investigación Agropecuaria. Plataforma de Investigación en Salud Animal; Uruguay
Fil: Ubios, Diego. Instituto Nacional de Investigación Agropecuaria. Programa de Carne y Lana; Uruguay
Fil: Lores, Pablo. Universidad de La República. Facultad de Medicina. Departamento de Inmunobiología. Laboratorio de Inmunomodulación y Vacunas; Uruguay
Fil: Capozzo, Alejandra. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina
Fil: Capozzo, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Freire, Teresa. Universidad de La República. Facultad de Medicina. Departamento de Inmunobiología. Laboratorio de Inmunomodulación y Vacunas; Uruguay
Fuente
Vaccine 42 (3) : 541-547 (January 2024)
Materia
Fasciola hepatica
Fiebre Aftosa
Vacuna
Respuesta Inmunológica
Foot-and-mouth Disease
Vaccines
Immune Response
Vaccination
Vacunación
Nivel de accesibilidad
acceso restringido
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/18430
Acceder
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oai_identifier_str oai:localhost:20.500.12123/18430
network_acronym_str INTADig
repository_id_str l
network_name_str INTA Digital (INTA)
spelling Fasciola hepatica infection modifies IgG1 specific immune response to foot-and-mouth disease virus induced by vaccinationCosta, MoniqueMansilla, Florencia CelesteSala, Juan ManuelSaravia, AndersonUbios, DiegoLores, PabloCapozzo, AlejandraFreire, TeresaFasciola hepaticaFiebre AftosaVacunaRespuesta InmunológicaFoot-and-mouth DiseaseVaccinesImmune ResponseVaccinationVacunaciónFasciola hepatica, a worldwide distributed helminth, has a robust immunoregulatory effect in the host, increasing the susceptibility to secondary infections. Foot and mouth disease (FMD) is a highly contagious acute vesicular viral disease effectively controlled by vaccination in endemic regions. Despite the evidence of immunoregulatory effects, the impact of fasciolosis on the immune response induced by FMD vaccination in cattle has never been assessed. Our objective was to evaluate whether the infection by F. hepatica in cattle influences the long-term immunity elicited by the currently used commercial FMD-inactivated vaccines. Aberdeen Angus steers negative for F. hepatica were vaccinated twice against FMD virus (FMDV) during the first 6 months of age using a commercial oil vaccine formulated with A24/Cruzeiro and O1/Campos strains. When maternal antibodies against F. hepatica were weaned (18––20 months of age) animals were divided into groups of 12 and infected or mock-infected with 500 metacercariae/animal. Individual serum samples were collected at 0-, 28-, 59-, 87- and 157-days post-infection (dpi). Indirect ELISAs were used to detect A24/Cruzeiro specific bovine IgG and IgG subtypes. The total IgG antibody levels and avidity against FMDV did not show significant differences between all the groups. The commercial vaccine induced higher IgG2 than IgG1 titers in vaccinated animals. Anti-FMDV IgG1 levels significantly decreased in the infected group at 28 dpi. In addition, the avidity of IgG1 FMDV-specific antibodies at day 28 in the infected group was reduced compared to the control. These results show that F. hepatica infection modified anamnestic responses against FMDV, reducing serum IgG1 titers and avidity. To our knowledge, this is the first report of immune-regulation of F. hepatica altering the immune response of FMD vaccines, one of the most globally used animal vaccines.Instituto de VirologíaFil: Costa, Monique. Universidad de La República. Facultad de Medicina. Departamento de Inmunobiología. Laboratorio de Inmunomodulación y Vacunas; UruguayFil: Mansilla, Florencia Celeste. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; ArgentinaFil: Sala, Juan Manuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; ArgentinaFil: Saravia, Anderson. Instituto Nacional de Investigación Agropecuaria. Plataforma de Investigación en Salud Animal; UruguayFil: Ubios, Diego. Instituto Nacional de Investigación Agropecuaria. Programa de Carne y Lana; UruguayFil: Lores, Pablo. Universidad de La República. Facultad de Medicina. Departamento de Inmunobiología. Laboratorio de Inmunomodulación y Vacunas; UruguayFil: Capozzo, Alejandra. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; ArgentinaFil: Capozzo, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Freire, Teresa. Universidad de La República. Facultad de Medicina. Departamento de Inmunobiología. Laboratorio de Inmunomodulación y Vacunas; UruguayElsevier2024-07-10T09:59:15Z2024-07-10T09:59:15Z2024-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/18430https://www.sciencedirect.com/science/article/abs/pii/S0264410X2301513X1873-2518https://doi.org/10.1016/j.vaccine.2023.12.067Vaccine 42 (3) : 541-547 (January 2024)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-29T13:46:38Zoai:localhost:20.500.12123/18430instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:46:39.003INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Fasciola hepatica infection modifies IgG1 specific immune response to foot-and-mouth disease virus induced by vaccination
title Fasciola hepatica infection modifies IgG1 specific immune response to foot-and-mouth disease virus induced by vaccination
spellingShingle Fasciola hepatica infection modifies IgG1 specific immune response to foot-and-mouth disease virus induced by vaccination
Costa, Monique
Fasciola hepatica
Fiebre Aftosa
Vacuna
Respuesta Inmunológica
Foot-and-mouth Disease
Vaccines
Immune Response
Vaccination
Vacunación
title_short Fasciola hepatica infection modifies IgG1 specific immune response to foot-and-mouth disease virus induced by vaccination
title_full Fasciola hepatica infection modifies IgG1 specific immune response to foot-and-mouth disease virus induced by vaccination
title_fullStr Fasciola hepatica infection modifies IgG1 specific immune response to foot-and-mouth disease virus induced by vaccination
title_full_unstemmed Fasciola hepatica infection modifies IgG1 specific immune response to foot-and-mouth disease virus induced by vaccination
title_sort Fasciola hepatica infection modifies IgG1 specific immune response to foot-and-mouth disease virus induced by vaccination
dc.creator.none.fl_str_mv Costa, Monique
Mansilla, Florencia Celeste
Sala, Juan Manuel
Saravia, Anderson
Ubios, Diego
Lores, Pablo
Capozzo, Alejandra
Freire, Teresa
author Costa, Monique
author_facet Costa, Monique
Mansilla, Florencia Celeste
Sala, Juan Manuel
Saravia, Anderson
Ubios, Diego
Lores, Pablo
Capozzo, Alejandra
Freire, Teresa
author_role author
author2 Mansilla, Florencia Celeste
Sala, Juan Manuel
Saravia, Anderson
Ubios, Diego
Lores, Pablo
Capozzo, Alejandra
Freire, Teresa
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Fasciola hepatica
Fiebre Aftosa
Vacuna
Respuesta Inmunológica
Foot-and-mouth Disease
Vaccines
Immune Response
Vaccination
Vacunación
topic Fasciola hepatica
Fiebre Aftosa
Vacuna
Respuesta Inmunológica
Foot-and-mouth Disease
Vaccines
Immune Response
Vaccination
Vacunación
dc.description.none.fl_txt_mv Fasciola hepatica, a worldwide distributed helminth, has a robust immunoregulatory effect in the host, increasing the susceptibility to secondary infections. Foot and mouth disease (FMD) is a highly contagious acute vesicular viral disease effectively controlled by vaccination in endemic regions. Despite the evidence of immunoregulatory effects, the impact of fasciolosis on the immune response induced by FMD vaccination in cattle has never been assessed. Our objective was to evaluate whether the infection by F. hepatica in cattle influences the long-term immunity elicited by the currently used commercial FMD-inactivated vaccines. Aberdeen Angus steers negative for F. hepatica were vaccinated twice against FMD virus (FMDV) during the first 6 months of age using a commercial oil vaccine formulated with A24/Cruzeiro and O1/Campos strains. When maternal antibodies against F. hepatica were weaned (18––20 months of age) animals were divided into groups of 12 and infected or mock-infected with 500 metacercariae/animal. Individual serum samples were collected at 0-, 28-, 59-, 87- and 157-days post-infection (dpi). Indirect ELISAs were used to detect A24/Cruzeiro specific bovine IgG and IgG subtypes. The total IgG antibody levels and avidity against FMDV did not show significant differences between all the groups. The commercial vaccine induced higher IgG2 than IgG1 titers in vaccinated animals. Anti-FMDV IgG1 levels significantly decreased in the infected group at 28 dpi. In addition, the avidity of IgG1 FMDV-specific antibodies at day 28 in the infected group was reduced compared to the control. These results show that F. hepatica infection modified anamnestic responses against FMDV, reducing serum IgG1 titers and avidity. To our knowledge, this is the first report of immune-regulation of F. hepatica altering the immune response of FMD vaccines, one of the most globally used animal vaccines.
Instituto de Virología
Fil: Costa, Monique. Universidad de La República. Facultad de Medicina. Departamento de Inmunobiología. Laboratorio de Inmunomodulación y Vacunas; Uruguay
Fil: Mansilla, Florencia Celeste. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina
Fil: Sala, Juan Manuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; Argentina
Fil: Saravia, Anderson. Instituto Nacional de Investigación Agropecuaria. Plataforma de Investigación en Salud Animal; Uruguay
Fil: Ubios, Diego. Instituto Nacional de Investigación Agropecuaria. Programa de Carne y Lana; Uruguay
Fil: Lores, Pablo. Universidad de La República. Facultad de Medicina. Departamento de Inmunobiología. Laboratorio de Inmunomodulación y Vacunas; Uruguay
Fil: Capozzo, Alejandra. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina
Fil: Capozzo, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Freire, Teresa. Universidad de La República. Facultad de Medicina. Departamento de Inmunobiología. Laboratorio de Inmunomodulación y Vacunas; Uruguay
description Fasciola hepatica, a worldwide distributed helminth, has a robust immunoregulatory effect in the host, increasing the susceptibility to secondary infections. Foot and mouth disease (FMD) is a highly contagious acute vesicular viral disease effectively controlled by vaccination in endemic regions. Despite the evidence of immunoregulatory effects, the impact of fasciolosis on the immune response induced by FMD vaccination in cattle has never been assessed. Our objective was to evaluate whether the infection by F. hepatica in cattle influences the long-term immunity elicited by the currently used commercial FMD-inactivated vaccines. Aberdeen Angus steers negative for F. hepatica were vaccinated twice against FMD virus (FMDV) during the first 6 months of age using a commercial oil vaccine formulated with A24/Cruzeiro and O1/Campos strains. When maternal antibodies against F. hepatica were weaned (18––20 months of age) animals were divided into groups of 12 and infected or mock-infected with 500 metacercariae/animal. Individual serum samples were collected at 0-, 28-, 59-, 87- and 157-days post-infection (dpi). Indirect ELISAs were used to detect A24/Cruzeiro specific bovine IgG and IgG subtypes. The total IgG antibody levels and avidity against FMDV did not show significant differences between all the groups. The commercial vaccine induced higher IgG2 than IgG1 titers in vaccinated animals. Anti-FMDV IgG1 levels significantly decreased in the infected group at 28 dpi. In addition, the avidity of IgG1 FMDV-specific antibodies at day 28 in the infected group was reduced compared to the control. These results show that F. hepatica infection modified anamnestic responses against FMDV, reducing serum IgG1 titers and avidity. To our knowledge, this is the first report of immune-regulation of F. hepatica altering the immune response of FMD vaccines, one of the most globally used animal vaccines.
publishDate 2024
dc.date.none.fl_str_mv 2024-07-10T09:59:15Z
2024-07-10T09:59:15Z
2024-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/18430
https://www.sciencedirect.com/science/article/abs/pii/S0264410X2301513X
1873-2518
https://doi.org/10.1016/j.vaccine.2023.12.067
url http://hdl.handle.net/20.500.12123/18430
https://www.sciencedirect.com/science/article/abs/pii/S0264410X2301513X
https://doi.org/10.1016/j.vaccine.2023.12.067
identifier_str_mv 1873-2518
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv restrictedAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Vaccine 42 (3) : 541-547 (January 2024)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.559606

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