Which are important targets in development of S. aureus mastitis vaccine?

Autores
Scali, F.; Camussone, Cecilia; Calvinho, Luis Fernando; Cipolla, M.; Zecconi, A.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Staphylococcus aureus represents one of the leading causes of mastitis in dairy cows worldwide. S. aureus IMI have variable outcomes due to virulence of the strain involved, immune defenses of the host, and by antibiotic resistance. The difficulty in eradication and the increasing concerns on antibiotics usages underscore the interest in developing new tools to control S. aureus mastitis. Vaccination represents one of the most studied of these tools but, so far, no vaccine seems to provide reliable protection. This review summarizes current knowledge on the major vaccine targets, including surface proteins, capsular polysaccharides, biofilm, and toxins. Finally, the present status of vaccination against S. aureus and the future of vaccine design were discussed, including how differences among in vivo models may influence vaccines development.
EEA Rafaela
Fil: Scali, F. Universita Degli Studi Di Milano. Department of Veterinary Sciences and Public Health; Italia
Fil: Camussone, Cecilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
Fil: Calvinho, Luis Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
Fil: Cipolla, M. Universita Degli Studi Di Milano. Department of Veterinary Sciences and Public Health; Italia
Fil: Zecconi, A. Universita Degli Studi Di Milano. Department of Veterinary Sciences and Public Health; Italia
Fuente
Research in Veterinary Science 100 : 88-99 (June 2015)
Materia
Mastítis Bovina
Enfermedades de los Animales
Ganado Bovino
Control de Enfermedades
Vacuna
Staphylococcus aureus
Bovine Mastitis
Animal Diseases
Cattle
Disease Control
Vaccines
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/2825
Acceder
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oai_identifier_str oai:localhost:20.500.12123/2825
network_acronym_str INTADig
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network_name_str INTA Digital (INTA)
spelling Which are important targets in development of S. aureus mastitis vaccine?Scali, F.Camussone, CeciliaCalvinho, Luis FernandoCipolla, M.Zecconi, A.Mastítis BovinaEnfermedades de los AnimalesGanado BovinoControl de EnfermedadesVacunaStaphylococcus aureusBovine MastitisAnimal DiseasesCattleDisease ControlVaccinesStaphylococcus aureus represents one of the leading causes of mastitis in dairy cows worldwide. S. aureus IMI have variable outcomes due to virulence of the strain involved, immune defenses of the host, and by antibiotic resistance. The difficulty in eradication and the increasing concerns on antibiotics usages underscore the interest in developing new tools to control S. aureus mastitis. Vaccination represents one of the most studied of these tools but, so far, no vaccine seems to provide reliable protection. This review summarizes current knowledge on the major vaccine targets, including surface proteins, capsular polysaccharides, biofilm, and toxins. Finally, the present status of vaccination against S. aureus and the future of vaccine design were discussed, including how differences among in vivo models may influence vaccines development.EEA RafaelaFil: Scali, F. Universita Degli Studi Di Milano. Department of Veterinary Sciences and Public Health; ItaliaFil: Camussone, Cecilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Calvinho, Luis Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; ArgentinaFil: Cipolla, M. Universita Degli Studi Di Milano. Department of Veterinary Sciences and Public Health; ItaliaFil: Zecconi, A. Universita Degli Studi Di Milano. Department of Veterinary Sciences and Public Health; Italia2018-07-19T13:46:49Z2018-07-19T13:46:49Z2015-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://www.sciencedirect.com/science/article/pii/S0034528815000934?via%3Dihubhttp://hdl.handle.net/20.500.12123/28250034-5288https://doi.org/10.1016/j.rvsc.2015.03.019Research in Veterinary Science 100 : 88-99 (June 2015)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-10-23T11:16:35Zoai:localhost:20.500.12123/2825instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-10-23 11:16:35.41INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Which are important targets in development of S. aureus mastitis vaccine?
title Which are important targets in development of S. aureus mastitis vaccine?
spellingShingle Which are important targets in development of S. aureus mastitis vaccine?
Scali, F.
Mastítis Bovina
Enfermedades de los Animales
Ganado Bovino
Control de Enfermedades
Vacuna
Staphylococcus aureus
Bovine Mastitis
Animal Diseases
Cattle
Disease Control
Vaccines
title_short Which are important targets in development of S. aureus mastitis vaccine?
title_full Which are important targets in development of S. aureus mastitis vaccine?
title_fullStr Which are important targets in development of S. aureus mastitis vaccine?
title_full_unstemmed Which are important targets in development of S. aureus mastitis vaccine?
title_sort Which are important targets in development of S. aureus mastitis vaccine?
dc.creator.none.fl_str_mv Scali, F.
Camussone, Cecilia
Calvinho, Luis Fernando
Cipolla, M.
Zecconi, A.
author Scali, F.
author_facet Scali, F.
Camussone, Cecilia
Calvinho, Luis Fernando
Cipolla, M.
Zecconi, A.
author_role author
author2 Camussone, Cecilia
Calvinho, Luis Fernando
Cipolla, M.
Zecconi, A.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Mastítis Bovina
Enfermedades de los Animales
Ganado Bovino
Control de Enfermedades
Vacuna
Staphylococcus aureus
Bovine Mastitis
Animal Diseases
Cattle
Disease Control
Vaccines
topic Mastítis Bovina
Enfermedades de los Animales
Ganado Bovino
Control de Enfermedades
Vacuna
Staphylococcus aureus
Bovine Mastitis
Animal Diseases
Cattle
Disease Control
Vaccines
dc.description.none.fl_txt_mv Staphylococcus aureus represents one of the leading causes of mastitis in dairy cows worldwide. S. aureus IMI have variable outcomes due to virulence of the strain involved, immune defenses of the host, and by antibiotic resistance. The difficulty in eradication and the increasing concerns on antibiotics usages underscore the interest in developing new tools to control S. aureus mastitis. Vaccination represents one of the most studied of these tools but, so far, no vaccine seems to provide reliable protection. This review summarizes current knowledge on the major vaccine targets, including surface proteins, capsular polysaccharides, biofilm, and toxins. Finally, the present status of vaccination against S. aureus and the future of vaccine design were discussed, including how differences among in vivo models may influence vaccines development.
EEA Rafaela
Fil: Scali, F. Universita Degli Studi Di Milano. Department of Veterinary Sciences and Public Health; Italia
Fil: Camussone, Cecilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
Fil: Calvinho, Luis Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
Fil: Cipolla, M. Universita Degli Studi Di Milano. Department of Veterinary Sciences and Public Health; Italia
Fil: Zecconi, A. Universita Degli Studi Di Milano. Department of Veterinary Sciences and Public Health; Italia
description Staphylococcus aureus represents one of the leading causes of mastitis in dairy cows worldwide. S. aureus IMI have variable outcomes due to virulence of the strain involved, immune defenses of the host, and by antibiotic resistance. The difficulty in eradication and the increasing concerns on antibiotics usages underscore the interest in developing new tools to control S. aureus mastitis. Vaccination represents one of the most studied of these tools but, so far, no vaccine seems to provide reliable protection. This review summarizes current knowledge on the major vaccine targets, including surface proteins, capsular polysaccharides, biofilm, and toxins. Finally, the present status of vaccination against S. aureus and the future of vaccine design were discussed, including how differences among in vivo models may influence vaccines development.
publishDate 2015
dc.date.none.fl_str_mv 2015-06
2018-07-19T13:46:49Z
2018-07-19T13:46:49Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://www.sciencedirect.com/science/article/pii/S0034528815000934?via%3Dihub
http://hdl.handle.net/20.500.12123/2825
0034-5288
https://doi.org/10.1016/j.rvsc.2015.03.019
url https://www.sciencedirect.com/science/article/pii/S0034528815000934?via%3Dihub
http://hdl.handle.net/20.500.12123/2825
https://doi.org/10.1016/j.rvsc.2015.03.019
identifier_str_mv 0034-5288
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Research in Veterinary Science 100 : 88-99 (June 2015)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.982451

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