Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle
- Autores
- Nani, Juan Pablo; Raschia, Maria Agustina; Carignano, Hugo; Poli, Mario Andres; Calvinho, Luis Fernando; Amadio, Ariel
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The prevention and control of bovine mastitis by enhancing natural defenses in animals is important to improve the quality of dairy products. Mastitis resistance is a complex trait which depends on genetic components, as well as environmental and physiological factors. The limitations of classical control measures have led to the search for alternative approaches to minimize the use of antibiotics by selecting naturally resistant animals. Polymorphisms in genes associated with the innate immune system are strong candidates to be evaluated as genetic markers. In this work, we evaluated a set of single nucleotide polymorphisms (SNPs) in candidate genes for health and production traits, and determined their association with the somatic cell score (SCS) as an indicator of mastitis in Argentinean dairy cattle. We evaluated 941 cows: Holstein (n = 677) and Holstein × Jersey (n = 264) crossbred, daughters from 22 bulls from 14 dairy farms located in the central dairy area of Argentina. Two of the 21 successfully genotyped markers were found to be significantly associated (p < 0.05) with the SCS: GHR_140 and OPN_8514C-T. The heterozygote genotype for GHR_140 showed a favorable effect in reducing the SCS. On the other hand, heterozygote genotypes for OPN8514C-T caused an increase in the SCS; moreover, combined genotypes for OPN SNPs showed an even larger effect. These findings can contribute to the design of effective marker-assisted selection programs.
EEA Rafaela
Fil: Nani, Juan Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina
Fil: Raschia, Maria Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Carignano, Hugo Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Calvinho, Luis Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina
Fil: Amadio, Ariel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Fuente
- Journal of Applied Genetics 56 (4) : 505–513 (November 2015)
- Materia
-
Ganado de Leche
Control de Enfermedades
Enfermedades de los Animales
Mastítis Bovina
Genes
Células Somáticas
Dairy Cattle
Disease Control
Animal Diseases
Bovine Mastitis
Somatic Cells
Argentina - Nivel de accesibilidad
- acceso restringido
- Condiciones de uso
- Repositorio
- Institución
- Instituto Nacional de Tecnología Agropecuaria
- OAI Identificador
- oai:localhost:20.500.12123/2823
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Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattleNani, Juan PabloRaschia, Maria AgustinaCarignano, HugoPoli, Mario AndresCalvinho, Luis FernandoAmadio, ArielGanado de LecheControl de EnfermedadesEnfermedades de los AnimalesMastítis BovinaGenesCélulas SomáticasDairy CattleDisease ControlAnimal DiseasesBovine MastitisSomatic CellsArgentinaThe prevention and control of bovine mastitis by enhancing natural defenses in animals is important to improve the quality of dairy products. Mastitis resistance is a complex trait which depends on genetic components, as well as environmental and physiological factors. The limitations of classical control measures have led to the search for alternative approaches to minimize the use of antibiotics by selecting naturally resistant animals. Polymorphisms in genes associated with the innate immune system are strong candidates to be evaluated as genetic markers. In this work, we evaluated a set of single nucleotide polymorphisms (SNPs) in candidate genes for health and production traits, and determined their association with the somatic cell score (SCS) as an indicator of mastitis in Argentinean dairy cattle. We evaluated 941 cows: Holstein (n = 677) and Holstein × Jersey (n = 264) crossbred, daughters from 22 bulls from 14 dairy farms located in the central dairy area of Argentina. Two of the 21 successfully genotyped markers were found to be significantly associated (p < 0.05) with the SCS: GHR_140 and OPN_8514C-T. The heterozygote genotype for GHR_140 showed a favorable effect in reducing the SCS. On the other hand, heterozygote genotypes for OPN8514C-T caused an increase in the SCS; moreover, combined genotypes for OPN SNPs showed an even larger effect. These findings can contribute to the design of effective marker-assisted selection programs.EEA RafaelaFil: Nani, Juan Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Raschia, Maria Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; ArgentinaFil: Carignano, Hugo Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; ArgentinaFil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; ArgentinaFil: Calvinho, Luis Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Amadio, Ariel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina2018-07-19T13:01:28Z2018-07-19T13:01:28Z2015-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://link.springer.com/article/10.1007%2Fs13353-015-0278-5http://hdl.handle.net/20.500.12123/28231234-19832190-3883https://doi.org/10.1007/s13353-015-0278-5Journal of Applied Genetics 56 (4) : 505–513 (November 2015)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-09-29T13:44:21Zoai:localhost:20.500.12123/2823instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:44:22.278INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse |
dc.title.none.fl_str_mv |
Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle |
title |
Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle |
spellingShingle |
Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle Nani, Juan Pablo Ganado de Leche Control de Enfermedades Enfermedades de los Animales Mastítis Bovina Genes Células Somáticas Dairy Cattle Disease Control Animal Diseases Bovine Mastitis Somatic Cells Argentina |
title_short |
Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle |
title_full |
Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle |
title_fullStr |
Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle |
title_full_unstemmed |
Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle |
title_sort |
Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle |
dc.creator.none.fl_str_mv |
Nani, Juan Pablo Raschia, Maria Agustina Carignano, Hugo Poli, Mario Andres Calvinho, Luis Fernando Amadio, Ariel |
author |
Nani, Juan Pablo |
author_facet |
Nani, Juan Pablo Raschia, Maria Agustina Carignano, Hugo Poli, Mario Andres Calvinho, Luis Fernando Amadio, Ariel |
author_role |
author |
author2 |
Raschia, Maria Agustina Carignano, Hugo Poli, Mario Andres Calvinho, Luis Fernando Amadio, Ariel |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Ganado de Leche Control de Enfermedades Enfermedades de los Animales Mastítis Bovina Genes Células Somáticas Dairy Cattle Disease Control Animal Diseases Bovine Mastitis Somatic Cells Argentina |
topic |
Ganado de Leche Control de Enfermedades Enfermedades de los Animales Mastítis Bovina Genes Células Somáticas Dairy Cattle Disease Control Animal Diseases Bovine Mastitis Somatic Cells Argentina |
dc.description.none.fl_txt_mv |
The prevention and control of bovine mastitis by enhancing natural defenses in animals is important to improve the quality of dairy products. Mastitis resistance is a complex trait which depends on genetic components, as well as environmental and physiological factors. The limitations of classical control measures have led to the search for alternative approaches to minimize the use of antibiotics by selecting naturally resistant animals. Polymorphisms in genes associated with the innate immune system are strong candidates to be evaluated as genetic markers. In this work, we evaluated a set of single nucleotide polymorphisms (SNPs) in candidate genes for health and production traits, and determined their association with the somatic cell score (SCS) as an indicator of mastitis in Argentinean dairy cattle. We evaluated 941 cows: Holstein (n = 677) and Holstein × Jersey (n = 264) crossbred, daughters from 22 bulls from 14 dairy farms located in the central dairy area of Argentina. Two of the 21 successfully genotyped markers were found to be significantly associated (p < 0.05) with the SCS: GHR_140 and OPN_8514C-T. The heterozygote genotype for GHR_140 showed a favorable effect in reducing the SCS. On the other hand, heterozygote genotypes for OPN8514C-T caused an increase in the SCS; moreover, combined genotypes for OPN SNPs showed an even larger effect. These findings can contribute to the design of effective marker-assisted selection programs. EEA Rafaela Fil: Nani, Juan Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina Fil: Raschia, Maria Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina Fil: Carignano, Hugo Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina Fil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina Fil: Calvinho, Luis Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina Fil: Amadio, Ariel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
The prevention and control of bovine mastitis by enhancing natural defenses in animals is important to improve the quality of dairy products. Mastitis resistance is a complex trait which depends on genetic components, as well as environmental and physiological factors. The limitations of classical control measures have led to the search for alternative approaches to minimize the use of antibiotics by selecting naturally resistant animals. Polymorphisms in genes associated with the innate immune system are strong candidates to be evaluated as genetic markers. In this work, we evaluated a set of single nucleotide polymorphisms (SNPs) in candidate genes for health and production traits, and determined their association with the somatic cell score (SCS) as an indicator of mastitis in Argentinean dairy cattle. We evaluated 941 cows: Holstein (n = 677) and Holstein × Jersey (n = 264) crossbred, daughters from 22 bulls from 14 dairy farms located in the central dairy area of Argentina. Two of the 21 successfully genotyped markers were found to be significantly associated (p < 0.05) with the SCS: GHR_140 and OPN_8514C-T. The heterozygote genotype for GHR_140 showed a favorable effect in reducing the SCS. On the other hand, heterozygote genotypes for OPN8514C-T caused an increase in the SCS; moreover, combined genotypes for OPN SNPs showed an even larger effect. These findings can contribute to the design of effective marker-assisted selection programs. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-11 2018-07-19T13:01:28Z 2018-07-19T13:01:28Z |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://link.springer.com/article/10.1007%2Fs13353-015-0278-5 http://hdl.handle.net/20.500.12123/2823 1234-1983 2190-3883 https://doi.org/10.1007/s13353-015-0278-5 |
url |
https://link.springer.com/article/10.1007%2Fs13353-015-0278-5 http://hdl.handle.net/20.500.12123/2823 https://doi.org/10.1007/s13353-015-0278-5 |
identifier_str_mv |
1234-1983 2190-3883 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/restrictedAccess |
eu_rights_str_mv |
restrictedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Journal of Applied Genetics 56 (4) : 505–513 (November 2015) reponame:INTA Digital (INTA) instname:Instituto Nacional de Tecnología Agropecuaria |
reponame_str |
INTA Digital (INTA) |
collection |
INTA Digital (INTA) |
instname_str |
Instituto Nacional de Tecnología Agropecuaria |
repository.name.fl_str_mv |
INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria |
repository.mail.fl_str_mv |
tripaldi.nicolas@inta.gob.ar |
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1844619123937509376 |
score |
12.559606 |