Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle

Autores
Nani, Juan Pablo; Raschia, Maria Agustina; Carignano, Hugo; Poli, Mario Andres; Calvinho, Luis Fernando; Amadio, Ariel
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The prevention and control of bovine mastitis by enhancing natural defenses in animals is important to improve the quality of dairy products. Mastitis resistance is a complex trait which depends on genetic components, as well as environmental and physiological factors. The limitations of classical control measures have led to the search for alternative approaches to minimize the use of antibiotics by selecting naturally resistant animals. Polymorphisms in genes associated with the innate immune system are strong candidates to be evaluated as genetic markers. In this work, we evaluated a set of single nucleotide polymorphisms (SNPs) in candidate genes for health and production traits, and determined their association with the somatic cell score (SCS) as an indicator of mastitis in Argentinean dairy cattle. We evaluated 941 cows: Holstein (n = 677) and Holstein × Jersey (n = 264) crossbred, daughters from 22 bulls from 14 dairy farms located in the central dairy area of Argentina. Two of the 21 successfully genotyped markers were found to be significantly associated (p < 0.05) with the SCS: GHR_140 and OPN_8514C-T. The heterozygote genotype for GHR_140 showed a favorable effect in reducing the SCS. On the other hand, heterozygote genotypes for OPN8514C-T caused an increase in the SCS; moreover, combined genotypes for OPN SNPs showed an even larger effect. These findings can contribute to the design of effective marker-assisted selection programs.
EEA Rafaela
Fil: Nani, Juan Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina
Fil: Raschia, Maria Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Carignano, Hugo Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Calvinho, Luis Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina
Fil: Amadio, Ariel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fuente
Journal of Applied Genetics 56 (4) : 505–513 (November 2015)
Materia
Ganado de Leche
Control de Enfermedades
Enfermedades de los Animales
Mastítis Bovina
Genes
Células Somáticas
Dairy Cattle
Disease Control
Animal Diseases
Bovine Mastitis
Somatic Cells
Argentina
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/2823
Acceder
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oai_identifier_str oai:localhost:20.500.12123/2823
network_acronym_str INTADig
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network_name_str INTA Digital (INTA)
spelling Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattleNani, Juan PabloRaschia, Maria AgustinaCarignano, HugoPoli, Mario AndresCalvinho, Luis FernandoAmadio, ArielGanado de LecheControl de EnfermedadesEnfermedades de los AnimalesMastítis BovinaGenesCélulas SomáticasDairy CattleDisease ControlAnimal DiseasesBovine MastitisSomatic CellsArgentinaThe prevention and control of bovine mastitis by enhancing natural defenses in animals is important to improve the quality of dairy products. Mastitis resistance is a complex trait which depends on genetic components, as well as environmental and physiological factors. The limitations of classical control measures have led to the search for alternative approaches to minimize the use of antibiotics by selecting naturally resistant animals. Polymorphisms in genes associated with the innate immune system are strong candidates to be evaluated as genetic markers. In this work, we evaluated a set of single nucleotide polymorphisms (SNPs) in candidate genes for health and production traits, and determined their association with the somatic cell score (SCS) as an indicator of mastitis in Argentinean dairy cattle. We evaluated 941 cows: Holstein (n = 677) and Holstein × Jersey (n = 264) crossbred, daughters from 22 bulls from 14 dairy farms located in the central dairy area of Argentina. Two of the 21 successfully genotyped markers were found to be significantly associated (p < 0.05) with the SCS: GHR_140 and OPN_8514C-T. The heterozygote genotype for GHR_140 showed a favorable effect in reducing the SCS. On the other hand, heterozygote genotypes for OPN8514C-T caused an increase in the SCS; moreover, combined genotypes for OPN SNPs showed an even larger effect. These findings can contribute to the design of effective marker-assisted selection programs.EEA RafaelaFil: Nani, Juan Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Raschia, Maria Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; ArgentinaFil: Carignano, Hugo Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; ArgentinaFil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; ArgentinaFil: Calvinho, Luis Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Amadio, Ariel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina2018-07-19T13:01:28Z2018-07-19T13:01:28Z2015-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://link.springer.com/article/10.1007%2Fs13353-015-0278-5http://hdl.handle.net/20.500.12123/28231234-19832190-3883https://doi.org/10.1007/s13353-015-0278-5Journal of Applied Genetics 56 (4) : 505–513 (November 2015)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-10-30T11:22:46Zoai:localhost:20.500.12123/2823instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-10-30 11:22:47.308INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle
title Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle
spellingShingle Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle
Nani, Juan Pablo
Ganado de Leche
Control de Enfermedades
Enfermedades de los Animales
Mastítis Bovina
Genes
Células Somáticas
Dairy Cattle
Disease Control
Animal Diseases
Bovine Mastitis
Somatic Cells
Argentina
title_short Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle
title_full Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle
title_fullStr Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle
title_full_unstemmed Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle
title_sort Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle
dc.creator.none.fl_str_mv Nani, Juan Pablo
Raschia, Maria Agustina
Carignano, Hugo
Poli, Mario Andres
Calvinho, Luis Fernando
Amadio, Ariel
author Nani, Juan Pablo
author_facet Nani, Juan Pablo
Raschia, Maria Agustina
Carignano, Hugo
Poli, Mario Andres
Calvinho, Luis Fernando
Amadio, Ariel
author_role author
author2 Raschia, Maria Agustina
Carignano, Hugo
Poli, Mario Andres
Calvinho, Luis Fernando
Amadio, Ariel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ganado de Leche
Control de Enfermedades
Enfermedades de los Animales
Mastítis Bovina
Genes
Células Somáticas
Dairy Cattle
Disease Control
Animal Diseases
Bovine Mastitis
Somatic Cells
Argentina
topic Ganado de Leche
Control de Enfermedades
Enfermedades de los Animales
Mastítis Bovina
Genes
Células Somáticas
Dairy Cattle
Disease Control
Animal Diseases
Bovine Mastitis
Somatic Cells
Argentina
dc.description.none.fl_txt_mv The prevention and control of bovine mastitis by enhancing natural defenses in animals is important to improve the quality of dairy products. Mastitis resistance is a complex trait which depends on genetic components, as well as environmental and physiological factors. The limitations of classical control measures have led to the search for alternative approaches to minimize the use of antibiotics by selecting naturally resistant animals. Polymorphisms in genes associated with the innate immune system are strong candidates to be evaluated as genetic markers. In this work, we evaluated a set of single nucleotide polymorphisms (SNPs) in candidate genes for health and production traits, and determined their association with the somatic cell score (SCS) as an indicator of mastitis in Argentinean dairy cattle. We evaluated 941 cows: Holstein (n = 677) and Holstein × Jersey (n = 264) crossbred, daughters from 22 bulls from 14 dairy farms located in the central dairy area of Argentina. Two of the 21 successfully genotyped markers were found to be significantly associated (p < 0.05) with the SCS: GHR_140 and OPN_8514C-T. The heterozygote genotype for GHR_140 showed a favorable effect in reducing the SCS. On the other hand, heterozygote genotypes for OPN8514C-T caused an increase in the SCS; moreover, combined genotypes for OPN SNPs showed an even larger effect. These findings can contribute to the design of effective marker-assisted selection programs.
EEA Rafaela
Fil: Nani, Juan Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina
Fil: Raschia, Maria Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Carignano, Hugo Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Calvinho, Luis Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina
Fil: Amadio, Ariel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The prevention and control of bovine mastitis by enhancing natural defenses in animals is important to improve the quality of dairy products. Mastitis resistance is a complex trait which depends on genetic components, as well as environmental and physiological factors. The limitations of classical control measures have led to the search for alternative approaches to minimize the use of antibiotics by selecting naturally resistant animals. Polymorphisms in genes associated with the innate immune system are strong candidates to be evaluated as genetic markers. In this work, we evaluated a set of single nucleotide polymorphisms (SNPs) in candidate genes for health and production traits, and determined their association with the somatic cell score (SCS) as an indicator of mastitis in Argentinean dairy cattle. We evaluated 941 cows: Holstein (n = 677) and Holstein × Jersey (n = 264) crossbred, daughters from 22 bulls from 14 dairy farms located in the central dairy area of Argentina. Two of the 21 successfully genotyped markers were found to be significantly associated (p < 0.05) with the SCS: GHR_140 and OPN_8514C-T. The heterozygote genotype for GHR_140 showed a favorable effect in reducing the SCS. On the other hand, heterozygote genotypes for OPN8514C-T caused an increase in the SCS; moreover, combined genotypes for OPN SNPs showed an even larger effect. These findings can contribute to the design of effective marker-assisted selection programs.
publishDate 2015
dc.date.none.fl_str_mv 2015-11
2018-07-19T13:01:28Z
2018-07-19T13:01:28Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://link.springer.com/article/10.1007%2Fs13353-015-0278-5
http://hdl.handle.net/20.500.12123/2823
1234-1983
2190-3883
https://doi.org/10.1007/s13353-015-0278-5
url https://link.springer.com/article/10.1007%2Fs13353-015-0278-5
http://hdl.handle.net/20.500.12123/2823
https://doi.org/10.1007/s13353-015-0278-5
identifier_str_mv 1234-1983
2190-3883
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Journal of Applied Genetics 56 (4) : 505–513 (November 2015)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.573905

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