Quantitative risk assessment of haemolytic uremic syndrome associated with beef consumption in Argentina

Autores
Brusa, Victoria; Costa, Magdalena; Padola, Nora Lía; Etcheverría, Analía Inés; Sampedro, Fernando; Fernandez, Pablo S.; Leotta, Gerardo Anibal; Signorini Porchiett, Marcelo Lisandro
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We developed a quantitative microbiological risk assessment (QMRA) of haemolytic uremic syndrome (HUS) associated with Shiga toxin-producing Escherichia coli (STEC)-contaminated beef (intact beef cuts, ground beef and commercial hamburgers) in children under 15 years of age from Argentina. The QMRA was used to characterize STEC prevalence and concentration levels in each product through the Argentinean beef supply chain, including cattle primary production, cattle transport, processing and storage in the abattoir, retail and home preparation, and consumption. Median HUS probability from beef cut, ground beef and commercial hamburger consumption was <10−15, 5.4x10-8 and 3.5x10-8, respectively. The expected average annual number of HUS cases was 0, 28 and 4, respectively. Risk of infection and HUS probability were sensitive to the type of abattoir, the application or not of Hazard Analysis and Critical Control Points (HACCP) for STEC (HACCP-STEC), stx prevalence in carcasses and trimmings, storage conditions from the abattoir to retailers and home, the joint consumption of salads and beef products, and cooking preference. The QMRA results showed that the probability of HUS was higher if beef cuts (1.7x) and ground beef (1.2x) were from carcasses provided by abattoirs not applying HACCP-STEC. Thus, the use of a single sanitary standard that included the application of HACCP-STEC in all Argentinean abattoirs would greatly reduce HUS incidence. The average number of annual HUS cases estimated by the QMRA (n = 32) would explain about 10.0% of cases in children under 15 years per year in Argentina. Since other routes of contamination can be involved, including those not related to food, further research on the beef production chain, other food chains, person-to-person transmission and outbreak studies should be conducted to reduce the impact of HUS on the child population of Argentina.
EEA Rafaela
Fil: Brusa, Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout"; Argentina
Fil: Brusa, Victoria. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina.
Fil: Costa, Magdalena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout"; Argentina
Fil: Costa, Magdalena. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
Fil: Padola, Nora Lía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Padola, Nora Lía. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Padola, Nora Lía. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Padola, Nora Lía. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Etcheverría, Analía Inés. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Etcheverría, Analía Inés. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Sampedro, Fernando. University of Minnesota. School of Public Health. Environmental Health Sciences Division; Estados Unidos
Fil: Fernandez, Pablo S. Universidad Politécnica de Cartagena. Escuela Técnica Superior de Ingeniería Agronómica; España
Fil: Leotta, Gerardo Anibal. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout"; Argentina
Fil: Leotta, Gerardo Aniba. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
Fil: Signorini, Marcelo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina.
Fil: Signorini, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fuente
PLoS ONE 15 (11) : e0242317. (2020)
Materia
Anemia Hemolítica
Enfermedades Humanas
Evaluación de Riesgos
Carne de Res
Escherichia coli
Haemolytic Anaemia
Human Diseases
Risk Assessment
Beef
Argentina
Síndrome Urémico Hemolítico
Haemolytic Uremic Syndrome
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/9101
Acceder
id INTADig_de46fa3d790beabe124ad7c9ab49585b
oai_identifier_str oai:localhost:20.500.12123/9101
network_acronym_str INTADig
repository_id_str l
network_name_str INTA Digital (INTA)
spelling Quantitative risk assessment of haemolytic uremic syndrome associated with beef consumption in ArgentinaBrusa, VictoriaCosta, MagdalenaPadola, Nora LíaEtcheverría, Analía InésSampedro, FernandoFernandez, Pablo S.Leotta, Gerardo AnibalSignorini Porchiett, Marcelo LisandroAnemia HemolíticaEnfermedades HumanasEvaluación de RiesgosCarne de ResEscherichia coliHaemolytic AnaemiaHuman DiseasesRisk AssessmentBeefArgentinaSíndrome Urémico HemolíticoHaemolytic Uremic SyndromeWe developed a quantitative microbiological risk assessment (QMRA) of haemolytic uremic syndrome (HUS) associated with Shiga toxin-producing Escherichia coli (STEC)-contaminated beef (intact beef cuts, ground beef and commercial hamburgers) in children under 15 years of age from Argentina. The QMRA was used to characterize STEC prevalence and concentration levels in each product through the Argentinean beef supply chain, including cattle primary production, cattle transport, processing and storage in the abattoir, retail and home preparation, and consumption. Median HUS probability from beef cut, ground beef and commercial hamburger consumption was <10−15, 5.4x10-8 and 3.5x10-8, respectively. The expected average annual number of HUS cases was 0, 28 and 4, respectively. Risk of infection and HUS probability were sensitive to the type of abattoir, the application or not of Hazard Analysis and Critical Control Points (HACCP) for STEC (HACCP-STEC), stx prevalence in carcasses and trimmings, storage conditions from the abattoir to retailers and home, the joint consumption of salads and beef products, and cooking preference. The QMRA results showed that the probability of HUS was higher if beef cuts (1.7x) and ground beef (1.2x) were from carcasses provided by abattoirs not applying HACCP-STEC. Thus, the use of a single sanitary standard that included the application of HACCP-STEC in all Argentinean abattoirs would greatly reduce HUS incidence. The average number of annual HUS cases estimated by the QMRA (n = 32) would explain about 10.0% of cases in children under 15 years per year in Argentina. Since other routes of contamination can be involved, including those not related to food, further research on the beef production chain, other food chains, person-to-person transmission and outbreak studies should be conducted to reduce the impact of HUS on the child population of Argentina.EEA RafaelaFil: Brusa, Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout"; ArgentinaFil: Brusa, Victoria. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina.Fil: Costa, Magdalena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout"; ArgentinaFil: Costa, Magdalena. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; ArgentinaFil: Padola, Nora Lía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Padola, Nora Lía. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Padola, Nora Lía. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Padola, Nora Lía. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Etcheverría, Analía Inés. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Etcheverría, Analía Inés. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Sampedro, Fernando. University of Minnesota. School of Public Health. Environmental Health Sciences Division; Estados UnidosFil: Fernandez, Pablo S. Universidad Politécnica de Cartagena. Escuela Técnica Superior de Ingeniería Agronómica; EspañaFil: Leotta, Gerardo Anibal. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout"; ArgentinaFil: Leotta, Gerardo Aniba. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; ArgentinaFil: Signorini, Marcelo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina.Fil: Signorini, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaPlos One2021-04-15T16:26:58Z2021-04-15T16:26:58Z2020-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/9101https://journals.plos.org/plosone/article?id=10.1371/journal.pone.02423171932-6203https://doi.org/10.1371/journal.pone.0242317PLoS ONE 15 (11) : e0242317. (2020)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-29T13:45:11Zoai:localhost:20.500.12123/9101instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:45:11.731INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Quantitative risk assessment of haemolytic uremic syndrome associated with beef consumption in Argentina
title Quantitative risk assessment of haemolytic uremic syndrome associated with beef consumption in Argentina
spellingShingle Quantitative risk assessment of haemolytic uremic syndrome associated with beef consumption in Argentina
Brusa, Victoria
Anemia Hemolítica
Enfermedades Humanas
Evaluación de Riesgos
Carne de Res
Escherichia coli
Haemolytic Anaemia
Human Diseases
Risk Assessment
Beef
Argentina
Síndrome Urémico Hemolítico
Haemolytic Uremic Syndrome
title_short Quantitative risk assessment of haemolytic uremic syndrome associated with beef consumption in Argentina
title_full Quantitative risk assessment of haemolytic uremic syndrome associated with beef consumption in Argentina
title_fullStr Quantitative risk assessment of haemolytic uremic syndrome associated with beef consumption in Argentina
title_full_unstemmed Quantitative risk assessment of haemolytic uremic syndrome associated with beef consumption in Argentina
title_sort Quantitative risk assessment of haemolytic uremic syndrome associated with beef consumption in Argentina
dc.creator.none.fl_str_mv Brusa, Victoria
Costa, Magdalena
Padola, Nora Lía
Etcheverría, Analía Inés
Sampedro, Fernando
Fernandez, Pablo S.
Leotta, Gerardo Anibal
Signorini Porchiett, Marcelo Lisandro
author Brusa, Victoria
author_facet Brusa, Victoria
Costa, Magdalena
Padola, Nora Lía
Etcheverría, Analía Inés
Sampedro, Fernando
Fernandez, Pablo S.
Leotta, Gerardo Anibal
Signorini Porchiett, Marcelo Lisandro
author_role author
author2 Costa, Magdalena
Padola, Nora Lía
Etcheverría, Analía Inés
Sampedro, Fernando
Fernandez, Pablo S.
Leotta, Gerardo Anibal
Signorini Porchiett, Marcelo Lisandro
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Anemia Hemolítica
Enfermedades Humanas
Evaluación de Riesgos
Carne de Res
Escherichia coli
Haemolytic Anaemia
Human Diseases
Risk Assessment
Beef
Argentina
Síndrome Urémico Hemolítico
Haemolytic Uremic Syndrome
topic Anemia Hemolítica
Enfermedades Humanas
Evaluación de Riesgos
Carne de Res
Escherichia coli
Haemolytic Anaemia
Human Diseases
Risk Assessment
Beef
Argentina
Síndrome Urémico Hemolítico
Haemolytic Uremic Syndrome
dc.description.none.fl_txt_mv We developed a quantitative microbiological risk assessment (QMRA) of haemolytic uremic syndrome (HUS) associated with Shiga toxin-producing Escherichia coli (STEC)-contaminated beef (intact beef cuts, ground beef and commercial hamburgers) in children under 15 years of age from Argentina. The QMRA was used to characterize STEC prevalence and concentration levels in each product through the Argentinean beef supply chain, including cattle primary production, cattle transport, processing and storage in the abattoir, retail and home preparation, and consumption. Median HUS probability from beef cut, ground beef and commercial hamburger consumption was <10−15, 5.4x10-8 and 3.5x10-8, respectively. The expected average annual number of HUS cases was 0, 28 and 4, respectively. Risk of infection and HUS probability were sensitive to the type of abattoir, the application or not of Hazard Analysis and Critical Control Points (HACCP) for STEC (HACCP-STEC), stx prevalence in carcasses and trimmings, storage conditions from the abattoir to retailers and home, the joint consumption of salads and beef products, and cooking preference. The QMRA results showed that the probability of HUS was higher if beef cuts (1.7x) and ground beef (1.2x) were from carcasses provided by abattoirs not applying HACCP-STEC. Thus, the use of a single sanitary standard that included the application of HACCP-STEC in all Argentinean abattoirs would greatly reduce HUS incidence. The average number of annual HUS cases estimated by the QMRA (n = 32) would explain about 10.0% of cases in children under 15 years per year in Argentina. Since other routes of contamination can be involved, including those not related to food, further research on the beef production chain, other food chains, person-to-person transmission and outbreak studies should be conducted to reduce the impact of HUS on the child population of Argentina.
EEA Rafaela
Fil: Brusa, Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout"; Argentina
Fil: Brusa, Victoria. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina.
Fil: Costa, Magdalena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout"; Argentina
Fil: Costa, Magdalena. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
Fil: Padola, Nora Lía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Padola, Nora Lía. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Padola, Nora Lía. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Padola, Nora Lía. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Etcheverría, Analía Inés. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Etcheverría, Analía Inés. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Sampedro, Fernando. University of Minnesota. School of Public Health. Environmental Health Sciences Division; Estados Unidos
Fil: Fernandez, Pablo S. Universidad Politécnica de Cartagena. Escuela Técnica Superior de Ingeniería Agronómica; España
Fil: Leotta, Gerardo Anibal. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout"; Argentina
Fil: Leotta, Gerardo Aniba. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
Fil: Signorini, Marcelo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina.
Fil: Signorini, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description We developed a quantitative microbiological risk assessment (QMRA) of haemolytic uremic syndrome (HUS) associated with Shiga toxin-producing Escherichia coli (STEC)-contaminated beef (intact beef cuts, ground beef and commercial hamburgers) in children under 15 years of age from Argentina. The QMRA was used to characterize STEC prevalence and concentration levels in each product through the Argentinean beef supply chain, including cattle primary production, cattle transport, processing and storage in the abattoir, retail and home preparation, and consumption. Median HUS probability from beef cut, ground beef and commercial hamburger consumption was <10−15, 5.4x10-8 and 3.5x10-8, respectively. The expected average annual number of HUS cases was 0, 28 and 4, respectively. Risk of infection and HUS probability were sensitive to the type of abattoir, the application or not of Hazard Analysis and Critical Control Points (HACCP) for STEC (HACCP-STEC), stx prevalence in carcasses and trimmings, storage conditions from the abattoir to retailers and home, the joint consumption of salads and beef products, and cooking preference. The QMRA results showed that the probability of HUS was higher if beef cuts (1.7x) and ground beef (1.2x) were from carcasses provided by abattoirs not applying HACCP-STEC. Thus, the use of a single sanitary standard that included the application of HACCP-STEC in all Argentinean abattoirs would greatly reduce HUS incidence. The average number of annual HUS cases estimated by the QMRA (n = 32) would explain about 10.0% of cases in children under 15 years per year in Argentina. Since other routes of contamination can be involved, including those not related to food, further research on the beef production chain, other food chains, person-to-person transmission and outbreak studies should be conducted to reduce the impact of HUS on the child population of Argentina.
publishDate 2020
dc.date.none.fl_str_mv 2020-11
2021-04-15T16:26:58Z
2021-04-15T16:26:58Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/9101
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0242317
1932-6203
https://doi.org/10.1371/journal.pone.0242317
url http://hdl.handle.net/20.500.12123/9101
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0242317
https://doi.org/10.1371/journal.pone.0242317
identifier_str_mv 1932-6203
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language eng
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rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Plos One
publisher.none.fl_str_mv Plos One
dc.source.none.fl_str_mv PLoS ONE 15 (11) : e0242317. (2020)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
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