Photosensitization induced by heterophyllaea pustulata in goats: sequential development of skin lesions

Autores
Micheloud, Juan Francisco; Luján, Lluís; Colque Caro, Luis Adrián; Núñez Montoya, Susana Carolina; Barbeito, Claudio Gustavo; Portiansky, Enrique Leo; Gimeno, Eduardo Juan
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Five adult Saanen goats received a single oral dose of Heterophyllaea pustulata containing 42.25 μg/kg rubiadin (anthraquinone). Treated goats, and three adult untreated goats (controls) were exposed to sunlight and sequential ear skin biopsies, collected before treatment, and at 32 h, 3 days, 8 days and 15 days after treatment, were examined. Changes at 32 h after dosing included epidermal spongiosis, single cell death and acantholysis, an increased BAX/BCL-2 protein ratio, and dermal edema. Lesions at day 3 included epidermal and adnexal necrosis, crust formation and acanthosis. Acanthosis, hyperkeratosis, and dermal fibrosis and neovascularization were present at day 15. Pro-apoptotic (BAX)/anti-apoptotic (BCL-2) protein ratio increased at 32 h, whereas epidermal and dermal PCNA immunolabelling increased between days 8 and 15 after treatment. The cutaneous lesions were consistent with sunlight-induced damage and the occurrence in treated but not control goats indicates photosensitization.
Fil: Micheloud, Juan Francisco. Instituto Nacional de Tecnología Agropecuaria; Argentina. Universidad Católica de Salta; Argentina
Fil: Luján, Lluís. Universidad de Zaragoza; España
Fil: Colque Caro, Luis Adrián. Instituto Nacional de Tecnología Agropecuaria; Argentina. Universidad Católica de Salta; Argentina
Fil: Núñez Montoya, Susana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Barbeito, Claudio Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina
Fil: Portiansky, Enrique Leo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina
Fil: Gimeno, Eduardo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina
Materia
CEGADERA
POISONOUS PLANTS
DERMATITIS
GOATS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/158342
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/158342
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Photosensitization induced by heterophyllaea pustulata in goats: sequential development of skin lesionsMicheloud, Juan FranciscoLuján, LluísColque Caro, Luis AdriánNúñez Montoya, Susana CarolinaBarbeito, Claudio GustavoPortiansky, Enrique LeoGimeno, Eduardo JuanCEGADERAPOISONOUS PLANTSDERMATITISGOATShttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Five adult Saanen goats received a single oral dose of Heterophyllaea pustulata containing 42.25 μg/kg rubiadin (anthraquinone). Treated goats, and three adult untreated goats (controls) were exposed to sunlight and sequential ear skin biopsies, collected before treatment, and at 32 h, 3 days, 8 days and 15 days after treatment, were examined. Changes at 32 h after dosing included epidermal spongiosis, single cell death and acantholysis, an increased BAX/BCL-2 protein ratio, and dermal edema. Lesions at day 3 included epidermal and adnexal necrosis, crust formation and acanthosis. Acanthosis, hyperkeratosis, and dermal fibrosis and neovascularization were present at day 15. Pro-apoptotic (BAX)/anti-apoptotic (BCL-2) protein ratio increased at 32 h, whereas epidermal and dermal PCNA immunolabelling increased between days 8 and 15 after treatment. The cutaneous lesions were consistent with sunlight-induced damage and the occurrence in treated but not control goats indicates photosensitization.Fil: Micheloud, Juan Francisco. Instituto Nacional de Tecnología Agropecuaria; Argentina. Universidad Católica de Salta; ArgentinaFil: Luján, Lluís. Universidad de Zaragoza; EspañaFil: Colque Caro, Luis Adrián. Instituto Nacional de Tecnología Agropecuaria; Argentina. Universidad Católica de Salta; ArgentinaFil: Núñez Montoya, Susana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Barbeito, Claudio Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; ArgentinaFil: Portiansky, Enrique Leo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; ArgentinaFil: Gimeno, Eduardo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; ArgentinaAmerican College of Veterinary Pathologists2021-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/158342Micheloud, Juan Francisco; Luján, Lluís; Colque Caro, Luis Adrián; Núñez Montoya, Susana Carolina; Barbeito, Claudio Gustavo; et al.; Photosensitization induced by heterophyllaea pustulata in goats: sequential development of skin lesions; American College of Veterinary Pathologists; Veterinary Pathology; 58; 4-2021; 568-5730300-9858CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/0300985821999322info:eu-repo/semantics/altIdentifier/doi/10.1177/0300985821999322info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:07:07Zoai:ri.conicet.gov.ar:11336/158342instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:07:07.765CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Photosensitization induced by heterophyllaea pustulata in goats: sequential development of skin lesions
title Photosensitization induced by heterophyllaea pustulata in goats: sequential development of skin lesions
spellingShingle Photosensitization induced by heterophyllaea pustulata in goats: sequential development of skin lesions
Micheloud, Juan Francisco
CEGADERA
POISONOUS PLANTS
DERMATITIS
GOATS
title_short Photosensitization induced by heterophyllaea pustulata in goats: sequential development of skin lesions
title_full Photosensitization induced by heterophyllaea pustulata in goats: sequential development of skin lesions
title_fullStr Photosensitization induced by heterophyllaea pustulata in goats: sequential development of skin lesions
title_full_unstemmed Photosensitization induced by heterophyllaea pustulata in goats: sequential development of skin lesions
title_sort Photosensitization induced by heterophyllaea pustulata in goats: sequential development of skin lesions
dc.creator.none.fl_str_mv Micheloud, Juan Francisco
Luján, Lluís
Colque Caro, Luis Adrián
Núñez Montoya, Susana Carolina
Barbeito, Claudio Gustavo
Portiansky, Enrique Leo
Gimeno, Eduardo Juan
author Micheloud, Juan Francisco
author_facet Micheloud, Juan Francisco
Luján, Lluís
Colque Caro, Luis Adrián
Núñez Montoya, Susana Carolina
Barbeito, Claudio Gustavo
Portiansky, Enrique Leo
Gimeno, Eduardo Juan
author_role author
author2 Luján, Lluís
Colque Caro, Luis Adrián
Núñez Montoya, Susana Carolina
Barbeito, Claudio Gustavo
Portiansky, Enrique Leo
Gimeno, Eduardo Juan
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv CEGADERA
POISONOUS PLANTS
DERMATITIS
GOATS
topic CEGADERA
POISONOUS PLANTS
DERMATITIS
GOATS
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Five adult Saanen goats received a single oral dose of Heterophyllaea pustulata containing 42.25 μg/kg rubiadin (anthraquinone). Treated goats, and three adult untreated goats (controls) were exposed to sunlight and sequential ear skin biopsies, collected before treatment, and at 32 h, 3 days, 8 days and 15 days after treatment, were examined. Changes at 32 h after dosing included epidermal spongiosis, single cell death and acantholysis, an increased BAX/BCL-2 protein ratio, and dermal edema. Lesions at day 3 included epidermal and adnexal necrosis, crust formation and acanthosis. Acanthosis, hyperkeratosis, and dermal fibrosis and neovascularization were present at day 15. Pro-apoptotic (BAX)/anti-apoptotic (BCL-2) protein ratio increased at 32 h, whereas epidermal and dermal PCNA immunolabelling increased between days 8 and 15 after treatment. The cutaneous lesions were consistent with sunlight-induced damage and the occurrence in treated but not control goats indicates photosensitization.
Fil: Micheloud, Juan Francisco. Instituto Nacional de Tecnología Agropecuaria; Argentina. Universidad Católica de Salta; Argentina
Fil: Luján, Lluís. Universidad de Zaragoza; España
Fil: Colque Caro, Luis Adrián. Instituto Nacional de Tecnología Agropecuaria; Argentina. Universidad Católica de Salta; Argentina
Fil: Núñez Montoya, Susana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Barbeito, Claudio Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina
Fil: Portiansky, Enrique Leo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina
Fil: Gimeno, Eduardo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina
description Five adult Saanen goats received a single oral dose of Heterophyllaea pustulata containing 42.25 μg/kg rubiadin (anthraquinone). Treated goats, and three adult untreated goats (controls) were exposed to sunlight and sequential ear skin biopsies, collected before treatment, and at 32 h, 3 days, 8 days and 15 days after treatment, were examined. Changes at 32 h after dosing included epidermal spongiosis, single cell death and acantholysis, an increased BAX/BCL-2 protein ratio, and dermal edema. Lesions at day 3 included epidermal and adnexal necrosis, crust formation and acanthosis. Acanthosis, hyperkeratosis, and dermal fibrosis and neovascularization were present at day 15. Pro-apoptotic (BAX)/anti-apoptotic (BCL-2) protein ratio increased at 32 h, whereas epidermal and dermal PCNA immunolabelling increased between days 8 and 15 after treatment. The cutaneous lesions were consistent with sunlight-induced damage and the occurrence in treated but not control goats indicates photosensitization.
publishDate 2021
dc.date.none.fl_str_mv 2021-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/158342
Micheloud, Juan Francisco; Luján, Lluís; Colque Caro, Luis Adrián; Núñez Montoya, Susana Carolina; Barbeito, Claudio Gustavo; et al.; Photosensitization induced by heterophyllaea pustulata in goats: sequential development of skin lesions; American College of Veterinary Pathologists; Veterinary Pathology; 58; 4-2021; 568-573
0300-9858
CONICET Digital
CONICET
url http://hdl.handle.net/11336/158342
identifier_str_mv Micheloud, Juan Francisco; Luján, Lluís; Colque Caro, Luis Adrián; Núñez Montoya, Susana Carolina; Barbeito, Claudio Gustavo; et al.; Photosensitization induced by heterophyllaea pustulata in goats: sequential development of skin lesions; American College of Veterinary Pathologists; Veterinary Pathology; 58; 4-2021; 568-573
0300-9858
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/0300985821999322
info:eu-repo/semantics/altIdentifier/doi/10.1177/0300985821999322
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American College of Veterinary Pathologists
publisher.none.fl_str_mv American College of Veterinary Pathologists
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.885934

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