Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells

Autores
Toscani, Andrés Martin; Aguilera, Pablo Nicolás; Coluccio Leskow, Federico
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The ErbB2 receptor tyrosine kinase plays a key role in mammary gland development. It forms large clusters which serve as signaling platforms for integration of extracellular information. The discoidin domain receptor (DDR) family are collagen receptor tyrosine kinases which, together with ErbB2, are involved in many physiological and pathological processes. Here, we investigated the interaction of ErbB2 and DDR1 receptors in breast cancer cells. In contrast to beta1-integrin, DDR1 colocalizes with ErbB2 in membrane clusters regardless of their expression levels. We demonstrated that this spatial coexistence is a consequence of the physical interaction between these receptors. In addition, these receptors are coexpressed in the normal mammary gland but not in breast tumor samples. Together, these results present DDR1 as a novel modulator of the ErbB2/ErbB3 signaling pathway.
Instituto de Biotecnología
Fil: Toscani, Andrés Martin. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN); Argentina
Fil: Toscani, Andrés Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aguilera, Pablo Nicolás. Universidad Nacional de Luján. Departamento de Ciencias Básicas; Argentina
Fil: Aguilera, Pablo Nicolás. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Aguilera, Pablo Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Coluccio Leskow, Federico. Universidad Nacional de Luján. Departamento de Ciencias Básicas; Argentina
Fuente
FEBS Letters 596 (21) : 2795-2807 (November 2022)
Materia
Mammary Glands
Genetics
Glándulas Mamarias
Genética
Epithelial Cells
Discoidin Domain Receptor
Células Epiteliales
Receptor del Dominio Discoidina
Nivel de accesibilidad
acceso restringido
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/16601
Acceder
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oai_identifier_str oai:localhost:20.500.12123/16601
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network_name_str INTA Digital (INTA)
spelling Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cellsToscani, Andrés MartinAguilera, Pablo NicolásColuccio Leskow, FedericoMammary GlandsGeneticsGlándulas MamariasGenéticaEpithelial CellsDiscoidin Domain ReceptorCélulas EpitelialesReceptor del Dominio DiscoidinaThe ErbB2 receptor tyrosine kinase plays a key role in mammary gland development. It forms large clusters which serve as signaling platforms for integration of extracellular information. The discoidin domain receptor (DDR) family are collagen receptor tyrosine kinases which, together with ErbB2, are involved in many physiological and pathological processes. Here, we investigated the interaction of ErbB2 and DDR1 receptors in breast cancer cells. In contrast to beta1-integrin, DDR1 colocalizes with ErbB2 in membrane clusters regardless of their expression levels. We demonstrated that this spatial coexistence is a consequence of the physical interaction between these receptors. In addition, these receptors are coexpressed in the normal mammary gland but not in breast tumor samples. Together, these results present DDR1 as a novel modulator of the ErbB2/ErbB3 signaling pathway.Instituto de BiotecnologíaFil: Toscani, Andrés Martin. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN); ArgentinaFil: Toscani, Andrés Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Aguilera, Pablo Nicolás. Universidad Nacional de Luján. Departamento de Ciencias Básicas; ArgentinaFil: Aguilera, Pablo Nicolás. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; ArgentinaFil: Aguilera, Pablo Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Coluccio Leskow, Federico. Universidad Nacional de Luján. Departamento de Ciencias Básicas; ArgentinaWiley2024-02-14T15:04:08Z2024-02-14T15:04:08Z2022-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/16601https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.145221873-3468https://doi.org/10.1002/1873-3468.14522FEBS Letters 596 (21) : 2795-2807 (November 2022)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-04T09:50:11Zoai:localhost:20.500.12123/16601instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:50:11.924INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells
title Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells
spellingShingle Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells
Toscani, Andrés Martin
Mammary Glands
Genetics
Glándulas Mamarias
Genética
Epithelial Cells
Discoidin Domain Receptor
Células Epiteliales
Receptor del Dominio Discoidina
title_short Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells
title_full Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells
title_fullStr Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells
title_full_unstemmed Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells
title_sort Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells
dc.creator.none.fl_str_mv Toscani, Andrés Martin
Aguilera, Pablo Nicolás
Coluccio Leskow, Federico
author Toscani, Andrés Martin
author_facet Toscani, Andrés Martin
Aguilera, Pablo Nicolás
Coluccio Leskow, Federico
author_role author
author2 Aguilera, Pablo Nicolás
Coluccio Leskow, Federico
author2_role author
author
dc.subject.none.fl_str_mv Mammary Glands
Genetics
Glándulas Mamarias
Genética
Epithelial Cells
Discoidin Domain Receptor
Células Epiteliales
Receptor del Dominio Discoidina
topic Mammary Glands
Genetics
Glándulas Mamarias
Genética
Epithelial Cells
Discoidin Domain Receptor
Células Epiteliales
Receptor del Dominio Discoidina
dc.description.none.fl_txt_mv The ErbB2 receptor tyrosine kinase plays a key role in mammary gland development. It forms large clusters which serve as signaling platforms for integration of extracellular information. The discoidin domain receptor (DDR) family are collagen receptor tyrosine kinases which, together with ErbB2, are involved in many physiological and pathological processes. Here, we investigated the interaction of ErbB2 and DDR1 receptors in breast cancer cells. In contrast to beta1-integrin, DDR1 colocalizes with ErbB2 in membrane clusters regardless of their expression levels. We demonstrated that this spatial coexistence is a consequence of the physical interaction between these receptors. In addition, these receptors are coexpressed in the normal mammary gland but not in breast tumor samples. Together, these results present DDR1 as a novel modulator of the ErbB2/ErbB3 signaling pathway.
Instituto de Biotecnología
Fil: Toscani, Andrés Martin. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN); Argentina
Fil: Toscani, Andrés Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aguilera, Pablo Nicolás. Universidad Nacional de Luján. Departamento de Ciencias Básicas; Argentina
Fil: Aguilera, Pablo Nicolás. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Aguilera, Pablo Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Coluccio Leskow, Federico. Universidad Nacional de Luján. Departamento de Ciencias Básicas; Argentina
description The ErbB2 receptor tyrosine kinase plays a key role in mammary gland development. It forms large clusters which serve as signaling platforms for integration of extracellular information. The discoidin domain receptor (DDR) family are collagen receptor tyrosine kinases which, together with ErbB2, are involved in many physiological and pathological processes. Here, we investigated the interaction of ErbB2 and DDR1 receptors in breast cancer cells. In contrast to beta1-integrin, DDR1 colocalizes with ErbB2 in membrane clusters regardless of their expression levels. We demonstrated that this spatial coexistence is a consequence of the physical interaction between these receptors. In addition, these receptors are coexpressed in the normal mammary gland but not in breast tumor samples. Together, these results present DDR1 as a novel modulator of the ErbB2/ErbB3 signaling pathway.
publishDate 2022
dc.date.none.fl_str_mv 2022-11
2024-02-14T15:04:08Z
2024-02-14T15:04:08Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/16601
https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.14522
1873-3468
https://doi.org/10.1002/1873-3468.14522
url http://hdl.handle.net/20.500.12123/16601
https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.14522
https://doi.org/10.1002/1873-3468.14522
identifier_str_mv 1873-3468
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv restrictedAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv FEBS Letters 596 (21) : 2795-2807 (November 2022)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.623145

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