Photosensitization Induced by Heterophyllaea pustulata in Goats: Sequential Development of Skin Lesions

Autores
Micheloud, Juan Francisco; Lujan, Lluís; Colque Caro, Luis Adrián; Núñez-Montoya, Susana C.; Barbeito, Claudio Gustavo; Portiansky, Enrique L.; Gimeno, Eduardo Juan
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Five adult Saanen goats received a single oral dose of Heterophyllaea pustulata containing 42.25 μg/kg rubiadin (anthraquinone) and 3 adult goats were untreated controls. All goats were exposed to sunlight and sequential ear skin biopsies were collected before treatment and at 32 hours, 3 days, 8 days, and 15 days after treatment. Changes at 32 hours after dosing included epidermal spongiosis, single cell death and acantholysis, an increased BAX/BCL-2 protein ratio, and dermal edema. Lesions at day 3 included epidermal and adnexal necrosis, crust formation, and acanthosis. Acanthosis, hyperkeratosis, and dermal fibrosis and neovascularization were present at day 15. The pro-apoptotic (BAX)/anti-apoptotic (BCL-2) protein ratio increased at 32 hours, whereas epidermal and dermal PCNA immunolabeling increased between days 8 and 15 after treatment. The cutaneous lesions were consistent with sunlight-induced damage, and the occurrence in treated but not control goats indicates photosensitization.
Estación Experimental Agropecuaria Salta
Fil: Micheloud, Juan Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Salta; Argentina. Universidad Católica de Salta, Argentina.
Fil: Luján, Lluís. Universidad de Zaragoza; España
Fil: Colque-Caro, Luis A. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Salta; Argentina. Universidad Católica de Salta, Argentina.
Fil: Múñez-Montoya, Susana C. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba; Argentina.
Fil: Barbeito, Claudio G. Universidad Nacional de La Plata; Argentina.
Fil: Portiansky, Enrique L. Universidad Nacional de La Plata; Argentina.
Fil: Gimeno, Eduardo J. Universidad Nacional de La Plata;Argentina.
Fuente
Veterinary Pathology 58 (3) : 568-573 (2021)
Materia
Photosensitivity
Animal Diseases
Goats
Poisonous Plants
Enfermedades de los Animales
Caprinos
Plantas Tóxicas
Fotosensibilidad
Heterophyllaea pustulata
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/9847
Acceder
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oai_identifier_str oai:localhost:20.500.12123/9847
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network_name_str INTA Digital (INTA)
spelling Photosensitization Induced by Heterophyllaea pustulata in Goats: Sequential Development of Skin LesionsMicheloud, Juan FranciscoLujan, LluísColque Caro, Luis AdriánNúñez-Montoya, Susana C.Barbeito, Claudio GustavoPortiansky, Enrique L.Gimeno, Eduardo JuanPhotosensitivityAnimal DiseasesGoatsPoisonous PlantsEnfermedades de los AnimalesCaprinosPlantas TóxicasFotosensibilidadHeterophyllaea pustulataFive adult Saanen goats received a single oral dose of Heterophyllaea pustulata containing 42.25 μg/kg rubiadin (anthraquinone) and 3 adult goats were untreated controls. All goats were exposed to sunlight and sequential ear skin biopsies were collected before treatment and at 32 hours, 3 days, 8 days, and 15 days after treatment. Changes at 32 hours after dosing included epidermal spongiosis, single cell death and acantholysis, an increased BAX/BCL-2 protein ratio, and dermal edema. Lesions at day 3 included epidermal and adnexal necrosis, crust formation, and acanthosis. Acanthosis, hyperkeratosis, and dermal fibrosis and neovascularization were present at day 15. The pro-apoptotic (BAX)/anti-apoptotic (BCL-2) protein ratio increased at 32 hours, whereas epidermal and dermal PCNA immunolabeling increased between days 8 and 15 after treatment. The cutaneous lesions were consistent with sunlight-induced damage, and the occurrence in treated but not control goats indicates photosensitization.Estación Experimental Agropecuaria SaltaFil: Micheloud, Juan Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Salta; Argentina. Universidad Católica de Salta, Argentina.Fil: Luján, Lluís. Universidad de Zaragoza; EspañaFil: Colque-Caro, Luis A. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Salta; Argentina. Universidad Católica de Salta, Argentina.Fil: Múñez-Montoya, Susana C. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba; Argentina.Fil: Barbeito, Claudio G. Universidad Nacional de La Plata; Argentina.Fil: Portiansky, Enrique L. Universidad Nacional de La Plata; Argentina.Fil: Gimeno, Eduardo J. Universidad Nacional de La Plata;Argentina.Sage Publishers2021-07-20T12:13:59Z2021-07-20T12:13:59Z2021-4info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/9847https://journals.sagepub.com/doi/abs/10.1177/03009858219993220300-98581544-2217https://doi.org/10.1177/0300985821999322Veterinary Pathology 58 (3) : 568-573 (2021)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-09-11T10:23:49Zoai:localhost:20.500.12123/9847instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-11 10:23:50.009INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Photosensitization Induced by Heterophyllaea pustulata in Goats: Sequential Development of Skin Lesions
title Photosensitization Induced by Heterophyllaea pustulata in Goats: Sequential Development of Skin Lesions
spellingShingle Photosensitization Induced by Heterophyllaea pustulata in Goats: Sequential Development of Skin Lesions
Micheloud, Juan Francisco
Photosensitivity
Animal Diseases
Goats
Poisonous Plants
Enfermedades de los Animales
Caprinos
Plantas Tóxicas
Fotosensibilidad
Heterophyllaea pustulata
title_short Photosensitization Induced by Heterophyllaea pustulata in Goats: Sequential Development of Skin Lesions
title_full Photosensitization Induced by Heterophyllaea pustulata in Goats: Sequential Development of Skin Lesions
title_fullStr Photosensitization Induced by Heterophyllaea pustulata in Goats: Sequential Development of Skin Lesions
title_full_unstemmed Photosensitization Induced by Heterophyllaea pustulata in Goats: Sequential Development of Skin Lesions
title_sort Photosensitization Induced by Heterophyllaea pustulata in Goats: Sequential Development of Skin Lesions
dc.creator.none.fl_str_mv Micheloud, Juan Francisco
Lujan, Lluís
Colque Caro, Luis Adrián
Núñez-Montoya, Susana C.
Barbeito, Claudio Gustavo
Portiansky, Enrique L.
Gimeno, Eduardo Juan
author Micheloud, Juan Francisco
author_facet Micheloud, Juan Francisco
Lujan, Lluís
Colque Caro, Luis Adrián
Núñez-Montoya, Susana C.
Barbeito, Claudio Gustavo
Portiansky, Enrique L.
Gimeno, Eduardo Juan
author_role author
author2 Lujan, Lluís
Colque Caro, Luis Adrián
Núñez-Montoya, Susana C.
Barbeito, Claudio Gustavo
Portiansky, Enrique L.
Gimeno, Eduardo Juan
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Photosensitivity
Animal Diseases
Goats
Poisonous Plants
Enfermedades de los Animales
Caprinos
Plantas Tóxicas
Fotosensibilidad
Heterophyllaea pustulata
topic Photosensitivity
Animal Diseases
Goats
Poisonous Plants
Enfermedades de los Animales
Caprinos
Plantas Tóxicas
Fotosensibilidad
Heterophyllaea pustulata
dc.description.none.fl_txt_mv Five adult Saanen goats received a single oral dose of Heterophyllaea pustulata containing 42.25 μg/kg rubiadin (anthraquinone) and 3 adult goats were untreated controls. All goats were exposed to sunlight and sequential ear skin biopsies were collected before treatment and at 32 hours, 3 days, 8 days, and 15 days after treatment. Changes at 32 hours after dosing included epidermal spongiosis, single cell death and acantholysis, an increased BAX/BCL-2 protein ratio, and dermal edema. Lesions at day 3 included epidermal and adnexal necrosis, crust formation, and acanthosis. Acanthosis, hyperkeratosis, and dermal fibrosis and neovascularization were present at day 15. The pro-apoptotic (BAX)/anti-apoptotic (BCL-2) protein ratio increased at 32 hours, whereas epidermal and dermal PCNA immunolabeling increased between days 8 and 15 after treatment. The cutaneous lesions were consistent with sunlight-induced damage, and the occurrence in treated but not control goats indicates photosensitization.
Estación Experimental Agropecuaria Salta
Fil: Micheloud, Juan Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Salta; Argentina. Universidad Católica de Salta, Argentina.
Fil: Luján, Lluís. Universidad de Zaragoza; España
Fil: Colque-Caro, Luis A. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Salta; Argentina. Universidad Católica de Salta, Argentina.
Fil: Múñez-Montoya, Susana C. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba; Argentina.
Fil: Barbeito, Claudio G. Universidad Nacional de La Plata; Argentina.
Fil: Portiansky, Enrique L. Universidad Nacional de La Plata; Argentina.
Fil: Gimeno, Eduardo J. Universidad Nacional de La Plata;Argentina.
description Five adult Saanen goats received a single oral dose of Heterophyllaea pustulata containing 42.25 μg/kg rubiadin (anthraquinone) and 3 adult goats were untreated controls. All goats were exposed to sunlight and sequential ear skin biopsies were collected before treatment and at 32 hours, 3 days, 8 days, and 15 days after treatment. Changes at 32 hours after dosing included epidermal spongiosis, single cell death and acantholysis, an increased BAX/BCL-2 protein ratio, and dermal edema. Lesions at day 3 included epidermal and adnexal necrosis, crust formation, and acanthosis. Acanthosis, hyperkeratosis, and dermal fibrosis and neovascularization were present at day 15. The pro-apoptotic (BAX)/anti-apoptotic (BCL-2) protein ratio increased at 32 hours, whereas epidermal and dermal PCNA immunolabeling increased between days 8 and 15 after treatment. The cutaneous lesions were consistent with sunlight-induced damage, and the occurrence in treated but not control goats indicates photosensitization.
publishDate 2021
dc.date.none.fl_str_mv 2021-07-20T12:13:59Z
2021-07-20T12:13:59Z
2021-4
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/9847
https://journals.sagepub.com/doi/abs/10.1177/0300985821999322
0300-9858
1544-2217
https://doi.org/10.1177/0300985821999322
url http://hdl.handle.net/20.500.12123/9847
https://journals.sagepub.com/doi/abs/10.1177/0300985821999322
https://doi.org/10.1177/0300985821999322
identifier_str_mv 0300-9858
1544-2217
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sage Publishers
publisher.none.fl_str_mv Sage Publishers
dc.source.none.fl_str_mv Veterinary Pathology 58 (3) : 568-573 (2021)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
_version_ 1842975499447435264
score 12.993085

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